journal
Journals Biochemical and Biophysical Re...

Biochemical and Biophysical Research Communications

https://read.qxmd.com/read/37290280/potential-direct-role-of-synuclein-in-dopamine-transport-and-its-implications-for-parkinson-s-disease-pathogenesis
#1
JOURNAL ARTICLE
Meewhi Kim, Ilya Bezprozvanny
Parkinson Disease (PD) is a progressive neurodegenerative disorder that is caused by dysfunction and death of dopaminergic neurons. Mutations in the gene encoding α-synuclein (ASYN) have been linked with familial PD (FPD). Despite important role of ASYN in PD pathology, its normal biological function has not been clarified, although direct action of ASYN in synaptic transmission and dopamine (DA+ ) release have been proposed. In the present report we propose a novel hypothesis that ASYN functions as DA+ /H+ exchanger that can facilitate transport of dopamine across synaptic vesicle (SV) membrane by taking advantage of proton gradient between SV lumen and cytoplasm...
June 6, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37290278/pvt1-alleviates-hypoxia-induced-endothelial-apoptosis-by-enhancing-autophagy-via-the-mir-15b-5p-atg14-and-mir-424-5p-atg14-axis
#2
JOURNAL ARTICLE
Ping Zhang, Shenghui Gong, Shuoshuo Li, Zengqiang Yuan
Endothelial dysfunction plays a crucial role in the pathogenesis of vascular disease. Long noncoding RNA (lncRNA) and microRNA (miRNA) play important roles in various cellular processes and are involved in several vascular endothelial cells (VECs) biological processes, including cell growth, migration, autophagy, and apoptosis. The functions of plasmacytoma variant translocation 1 (PVT1) in VECs have been progressively investigated in recent years, mainly with regard to proliferation and migration of endothelial cells (ECs)...
June 1, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37285721/pioglitazone-treatment-increases-the-cellular-acid-labile-and-protein-bound-sulfane-sulfur-fractions
#3
JOURNAL ARTICLE
Mohammad Z Islam, Rodney E Shackelford
BACKGROUND: Iron-sulfur clusters play a central role in cellular function and are regulated by the ATM protein. Iron-sulfur clusters are part of the cellular sulfide pool, which functions to maintain cardiovascular health, and consists of free hydrogen sulfide, iron-sulfur clusters, protein bound sulfides, which constitute the total cellular sulfide fraction. ATM protein signaling and the drug pioglitazone share some cellular effects, which led us to examine the effects of this drug on cellular iron-sulfur cluster formation...
June 1, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37276792/mt1m-regulates-gastric-cancer-progression-and-stemness-by-modulating-the-hedgehog-pathway-protein-gli1
#4
JOURNAL ARTICLE
Kai Li, Shuyang Sun, Yixun Lu, Wenquan Liang, Xinxin Xu, Huan Zhang, Zhengyao Chang, Chuang Wang, Yunhe Gao, Lin Chen
Gastric cancer (GC) is a highly prevalent and aggressive malignancy with a poor prognosis. Recent evidence suggested that metallothionein 1 M (MT1M) may play a critical role in cancer development, progression, and drug resistance; however, its role in GC remains largely unknown. In this study, we investigated the expression and function of MT1M in GC both in vitro and in vivo. We found that MT1M expression was significantly downregulated in GC tissues and cell lines. Decreased expression of MT1M was associated with worse clinical prognosis, particularly in patients treated with 5-fluorouracil...
June 1, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37290284/preliminary-studies-on-intimal-injury-related-to-stent-retrieval-in-a-canine-model
#5
JOURNAL ARTICLE
Cong Li, Houliang Chen, Minghong Wang, Shujie Zhang, Yujuan Jiang, Zhihong Xian, Cuiqin Shen, Jingzhen Guo, Chengli Song, Hui Gong, Nan Ye, Xue Zhao
OBJECTIVE: This pilot study aimed to observe intimal injuries related to stent retrieval in the iliac artery of a canine. BACKGROUND: In-stent restenosis remains challenging owing to permanent stent implantation. A retrievable stent may be alternative for intervention without permanent residue. METHODS: Five retrievable stents with point-to-point overlapped double-layer scaffolds were deployed into the iliac arteries and retrieved on days 14, 21, 28, 35, and 42 from five canines...
