journal
https://read.qxmd.com/read/38598969/clinical-practice-recommendations-on-lipoprotein-apheresis-for-children-with-homozygous-familial-hypercholesterolaemia-an-expert-consensus-statement-from-erknet-and-espn
#1
REVIEW
M Doortje Reijman, D Meeike Kusters, Jaap W Groothoff, Klaus Arbeiter, Eldad J Dann, Lotte M de Boer, Sarah D de Ferranti, Antonio Gallo, Susanne Greber-Platzer, Jacob Hartz, Lisa C Hudgins, Daiana Ibarretxe, Meral Kayikcioglu, Reinhard Klingel, Genovefa D Kolovou, Jun Oh, R Nils Planken, Claudia Stefanutti, Christina Taylan, Albert Wiegman, Claus Peter Schmitt
Homozygous familial hypercholesterolaemia is a life-threatening genetic condition, which causes extremely elevated LDL-C levels and atherosclerotic cardiovascular disease very early in life. It is vital to start effective lipid-lowering treatment from diagnosis onwards. Even with dietary and current multimodal pharmaceutical lipid-lowering therapies, LDL-C treatment goals cannot be achieved in many children. Lipoprotein apheresis is an extracorporeal lipid-lowering treatment, which is used for decades, lowering serum LDL-C levels by more than 70% directly after the treatment...
March 27, 2024: Atherosclerosis
https://read.qxmd.com/read/38598970/ten-year-mortality-after-treating-obstructive-coronary-atherosclerosis-with-contemporary-stents-in-patients-with-or-without-concomitant-peripheral-arterial-disease
#2
JOURNAL ARTICLE
Tineke H Pinxterhuis, Eline H Ploumen, Daphne van Vliet, K Gert van Houwelingen, Martin G Stoel, Frits Haf de Man, Marc Hartmann, Paolo Zocca, Gerard Cm Linssen, Robert H Geelkerken, Carine Jm Doggen, Clemens von Birgelen
BACKGROUND AND AIMS: Previous studies in percutaneous coronary intervention (PCI) patients showed a higher 3-year adverse event risk, including all-cause mortality, in those with concomitant peripheral arterial disease (PADs). Ten-year data of mortality and causes of death are scarce. This analysis assessed PCI patients, treated with contemporary drug-eluting stents, the impact of concomitant PADs on very long-term mortality, and causes of death. METHODS: We assessed PCI all-comers from our center who participated in the TWENTE and DUTCH PEERS trials (clinicaltrials...
March 26, 2024: Atherosclerosis
https://read.qxmd.com/read/38594114/pancreatitis-risk-in-genetic-subtypes-of-multifactorial-chylomicronemia-syndrome
#3
EDITORIAL
Amanda J Berberich, Robert A Hegele
No abstract text is available yet for this article.
March 26, 2024: Atherosclerosis
https://read.qxmd.com/read/38583287/evaluation-of-fractional-flow-reserve-and-atherosclerotic-plaque-characteristics-on-coronary-non-contrast-t1-weighted-magnetic-resonance-imaging
#4
JOURNAL ARTICLE
Hiroki Sugane, Yasuhide Asaumi, Soshiro Ogata, Michito Kimura, Tomoaki Kanaya, Tomoya Hoshi, Akira Sato, Hiroyuki Miura, Yoshiyuki Tomishima, Yoshiaki Morita, Kazuhiro Nakao, Fumiyuku Otsuka, Yu Kataoka, Tomohiro Kawasaki, Kunihiro Nishimura, Jagat Narula, Satoshi Yasuda, Teruo Noguchi
BACKGROUND AND AIMS: The relationship between high-risk coronary plaque characteristics regardless of the severity of lesion stenosis and myocardial ischemia remains unsettled. High-intensity plaques (HIPs) on non-contrast T1-weighted magnetic resonance imaging (T1WI) have been characterized as high-risk coronary plaques. We sought to elucidate whether the presence of coronary HIPs on T1WI influences fractional flow reserve (FFR) in the distal segment of the vessel. METHODS: We retrospectively analyzed 281 vessels in 231 patients with chronic coronary syndrome who underwent invasive FFR measurement and coronary T1WI using a multicenter registry...
