journal
https://read.qxmd.com/read/38641080/wighteone-a-prenylated-flavonoid-from-licorice-inhibits-growth-of-sw480-colorectal-cancer-cells-by-allosteric-inhibition-of-akt
#1
JOURNAL ARTICLE
Xiaofei Chen, Ruili Ma, Weiguo Wu, Ran Gao, Yikang Shu, Mingxin Dong, Mengzhe Guo, Daoquan Tang, Danhua Li, Shuai Ji
ETHNOPHARMACOLOGICAL RELEVANCE: Licorice is a frequently used herbal medicine worldwide, and is used to treat cough, hepatitis, cancer and influenza in clinical practice of traditional Chinese medicine. Modern pharmacological studies indicate that prenylated flavonoids play an important role in the anti-tumor activity of licorice, especially the tumors in stomach, lung, colon and liver. Wighteone is one of the main prenylated flavonoids in licorice, and its possible effect and target against colorectal cancer have not been investigated...
April 17, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38641079/ginsenoside-rg1-alleviates-chronic-inflammation-induced-neuronal-ferroptosis-and-cognitive-impairments-via-regulation-of-aim2-nrf2-signaling-pathway
#2
JOURNAL ARTICLE
Liangliang Kong, Yan Liu, Jingwei Li, Yanyan Wang, Pengmin Ji, Qifeng Shi, Min Han, Hanyang Xu, Weiping Li, Weizu Li
ETHNOPHARMACOLOGICAL RELEVANCE: Ginseng is a valuable herb in traditional Chinese medicine. Modern research has shown that it has various benefits, including tonifying vital energy, nourishing and strengthening the body, calming the mind, improving cognitive function, regulating fluids, and returning blood pressure, etc. Rg1 is a primary active component of ginseng. It protects hippocampal neurons, improves synaptic plasticity, enhances cognitive function, and boosts immunity. Furthermore, it exhibits anti-aging and anti-fatigue properties and holds great potential for preventing and managing neurodegenerative diseases (NDDs)...
April 17, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38641078/in-vitro-and-in-vivo-evaluation-of-the-anti-infective-potential-of-the-essential-oil-extracted-from-the-leaves-of-plectranthus-amboinicus-lour-spreng-against-klebsiella-pneumoniae-and-elucidation-of-its-mechanism-of-action-through-proteomics-approach
#3
JOURNAL ARTICLE
Akshaya Rani Augustus, Sudipta Jana, Malik Basha Samsudeen, Hari Prasath Nagaiah, Karutha Pandian Shunmugiah
ETHNOPHARMACOLOGICAL RELEVANCE: Members of Plectranthus genus such as Plectranthus amboinicus (Lour.) Spreng is a well-known folkloric medicine around the globe in treating several human ailments such as cardiovascular, respiratory, digestive, urinary tract, skin and infective diseases. Its therapeutic value is primarily attributed to its essential oil. Although several properties of Plectranthus amboinicus essential oil have been documented, its mechanism of action and safety has not been completely elucidated...
April 17, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38641077/the-water-extracts-from-the-oil-cakes-of-prinsepia-utilis-repair-the-epidermal-barrier-via-up-regulating-corneocyte-envelope-proteins-lipid-synthases-and-tight-junction-proteins
#4
JOURNAL ARTICLE
Ying Tu, Ran An, Hua Gu, Na Li, Huan Yan, Hai-Yang Liu, Li He
ETHNOPHARMACOLOGICAL RELEVANCE: Prinsepia utilis Royle, native to the Himalayan region, has a long history of use in traditional medicine for its heat-clearing, detoxification, anti-inflammatory, and analgesic properties. Oils extracted from P. utilis seeds are also used in cooking and cosmetics. With the increasing market demand, this extraction process generates substantial industrial biowastes. Recent studies have found many health benefits with using aqueous extracts of these biowastes, which are also rich in polysaccharides...
April 17, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38641076/salvia-miltiorrhiza-suppresses-cardiomyocyte-ferroptosis-after-myocardial-infarction-by-activating-nrf2-signaling
#5
JOURNAL ARTICLE
Yu-Ting Wu, Guo-Yong Zhang, Lei Li, Bin Liu, Ru-Yu Wang, Rong-Qiang Song, Yue Hua, Yi-Ming Bi, Xin Han, Feng Zhang, Dong Wang, Ling-Peng Xie, Ying-Chun Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Ferroptosis, a recently identified non-apoptotic form of cell death reliant on iron, is distinguished by an escalation in lipid reactive oxygen species (ROS) that are iron-dependent. This phenomenon has a strong correlation with irregularities in iron metabolism and lipid peroxidation. Salvia miltiorrhiza Bunge (DS), a medicinal herb frequently utilized in China, is highly esteemed for its therapeutic effectiveness in enhancing blood circulation and ameliorating blood stasis, particularly during the treatment of cardiovascular diseases (CVDs)...
