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Journal of Ethnopharmacology

Shuo Tian, Ming-San Miao, Xiu-Min Li, Ming Bai, Yan-Yi Wu, Zhen-Zhen Wei
ETHNOPHARMACOLOGICAL RELEVANCE: Desertliving Cistanche herb was first recorded in "Shen Nong'Herbal Classic" and listed as the top grade herbal medicine in it. Phenylethanoid glycosides are indicative components for identification and content determination of Desertliving Cistanche herb in Chinese pharmacopoeia, which is also one of the main active components. In this research, we explored the mechanism of phenylethanoid glycosides of Desertliving Cistanche herb to the perimenopausal model rats...
April 14, 2019: Journal of Ethnopharmacology
Ibrahim Mohamed Abdel-Salam, A A Abou-Bakr, Mohamed Ashour
ETHNOPHARMACOLOGICAL RELEVANCE: Luffa cylindrica (L.) M.Roem is a climbing plant its parts have been used as traditional medicine for the treatment of different types of diseases including diarrhea, inflammation, cancer and viral infections. The parts used include fruit, seeds and leaves. AIM OF THE STUDY: Our study aims to investigate the effect of the aqueous-ethanol extract of Luffa cylindrica leaves on breast cancer stem cells CD44+ /24- and other cell sub-populations using clinical samples with different molecular sub-types of breast cancer in vitro...
April 14, 2019: Journal of Ethnopharmacology
Jin-Xiu Liang, Qun-Qun Zhang, Yan-Fei Huang, Han-Qing Pang, Xin-Guang Liu, Wen Gao, Ping Li, Hua Yang
ETHNOPHARMACOLOGICAL RELEVANCE: Monascus-fermented rice product (MFRP) has been regarded as a dietary supplement and traditional medicine with circulation-promoting effects in China and other countries for centuries. AIM OF THE STUDY: This study was carried out to profile the chemical components in MFRP, and provide available information for elucidating the potential lipid-lowering compounds other than monacolins. MATERIALS AND METHODS: High-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-QTOF MS) and gas chromatography coupled with mass spectrometry (GC-MS) methods were applied to comprehensive analysis of chemical components in MFRP...
April 13, 2019: Journal of Ethnopharmacology
Gabriel Manarin, Daniela Anderson, Jorgete Maria E Silva, Juliana da Silva Coppede, Persio Roxo-Junior, Ana Maria Soares Pereira, Fabio Carmona
ETHNOPHARMACOLOGICAL RELEVANCE: Roots of Curcuma longa L. are used as medicine for millennia. They possess several pharmacological properties, including anti-inflammatory action, and can be suitable for asthma treatment. AIM OF THE STUDY: We aimed to test the hypothesis that, in children and adolescents with persistent asthma, the administration of powdered roots of C. longa for 6 months, in addition to standard treatment, compared to placebo, will result in better disease control...
April 13, 2019: Journal of Ethnopharmacology
Tahereh Kerdar, Nazli Rabienejad, Yousef Alikhani, Shirin Moradkhani, Dara Dastan
ETHNOPHARMACOLOGICAL RELEVANCE: Chronic periodontitis is an inflammatory process of the oral cavity that is caused by different reasons. Streptococcus mutans bacteria is the main cause of the disease. Scrophularia striata in Iranian traditional medicine is used to heal inflammation of gum and mouth. Also, In vitro anti-bacterial effect of S. striata in S. mutans have been demonstrated. AIM OF THE STUDY: Clinical, in vitro and chemical constituent studies of S. striata on chronic periodontitis disease...
April 13, 2019: Journal of Ethnopharmacology
Chunhui Chen, Xueqing Yao, Yihua Xu, Qingyuan Zhang, Hao Wang, Liang Zhao, Ge Wen, Yawei Liu, Linlin Jing, Xuegang Sun
ETHNOPHARMACOLOGICAL RELEVANCE: Dahuang Zhechong Pill (DZP) is a classical formula from "Synopsis of Prescriptions of the Golden Chamber". It has been used for treatment of abdominal masses (including tumorous diseases) for thousands of years. AIM OF THE STUDY: Our previous work showed that DZP suppresses CCl-4 induced hepatic fibrosis by downregulating the expression of interleukin-13. We aimed to test if DZP suppresses the metastasis of colorectal cancer (CRC) by ameliorating the fibrosis status of the future metastatic organ...