March 26, 2024: Atherosclerosis
https://read.qxmd.com/read/38583286/l-thyroxine-attenuates-extracellular-hsp90%C3%AE-induced-vascular-endothelial-calcification-in-diabetes-mellitus-as-revealed-by-parallel-metabolic-profiles
#5
JOURNAL ARTICLE
Xinyi Ding, Yan Qiu, Guozhen Wu, Shuxian Li, Mengyi Cai, Yongqi Liang, Dongling Li, Xiangrong Luo, Jianfu Meng, Run Yang, Ying Cao, Fang Gao, Yaoming Xue, Fei Zou, Mengchen Zou
BACKGROUND AND AIMS: Diabetic atherosclerotic vascular disease is characterized by extensive vascular calcification. However, an elevated blood glucose level alone does not explain this pathogenesis. We investigated the metabolic markers underlying diabetic atherosclerosis and whether extracellular Hsp90α (eHsp90α) triggers vascular endothelial calcification in this particular metabolic environment. METHODS: A parallel human/animal model metabolomics approach was used...
March 26, 2024: Atherosclerosis
https://read.qxmd.com/read/38583289/inhibition-of-pcsk9-with-evolocumab-modulates-lipoproteins-and-monocyte-activation-in-high-risk-ascvd-subjects
#6
JOURNAL ARTICLE
Robert S Rosenson, Ashley Tate, Phyu Mar, Olga Grushko, Qinzhong Chen, Sascha N Goonewardena
BACKGROUND: Mechanistic studies suggest that proprotein convertase subtilisin/kexin type 9 inhibitors can modulate inflammation. METHODS: Double-blind, placebo-controlled trial randomized 41 ASCVD subjects with type 2 diabetes with microalbuminuria and LDL-C level >70 mg/dL on maximum tolerated statin therapy received subcutaneous evolocumab 420 mg every 4 weeks or matching placebo. The primary outcomes were change in circulating immune cell transcriptional response, lipoproteins and blood viscosity at 2 weeks and 12 weeks...
March 25, 2024: Atherosclerosis
https://read.qxmd.com/read/38627162/stromal-cell-derived-factor-1-alpha-improves-cardiac-function-in-a-novel-diet-induced-coronary-atherosclerosis-model-the-sr-b1%C3%AE-ct-ldlr-ko-mouse
#7
JOURNAL ARTICLE
Danielle M Mullis, Amanda Padilla-Lopez, Hanjay Wang, Yuanjia Zhu, Stefan Elde, Spencer A Bonham, Shin Yajima, Olivier N Kocher, Monty Krieger, Y Joseph Woo
BACKGROUND AND AIMS: There are a limited number of pharmacologic therapies for coronary artery disease, and few rodent models of occlusive coronary atherosclerosis and consequent myocardial infarction with which one can rapidly test new therapeutic approaches. Here, we characterize a novel, fertile, and easy-to-use HDL receptor (SR-B1)-based model of atherogenic diet-inducible, fatal coronary atherosclerosis, the SR-B1ΔCT/LDLR KO mouse. Additionally, we test intramyocardial injection of Stromal Cell-Derived Factor-1 alpha (SDF-1α), a potent angiogenic cytokine, as a possible therapy to rescue cardiac function in this mouse...
March 22, 2024: Atherosclerosis
https://read.qxmd.com/read/38581738/a-universal-plasma-metabolites-derived-signature-predicts-cardiovascular-disease-risk-in-mafld
#8
JOURNAL ARTICLE
Zhonglin Li, Rui Gong, Huikuan Chu, Junchao Zeng, Can Chen, Sanping Xu, Lilin Hu, Wenkang Gao, Li Zhang, Hang Yuan, Zilu Cheng, Cheng Wang, Meng Du, Qingjing Zhu, Li Zhang, Lin Rong, Xiaoqing Hu, Ling Yang
BACKGROUND: Metabolic associated fatty liver disease (MAFLD) is a novel concept proposed in 2020, which is more practical for identifying patients with fatty liver disease with high risk of disease progression. Fatty liver is a driver for extrahepatic complications, particularly cardiovascular diseases (CVD). Although the risk of CVD in MAFLD could be predicted by carotid ultrasound test, a very early stage prediction method before the formation of pathological damage is still lacking...
