Analgesic and anti-inflammatory activities of Cnestis ferruginea Vahl ex DC (Connaraceae) methanolic root extract

Ismail O Ishola, Abidemi J Akindele, Olufunmilayo O Adeyemi
Journal of Ethnopharmacology 2011 April 26, 135 (1): 55-62

ETHNOPHARMACOLOGICAL RELEVANCE: Cnestis ferruginea Vahl ex DC (Connaraceae) is a shrub widely used in traditional African Medicine (TAM) for the treatment of various painful and inflammatory conditions.

AIM OF THE STUDY: The objective of this study was to investigate the analgesic and anti-inflammatory properties of the methanolic root extract of Cnestis ferruginea.

MATERIALS AND METHODS: Analgesic activity was evaluated using the acetic acid-induced writhing, formalin, tail clip, and hot plate tests in mice. The carrageenan- and egg albumin-induced rat paw oedema, formaldehyde-induced arthritis inflammation, and xylene-induced ear oedema tests were used to investigate the anti-inflammatory actions of Cnestis ferruginea.

RESULTS: The methanolic root extract of Cnestis ferruginea (100, 200, and 400mg/kg; p.o.) produced significant (P<0.05) dose-dependent inhibition of pain response elicited by acetic acid and formalin while also increasing the nociceptive reaction latency in the tail clip and hot plate tests. In respect of anti-inflammatory activity, Cnestis ferruginea caused significant (P<0.05) dose-dependent inhibition of oedema development in the carrageenan, egg albumin, formaldehyde, and xylene-induced inflammation tests. The effects of the extract in the various models were generally comparable to those of the standard drugs used.

CONCLUSION: The findings in this study suggest that the methanolic root extract of Cnestis ferruginea possesses analgesic and anti-inflammatory activities possibly mediated through peripheral and central mechanisms involving inhibition of release and/or actions of vasoactive substances (histamine, serotonin and kinins) and prostaglandins. The results justify the use of the extract in TAM for the treatment of painful and inflammatory conditions.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"