Ki Seong Ko, Jae Yong Yoo, Bich Ngoc Vu, Young Eun Lee, Ha Na Choi, Yoo Na Lee, Wahyu Indra Duwi Fanata, Rikno Harmoko, Woo Sik Chung, Jong Chan Hong, Kyun Oh Lee
Protein phosphatase 2A (PP2A) is a key regulator of plant growth and development, but its role in the endoplasmic reticulum (ER) stress response remains elusive. In this study, we investigated the function of PP2A under ER stress using loss-of-function mutants of ROOTS CURL of NAPHTHYLPHTHALAMIC ACID1 (RCN1), a regulatory A1 subunit isoform of Arabidopsis PP2A. RCN1 mutants (rcn1-1 and rcn1-2) exhibited reduced sensitivity to tunicamycin (TM), an inhibitor of N-linked glycosylation and inducer of unfolded protein response (UPR) gene expression, resulting in less severe effects compared to wild-type plants (Ws-2 and Col-0)...
May 26, 2023: Biochemical and Biophysical Research Communications