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Leila Dorling, Sara Carvalho, Jamie Allen, Anna González-Neira, Craig Luccarini, Cecilia Wahlström, Karen A Pooley, Michael T Parsons, Cristina Fortuno, Qin Wang, Manjeet K Bolla, Joe Dennis, Renske Keeman, M Rosario Alonso, Nuria Álvarez, Belen Herraez, Victoria Fernandez, Rocio Núñez-Torres, Ana Osorio, Jeanette Valcich, Minerva Li, Therese Törngren, Patricia A Harrington, Caroline Baynes, Don M Conroy, Brennan Decker, Laura Fachal, Nasim Mavaddat, Thomas Ahearn, Kristiina Aittomäki, Natalia N Antonenkova, Norbert Arnold, Patrick Arveux, Margreet G E M Ausems, Päivi Auvinen, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Marina Bermisheva, Katarzyna Białkowska, Carl Blomqvist, Natalia V Bogdanova, Nadja Bogdanova-Markov, Stig E Bojesen, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Michael Bremer, Ignacio Briceno, Thomas Brüning, Barbara Burwinkel, David A Cameron, Nicola J Camp, Archie Campbell, Angel Carracedo, Jose E Castelao, Melissa H Cessna, Stephen J Chanock, Hans Christiansen, J Margriet Collée, Emilie Cordina-Duverger, Sten Cornelissen, Kamila Czene, Thilo Dörk, Arif B Ekici, Christoph Engel, Mikael Eriksson, Peter A Fasching, Jonine Figueroa, Henrik Flyger, Asta Försti, Marike Gabrielson, Manuela Gago-Dominguez, Vassilios Georgoulias, Fabian Gil, Graham G Giles, Gord Glendon, Encarna B Gómez Garcia, Grethe I Grenaker Alnæs, Pascal Guénel, Andreas Hadjisavvas, Lothar Haeberle, Eric Hahnen, Per Hall, Ute Hamann, Elaine F Harkness, Jaana M Hartikainen, Mikael Hartman, Wei He, Bernadette A M Heemskerk-Gerritsen, Peter Hillemanns, Frans B L Hogervorst, Antoinette Hollestelle, Weang Kee Ho, Maartje J Hooning, Anthony Howell, Keith Humphreys, Faiza Idris, Anna Jakubowska, Audrey Jung, Pooja Middha Kapoor, Michael J Kerin, Elza Khusnutdinova, Sung-Won Kim, Yon-Dschun Ko, Veli-Matti Kosma, Vessela N Kristensen, Kyriacos Kyriacou, Inge M M Lakeman, Jong Won Lee, Min Hyuk Lee, Jingmei Li, Annika Lindblom, Wing-Yee Lo, Maria A Loizidou, Artitaya Lophatananon, Jan Lubiński, Robert J MacInnis, Michael J Madsen, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Maria Elena Martinez, Tabea Maurer, Dimitrios Mavroudis, Catriona McLean, Alfons Meindl, Arjen R Mensenkamp, Kyriaki Michailidou, Nicola Miller, Nur Aishah Mohd Taib, Kenneth Muir, Anna Marie Mulligan, Heli Nevanlinna, William G Newman, Børge G Nordestgaard, Pei-Sze Ng, Jan C Oosterwijk, Sue K Park, Tjoung-Won Park-Simon, Jose I A Perez, Paolo Peterlongo, David J Porteous, Karolina Prajzendanc, Darya Prokofyeva, Paolo Radice, Muhammad U Rashid, Valerie Rhenius, Matti A Rookus, Thomas Rüdiger, Emmanouil Saloustros, Elinor J Sawyer, Rita K Schmutzler, Andreas Schneeweiss, Peter Schürmann, Mitul Shah, Christof Sohn, Melissa C Southey, Harald Surowy, Maija Suvanto, Somchai Thanasitthichai, Ian Tomlinson, Diana Torres, Thérèse Truong, Maria Tzardi, Yana Valova, Christi J van Asperen, Rob M Van Dam, Ans M W van den Ouweland, Lizet E van der Kolk, Elke M van Veen, Camilla Wendt, Justin A Williams, Xiaohong R Yang, Sook-Yee Yoon, M Pilar Zamora, D Gareth Evans, Miguel de la Hoya, Jacques Simard, Antonis C Antoniou, Åke Borg, Irene L Andrulis, Jenny Chang-Claude, Montserrat García-Closas, Georgia Chenevix-Trench, Roger L Milne, Paul D P Pharoah, Marjanka K Schmidt, Amanda B Spurdle, Maaike P G Vreeswijk, Javier Benitez, Alison M Dunning, Anders Kvist, Soo H Teo, Peter Devilee, Douglas F Easton
BACKGROUND: Genetic testing for breast cancer susceptibility is widely used, but for many genes, evidence of an association with breast cancer is weak, underlying risk estimates are imprecise, and reliable subtype-specific risk estimates are lacking. METHODS: We used a panel of 34 putative susceptibility genes to perform sequencing on samples from 60,466 women with breast cancer and 53,461 controls. In separate analyses for protein-truncating variants and rare missense variants in these genes, we estimated odds ratios for breast cancer overall and tumor subtypes...