May 31, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37290281/mechanisms-underlying-the-therapeutic-effects-of-isoflavones-isolated-from-chickpea-sprouts-in-treating-osteoporosis-based-on-network-pharmacology
#6
JOURNAL ARTICLE
Jinyong Huang, Xin Wang, Jingjie Zheng, Qiyu Jia, Xi Wang, Zengru Xie, Hairong Ma
Osteoporosis is a systemic bone disease that is caused by multiple factors that lead to an imbalance in bone metabolism. Isoflavones can prevent and treat osteoporosis by regulating bone metabolism through a variety of pathways. The germination of chickpeas can significantly increase their isoflavone contents. However, the use of isoflavones isolated from chickpea sprouts (ICS) to prevent and treat osteoporosis by regulating bone metabolism has not been widely studied. In vivo experimental studies in ovariectomized rats showed that ICS significantly improved femoral bone mineral density (BMD) and trabecular structure, with effects similar to raloxifene...
May 29, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37271037/nicotinamide-mononucleotide-improves-the-alzheimer-s-disease-by-regulating-intestinal-microbiota
#7
JOURNAL ARTICLE
Xiaodong Zhao, Mengmeng Kong, Yilin Wang, Yingxin Mao, Huilian Xu, Wenxing He, Yan He, Jinsong Gu
Alzheimer's disease (AD) is the most common progressive neurodegenerative disease, and the intestinal flora and its metabolites play an important role in the amelioration of central nervous system (CNS) disorders such as AD through a bidirectional interaction between the gut-brain axis (GBA). Nicotinamide mononucleotide (NMN), one of the precursors for nicotinamide adenine dinucleotide (NAD+ ) synthesis, reduces the brain features of AD, including neuroinflammation, mitochondrial abnormalities, synaptic dysfunction, and cognitive impairment...
May 29, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37271034/mesp1-knockdown-inhibits-the-proliferation-and-epithelial-mesenchymal-transition-of-hepatocellular-carcinoma-and-enhances-the-tumor-suppressive-effect-of-5-fluorouracil
#8
JOURNAL ARTICLE
Shuqin Ji, Man Xu, Chenyu Cai, Xinyue He
Primary liver hepatocellular carcinoma (HCC) is the third most deadly malignancy worldwide,in part, because it is often diagnosed at an advanced stage. Thus, molecular markers are needed to aid in the early diagnosis and treatment of HCC. Expression of abnormal mesoderm posterior-1 (MESP1) promotes tumorigenesis; however,its role in the regulation of HCC proliferation, apoptosis,and invasion is unknown. Here,we analyzed data in The Cancer Genome Atlas (TCGA)and Genotype Tissue Expression (GTEx) databases on the pan-cancer expression of MESP1 and its relationship with clinical characteristics and prognosis of patients with HCC...
May 29, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37276791/p38-mapk-inhibitor-sb203580-enhances-anticancer-activity-of-parp-inhibitor-olaparib-in-a-synergistic-way-on-non-small-cell-lung-carcinoma-a549%C3%A2-cells
#9
JOURNAL ARTICLE
Payel Dey, Soumyajit Biswas, Rima Das, Sandipan Chatterjee, Utpal Ghosh
The Poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) olaparib gives promising results against various types of cancers in clinical trials. The combination of drugs always increases therapeutic efficacy because of targeting multiple pathways of cancer progression. Our objective was to explore the potential synergistic anticancer activities of olaparib combined with p38 MAPK inhibitor (MAPKi) SB203580 on non-small cell lung carcinoma (NSCLC) A549 cells. The effects of the individual compound and their combination on cell survival, DNA damage as detected by γH2AX foci, expression of key proteins in Homologous Recombination (HR) and Non-Homologous End Joining (NHEJ) repair, caspase 3 activation, nuclear fragmentation and telomerase regulation were studied in A549 cells...
May 27, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37276790/investigating-membrane-binding-properties-of-lipoxygenases-using-surface-plasmon-resonance
#10
JOURNAL ARTICLE
Denise L Rohlik, Ethan Patel, Nathaniel C Gilbert, Adam R Offenbacher, Brandon L Garcia
Lipoxygenases (LOXs) catalyze the oxidation of polyunsaturated fatty acids and synthesize oxylipin products that drive important cellular signaling processes in plants and animals. While there has been indirect evidence presented for the interaction of mammalian LOXs with membranes, a quantitative study of the molecular details of LOX-membrane interactions is lacking. Here, we mimicked biological membranes using surface plasmon resonance (SPR) sensor chips derivatized with 2-D planar lipophilic anchors (2D LP) to capture liposomes of varying phospholipid compositions that self-assemble into lipid bilayers on the SPR chip...
