Use of EUS-FNA in diagnosing pancreatic neoplasm without a definitive mass on CT

Wei Wang, Alexander Shpaner, Somashekar G Krishna, William A Ross, Manoop S Bhutani, Eric P Tamm, Gottumukkala S Raju, Lianchun Xiao, Robert A Wolff, Jason B Fleming, Jeffrey H Lee
Gastrointestinal Endoscopy 2013, 78 (1): 73-80

BACKGROUND: Diagnosis of pancreatic neoplasm is challenging in patients with inconclusive findings on pancreatic multidetector row CT (MDCT).

OBJECTIVE: To determine the diagnostic accuracy and to identify predictors of pancreatic neoplasm by EUS with FNA in this setting.

DESIGN: Retrospective chart review during the study period of January 2002 to December 2010.

SETTING: Tertiary referral center.

PATIENTS: Of the 1046 patients who underwent pancreatic EUS, 116 patients were selected because their clinical presentation was suspicious for pancreatic malignancy, but their MDCT findings were inconclusive.


MAIN OUTCOME MEASUREMENTS: Diagnostic yield of malignancy and significance of clinical variables.

RESULTS: When surgical pathology or subsequent clinical course was used as the criterion standard, EUS with FNA had a sensitivity, specificity, positive predictive value, and accuracy of 87.3%, 98.3%, 98.5%, and 92.1%, respectively, in diagnosing a pancreatic neoplasm that was indeterminate on MDCT. Factors significantly associated with EUS detection of pancreatic ductal adenocarcinoma were total bilirubin level greater than 2 mg/dL (P < .001), CT finding of pancreatic duct dilation (P < .001), bile duct stricture (P < .001), and tumor size 1.5 cm or larger detected by EUS (P = .004). Among them, pancreatic duct dilation on CT (odds ratio 4.10; 95% confidence interval, 1.52-11.05), and tumor size 1.5 cm or larger detected by EUS (odds ratio 8.46; 95% confidence interval, 2.02-35.45) were independent risk factors.

LIMITATIONS: Retrospective design and patient referral bias.

CONCLUSIONS: When MDCT is indeterminate, EUS is a highly sensitive and accurate modality for the detection of pancreatic neoplasm, especially when the tumor is smaller than 2.0 cm.

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