January 20, 2021: New England Journal of Medicine
#2
Perri Klass, Adam J Ratner
No abstract text is available yet for this article.
January 20, 2021: New England Journal of Medicine
#3
Mary Kathryn Poole, Sheila E Fleischhacker, Sara N Bleich
No abstract text is available yet for this article.
January 20, 2021: New England Journal of Medicine
#4
EDITORIAL
Steven A Narod
No abstract text is available yet for this article.
January 20, 2021: New England Journal of Medicine
#5
Chunling Hu, Steven N Hart, Rohan Gnanaolivu, Hongyan Huang, Kun Y Lee, Jie Na, Chi Gao, Jenna Lilyquist, Siddhartha Yadav, Nicholas J Boddicker, Raed Samara, Josh Klebba, Christine B Ambrosone, Hoda Anton-Culver, Paul Auer, Elisa V Bandera, Leslie Bernstein, Kimberly A Bertrand, Elizabeth S Burnside, Brian D Carter, Heather Eliassen, Susan M Gapstur, Mia Gaudet, Christopher Haiman, James M Hodge, David J Hunter, Eric J Jacobs, Esther M John, Charles Kooperberg, Allison W Kurian, Loic Le Marchand, Sara Lindstroem, Tricia Lindstrom, Huiyan Ma, Susan Neuhausen, Polly A Newcomb, Katie M O'Brien, Janet E Olson, Irene M Ong, Tuya Pal, Julie R Palmer, Alpa V Patel, Sonya Reid, Lynn Rosenberg, Dale P Sandler, Christopher Scott, Rulla Tamimi, Jack A Taylor, Amy Trentham-Dietz, Celine M Vachon, Clarice Weinberg, Song Yao, Argyrios Ziogas, Jeffrey N Weitzel, David E Goldgar, Susan M Domchek, Katherine L Nathanson, Peter Kraft, Eric C Polley, Fergus J Couch
BACKGROUND: Population-based estimates of the risk of breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for risk assessment and management in women with inherited pathogenic variants. METHODS: In a population-based case-control study, we performed sequencing using a custom multigene amplicon-based panel to identify germline pathogenic variants in 28 cancer-predisposition genes among 32,247 women with breast cancer (case patients) and 32,544 unaffected women (controls) from population-based studies in the Cancer Risk Estimates Related to Susceptibility (CARRIERS) consortium...
January 20, 2021: New England Journal of Medicine
#6
Katharine Van Tassel, Carmel Shachar, Sharona Hoffman
No abstract text is available yet for this article.
January 20, 2021: New England Journal of Medicine
#7
Mark T Hughes, Jeffrey Kahn, Allen Kachalia
No abstract text is available yet for this article.
January 20, 2021: New England Journal of Medicine
#8
Simar Singh Bajaj, Fatima Cody Stanford
No abstract text is available yet for this article.
