Chen Xing, Bing Zhai, Yifan Zhang, Ying Fang, Min Zhang, Chongchong Zhang, Wei Wang, Mengnan Ding, Xin Huang, Beifen Shen, Renxi Wang, Lun Song
Sleep deprivation (SD) weakens the immune system and leads to increased susceptibility to infectious or inflammatory diseases. However, it is still unclear how SD affects humoral immunity. In the present study, sleep disturbance was conducted using an sleep deprivation instrument, and the bacterial endotoxin lipopolysaccharide (LPS) was used to activate the immune response. It was found that SD-pretreatment reduced LPS-induced IgG2b+ B cells and IgG2b isotype antibody production in lymphocytes of spleen. And, SD-pretreatment decreased the proportion of CD4+ T cells, production of CD4+ T cells derived TGF-β1 and its contribution in helping IgG2b production...
November 25, 2023: Biochemical and Biophysical Research Communications