journal
https://read.qxmd.com/read/38631949/safe-plant-hsp90-adjuvants-elicit-an-effective-immune-response-against-sars-cov2-derived-rbd-antigen
#1
JOURNAL ARTICLE
Victor A Ramos-Duarte, Alejandro Orlowski, Carolina Jaquenod de Giusti, Mariana G Corigliano, Ariel Legarralde, Luisa F Mendoza-Morales, Agustín Atela, Manuel A Sánchez, Valeria A Sander, Sergio O Angel, Marina Clemente
To better understand the role of pHsp90 adjuvant in immune response modulation, we proposed the use of the Receptor Binding Domain (RBD) of the Spike protein of SARS-CoV2, the principal candidate in the design of subunit vaccines. We evaluated the humoral and cellular immune responses against RBD through the strategy "protein mixture" (Adjuvant + Antigen). The rRBD adjuvanted with rAtHsp81.2 group showed a higher increase of the anti-rRBD IgG1, while the rRBD adjuvanted with rNbHsp90.3 group showed a significant increase in anti-rRBD IgG2b/2a...
April 17, 2024: Vaccine
https://read.qxmd.com/read/38631948/cost-effectiveness-of-high-dose-influenza-vaccination-in-the-netherlands-incorporating-the-impact-on-both-respiratory-and-cardiovascular-hospitalizations
#2
JOURNAL ARTICLE
Simon van der Pol, Florian Zeevat, Maarten J Postma, Cornelis Boersma
OBJECTIVES: We assess the cost-effectiveness of switching from standard-dose quadrivalent influenza vaccination (SD-QIV) to high-dose vaccination (HD-QIV) for Dutch adults aged 60 years and older. METHODS: A health-economic model was used to compare the scenario where HD-QIV was implemented compared to the current standard, SD-QIV. This model used a lifetime horizon and assessed the cost-effectiveness from a societal perspective. A recently published meta-analysis was used to incorporate the benefits of HD-QIV, including cardiorespiratory hospitalizations, in analyses considering RCT only or combining RCT and RWE estimates in a scenario analysis...
April 17, 2024: Vaccine
https://read.qxmd.com/read/38631956/identifying-major-histocompatibility-complex-class-ii-dr-molecules-in-bovine-and-swine-peripheral-blood-monocyte-derived-macrophages-using-mab-l243
#3
JOURNAL ARTICLE
Carmen Celis-Giraldo, Diego Ordoñez, Diana Díaz-Arévalo, Michel D Bohórquez, Nieves Ibarrola, Carlos F Suárez, Kewin Rodríguez, Yoelis Yepes, Alexander Rodríguez, Catalina Avendaño, Julio López-Abán, Raúl Manzano-Román, Manuel Alfonso Patarroyo
Major histocompatibility complex class II (MHC-II) molecules are involved in immune responses against pathogens and vaccine candidates' immunogenicity. Immunopeptidomics for identifying cancer and infection-related antigens and epitopes have benefited from advances in immunopurification methods and mass spectrometry analysis. The mouse anti-MHC-II-DR monoclonal antibody L243 (mAb-L243) has been effective in recognising MHC-II-DR in both human and non-human primates. It has also been shown to cross-react with other animal species, although it has not been tested in livestock...
April 16, 2024: Vaccine
https://read.qxmd.com/read/38631955/erratum-to-immunogenicity-of-an-adenovirus-vectored-bivalent-vaccine-against-wild-type-sars-cov-2-and-omicron-variants-in-a-murine-model-vaccine-42-6-2024-1292-1299
#4
Yuanyuan Ji, Xiuwen Sui, Wei Miao, Chang Wang, Qing Wang, Zhuojun Duan, Bochao Wei, Dan Wu, Menghan Wei, Juan Shao, Xiuyu Zheng, Tao Zhu
No abstract text is available yet for this article.
