JOURNAL ARTICLE

Obstructive sleep apnea and atrial fibrillation

Keith Todd, William F McIntyre, Adrian Baranchuk
Nature and Science of Sleep 2010, 2: 39-45
23616697
Atrial fibrillation (AF) is the most common sustained arrhythmia. The clinical impact of AF results primarily from its association with stroke, heart failure, and increased overall mortality. Recently there has been increasing evidence of an important association between obstructive sleep apnea (OSA) and AF. OSA is a common breathing disorder affecting an estimated 5% of the population and is highly prevalent in patients with established cardiovascular disease. The prevalence of OSA among patients with AF is remarkable with estimates ranging from 32%-49%. The pathophysiological connection between AF and OSA remains speculative, but appears to be the result of apnea-induced hypoxia, intrathoracic pressure shifts, inflammation, heightened sympathetic activity, and autonomic instability leading to hypertension, diastolic dysfunction, left atrial enlargement, and electrical remodeling. Initial results appear promising that intervention with continuous positive airway pressure may be effective in reducing the burden of AF in this population, however, further investigations are needed. Here, we review the literature on the current epidemiologic data, pathophysiology, and therapeutics linking these two common conditions.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
23616697
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"