JOURNAL ARTICLE
RANDOMIZED CONTROLLED TRIAL

Vitamin D levels and menopause-related symptoms

Erin S LeBlanc, Manisha Desai, Nancy Perrin, Jean Wactawski-Wende, JoAnn E Manson, Jane A Cauley, Yvonne L Michael, Jean Tang, Catherine Womack, Yiqing Song, Karen C Johnson, Mary J O'Sullivan, Nancy Woods, Marcia L Stefanick
Menopause: the Journal of the North American Menopause Society 2014, 21 (11): 1197-203
24736200

OBJECTIVE: This study aims to determine whether vitamin D levels are associated with menopause-related symptoms in older women.

METHODS: A randomly selected subset of 1,407 women, among 26,104 potentially eligible participants of the Women's Health Initiative Calcium and Vitamin D trial of postmenopausal women aged 51 to 80 years, had 25-hydroxyvitamin D [25(OH)D] levels measured at the Women's Health Initiative Calcium and Vitamin D trial baseline visit. Information about menopause-related symptoms at baseline was obtained by questionnaire and included overall number of symptoms and composite measures of sleep disturbance, emotional well-being, and energy/fatigue, as well as individual symptoms. After exclusions for missing data, 530 women (mean [SD] age, 66.2 [6.8] y) were included in these analyses.

RESULTS: Borderline significant associations between 25(OH)D levels and total number of menopausal symptoms were observed (with P values ranging from 0.05 to 0.06 for fully adjusted models); however, the effect was clinically insignificant and disappeared with correction for multiple testing. No associations between 25(OH)D levels and composite measures of sleep disturbance, emotional well-being, or energy/fatigue were observed (P's > 0.10 for fully adjusted models).

CONCLUSIONS: There is no evidence for a clinically important association between serum 25(OH)D levels and menopause-related symptoms in postmenopausal women.

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