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Feasibility and safety of EUS-guided transgastric/transduodenal gallbladder drainage with single-step placement of a modified covered self-expandable metal stent in patients unsuitable for cholecystectomy

Ji Woong Jang, Sang Soo Lee, Do Hyun Park, Dong-Wan Seo, Sung-Koo Lee, Myung-Hwan Kim
Gastrointestinal Endoscopy 2011, 74 (1): 176-81
21704816

BACKGROUND: Although early laparoscopic cholecystectomy is the treatment of choice for patients with acute cholecystitis, percutaneous cholecystostomy has been performed in patients unsuitable for cholecystectomy. EUS-guided transgastric/transduodenal gallbladder drainage by using a plastic stent and/or nasobiliary drainage may be an alternative effective treatment for these patients, but bile leakage into the peritoneal space causing bile peritonitis is not uncommon during placement of a plastic stent.

OBJECTIVE: To evaluate the technical feasibility and safety of EUS-guided transgastric/transduodenal gallbladder drainage with single-step placement of a modified covered self-expandable metal stent (CSEMS) in patients with acute cholecystitis who are unsuitable for cholecystectomy.

DESIGN: Prospective feasibility study.

SETTING: Tertiary-care referral center.

PATIENTS: This study involved 15 patients with acute cholecystitis who did not respond to initial medical treatment and were unsuitable for cholecystectomy.

INTERVENTION: EUS-guided transgastric/transduodenal gallbladder drainage with single-step placement of a modified CSEMS.

MAIN OUTCOME MEASUREMENTS: Technical success, functional success, complications associated with the placement of a metal stent, and recurrence of acute cholecystitis.

RESULTS: Modified CSEMSs were successfully placed in all patients through the stomach (n = 10) or duodenum (n = 5). All patients achieved functional success within 3 days of metal stent placement. Pneumoperitoneum occurred in two patients during or after the procedure, but both patients improved with conservative management. During follow-up (median 145 days, range 60-297 days), no patient experienced recurrent cholecystitis.

LIMITATIONS: Small patient population without long-term follow-up.

CONCLUSION: Placement of a modified CSEMS after EUS-guided transgastric/transduodenal gallbladder drainage may be a feasible and safe alternative to treatments such as percutaneous cholecystostomy in patients with acute cholecystitis who are unsuitable for cholecystectomy.

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