April 17, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38641075/bioeconomy-and-ethnopharmacology-translational-perspective-and-sustainability-of-the-bioresources-of-northeast-region-of-india
#6
REVIEW
Bhaskar Das, Pardeep K Bhardwaj, Sushil K Chaudhary, Neeta Pathaw, Huidrom Khelemba Singh, Soibam Tampha, Khaidem Kennedy Singh, Nanaocha Sharma, Pulok Kumar Mukherjee
ETHNOPHARMACOLOGICAL RELEVANCE: The ecological environment of Northeast region of India (NER), with its high humidity, has resulted in greater speciation and genetic diversity of plant, animal, and microbial species. This region is not only rich in ethnic and cultural diversity, but it is also a major biodiversity hotspot. The sustainable use of these bioresources can contribute to the region's bioeconomic development. AIM OF THE STUDY: The review aimed to deliver various perspectives on the development of bioeconomy from NER bioresources under the tenets of sustainable utilization and socioeconomic expansion...
April 17, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38641074/radix-sophorae-flavescentis-of-sophora-flavescens-aiton-inhibits-lps-induced-macrophage-pro-inflammatory-response-via-regulating-cfhr2-expression
#7
JOURNAL ARTICLE
Xiaoying Wu, Li Li, Jinhabure, Xiaofeng, Eerdunchaolu
ETHNOPHARMACOLOGICAL RELEVANCE: Long-term chronic inflammation often leads to chronic diseases. Although Sophora flavescens has been shown to have anti-inflammatory properties, its detailed molecular mechanism is still unknown. AIM OF STUDY: This study investigated the effect of Radix Sophorae Flavescentis on the LPS-induced inflammatory response in macrophages. MATERIALS AND METHODS: LPS was used to induce the peritoneal macrophages to simulate the inflammatory environment in vitro...
April 17, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38641073/orostachys-malacophylla-pall-fisch-extracts-alleviate-intestinal-inflammation-in-drosophila
#8
JOURNAL ARTICLE
Hyonil Kim, Hongmei Xue, Xiao Li, Guanhua Yue, Jiahua Zhu, Tongju Eh, Sihong Wang, Li Hua Jin
ETHNOPHARMACOLOGICAL RELEVANCE: Orostachys malacophylla (Pall.) Fisch (O. malacophylla) is a succulent herbaceous plant that is the Orostachys genus of Crassulaceae family. O. malacophylla has been widely used as a traditional Chinese medicine with antioxidant, anti-inflammatory, anti-febrile, antidote, anti-Toxoplasma gondii properties. However, the biological function of alleviating intestinal inflammation and key bioactive compounds were still unknown. AIM OF THE STUDY: We used a Drosophila model to study the protective effects and bioactive compounds of O...
April 17, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38641072/ligustilide-covalently-binds-to-cys703-in-the-pre-s1-helix-of-trpa1-blocking-the-opening-of-channel-and-relieving-pain-in-rats-with-acute-soft-tissue-injury
#9
JOURNAL ARTICLE
Kaixue Zhang, Wenjuan Liu, Fukui Shen, Guoqing Luan, Yanqi Han, Jun Xu, Cheng Fu, Weidong Wu, Yuanyuan Hou, Min Jiang, Tiejun Zhang, Gang Bai
ETHNOPHARMACOLOGICAL RELEVANCE: The natural anodyne Ligustilide (Lig), derived from Angelica sinensis (Oliv.) Diels and Ligusticum chuanxiong Hort., has been traditionally employed for its analgesic properties in the treatment of dysmenorrhea and migraine, and rheumatoid arthritis pain. Despite the existing reports on the correlation between TRP channels and the analgesic effects of Lig, a comprehensive understanding of their underlying mechanisms of action remains elusive. AIM OF THE STUDY: The objective of this study is to elucidate the mechanism of action of Lig on the analgesic target TRPA1 channel...
April 17, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38636581/zhilong-huoxue-tongyu-capsule-regulates-the-macrophage-polarization-and-inflammatory-response-via-the-let-7i-tlr9-myd88-signaling-pathway
#10
JOURNAL ARTICLE
Ya-Fei Kang, Xue Bai, Kong-Yu Wang, Tao Wang, Chuan-Ling Pan, Cheng Xie, Bo Liang, Hui-Ling Liao
ETHNOPHARMACOLOGICAL RELEVANCE: Zhilong Huoxue Tongyu Capsule (ZL) is clinically prescribed for acute ischemic stroke (AIS). However, only a few studies have addressed the mechanisms of ZL in treating AIS. AIM OF THE STUDY: To explore the underlying mechanism of macrophage polarization and inflammation mediated by ZL, and to provide a reference for AIS treatment. MATERIALS AND METHODS: Sixteen SD rats were fed with different dose of ZL (0, 0...