March 22, 2024: Atherosclerosis
https://read.qxmd.com/read/38582639/subclinical-atherosclerosis-in-young-adults-predicting-cardiovascular-disease-the-cardiovascular-risk-in-young-finns-study
#9
JOURNAL ARTICLE
Olli T Raitakari, Costan G Magnussen, Markus Juonala, Noora Kartiosuo, Katja Pahkala, Suvi Rovio, Juhani S Koskinen, Juha Mykkänen, Tomi P Laitinen, Mika Kähönen, Joel Nuotio, Jorma S A Viikari
BACKGROUND AND AIMS: Atherosclerosis is accompanied by pre-clinical vascular changes that can be detected using ultrasound imaging. We examined the value of such pre-clinical features in identifying young adults who are at risk of developing atherosclerotic cardiovascular disease (ASCVD). METHODS: A total of 2641 individuals free of ASCVD were examined at the mean age of 32 years (range 24-45 years) for carotid artery intima-media thickness (IMT) and carotid plaques, carotid artery elasticity, and brachial artery flow-mediated endothelium-dependent vasodilation (FMD)...
March 19, 2024: Atherosclerosis
https://read.qxmd.com/read/38581737/heparanase-promotes-the-onset-and-progression-of-atherosclerosis-in-apolipoprotein-e-gene-knockout-mice
#10
JOURNAL ARTICLE
Tien K Nguyen, Stephanie Paone, Amy A Baxter, Alyce J Mayfosh, Thanh Kha Phan, Enoch Chan, Karlheinz Peter, Ivan K H Poon, Shane R Thomas, Mark D Hulett
BACKGROUND AND AIMS: Atherosclerosis is the primary underlying cause of myocardial infarction and stroke, which are the major causes of death globally. Heparanase (Hpse) is a pro-inflammatory extracellular matrix degrading enzyme that has been implicated in atherogenesis. However, to date the precise roles of Hpse in atherosclerosis and its mechanisms of action are not well defined. This study aims to provide new insights into the contribution of Hpse in different stages of atherosclerosis in vivo...
March 19, 2024: Atherosclerosis
https://read.qxmd.com/read/38616451/impact-of-optimal-cholesterol-levels-on-subclinical-atherosclerosis-in-the-absence-of-risk-factors-in-young-adults
#11
JOURNAL ARTICLE
Soroush Masrouri, Seyed Saeed Tamehri Zadeh, Michael D Shapiro, Davood Khalili, Farzad Hadaegh
BACKGROUND AND AIMS: We aimed to assess the association of blood lipids with the prevalence, incidence, and progression of subclinical atherosclerosis among young individuals without dyslipidemia and other traditional cardiovascular risk factors (CVRFs). METHODS: A total of 1270 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study aged 32-46 years free of cardiovascular disease, diabetes, hypertension, current smoking, and dyslipidemia (total cholesterol [TC] ≥ 240 mg/dL, triglycerides [TG] ≥ 150 mg/dL, low-density lipoprotein cholesterol [LDL-C] ≥ 160 mg/dL, high-density lipoprotein cholesterol [HDL-C] < 40 mg/dL, or taking lipid-lowering medications) were included...
March 17, 2024: Atherosclerosis
https://read.qxmd.com/read/38583288/association-of-cardiovascular-health-with-subclinical-coronary-atherosclerosis-progression-among-five-racial-and-ethnic-groups-the-masala-and-mesa-studies
#12
JOURNAL ARTICLE
Vardhmaan Jain, Mahmoud Al Rifai, Alka M Kanaya, Nilay S Shah, Sameera A Talegawkar, Salim S Virani, Erin D Michos, Roger S Blumenthal, Jaideep Patel
BACKGROUND AND AIMS: South Asian adults (SA) are at higher risk for atherosclerotic cardiovascular disease (ASCVD) compared with other racial/ethnic groups. Life's Simple 7 (LS7) is a guideline-recommended, cardiovascular health (CVH) construct to guide optimization of cardiovascular risk factors. We sought to assess if the LS7 metrics predict coronary artery calcium (CAC) incidence and progression in asymptomatic SA compared with four other racial/ethnic groups. METHODS: We assessed the distribution of CVH metrics (inadequate: score 0-8, average: 9-10, optimal: 11-14, and per 1-unit higher score) and its association with incidence and progression of CAC among South Asians in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study compared with other race/ethnic groups from the Multiethnic Study of Atherosclerosis (MESA)...
