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Jun-Jun Yeh, Cheng-Li Lin, Chung Y Hsu, Zonyin Shae, Chia-Hung Kao
BACKGOUND AND AIMS: We aimed at determining the effects of statin use on coronary artery disease (CAD) and stroke risks in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS). METHODS: We retrospectively enrolled patients with ACOS treated with (N = 916) and without (N = 6338) statins. The cumulative incidence of CAD and stroke (ischemic and hemorrhagic) was analyzed through time-dependent Cox proportional regression. After adjustment for sex, age, comorbidities, inhaled corticosteroid steroid (ICS) use, and oral steroid (OS) use, we calculated the adjusted hazard ratios (aHRs) and their 95% confidence intervals (CIs) for CAD or stroke in the statin users (long-term [>600 days] and short-term [≤600 days]) compared with the non-users...
February 11, 2019: Atherosclerosis
Francisco Blanco-Vaca, Jesús M Martin-Campos, Ángel Beteta-Vicente, Marina Canyelles, Susana Martínez, Rosa Roig, Núria Farré, Josep Julve, Mireia Tondo
BACKGROUND AND AIMS: Primary hypobetalipoproteinemia is generally considered a heterogenic group of monogenic, inherited lipoprotein disorders characterized by low concentrations of LDL cholesterol and apolipoprotein B in plasma. Lipoprotein disorders include abetalipoproteinemia, familial hypobetalipoproteinemia, chylomicron retention disease, and familial combined hypolipidemia. Our aim was to review and analyze the results of the molecular analysis of hypolipidemic patients studied in our laboratory over the last 15 years...
February 11, 2019: Atherosclerosis
Zihou Liu, Shunjun Wang, Yongqiang Wang, Ningbo Zhou, Jie Shu, Christof Stamm, Meng Jiang, Fanyan Luo
BACKGROUND AND AIMS: Density may indicate some tissue characteristics and help reveal the role of epicardial adipose tissue (EAT) in coronary artery disease (CAD). Therefore, we assessed the association of EAT density with the coronary artery plaque burden in patients presenting with chest pain. METHODS: This retrospective cohort study comprised 614 patients (mean age 61 ± 9 years, 61% males) with a high cardiovascular disease risk, who underwent cardiac computed tomography angiography...
February 6, 2019: Atherosclerosis
In-Hwan Oh, Junho K Hur, Jae-Hong Ryoo, Ju Young Jung, Sung Keun Park, Hong Jun Yang, Joong-Myung Choi, Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh
BACKGROUND AND AIMS: Our study aimed to investigate the association between high-density lipoprotein cholesterol (HDL-C) and all-cause and cause-specific mortality in Korean adults. METHODS: A total of 365,457 participants aged ≥40 years were selected from the Korean National Health Insurance Service-National Sample Cohort from 2009 to 2015. HDL-C level was categorized into <1.0, 1.0-1.19, 1.2-1.39, 1.4-1.59, 1.6-1.79 (reference), 1.8-1.99, 2.0-2.19 and ≥ 2...
February 5, 2019: Atherosclerosis
Latifah Alothman, Jacques Genest
No abstract text is available yet for this article.
February 5, 2019: Atherosclerosis
Katrine Pilely, Siril S Bakke, Yaseelan Palarasah, Mikkel-Ole Skjoedt, Emil D Bartels, Terje Espevik, Peter Garred
BACKGROUND AND AIMS: Cholesterol crystal (CC)-induced inflammation is a critical step in the development of atherosclerosis. CCs activate the complement system and induce an inflammatory response resulting in phagocytosis of the CCs, production of reactive oxygen species (ROS) and release of cytokines. The cyclodextrin 2-hydroxypropyl-β-cyclodextrin has been found to reduce CC-induced complement activation and induce regression of established atherosclerotic plaques in a mouse model of atherosclerosis, thus inhibition of complement with cyclodextrins is a potential new strategy for treatment of inflammation during atherosclerosis...
February 3, 2019: Atherosclerosis
Ji Eun Jun, In-Jin Cho, Kyungdo Han, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung, You-Cheol Hwang
BACKGROUND AND AIMS: There is inadequate evidence to establish statin treatment for primary prevention in the elderly. This study evaluated whether statins are beneficial for primary prevention of cardiovascular disease (CVD) and all-cause death in adults aged ≥ 75 years. METHODS: A nationwide, nested case-control study was conducted in Korea. Individuals who developed CVD, including myocardial infarction (MI), stroke, or death from all causes, were matched to controls based on duration of follow-up, age, and sex at the index date...