January 20, 2021: New England Journal of Medicine
#9
Olav L Schjørring, Thomas L Klitgaard, Anders Perner, Jørn Wetterslev, Theis Lange, Martin Siegemund, Minna Bäcklund, Frederik Keus, Jon H Laake, Matthew Morgan, Katrin M Thormar, Søren A Rosborg, Jannie Bisgaard, Annette E S Erntgaard, Anne-Sofie H Lynnerup, Rasmus L Pedersen, Elena Crescioli, Theis C Gielstrup, Meike T Behzadi, Lone M Poulsen, Stine Estrup, Jens P Laigaard, Cheme Andersen, Camilla B Mortensen, Björn A Brand, Jonathan White, Inge-Lise Jarnvig, Morten H Møller, Lars Quist, Morten H Bestle, Martin Schønemann-Lund, Maj K Kamper, Mathias Hindborg, Alexa Hollinger, Caroline E Gebhard, Núria Zellweger, Christian S Meyhoff, Mathias Hjort, Laura K Bech, Thorbjørn Grøfte, Helle Bundgaard, Lars H M Østergaard, Maria A Thyø, Thomas Hildebrandt, Bülent Uslu, Christoffer G Sølling, Nette Møller-Nielsen, Anne C Brøchner, Morten Borup, Marjatta Okkonen, Willem Dieperink, Ulf G Pedersen, Anne S Andreasen, Lone Buus, Tayyba N Aslam, Robert R Winding, Joerg C Schefold, Stine B Thorup, Susanne A Iversen, Janus Engstrøm, Maj-Brit N Kjær, Bodil S Rasmussen
BACKGROUND: Patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are treated with supplemental oxygen, but the benefits and harms of different oxygenation targets are unclear. We hypothesized that using a lower target for partial pressure of arterial oxygen (Pao2 ) would result in lower mortality than using a higher target. METHODS: In this multicenter trial, we randomly assigned 2928 adult patients who had recently been admitted to the ICU (≤12 hours before randomization) and who were receiving at least 10 liters of oxygen per minute in an open system or had a fraction of inspired oxygen of at least 0...
January 20, 2021: New England Journal of Medicine
#10
Jerald Sadoff, Mathieu Le Gars, Georgi Shukarev, Dirk Heerwegh, Carla Truyers, Anne M de Groot, Jeroen Stoop, Sarah Tete, Wim Van Damme, Isabel Leroux-Roels, Pieter-Jan Berghmans, Murray Kimmel, Pierre Van Damme, Jan de Hoon, William Smith, Kathryn E Stephenson, Stephen C De Rosa, Kristen W Cohen, M Juliana McElrath, Emmanuel Cormier, Gert Scheper, Dan H Barouch, Jenny Hendriks, Frank Struyf, Macaya Douoguih, Johan Van Hoof, Hanneke Schuitemaker
BACKGROUND: Efficacious vaccines are urgently needed to contain the ongoing coronavirus disease 2019 (Covid-19) pandemic of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A candidate vaccine, Ad26.COV2.S, is a recombinant, replication-incompetent adenovirus serotype 26 (Ad26) vector encoding a full-length and stabilized SARS-CoV-2 spike protein. METHODS: In this multicenter, placebo-controlled, phase 1-2a trial, we randomly assigned healthy adults between the ages of 18 and 55 years (cohort 1) and those 65 years of age or older (cohort 3) to receive the Ad26...
January 13, 2021: New England Journal of Medicine
#11
William B Feldman, Benjamin N Rome, Jerry Avorn, Aaron S Kesselheim
No abstract text is available yet for this article.
January 13, 2021: New England Journal of Medicine
#12
EDITORIAL
Louis M Katz
No abstract text is available yet for this article.
January 13, 2021: New England Journal of Medicine
#13
Brad Smith
No abstract text is available yet for this article.