March 17, 2024: Atherosclerosis
https://read.qxmd.com/read/38582637/applicability-and-impact-of-the-compass-trial-in-a-canadian-population-of-patients-with-atherosclerotic-disease
#13
JOURNAL ARTICLE
Robert C Welsh, Pishoy Gouda, Doug Dover, Kevin R Bainey, Finlay A McAlister, Padma Kaul
BACKGROUND AND AIMS: In the COMPASS trial, low-dose rivaroxaban with aspirin improved cardiovascular outcomes in patients with atherosclerotic cardiovascular disease (ASCVD). We aimed to assess the potential clinical implications of this therapy in a generalizable population. METHODS AND RESULTS: A retrospective cohort of adults with ASVCD was formed using healthcare administrative databases in Alberta, Canada (population 4.4 million). Patients with a new diagnosis between 2008 and 2019 formed the epidemiological cohort (n = 224,600) and those with long-term follow-up (>5 years) formed the outcomes cohort (n = 232,460)...
March 16, 2024: Atherosclerosis
https://read.qxmd.com/read/38523000/improved-lipid-lowering-treatment-and-reduction-in-cardiovascular-disease-burden-in-homozygous-familial-hypercholesterolemia-the-safeheart-follow-up-study
#14
JOURNAL ARTICLE
Rodrigo Alonso, Raquel Arroyo-Olivares, Jose Luis Díaz-Díaz, Francisco Fuentes-Jiménez, Francisco Arrieta, Raimundo de Andrés, Pablo Gonzalez-Bustos, Rosa Argueso, Mercedes Martin-Ordiales, Ceferino Martinez-Faedo, Fátima Illán, Pedro Saenz, José María Donate, Juan F Sanchez Muñoz-Torrero, Sergio Martinez-Hervas, Pedro Mata
AIM: We aimed to describe clinical and genetic characteristics, lipid-lowering treatment and atherosclerotic cardiovascular disease (ASCVD) outcomes over a long-term follow-up in homozygous familial hypercholesterolemia (HoFH). METHODS: SAFEHEART (Spanish Familial Hypercholesterolaemia Cohort Study) is a long-term study in molecularly diagnosed FH. Data analyzed in HoFH were prospectively obtained from 2004 until 2022. ASCVD events, lipid profile and lipid-lowering treatment were determined...
March 16, 2024: Atherosclerosis
https://read.qxmd.com/read/38522165/metabolic-dysfunction-associated-steatotic-liver-disease-an-opportunity-for-collaboration-between-cardiology-and-hepatology
#15
REVIEW
Paolo Raggi, Jovana Milic, Marcella Manicardi, Felice Cinque, Mark G Swain, Giada Sebastiani, Giovanni Guaraldi
Altered metabolic function has many detrimental effects on the body that can manifest as cardiovascular and liver diseases. Traditional approaches to understanding and treating metabolic dysfunction-associated disorders have been organ-centered, leading to silo-type disease care. However, given the broad impact that systemic metabolic dysfunction has on the human body, approaches that simultaneously involve multiple medical specialists need to be developed and encouraged to optimize patient outcomes. In this review, we highlight how several of the treatments developed for cardiac care may have a beneficial effect on the liver and vice versa, suggesting that there is a need to target the disease process, rather than specifically target the cardiovascular or liver specific sequelae of metabolic dysfunction...
