JOURNAL ARTICLE

Serotype replacement in perspective

Ron Dagan
Vaccine 2009 August 21, 27: C22-4
19545935
An increase in the incidence of invasive pneumococcal disease (IPD) caused by non-vaccine serotypes (NVTs) (serotype replacement) has been observed since the introduction of the seven-valent pneumococcal conjugate vaccine (PCV7), primarily in the elderly, HIV-positive adults, and children with underlying medical conditions. In children aged <5 years, only a slight increase in replacement disease due to NVTs has been observed, but the relationship of changes in serotype carriage to replacement disease is not well understood. Predominant post-PCV7 NVTs include serotypes 15, 19A, and 33F, but the increasing antibiotic resistance of 19A is of particular concern in both vaccinated and unvaccinated populations.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
19545935
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"