January 13, 2021: New England Journal of Medicine
#14
Aaron Waxman, Ricardo Restrepo-Jaramillo, Thenappan Thenappan, Ashwin Ravichandran, Peter Engel, Abubakr Bajwa, Roblee Allen, Jeremy Feldman, Rahul Argula, Peter Smith, Kristan Rollins, Chunqin Deng, Leigh Peterson, Heidi Bell, Victor Tapson, Steven D Nathan
BACKGROUND: No therapies are currently approved for the treatment of pulmonary hypertension in patients with interstitial lung disease. The safety and efficacy of inhaled treprostinil for patients with this condition are unclear. METHODS: We enrolled patients with interstitial lung disease and pulmonary hypertension (documented by right heart catheterization) in a multicenter, randomized, double-blind, placebo-controlled, 16-week trial. Patients were assigned in a 1:1 ratio to receive inhaled treprostinil, administered by means of an ultrasonic, pulsed-delivery nebulizer in up to 12 breaths (total, 72 μg) four times daily, or placebo...
January 13, 2021: New England Journal of Medicine
#15
EDITORIAL
Darren B Taichman
No abstract text is available yet for this article.
January 13, 2021: New England Journal of Medicine
#16
LETTER
Erika A Kaske, Samuel W Cramer, Isabela Pena Pino, Truong H Do, Bryan M Ladd, Dylan T Sturtevant, Aliya Ahmadi, Birra Taha, David Freeman, Joel T Wu, Brooke A Cunningham, Rachel R Hardeman, David J Satin, David P Darrow
No abstract text is available yet for this article.
January 13, 2021: New England Journal of Medicine
#17
James A Diao, Lesley A Inker, Andrew S Levey, Hocine Tighiouart, Neil R Powe, Arjun K Manrai
No abstract text is available yet for this article.
January 6, 2021: New England Journal of Medicine
#18
Romina Libster, Gonzalo Pérez Marc, Diego Wappner, Silvina Coviello, Alejandra Bianchi, Virginia Braem, Ignacio Esteban, Mauricio T Caballero, Cristian Wood, Mabel Berrueta, Aníbal Rondan, Gabriela Lescano, Pablo Cruz, Yvonne Ritou, Valeria Fernández Viña, Damián Álvarez Paggi, Sebastián Esperante, Adrián Ferreti, Gastón Ofman, Álvaro Ciganda, Rocío Rodriguez, Jorge Lantos, Ricardo Valentini, Nicolás Itcovici, Alejandra Hintze, M Laura Oyarvide, Candela Etchegaray, Alejandra Neira, Ivonne Name, Julieta Alfonso, Rocío López Castelo, Gisela Caruso, Sofía Rapelius, Fernando Alvez, Federico Etchenique, Federico Dimase, Darío Alvarez, Sofía S Aranda, Clara Sánchez Yanotti, Julián De Luca, Sofía Jares Baglivo, Sofía Laudanno, Florencia Nowogrodzki, Ramiro Larrea, María Silveyra, Gabriel Leberzstein, Alejandra Debonis, Juan Molinos, Miguel González, Eduardo Perez, Nicolás Kreplak, Susana Pastor Argüello, Luz Gibbons, Fernando Althabe, Eduardo Bergel, Fernando P Polack
BACKGROUND: Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because antibodies should be administered earlier in the course of illness. METHODS: We conducted a randomized, double-blind, placebo-controlled trial of convalescent plasma with high IgG titers against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in older adult patients within 72 hours after the onset of mild Covid-19 symptoms...
January 6, 2021: New England Journal of Medicine
#19
LETTER
Jonas F Ludvigsson, Lars Engerström, Charlotta Nordenhäll, Emma Larsson
No abstract text is available yet for this article.
January 6, 2021: New England Journal of Medicine
#20
Christina Amutah, Kaliya Greenidge, Adjoa Mante, Michelle Munyikwa, Sanjna L Surya, Eve Higginbotham, David S Jones, Risa Lavizzo-Mourey, Dorothy Roberts, Jennifer Tsai, Jaya Aysola
No abstract text is available yet for this article.
January 6, 2021: New England Journal of Medicine
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