Family history of coronary heart disease is more strongly associated with coronary than with carotid atherosclerosis in healthy asymptomatic adults

Beomseok Suh, Dong Wook Shin, Seung-Pyo Lee, Haewon Lee, Hyejin Lee, Eun-Ah Park, BeLong Cho
Atherosclerosis 2014, 233 (2): 584-9

OBJECTIVE: To investigate the potentially different relationship between family history (FH) of coronary heart disease (CHD) and carotid or coronary atherosclerosis.

METHODS: Asymptomatic healthy Korean adults older than 30 years who received both coronary CTA and carotid USG as part of a self-referred health check-up were retrospectively investigated (N=662). Multivariable logistic regression analysis was employed to investigate the relationship between FH of CHD and either coronary CTA or carotid USG results.

RESULTS: Adjusted for major CVD risk factors, FH of CHD was significantly associated with presence of any plaque in coronary arteries (aOR 2.10, 95% CI 1.07-4.16) and significant coronary stenosis (aOR 4.92, 95% CI 1.58-15.4), but was not associated with presence of any plaque in carotid arteries (aOR 1.27, 95% CI 0.61-2.63) and increased carotid IMT (aOR 1.44, 95% CI 0.40-5.22). Addition of FH of CHD had significant incremental predictive value to models for any coronary plaque (AUC 0.781 vs. 0.786, p=0.0351), and significant coronary stenosis (AUC 0.772 vs. 0.808, p=0.0129), but not for any carotid plaque (AUC 0.748 vs. 0.748, p=0.528), and increased carotid IMT (AUC 0.778 vs. 0.783, p=0.591).

CONCLUSION: To our knowledge, our study is the first to show specific comparative evidence that FH of CHD is more strongly associated with coronary than with carotid atherosclerosis. Our results suggest FH of CHD adds predictive value specifically to coronary atherosclerosis, but not carotid atherosclerosis, and suggest the possibility that screening for coronary atherosclerosis (via CAC) among low to intermediate risk asymptomatic adults with FH of CHD may be beneficial, who otherwise would not be screened according to traditional risk algorithms.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"