February 2, 2019: Atherosclerosis
Takashi Miki, Toru Miyoshi, Kazuhiko Kotani, Kunihisa Kohno, Hirohiko Asonuma, Satoru Sakuragi, Yasushi Koyama, Kazufumi Nakamura, Hiroshi Ito
BACKGROUND AND AIMS: Oxidized high-density lipoprotein (oxHDL) is characterized by reduced anti-inflammatory properties compared with HDL. However, the role of oxHDL in the pathogenesis of coronary artery calcification (CAC), a marker of subclinical atherosclerosis, remains unclear. We prospectively investigated the association between the change in oxHDL and progression of CAC in a substudy of a multicenter study. METHODS: In the principal study, patients with a CAC score of 1-999 were treated with pitavastatin with/without eicosapentaenoic acid...
February 1, 2019: Atherosclerosis
Carrie B Wiese, Jianyong Zhong, Zhi-Qi Xu, Youmin Zhang, Marisol A Ramirez Solano, Wanying Zhu, MacRae F Linton, Quanhu Sheng, Valentina Kon, Kasey C Vickers
BACKGROUND AND AIMS: Cardiovascular disease (CVD) is the leading cause of death in chronic kidney disease (CKD) patients, however, the underlying mechanisms that link CKD and CVD are not fully understood and limited treatment options exist in this high-risk population. microRNAs (miRNA) are critical regulators of gene expression for many biological processes in atherosclerosis, including endothelial dysfunction and inflammation. We hypothesized that renal injury-induced endothelial miRNAs promote atherosclerosis...
January 30, 2019: Atherosclerosis
Raul D Santos, Luca Valenti, Stefano Romeo
Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and includes a spectrum of abnormalities ranging from steatosis to cirrhosis. In this review, we address recent evidence and limitations of studies that evaluated the association of NAFLD with atherosclerotic cardiovascular disease. NAFLD is considered an ectopic fat deposit associated with metabolic (insulin resistance, hyperglycemia and dyslipidemia), inflammatory, coagulation and blood pressure disturbances. Prospective studies have associated NAFLD presence and severity, particularly steatohepatitis and fibrosis, with an increased risk of cardiovascular disease...
January 30, 2019: Atherosclerosis
George Lazaros, Evangelos Oikonomou, Georgia Vogiatzi, Evangelia Christoforatou, Sotirios Tsalamandris, Athina Goliopoulou, Maria Tousouli, Vasiliki Mystakidou, Christos Chasikidis, Dimitris Tousoulis
BACKGROUND AND AIMS: Sedentary lifestyle, unlike leisure time physical activity (PA), is associated with atherosclerosis progression. Regarding the interrelationship between television watching, as a sedentary behavior pattern, and cardiovascular disease burden, few data exist. METHODS: In this cross-sectional epidemiological study based on 2043 inhabitants of the Corinthia region, in Greece, ultrasonography was used to measure carotid intima-media thickness (IMT) in both carotid arteries...
January 29, 2019: Atherosclerosis
Ana M Bea, Itziar Lamiquiz-Moneo, Victoria Marco-Benedí, Rocio Mateo-Gallego, Sofía Pérez-Calahorra, Estíbaliz Jarauta, César Martín, Ana Cenarro, Fernando Civeira
BACKGROUND AND AIMS: The aim of this work was to compared the effect of lipid lowering drugs among familial hypercholesterolemia (FH) subjects with a functional mutation in LDLR (LDLR FH) and FH with the p.(Leu167del) mutation in APOE. METHODS: We retrospectively selected all adults with the p.(Leu167del) mutation on lipid-lowering treatment (n = 22) attending the Lipid Unit at the Hospital Miguel Servet. Age and sex matched LDLR FH from the same Unit were randomly selected as a control group (n = 44)...