May 27, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37271035/cardiomyopathy-associated-variants-alter-the-structure-and-function-of-the-%C3%AE-actinin-2-actin-binding-domain
#11
JOURNAL ARTICLE
Alexandra E Atang, Robyn T Rebbeck, David D Thomas, Adam W Avery
Hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM) are characterized by thickening, thinning, or stiffening, respectively, of the ventricular myocardium, resulting in diastolic or systolic dysfunction that can lead to heart failure and sudden cardiac death. Recently, variants in the ACTN2 gene, encoding the protein α-actinin-2, have been reported in HCM, DCM, and RCM patients. However, functional data supporting the pathogenicity of these variants is limited, and potential mechanisms by which these variants cause disease are largely unexplored...
May 27, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37269595/outcomes-of-pregnancy-in-mice-with-pulmonary-hypertension-induced-by-hypoxia-su5416
#12
JOURNAL ARTICLE
Yang Liu, Jing Deng, Yichen Zhao, Kemin Liu, Wenbo Zhang, Qiang Wang, Jiangang Wang, Chunmei Piao
BACKGROUND: Pulmonary hypertension (PH) seriously affects the health of patients. We have found in clinical studies that PH has adverse effects on both maternal and offspring. OBJECTIVE: To establish a animal model of PH induced by hypoxia/SU5416 and observe the effects of PH on pregnant mice and their fetuses. METHODS: Twenty-four C57 mice aged 7-9 weeks were selected and divided into 4 groups with 6 mice in each group. ① Female mice with normal oxygen; ② Female mice with hypoxia/SU5416; ③ Pregnant mice with normal oxygen; ④ Pregnant mice with hypoxia/SU5416...
May 27, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37269592/traf6-signaling-in-dendritic-cells-plays-protective-role-against-infectious-colitis-by-limiting-c-%C3%A2-rodentium-infection-through-the-induction-of-th1-and-th17-responses
#13
JOURNAL ARTICLE
Thanyakorn Chalalai, Naganori Kamiyama, Benjawan Saechue, Nozomi Sachi, Sotaro Ozaka, Shimpei Ariki, Astri Dewayani, Yasuhiro Soga, Yomei Kagoshima, Supanuch Ekronarongchai, Ryu Okumura, Hisako Kayama, Kiyoshi Takeda, Takashi Kobayashi
Tumor necrosis factor receptor-associated factor 6 (TRAF6) plays a pivotal role in the induction of inflammatory responses not only in innate immune cells but also in non-immune cells, leading to the activation of adaptive immunity. Signal transduction mediated by TRAF6, along with its upstream molecule MyD88 in intestinal epithelial cells (IECs) is crucial for the maintenance of mucosal homeostasis following inflammatory insult. The IEC-specific TRAF6-deficient (TRAF6ΔIEC) and MyD88-deficient (MyD88ΔIEC) mice exhibit increased susceptibility to DSS-induced colitis, emphasizing the critical role of this pathway...
May 27, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37290287/the-role-of-protein-phosphatase-2a-pp2a-in-the-unfolded-protein-response-upr-of-plants
#14
JOURNAL ARTICLE
Ki Seong Ko, Jae Yong Yoo, Bich Ngoc Vu, Young Eun Lee, Ha Na Choi, Yoo Na Lee, Wahyu Indra Duwi Fanata, Rikno Harmoko, Woo Sik Chung, Jong Chan Hong, Kyun Oh Lee
Protein phosphatase 2A (PP2A) is a key regulator of plant growth and development, but its role in the endoplasmic reticulum (ER) stress response remains elusive. In this study, we investigated the function of PP2A under ER stress using loss-of-function mutants of ROOTS CURL of NAPHTHYLPHTHALAMIC ACID1 (RCN1), a regulatory A1 subunit isoform of Arabidopsis PP2A. RCN1 mutants (rcn1-1 and rcn1-2) exhibited reduced sensitivity to tunicamycin (TM), an inhibitor of N-linked glycosylation and inducer of unfolded protein response (UPR) gene expression, resulting in less severe effects compared to wild-type plants (Ws-2 and Col-0)...
May 26, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37290285/yap-nuclear-translocation-facilitates-radiation-resistance-in-nasopharyngeal-carcinoma-cells
#15
JOURNAL ARTICLE
Feifei Li, Xinhao Peng, Linlin Zheng, Yiqiang Liu, Qianshi Liu, Biqin Zhang, Ying Shi, Hong Wu, Chuan Xu
OBJECTIVES: Investigate the role of the Hippo-YAP signaling pathway in radioresistant Nasopharyngeal Carcinoma (NPC). METHODS: Establishment of radioresistant CNE-1 cells (CNE-1-RR) by gradually increasing ionizing radiation (IR) doses, and identifying the apoptosis of CNE-1-RR by flow cytometry. We employed immunoblot and immunofluorescence staining to detect the expression of YAP in both CNE-1-RR and control group cells. Moreover, we validated the role of YAP in CNE-1-RR by inhibiting its nuclear translocation...
