JOURNAL ARTICLE

Hepatitis E virus and chronic hepatitis in organ-transplant recipients

Nassim Kamar, Janick Selves, Jean-Michel Mansuy, Leila Ouezzani, Jean-Marie Péron, Joëlle Guitard, Olivier Cointault, Laure Esposito, Florence Abravanel, Marie Danjoux, Dominique Durand, Jean-Pierre Vinel, Jacques Izopet, Lionel Rostaing
New England Journal of Medicine 2008 February 21, 358 (8): 811-7
18287603
Hepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis. We identified 14 cases of acute HEV infection in three patients receiving liver transplants, nine receiving kidney transplants, and two receiving kidney and pancreas transplants. All patients were positive for serum HEV RNA. Chronic hepatitis developed in eight patients, as confirmed by persistently elevated aminotransferase levels, serum HEV RNA, and histologic features of chronic hepatitis. The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.

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