April 16, 2024: Vaccine
https://read.qxmd.com/read/38631954/analysis-of-causal-relations-between-vaccine-hesitancy-for-covid-19-vaccines-and-ideological-orientations-in-brazil
#5
JOURNAL ARTICLE
Eanes Torres Pereira, Sylvia Iasulaitis, Bruno Cardoso Greco
This article presents a causal inference analysis of vaccine hesitancy for Coronavirus disease 2019 (COVID-19) vaccines based on socio-demographic data obtained via questionnaires applied to a sample of the Brazilian population. This data includes the respondents' political preferences, age group, education, salary range, country region, sex, believing fake news, vaccine confidence, and intention to get the COVID-19 vaccine. The research created a causal graph using these variables, seeking to answer questions about the probability of people getting vaccinated...
April 16, 2024: Vaccine
https://read.qxmd.com/read/38631953/avoidable-covid-19-related-deaths-and-hospitalizations-in-brazil-2020-2023
#6
JOURNAL ARTICLE
Emil Kupek
OBJECTIVE: To estimate the number of avoidable COVID-19 deaths and hospitalizations in Brazil. METHODS: Secondary data on COVID-19 deaths and hospitalizations were related to two measures of cumulative vaccine coverage (in the last six months and before this period) by negative binomial regression to estimate population-level protective effectiveness (PLPE) against severe disease. The latter includes the overall protective effect of all COVID-19-preventive measures, such as direct and indirect vaccine effectiveness, social distancing, and lockdown, but only the vaccine coverage data were available for the regression analysis...
April 16, 2024: Vaccine
https://read.qxmd.com/read/38631952/overview-of-u-s-covid-19-vaccine-safety-surveillance-systems
#7
JOURNAL ARTICLE
Julianne Gee, Tom T Shimabukuro, John R Su, David Shay, Margaret Ryan, Sridhar V Basavaraju, Karen R Broder, Matthew Clark, C Buddy Creech, Francesca Cunningham, Kristin Goddard, Harrison Guy, Kathryn M Edwards, Richard Forshee, Tanya Hamburger, Anne M Hause, Nicola P Klein, Ian Kracalik, Chris Lamer, David A Loran, Michael M McNeil, Jay Montgomery, Pedro Moro, Tanya R Myers, Christine Olson, Matthew E Oster, Andrea J Sharma, Ryan Schupbach, Eric Weintraub, Brett Whitehead, Steven Anderson
The U.S. COVID-19 vaccination program, which commenced in December 2020, has been instrumental in preventing morbidity and mortality from COVID-19 disease. Safety monitoring has been an essential component of the program. The federal government undertook a comprehensive and coordinated approach to implement complementary safety monitoring systems and to communicate findings in a timely and transparent way to healthcare providers, policymakers, and the public. Monitoring involved both well-established and newly developed systems that relied on both spontaneous (passive) and active surveillance methods...
April 16, 2024: Vaccine
https://read.qxmd.com/read/38631951/covid-19-vaccination-communication-effects-of-vaccine-conspiracy-beliefs-and-message-framing-among-black-and-white-participants
#8
JOURNAL ARTICLE
Namyeon Lee, Yoorim Hong, Ciera E Kirkpatrick, Sisi Hu, Sungkyoung Lee, Amanda Hinnant
BACKGROUND: The importance of vaccination in combating the COVID-19 pandemic is widely acknowledged. The aim of this study was (1) to understand how one's vaccine conspiracy beliefs would influence their public health news processing, (2) to examine how specific public health news features (i.e., news frame) would influence message processing, and (3) to examine if there were any differences between Black and White participants in their message processing. METHODS: A nationwide online experiment (N = 821) with a 3 (vaccine conspiracy beliefs: high vs...
April 16, 2024: Vaccine
https://read.qxmd.com/read/38631950/understanding-the-views-of-adult-migrants-around-catch-up-vaccination-for-missed-routine-immunisations-to-define-strategies-to-improve-coverage-a-uk-in-depth-interview-study
#9
JOURNAL ARTICLE
Anna Deal, Alison F Crawshaw, Maha Salloum, Sally E Hayward, Jessica Carter, Felicity Knights, Farah Seedat, Oumnia Bouaddi, Nuria Sanchez-Clemente, Laura Muzinga Lutumba, Lusau Mimi Kitoko, Sarah Nkembi, Caroline Hickey, Sandra Mounier-Jack, Azeem Majeed, Sally Hargreaves
BACKGROUND: The World Health Organization's (WHO) Immunization Agenda 2030 emphasises ensuring equitable access to vaccination across the life course. This includes placing an emphasis on migrant populations who may have missed key childhood vaccines, doses, and boosters due to disrupted healthcare systems and the migration process, or differing vaccination schedules in home countries. Guidelines exist in the UK for offering catch-up vaccinations to adolscent and adult migrants with incomplete or uncertain vaccination status (including MMR, Td-IPV, MenACWY, HPV), but emerging evidence suggests awareness and implementation in primary care is poor...