April 16, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38636580/qilong-capsule-prevents-myocardial-ischemia-reperfusion-injury-by-inhibiting-platelet-activation-via-the-platelet-cd36-signaling-pathway
#11
JOURNAL ARTICLE
Min Wang, Lingxu Li, Shuang Tang, Jianxun Liu, Shusen Liu, Jingxue Ye, Gang Ding, Guibo Sun
ETHNOPHARMACOLOGICAL RELEVANCE: Qilong capsule (QC) is developed from the traditional Chinese medicine formula Buyang Huanwu Decoction, which has been clinically used to invigorate Qi and promote blood circulation to eliminate blood stasis. Myocardial ischemia‒reperfusion injury (MIRI) can be attributed to Qi deficiency and blood stasis. However, the effects of QC on MIRI remain unclear. AIM OF THE STUDY: This study aimed to investigate the protective effect and possible mechanism of QC on platelet function in MIRI rats...
April 16, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38636579/neuroprotective-potential-of-traditionally-used-medicinal-plants-of-manipur-against-rotenone-induced-neurotoxicity-in-sh-sy5y-neuroblastoma-cells
#12
JOURNAL ARTICLE
Aruna Chanu Hijam, Yaiphabi Chanu Tongbram, Pooja Devi Nongthombam, Heikrujam Nilkanta Meitei, Arunkumar Singh Koijam, Yallapa Rajashekar, Reena Haobam
ETHNOPHARMACOLOGICAL RELEVANCE: Alternanthera sessilis (L.) R. Br. ex DC., Eryngium foetidum L., and Stephania japonica (Thunb.) Miers plants are traditionally used to treat various central nervous system disorders like paralysis, epilepsy, seizure, convulsion, chronic pain, headache, sleep disturbances, sprain, and mental disorders. However, their possible neuroprotective effects have not been evaluated experimentally so far. AIM OF THE STUDY: The study aims to examine the neuroprotective potential of the three plants against cytotoxicity induced by rotenone in SH-SY5Y neuroblastoma cells and assess its plausible neuroprotection mechanisms...
April 16, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38636578/mechanism-and-functional-substances-of-saiga-antelope-horn-in-treating-hypertension-with-liver-yang-hyperactivity-syndrome-explored-using-network-pharmacology-and-metabolomics
#13
JOURNAL ARTICLE
Wenxing Wu, Rui Liu, Sheng Guo, Wencong Song, Yongqing Hua, Min Hong, Jie Zheng, Yue Zhu, Peng Cao, Jin-Ao Duan
ETHNOPHARMACOLOGICAL RELEVANCE: Saiga antelope horn (SAH) is a traditional Chinese medicine for treating hypertension with liver-yang hyperactivity syndrome (Gan-Yang-Shang-Kang, GYSK), that has a long history of clinical application and precise efficacy, but its mechanism and functional substances are still unknown. Based on the demand for alternative research on the rare and endangered SAH, the group designed and carried out the following studies. AIM OF THE STUDY: The purpose of this research was to demonstrate the functional substances and mechanisms of SAH in the treatment of GYSK hypertension...
April 16, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38636577/investigation-of-the-drug-drug-interaction-and-incompatibility-mechanism-between-aconitum-carmichaelii-debx-and-pinellia-ternata-thunb-breit
#14
JOURNAL ARTICLE
Minglei Ge, Huizi Ouyang, Ye Shang, Abdulmumin Muhammad Biu, Xiwei Wu, Caixia Li, Fanjiao Zuo, Yameng Zhu, Zixiang Xue, Jia Hao, Jun He
ETHNOPHARMACOLOGICAL RELEVANCE: The combination of Aconitum carmichaelii Debx (Chuanwu, CW) and Pinellia ternata (Thunb.) Breit (Banxia, BX) forms an herbal pair within the eighteen incompatible medicaments (EIM), indicating that BX and CW are incompatible. However, the scientific understanding of this incompatibility mechanism, especially the corresponding drug-drug interaction (DDI), remains complex and unclear. AIM OF THE STUDY: This study aims to explain the DDI and potential incompatibility mechanism between CW and BX based on pharmacokinetics and cocktail approach...