April 12, 2019: Journal of Ethnopharmacology
Jun-Won Yun, Seung-Hyun Kim, Yun-Soon Kim, Eun Jin Choi, Ji-Ran You, Eun-Young Cho, Jung-Hee Yoon, Euna Kwon, Hyoung-Chin Kim, Ja-June Jang, Jin-Sung Park, Jeong-Hwan Che, Byeong-Cheol Kang
ETHNOPHARMACOLOGY RELEVANCE: Dendropanax morbifera Leveille (DM) has been used in traditional medicines for infectious and skin diseases, and dysmenorrhea. It exhibits a diverse therapeutic potential including anti-cancer, anti-thrombotic, anti-diabetic, anti-oxidant, and anti-inflammatory activities. AIM OF THE STUDY: Despite promising health benefits of DM, knowledge of its potential adverse effects is very limited. The current study focused on the investigation of subchronic toxicity and genotoxicity of extract obtained from DM according to the test guidelines published by the Organization for Economic Cooperation and Development...
April 12, 2019: Journal of Ethnopharmacology
Sara Emilia Lima Tolouei, Rhanany Alan Calloi Palozi, Cleide Adriane Signor Tirloni, Aline Aparecida Macedo Marques, Maysa Isernhagen Schaedler, Lucas Pires Guarnier, Aniely Oliveira Silva, Valter Paes de Almeida, Jane Manfron Budel, Roosevelt Isaias Carvalho Souza, Ariany Carvalho Dos Santos, Denise Brentan Silva, Emerson Luiz Botelho Lourenço, Paulo Roberto Dalsenter, Arquimedes Gasparotto Junior
ETHNOPHARMACOLOGICAL RELEVANCE: Talinum paniculatum (Jacq.) Gaertn. (Talinaceae), popularly known as "major gomes" and "erva gorda", is a non-conventional food plant extensively distributed throughout the Brazilian territory. In Brazilian folk medicine, this species is used as aphrodisiac, to treat gastrointestinal problems, and as a cardioprotective agent. However, there are no reports in the literature proving its cardiovascular effects. AIM: To perform a whole-ethnopharmacological investigation of the cardiorenal properties of the ethanol soluble fraction from T...
April 12, 2019: Journal of Ethnopharmacology
Jia-Qian Chen, Duan-Wei Li, Yan-Yan Chen, Hui-Juan Tao, Zong-Jin Pu, Jing Zhang, Ya-Jie Tan, Xu-Qin Shi, Shi-Jun Yue, Gui-Sheng Zhou, Yu-Ping Tang, Jin-Ao Duan
ETHNOPHARMACOLOGICAL RELEVANCE: Rhei Radix et Rhizoma (rhubarb), as the preferred representative of cathartic drugs of traditional Chinese medicine (TCM), has a long history of medicinal use and multifarious functions that produce a wide range of dosage. In modern times, rhubarb and its prescriptions are not only used to treat common clinical diseases, but also achieve good results in the treatment of acute, dangerous, severe and difficult diseases. However, rhubarb also has an alias called "General", which means that its efficacy is relatively rapid...
April 11, 2019: Journal of Ethnopharmacology
Gonzalo R Malca-Garcia, Daniel Zagal, James Graham, Dejan Nikolić, J Brent Friesen, David C Lankin, Shao-Nong Chen, Guido F Pauli
ETHNOPHARMACOLOGICAL RELEVANCE: The flowering tops of Trifolium pratense L., popularly known as red clover, are used in ethnic Western and Traditional Chinese medicine, in a variety of preparations, including infusions, decoctions and tinctures. Red clover has been reported to be helpful for treatment of menopausal symptoms, premenstrual syndrome, mastalgia, high cholesterol, and other conditions. AIMS OF THE STUDY: The aims were to compare the chemical dynamics between traditional preparations of infusions, decoctions, and tinctures, as well as to identify the chemical variability over time in a traditional red clover tincture...