April 16, 2024: Vaccine
https://read.qxmd.com/read/38627149/measles-outbreak-associated-with-a-preschool-setting-among-partially-vaccinated-children-in-the-tel-aviv-district-israel-october-2023
#10
JOURNAL ARTICLE
Rivka Sheffer, Efrat Bucris, Ziva Amitai, Victoria Indenbaum, Yaniv Lustig, Michal Savion, Naama Nuss, Shepherd Roee Singer, Sharon Alroy Preis, Sharon Almagor, Eyal Leshem, Matanelle Salama
In October 2023, the Tel Aviv District was notified of ten cases of measles. The outbreak initiated in a preschool with high vaccination coverage with one dose of MMR vaccine. Serological testing was available for eight patients (six children and two adults). Among the six children vaccinated with one dose of MMR vaccine, primary vaccine failure was demonstrated. Among the adults, secondary vaccine failure was confirmed. The outbreak was successfully contained due to a combination of factors, notably its occurrence within a population characterized by high vaccination coverage in Tel Aviv, during a period of restricted public interactions due to the prevailing state of war in the country...
April 15, 2024: Vaccine
https://read.qxmd.com/read/38627148/patient-concerns-and-physician-strategies-for-addressing-covid-19-vaccine-hesitancy
#11
JOURNAL ARTICLE
Joy Melnikow, Andrew Padovani, Jingwen Zhang, Marykate Miller, Melissa Gosdin, Sabrina Loureiro, Brock Daniels
OBJECTIVE: COVID-19 vaccination is critical for reducing serious illness and hospitalizations, yet many remain hesitant. We conducted a survey of frontline physicians to identify patient concerns and physician strategies to address COVID-19 vaccine-hesitancy. METHODS: A national random sample of physicians in frontline specialties selected from a comprehensive list of practicing physicians in the U.S. were emailed a survey in August 2021. Multiple choice and open-ended questions inquired about patient concerns related to the COVID-19 vaccines and strategies used by physicians to counter vaccine misinformation and encourage vaccine-hesitant patients...
April 15, 2024: Vaccine
https://read.qxmd.com/read/38627147/antibody-kinetics-between-birth-and-three-months-of-life-in-healthy-infants-with-natural-exposure-to-group-b-streptococcus-a-uk-cohort-study
#12
JOURNAL ARTICLE
Konstantinos Karampatsas, Tom Hall, Merryn Voysey, Clara Carreras-Abad, Madeleine Cochet, Laxmee Ramkhelawon, Elisabeth Peregrine, Nick Andrews, Paul T Heath, Kirsty Le Doare
INTRODUCTION: Capsular polysaccharide (CPS) serotype-specific Immunoglobulin G (IgG) in cord blood has been proposed as a correlate of protection against invasive Group B Streptococcus (iGBS) disease. Although protective levels are required in infants throughout the window of vulnerability up to 3 months of age, little is known regarding the kinetics of GBS-specific IgG over this period. METHODS: We enrolled 33 healthy infants born to mothers colonized with GBS...
April 15, 2024: Vaccine
https://read.qxmd.com/read/38627146/assessment-of-the-impact-of-the-vaccine-pass-policy-on-covid-19-vaccine-hesitancy-and-uptake-among-chinese-adults-in-hong-kong
#13
JOURNAL ARTICLE
Irene O L Wong, Cherry Wong, Nelly Mak, Alan Dai, Jingyi Xiao, Peng Wu, Michael Y Ni, Qiuyan Liao, Benjamin J Cowling
BACKGROUND: Recognising the importance of attaining high vaccine coverage to mitigate the COVID-19 impact, a Vaccine Pass scheme was implemented during and after the first large Omicron wave with high mortality in older ages in Hong Kong in early 2022 requiring three doses by June 2022. We did not identify any studies evaluating the policy impact of vaccination mandates with vaccine uptake over whole policy period of time in a Chinese population. We aim to evaluate the impact of the Vaccine Pass policy on COVID-19 vaccine uptake in adults in a Chinese population in Hong Kong...