April 16, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38636576/anti-angiogenic-and-anti-tumour-activities-of-lignosus-rhinocerus-cooke-ryvarden-water-extracts-on-hct116-human-colorectal-carcinoma-cells-implanted-in-chick-embryos
#15
JOURNAL ARTICLE
Gong Yi Yong, Nishalini Muniandy, Adilet Beishenaliev, Beng Fye Lau, Chin Siang Kue
ETHNOPHARMACOLOGICAL RELEVANCE: The sclerotium of Lignosus rhinocerus (Cooke) Ryvarden is used by the local communities in Southeast Asia and China to treat cancer, asthma, fever, and other ailments based on traditional knowledge. The sclerotial water extracts were previously reported to exhibit cytotoxic, apoptotic, and immunomodulatory activities - providing a scientific basis for its use in treating cancer; however, there is still a lack of evidence on its potential anti-angiogenic activity...
April 16, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38636575/chinese-herbal-medicine-for-the-treatment-of-diabetic-nephropathy-from-clinical-evidence-to-potential-mechanisms
#16
REVIEW
Xiao-Xiao Gong, Lin-Hai Cao, Hong-Xia Ni, Zi-Yan Zang, Hui Chang
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetic nephropathy (DN) is a typical chronic microvascular complication of diabetes, characterized by proteinuria and a gradual decline in renal function. At present, there are limited clinical interventions aimed at preventing the progression of DN to end-stage renal disease (ESRD). However, Chinese herbal medicine presents a distinct therapeutic approach that can be effectively combined with conventional Western medicine treatments to safeguard renal function...
April 16, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38636574/active-fractions-from-jingfang-baidu-powder-alleviate-klebsiella-induced-pneumonia-by-inhibiting-tlr4-myd88-erk-signaling-pathway
#17
JOURNAL ARTICLE
Chuanbo Sun, Yuting Xu, Guangpei Xu, Xu Ji, Ping Jiang, Yanfei He
ETHNOPHARMACOLOGICAL RELEVANCE: Jingfang Baidu Powder (JFBDP) is a classic traditional Chinese medicine prescription. Although Jingfang Baidu powder obtained a general consensus on clinical efficacy in treating pneumonia, there were many Chinese herbal drugs in formula, complex components, and large oral dosage, which brings certain obstacles to clinical application. AIM OF THE STUDY: Therefore, screening of the active fraction that exerts anti-pneumonia helps improve the pharmaceutical preparation, improve the treatment compliance of patients, and further contribute to the clinical application, and the screening of the new active ingredients with anti-pneumonia...
April 16, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38636573/future-aspects-of-plant-derived-bioactive-metabolites-as-therapeutics-to-combat-benign-prostatic-hyperplasia
#18
REVIEW
Raman Krishnamoorthi, Anand Ganapathy A, Hari Priya V M, Alaganandam Kumaran
ETHNOPHARMACOLOGICAL RELEVANCE: Benign prostatic hyperplasia (BPH), characterized by prostate enlargement due to cell proliferation, is a common urinary disorder in men over 50, manifesting as lower urinary tract symptoms (LUTS). Currently, several therapeutic options are accessible for treating BPH, including medication therapy, surgery and watchful waiting. Conventional drugs such as finasteride and dutasteride are used as 5α-reductase inhibitors for the treatment of BPH. However long-term use of these drugs is restricted due to their unpleasant side effects...
April 16, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38636572/cytotoxic-acute-oral-toxicity-genotoxic-and-mutagenic-assessment-of-the-essential-oil-from-fresh-leaves-of-croton-argyrophyllus-kunth
#19
JOURNAL ARTICLE
Marcela Albuquerque de Oliveira, Marília Gabriela Muniz Arruda, Nabuêr Francieli da Silva, Rômulo Carlos Dantas da Cruz, Suelen Cristina Lourenço de Barros, Marcilene Souza da Silva, Talita Giselly Dos Santos Souza, Erwelly Barros de Oliveira, Cristiano Aparecido Chagas, Jaciana Dos Santos Aguiar, Alisson Macário de Oliveira, Roberta Jeane Bezerra Jorge, Ivone Antonia de Souza
ETHNOPHARMACOLOGICAL RELEVANCE: Croton argyrophyllus Kunth., commonly known as "marmeleiro" or "cassetinga," is widely distributed in the Brazilian Northeast region. Its leaves and flowers are used in traditional medicine as tranquilizers to treat flu and headaches. AIM OF THE STUDY: This study was conducted to determine the chemical composition and toxicological safety of essential oil from C. argyrophyllus leaves using in vitro and in vivo models. MATERIALS AND METHODS: The chemical composition of the essential oil was determined using a gas chromatograph coupled to a mass spectrometer...
April 16, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38632031/corrigendum-to-a-study-on-the-anti-senescent-effects-of-flavones-derived-from-prinsepia-utilis-royle-j-ethnopharmacol-328-2024-118021
#20
Junxi Liu, Liping Qu, Feifei Wang, Zaoju Mei, Xinlang Wu, Bo Wang, Haiyang Liu, Li He
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April 16, 2024: Journal of Ethnopharmacology
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