May 26, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37285722/identification-of-a-novel-klhl3-interacting-motif-in-the-c-terminal-region-of-wnk4
#16
JOURNAL ARTICLE
Lingyun Wang, Guojin Wu, Ji-Bin Peng
Mutations in with-no-lysine [K] kinase 4 (WNK4) and kelch-like 3 (KLHL3) are linked to pseudohypoaldosteronism type 2 (PHAII, also known as familial hyperkalemic hypertension or Gordon's syndrome). WNK4 is degraded by a ubiquitin E3 ligase with KLHL3 as the substrate adaptor for WNK4. Several PHAII-causing mutations, e.g. those in the acidic motif (AM) of WNK4 and in the Kelch domain of KLHL3, impair the binding between WNK4 and KLHL3. This results in a reduction in WNK4 degradation and an increase in WNK4 activity, leading to PHAII...
May 26, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37285720/crystal-structure-of-the-3-ketodihydrosphingosine-reductase-tsc10-from-cryptococcus-neoformans
#17
JOURNAL ARTICLE
Panqi Zhao, Zewen Zhuang, Xueyan Guan, Jinjin Yang, Weiwei Wang, Zhihe Kuang
The second step in the de novo sphingolipid biosynthesis is the reduction of 3-ketodihydrosphingosine by 3-ketodihydrosphingosine reductase (KDSR) to produce dihydrosphingosine (sphinganine). Fungal TSC10 and mammalian KDSR (also named FVT-1) proteins are the enzymes responsible for this process and they belong to the short-chain dehydrogenase/reductase (SDR) superfamily. Albeit that both fungal and mammalian 3-ketodihydrosphingosine reductases were identified more than a decade ago, no structure of these enzymes from any species has been experimentally determined...
May 26, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37271038/rhoj-as-a-novel-mechanosensitive-modulator-of-endothelial-inflammation
#18
JOURNAL ARTICLE
WenQiang Liu, Yue Zeng, LiHan Huang, XiaoZhe Zhang, LianRu Bi, WenDong Fan, GuiFu Wu
Physiological high shear stress (HSS), a frictional force generated by flowing blood, is essential for endothelial homeostasis under normal physiological conditions. HSS suppresses atherosclerosis by inhibiting endothelial inflammation. However, the molecular mechanisms underlying this process have not been fully elucidated. Here, we report that HSS downregulated the mRNA and protein levels of ras homolog family member J (RHOJ) in endothelial cells (ECs). Silencing endogenous RHOJ expression decreased the mRNA and protein levels of proinflammatory vascular cell adhesion molecule 1 (VCAM-1) and intercellular cell adhesion molecule 1 (ICAM-1) in ECs, leading to a reduction in monocyte adhesion to ECs...
May 26, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37271036/diamide-insecticides-targeting-insect-ryanodine-receptors-mechanism-and-application-prospect
#19
JOURNAL ARTICLE
Juan Du, Yuejun Fu
As a Lepidoptera pest, Spodoptera frugiperda has become one of the major migratory pests causing significant damage to crops. It should prevent and control Spodoptera frugiperda with strong reproductive ability, adaptability, and migration ability, and reduce economic losses as much as possible. Chemical insecticides are mainly used in the emergency control of Spodoptera frugiperda. Diamide insecticide is a kind of pesticide that specifically targets the ryanodine receptor of Lepidopteran pests, which makes it safe, effective, targeted, and low toxicity to mammals...
May 26, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37271026/efficient-generation-of-tbx3-atrioventricular-conduction-like-cardiomyocytes-from-human-pluripotent-stem-cells
#20
JOURNAL ARTICLE
Rulong Du, Shuyun Bai, Ya Zhao, Yue Ma
Atrioventricular conduction cardiomyocytes (AVCCs) regulate the rate and rhythm of heart contractions. Dysfunction due to aging or disease can cause atrioventricular (AV) block, interrupting electrical impulses from the atria to the ventricles. Generation of functional atrioventricular conduction like cardiomyocytes (AVCLCs) from human pluripotent stem cells (hPSCs) provides a promising approach to repair damaged atrioventricular conduction tissue by cell transplantation. In this study, we put forward the generation of AVCLCs from hPSCs by stage-specific manipulation of the retinoic acid (RA), WNT, and bone morphogenetic protein (BMP) signaling pathways...
May 26, 2023: Biochemical and Biophysical Research Communications
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