April 11, 2019: Journal of Ethnopharmacology
Li Cheng, Wen Liu, Tao Zhang, Ting Xu, Yi-Xuan Su, Bo Yuan, Ying-Ming Yang, Tao Hu
ETHNOPHARMACOLOGICAL RELEVANCE: Pudilan is a famous traditional Chinese medicine compound which contains several Chinese herbal ingredients, is wildly used to treat a variety of inflammatory diseases in China. Recently, it was reported that Pudilan extract had been used in the oral field, especially in the treat of minor oral ulcers for its anti-inflammatory, pain relieving, antibacterial, clearing heat, and detoxifying effects. AIM OF THE STUDY: To evaluate the effectiveness and safety of Pudilan extract-containing toothpaste in controlling plaques and reducing chronic gingivitis...
April 10, 2019: Journal of Ethnopharmacology
Fabian Ifeanyi Eze, Xavier Siwe Noundou, Patience O Osadebe, Rui W M Krause
ETHNOPHARMACOLOGICAL RELEVANCE: Anthocleista vogelii Planch (Loganiaceae) is used in African Traditional Medicine for the treatment of pain and inflammatory disorders as well as sleeping sickness. AIM OF THE STUDY: To determine the in vivo anti-inflammatory and in vitro anti-trypanosomal activities of the extracts of A. vogelii stem bark and identify the phytochemical classes of the fractions responsible for the activities. MATERIALS AND METHODS: The in vivo anti-inflammatory activity of the extracts was evaluated using the egg albumin-induced rat paw oedema model while the in vitro anti-trypanosomal activity was assessed on Trypanosoma brucei brucei...
April 9, 2019: Journal of Ethnopharmacology
Yan Zhang, Tingting Ye, Zhuping Hong, Shuqing Gong, Xiangshan Zhou, Haibin Liu, Jing Qian, Haibin Qu
ETHNOPHARMACOLOGICAL RELEVANCE: Fufang E'jiao Jiang (FEJ), a famous traditional Chinese medicine formula from "Liangyi Ointment", consists of five crude drugs, Colla corii asini, Radix Ginseng Rubra, Radix Rehmanniae Preparata, Codonopsis pilosula, and Crataegus pinnatifida Bge. It has pronounced functions of qi-nourishing and blood-activating. Recently, it has been widely used in China as a medication against myelosuppression in cancer treatment. AIM OF THE STUDY: We aimed to investigate the complex mode of action and underlying mechanisms of Fufang E'jiao Jiang (FEJ) regarding its hematopoietic effect...
April 9, 2019: Journal of Ethnopharmacology
K Kharsany, A Viljoen, C Leonard, S van Vuuren
ETHNOPHARMACOLOGICAL RELEVANCE: Propolis, a resinous substance produced by the Apis mellifera bee, contains a number of flavonoids sourced from plants found in the surrounding region. Whilst bees use this substance to seal off and protect the beehive, humans have used propolis therapeutically for centuries, making use of its antibacterial, antiseptic, antipyretic and wound healing properties, among others. South African propolis is rich in the flavonoids pinocembrin, galangin, and chrysin and very little previous research has been conducted on the antimicrobial effects of these compounds...
April 9, 2019: Journal of Ethnopharmacology
Dáfiner Pergher, Aline Picolotto, Pauline Rosales, Keilla G Machado, Aline Fagundes Cerbaro, Raqueli T França, Mirian Salvador, Mariana Roesch-Ely, Leandro Tasso, Jozi Godoy Figueiredo, Sidnei Moura
ETHNOPHARMACOLOGICAL RELEVANCE: Ethnopharmacological knowledge is important for the identification of active compounds from natural products. Pain may have different aetiologies with complex mechanisms. Tabernaemontana catharinensis is well known for indole alkaloids, being used empirically in folk medicine, with antimicrobial and anti-inflammatory as well as antiofidic actions among others. AIM OF THE STUDY: This work aims to evaluate the antinociceptive effect and modulation of oxidativo stress in mice of the alkaloids extract from leaves of Tabernaemontana catharinensis (AITc)...