April 15, 2024: Vaccine
https://read.qxmd.com/read/38627145/the-immunodominance-of-antigenic-site-sb-on-the-h1-influenza-virus-hemagglutinin-increases-with-high-immunoglobulin-titers-of-the-cohorts-and-with-young-age-but-not-sex
#14
JOURNAL ARTICLE
Jose L Martínez, Nicholas Lemus, Tsoi Ying Lai, Mitali Mishra, Irene González-Domínguez, Eduard Puente-Massaguer, Madhumathi Loganathan, Benjamin Francis, Marie I Samanovic, Florian Krammer, Mark J Mulligan, Viviana Simon, Peter Palese, Weina Sun
The head domain of the hemagglutinin of influenza viruses plays a dominant role in the antibody response due to the presence of immunodominant antigenic sites that are the main targets of host neutralizing antibodies. For the H1 hemagglutinin, five major antigenic sites defined as Sa, Sb, Ca1, Ca2, and Cb have been described. Although previous studies have focused on defining the hierarchy of the antigenic sites of the hemagglutinin in different human cohorts, it is still unclear if the immunodominance profile of the antigenic sites might change with the antibody levels of individuals or if other demographic factors (such as exposure history, sex, or age) could also influence the importance of the antigenic sites...
April 15, 2024: Vaccine
https://read.qxmd.com/read/38627144/immunogenicity-of-quadrivalent-human-papillomavirus-vaccine-among-alaska-native-children-aged-9-14%C3%A2-years-at-5%C3%A2-years-after-vaccination
#15
JOURNAL ARTICLE
Bionca M Davis, Ian Blake, Gitika Panicker, Elissa Meites, Gail Thompson, Jesse Geis, Dana Bruden, Marc Fischer, Rosalyn Singleton, Elizabeth R Unger, Lauri E Markowitz, Michael G Bruce
BACKGROUND: Persistent human papillomavirus (HPV) infection can cause anogenital and oropharyngeal cancers. Many HPV infections and HPV-associated cancers are vaccine-preventable. Studies suggest long-term persistence of vaccine-induced antibodies. However, data are limited among Alaska Native people. METHODS: During 2011-2014, we enrolled Alaska Native children aged 9-14 years who received a 3-dose series of quadrivalent HPV vaccine (4vHPV). We collected sera at 1 month and 1, 2, 3, and 5 years post-vaccination to evaluate trends in type-specific immunoglobulin G antibody concentrations for the 4vHPV types (HPV 6/11/16/18)...
April 15, 2024: Vaccine
https://read.qxmd.com/read/38627143/prevalence-of-and-factors-associated-with-zero-dose-and-under-immunized-children-in-selected-areas-of-bangladesh-findings-from-lot-quality-assurance-sampling-survey
#16
JOURNAL ARTICLE
Hemel Das, Zerin Jannat, Kaniz Fatema, Jannat-E-Tajreen Momo, Md Wazed Ali, Nurul Alam, Mahbub E Elahi Khan Chowdhury, Christopher Morgan, Elizabeth Oliveras, Gustavo Caetano Correa, Heidi W Reynolds, Md Jasim Uddin, Tasnuva Wahed
BACKGROUND: In the era of Gavi's 5.0 vision of "leaving no one behind with immunization", childhood routine vaccination in missed communities is considered as a priority concern. Despite having a success story at the national level, low uptake of immunization is still persistent in selected pocket areas of Bangladesh. However, prevalence and the associated factors of zero-dose (ZD) and under-immunization (UI) are still unknown at those geo-pockets of Bangladesh. Thus, the study aims to report and identify the factors associated with ZD and UI in selected geographical locations...