March 16, 2024: Atherosclerosis
https://read.qxmd.com/read/38552474/subclinical-vascular-composites-predict-clinical-cardiovascular-disease-stroke-and-dementia-the-multi-ethnic-study-of-atherosclerosis-mesa
#16
JOURNAL ARTICLE
Timothy M Hughes, Jordan Tanley, Haiying Chen, Christopher L Schaich, Joseph Yeboah, Mark A Espeland, Joao A C Lima, Bharath Ambale-Venkatesh, Erin D Michos, Jingzhong Ding, Kathleen Hayden, Ramon Casanova, Suzanne Craft, Stephen R Rapp, José A Luchsinger, Annette L Fitzpatrick, Susan R Heckbert, Wendy S Post, Gregory L Burke
BACKGROUND AND AIMS: Subclinical cardiovascular disease (CVD) measures may reflect biological pathways that contribute to increased risk for coronary heart disease (CHD) events, stroke, and dementia beyond conventional risk scores. METHODS: The Multi-Ethnic Study of Atherosclerosis (MESA) followed 6814 participants (45-84 years of age) from baseline in 2000-2002 to 2018 over 6 clinical examinations and annual follow-up interviews. MESA baseline subclinical CVD procedures included: seated and supineblood pressure, coronary calcium scan, radial artery tonometry, and carotid ultrasound...
March 15, 2024: Atherosclerosis
https://read.qxmd.com/read/38523001/reply-to-insulin-resistance-is-an-important-index-to-assess-glucose-and-insulin-metabolism-but-not-a-biological-risk-factor-for-high-risk-coronary-artery-plaque-composition
#17
LETTER
Johanna Larsson, Søren Auscher, Gokulan Pararajasingam, Laurits Juhl Heinsen, Thomas Rueskov Andersen, Jess Lambrechtsen, Kenneth Egstrup
No abstract text is available yet for this article.
March 15, 2024: Atherosclerosis
https://read.qxmd.com/read/38582638/serial-pet-imaging-to-evaluate-medical-therapies-is-it-ready-for-prime-time
#18
EDITORIAL
Stephen J Nicholls
No abstract text is available yet for this article.
March 14, 2024: Atherosclerosis
https://read.qxmd.com/read/38570208/insulin-resistance-potentiates-the-effect-of-remnant-cholesterol-on-cardiovascular-mortality-in-individuals-without-diabetes
#19
JOURNAL ARTICLE
Arsenio Vargas-Vázquez, Carlos A Fermín-Martínez, Neftali Eduardo Antonio-Villa, Luisa Fernández-Chirino, Daniel Ramírez-García, Gael Dávila-López, Juan Pablo Díaz-Sánchez, Carlos A Aguilar-Salinas, Jacqueline A Seiglie, Omar Yaxmehen Bello-Chavolla
BACKGROUND AND AIMS: Remnant cholesterol (RC) and insulin resistance (IR) have been independently associated with cardiovascular risk. Here, we evaluated the role of IR and RC on cardiovascular disease (CVD) mortality. METHODS: We conducted an analysis of 16,113 individuals ≥20 years without diabetes from the National Health and Nutrition Examination Survey (NHANES-III/IV). RC levels were calculated using total cholesterol, non-HDL-c, and LDL-c; IR was defined as HOMA2-IR≥2...
March 13, 2024: Atherosclerosis
https://read.qxmd.com/read/38518516/multifaceted-roles-of-meg3-in-cellular-senescence-and-atherosclerosis
#20
JOURNAL ARTICLE
Xiao Cheng, Mohamed Sham Shihabudeen Haider Ali, Vijaya Bhaskar Baki, Matthew Moran, Huabo Su, Xinghui Sun
BACKGROUND AND AIMS: Long noncoding RNAs are involved in the pathogenesis of atherosclerosis. As long noncoding RNAs maternally expressed gene 3 (Meg3) prevents cellular senescence of hepatic vascular endothelium and obesity-induced insulin resistance, we decided to examine its role in cellular senescence and atherosclerosis. METHODS AND RESULTS: By analyzing our data and human and mouse data from the Gene Expression Omnibus database, we found that Meg3 expression was reduced in humans and mice with cardiovascular disease, indicating its potential role in atherosclerosis...
March 8, 2024: Atherosclerosis
journal
journal
22445
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.