April 9, 2019: Journal of Ethnopharmacology
Yohei Tanimura, Masato Yoshida, Masahiro Ohsawa, Toshiaki Makino
ETHNOPHARMACOLOGICAL RELEVANCE: Processed aconite root (PA), the root of Aconitum carmichaeli (Ranunculaceae), is a crude drug used in traditional Chinese or Japanese kampo medicine to treat pain associated with coldness. In our previous study, PA and its active ingredient, neoline, alleviated oxaliplatin-induced peripheral neuropathy in mice. AIM OF THE STUDY: The present study investigated the effects of PA on a murine peripheral neuropathy model induced by intraperitoneal injection of paclitaxel and partial ligation of the sciatic nerve (Seltzer model), and identified its active ingredients...
April 8, 2019: Journal of Ethnopharmacology
Ghazala Akhtar, Arham Shabbir
ETHNOPHARMACOLOGICAL RELEVANCE: Urginea indica has been used in the traditional system of medicine to treat various inflammatory diseases. AIM OF THE STUDY: Present study investigates the effects of aqueous and ethanolic extracts of U. indica on joint inflammation using different models of acute and chronic inflammation. MATERIALS AND METHODS: FCA-induced arthritic rat model, a model of chronic joint inflammation, was used to evaluate the anti-arthritic effects of plant extracts (500 mg/kg, each extract)...
April 7, 2019: Journal of Ethnopharmacology
Youxu Wang, Hanxue Wang, Liuhong Zhang, Yunpeng Zhang, Yuchen Sheng, Gang Deng, Shuping Li, Ning Cao, Huida Guan, Xuemei Cheng, Changhong Wang
ETHNOPHARMACOLOGICAL RELEVANCE: The seeds of Peganum harmala Linn, in which the most abundant active compounds are harmaline and harmine, have been widely used as a traditional medicine in various countries to treat a broad spectrum of diseases including asthma, cough, depression, Parkinson's and Alzheimer's diseases. However, few studies on long-term or subchronic toxicity of seeds of P. harmala were reported after overdose. AIM OF THE STUDY: To investigate the subchronic toxicity and concomitant toxicokinetics of total alkaloid extracts from seeds of P...
April 7, 2019: Journal of Ethnopharmacology
Bin Fang, Ying Li, Chen Chen, Qiushi Wei, Jiaqian Zheng, Yamei Liu, Wei He, Dingkun Lin, Gang Li, Yonghui Hou, Liangliang Xu
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese medicine has a long history of treating various bone diseases including osteoporosis and osteonecrosis etc. In clinical treatment, Huo Xue Tong Luo capsule (HXTL capsule) containing Peach kernel, Safflower carthamus, Angelica sinensis, Ligusticum wallichii etc, is one of the mostly used prescriptions for treating osteonecrosis of the femoral head (ONFH) with promising effects. OBJECTIVES: This study aims to identify the underlying molecular mechanism of how HXTL capsule exerts its function to ameliorate ONFH...
April 7, 2019: Journal of Ethnopharmacology
Guoxue Zhu, Fang Feng
ETHNOPHARMACOLOGICAL RELEVANCE: Cholestasis, caused by hepatic accumulation of bile acids, is a serious manifestation of liver diseases resulting in liver injury, fibrosis, and liver failure with limited therapies. Da-Huang-Xiao-Shi decoction (DHXSD) is a representative formula for treating jaundice and displays bright prospects in liver protective effect. AIM OF THE STUDY: This study was designed to assess the effects and possible mechanisms of DHXSD against alpha-naphthylisothiocyanate-induced liver injury based on ultra-high performance liquid chromatography-hybrid quadrupole-Orbitrap mass spectrometry (UHPLC-Q-Orbitrap MS) metabonomic approach...
April 6, 2019: Journal of Ethnopharmacology
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