April 15, 2024: Vaccine
https://read.qxmd.com/read/38616440/hpv-vaccine-issues-in-japan-a-review-of-our-attempts-to-promote-the-hpv-vaccine-and-to-provide-effective-evaluation-of-the-problem-through-social-medical-and-behavioral-economic-perspectives
#17
JOURNAL ARTICLE
Asami Yagi, Yutaka Ueda, Tadashi Kimura
In Japan, subsidies from local and national government programs for HPV vaccination of girls aged 13-16 began in 2010. By 2013, HPV vaccines were being used routinely for vaccinating girls aged 12-16 as part of its national immunization program. However, in June of 2013, in response to reports of possible adverse reactions to the vaccine, Japan's Ministry of Health, Labor, and Welfare (MHLW) announced a 'temporary suspension' of its governmental recommendation for HPV vaccination. The vaccination rate quickly dropped from 70 % of age-eligible girls to almost zero...
April 13, 2024: Vaccine
https://read.qxmd.com/read/38616439/effectiveness-of-two-and-three-doses-of-covid-19-mrna-vaccines-against-infection-symptoms-and-severity-in-the-pre-omicron-era-a-time-dependent-gradient
#18
JOURNAL ARTICLE
Layan Sukik, Hiam Chemaitelly, Houssein H Ayoub, Peter Coyle, Patrick Tang, Hadi M Yassine, Asmaa A Al Thani, Mohammad R Hasan, Zaina Al-Kanaani, Einas Al-Kuwari, Andrew Jeremijenko, Anvar Hassan Kaleeckal, Ali Nizar Latif, Riyazuddin Mohammad Shaik, Hanan F Abdul-Rahim, Gheyath K Nasrallah, Mohamed Ghaith Al-Kuwari, Adeel A Butt, Hamad Eid Al-Romaihi, Mohamed H Al-Thani, Abdullatif Al-Khal, Roberto Bertollini, Manar E Abdel-Rahman, Laith J Abu-Raddad
BACKGROUND: Vaccines were developed and deployed to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aimed to characterize patterns in the protection provided by the BNT162b2 and mRNA-1273 mRNA vaccines against a spectrum of SARS-CoV-2 infection symptoms and severities. METHODS: A national, matched, test-negative, case-control study was conducted in Qatar between January 1 and December 18, 2021, utilizing a sample of 238,896 PCR-positive tests and 6,533,739 PCR-negative tests...
April 13, 2024: Vaccine
https://read.qxmd.com/read/38616438/equivalent-immunogenicity-across-three-rsvpref-vaccine-lots-in-healthy-adults-18-49-years-of-age-results-of-a-randomized-phase-3-study
#19
JOURNAL ARTICLE
Jeffrey Baker, Negar Aliabadi, Iona Munjal, Qin Jiang, Ye Feng, Linda G Brock, David Cooper, Annaliesa S Anderson, Kena A Swanson, William C Gruber, Alejandra Gurtman
BACKGROUND: Bivalent RSV prefusion F subunit vaccine (RSVpreF), comprised of equal quantities of stabilized prefusion F antigens from the major circulating subgroups (RSV A, RSV B), is licensed for prevention of RSV-associated lower respiratory tract illness (LRTI) in older adults and for maternal vaccination for prevention of RSV-associated LRTI in infants. To support licensure and large-scale manufacturing, this lot consistency study was conducted to demonstrate equivalence in immunogenicity across 3 RSVpreF lots...
April 13, 2024: Vaccine
https://read.qxmd.com/read/38616437/super-epitope-dengue-vaccine-instigated-serotype-independent-immune-protection-in-silico
#20
JOURNAL ARTICLE
Shovan Naskar, Hitesh Harsukhbhai Chandpa, Shalini Agarwal, Jairam Meena
Dengue becomes the most common life-threatening infectious arbovirus disease globally, with prevalence in the tropical and subtropical areas. The major clinical features include dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS), a condition of hypovolemic shock. Four different serotypes of the dengue virus, known as dengue virus serotype (DENV)- 1, 2, 3 and 4 can infect humans. Only one vaccine is available in the market, named Dengvaxia by Sanofi Pasteur, but there is no desired outcome of this treatment due the antibody dependent enhancement (ADE) of the multiple dengue serotypes...
April 13, 2024: Vaccine
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