Bone mineral density in postmenopausal Mexican-Mestizo women with normal body mass index, overweight, or obesity

Juan Pablo Méndez, David Rojano-Mejía, Javier Pedraza, Ramón Mauricio Coral-Vázquez, Ruth Soriano, Eduardo García-García, María Del Carmen Aguirre-García, Agustín Coronel, Patricia Canto
Menopause: the Journal of the North American Menopause Society 2013, 20 (5): 568-72

OBJECTIVE: Obesity and osteoporosis are two important public health problems that greatly impact mortality and morbidity. Several similarities between these complex diseases have been identified. The aim of this study was to analyze if different body mass indexes (BMIs) are associated with variations in bone mineral density (BMD) among postmenopausal Mexican-Mestizo women with normal weight, overweight, or different degrees of obesity.

METHODS: We studied 813 postmenopausal Mexican-Mestizo women. A structured questionnaire for risk factors was applied. Height and weight were used to calculate BMI, whereas BMD in the lumbar spine (LS) and total hip (TH) was measured by dual-energy x-ray absorptiometry. We used ANCOVA to examine the relationship between BMI and BMDs of the LS, TH, and femoral neck (FN), adjusting for confounding factors.

RESULTS: Based on World Health Organization criteria, 15.13% of women had normal BMI, 39.11% were overweight, 25.96% had grade 1 obesity, 11.81% had grade 2 obesity, and 7.99% had grade 3 obesity. The higher the BMI, the higher was the BMD at the LS, TH, and FN. The greatest differences in size variations in BMD at these three sites were observed when comparing women with normal BMI versus women with grade 3 obesity.

CONCLUSIONS: A higher BMI is associated significantly and positively with a higher BMD at the LS, TH, and FN.

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