January 29, 2019: Atherosclerosis
Anna Planas-Ballvé, Ane Miren Crespo, Lorena Martín Aguilar, María Hernández-Pérez, Tamara Canento, Laura Dorado, María T Alzamora, Pere Torán, Guillem Pera, Laura Muñoz-Ortiz, Juan F Arenillas, María Castañón, Antoni Dávalos, Mónica Millán, Elena López-Cancio
BACKGROUND AND AIMS: Symptomatic intracranial atherosclerosis (ICAS) is associated with a high risk of stroke recurrence and occurrence of other vascular events. However, ICAS has been poorly studied from its asymptomatic stage. The objective of our study was to determine if subclinical intracranial atherosclerosis is associated with long-term incident vascular events in Caucasians. METHODS: The Barcelona-Asymptomatic Intracranial Atherosclerosis (AsIA) Study is a population-based study that enrolled 933 subjects with a moderate-high vascular risk and without history of stroke or coronary disease, and determined the prevalence of asymptomatic ICAS and associated risk factors...
January 29, 2019: Atherosclerosis
Xuejing Liu, Jingyi Li, Jiawei Liao, Huan Wang, Xiaomin Huang, Zhao Dong, Qiang Shen, Ling Zhang, Yuhui Wang, Wei Kong, George Liu, Wei Huang
BACKGROUND AND AIMS: Glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 (GPIHBP1) plays a crucial role in triglyceride hydrolysis, and GPIHBP1 deficiency leads to severe hypertriglyceridemia (HTG). Gpihbp1 knockout (GKO) mice develop mild lesions in the aortic root at the age of 11 months. Herein, we investigated the effect of Gpihbp1 deficiency on atherosclerosis (AS) under diabetic conditions. METHODS: For experiment 1, diabetes was induced in GKO and wild-type (WT) mice by injection of streptozotocin at 3 months of age and lasted for 4 months...
January 29, 2019: Atherosclerosis
Giovanni Mario Pes, Guido Parodi, Maria Pina Dore
BACKGROUND AND AIMS: Cardiovascular disease (CVD) is associated with high morbidity and mortality. Studies in animal models and humans suggested that glucose‒6‒phosphate dehydrogenase (G6PD) deficiency, a genetically inherited condition causing haemolytic anemia, may be a risk factor for CVD. This hypothesis was tested in a large cohort from Northern Sardinia, where the population prevalence of G6PD deficiency is the highest in the Mediterranean area. METHODS: A retrospective observational case‒control study was performed using clinical records of 9604 patients undergoing digestive endoscopy between 2002 and 2017, with a known G6PD status and a complete clinical history including CVD and leading CVD risk factors...
January 28, 2019: Atherosclerosis
Raimondo Feminò, Giovanni Feminò
No abstract text is available yet for this article.
January 26, 2019: Atherosclerosis
Paolo Raggi
No abstract text is available yet for this article.
January 26, 2019: Atherosclerosis
Fai Lam, Ta-Liang Chen, Chun-Chuan Shih, Chao-Shun Lin, Chun-Chieh Yeh, Yuarn-Jang Lee, Chaur-Jong Hu, Hung-Yi Chiou, Chien-Chang Liao
BACKGROUND AND AIMS: The effects of influenza vaccination (IV) on stroke outcomes are unclear. The purpose of this study is to evaluate the outcomes after stroke in elderly individuals who have received an IV. METHODS: We used Taiwan's National Health Insurance Research Database 2000-2009 claims data to conduct a nested stroke cohort study including 148,909 hospitalized stroke patients aged 66 years and older. Using a matching procedure by propensity score, we selected 25,248 stroke patients with IV and 25,248 stroke patients without IV for comparison...
January 26, 2019: Atherosclerosis
Carmen Rodríguez-Jiménez, Diego Gómez-Coronado, Manuel Frías Vargas, Francisca Cerrato, Carlos Lahoz, Jose Saban-Ruiz, Daniel González-Nieto, Miguel A Lasunción, José M Mostaza, Sonia Rodríguez-Nóvoa
BACKGROUND AND AIMS: Autosomal recessive hypercholesterolemia (ARH) is a rare disorder caused by mutations in LDLRAP1, which impairs internalization of hepatic LDL receptor (LDLR). ARH patients respond relatively well to statins or the combination of statins and Ezetimibe, but scarce and variable data on treatment with PCSK9 inhibitors is available. We aimed to identify and characterize the defect in a hypercholesterolemic patient with premature cardiovascular disease and determine the response to lipid-lowering treatment...
January 25, 2019: Atherosclerosis
Jun Shu, Gaetano Santulli
No abstract text is available yet for this article.
January 25, 2019: Atherosclerosis
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