Rita Peila, Xiaonan Xue, Michael J LaMonte, Aladdin H Shadyab, Jean Wactawski-Wende, Su Yon Jung, Karen C Johnson, Mace Coday, Phyllis Richey, Charles P Mouton, Nazums Saquib, Rowan T Chlebowski, Kathy Pan, Yvonne L Michael, Meryl S LeBoff, JoAnn E Manson, Thomas E Rohan
OBJECTIVE: The menopausal transition results in a progressive decrease in circulating estrogen levels. Experimental evidence in rodents has indicated that estrogen depletion leads to a reduction of energy expenditure and physical activity. It is unclear whether treatment with estrogen therapy increases physical activity level in postmenopausal women. METHODS: A total of 27,327 postmenopausal women aged 50-79 years enrolled in the Women's Health Initiative randomized double-blind trials of menopausal hormone therapy...
August 1, 2023: Menopause: the Journal of the North American Menopause Society