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Gregory K Friedman, James M Johnston, Asim K Bag, Joshua D Bernstock, Rong Li, Inmaculada Aban, Kara Kachurak, Li Nan, Kyung-Don Kang, Stacie Totsch, Charles Schlappi, Allison M Martin, Devang Pastakia, Rene McNall-Knapp, Sameer Farouk Sait, Yasmin Khakoo, Matthias A Karajannis, Karina Woodling, Joshua D Palmer, Diana S Osorio, Jeffrey Leonard, Mohamed S Abdelbaki, Avi Madan-Swain, T Prescott Atkinson, Richard J Whitley, John B Fiveash, James M Markert, G Yancey Gillespie
BACKGROUND: Outcomes in children and adolescents with recurrent or progressive high-grade glioma are poor, with a historical median overall survival of 5.6 months. Pediatric high-grade gliomas are largely immunologically silent or "cold," with few tumor-infiltrating lymphocytes. Preclinically, pediatric brain tumors are highly sensitive to oncolytic virotherapy with genetically engineered herpes simplex virus type 1 (HSV-1) G207, which lacks genes essential for replication in normal brain tissue...
April 10, 2021: New England Journal of Medicine
#2
Andreas Greinacher, Thomas Thiele, Theodore E Warkentin, Karin Weisser, Paul A Kyrle, Sabine Eichinger
BACKGROUND: Several cases of unusual thrombotic events and thrombocytopenia have developed after vaccination with the recombinant adenoviral vector encoding the spike protein antigen of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (ChAdOx1 nCov-19, AstraZeneca). More data were needed on the pathogenesis of this unusual clotting disorder. METHODS: We assessed the clinical and laboratory features of 11 patients in Germany and Austria in whom thrombosis or thrombocytopenia had developed after vaccination with ChAdOx1 nCov-19...
April 9, 2021: New England Journal of Medicine
#3
Nina H Schultz, Ingvild H Sørvoll, Annika E Michelsen, Ludvig A Munthe, Fridtjof Lund-Johansen, Maria T Ahlen, Markus Wiedmann, Anne-Hege Aamodt, Thor H Skattør, Geir E Tjønnfjord, Pål A Holme
We report findings in five patients who presented with venous thrombosis and thrombocytopenia 7 to 10 days after receiving the first dose of the ChAdOx1 nCoV-19 adenoviral vector vaccine against coronavirus disease 2019 (Covid-19). The patients were health care workers who were 32 to 54 years of age. All the patients had high levels of antibodies to platelet factor 4-polyanion complexes; however, they had had no previous exposure to heparin. Because the five cases occurred in a population of more than 130,000 vaccinated persons, we propose that they represent a rare vaccine-related variant of spontaneous heparin-induced thrombocytopenia that we refer to as vaccine-induced immune thrombotic thrombocytopenia...
April 9, 2021: New England Journal of Medicine
#4
LETTER
Xiaoying Shen, Haili Tang, Rolando Pajon, Gale Smith, Gregory M Glenn, Wei Shi, Bette Korber, David C Montefiori
No abstract text is available yet for this article.
April 7, 2021: New England Journal of Medicine
#5
Ryan Essex, Sharon M Weldon
No abstract text is available yet for this article.
April 7, 2021: New England Journal of Medicine
#6
Ram Sasisekharan
No abstract text is available yet for this article.
April 7, 2021: New England Journal of Medicine
#7
LETTER
Thandeka Moyo-Gwete, Mashudu Madzivhandila, Zanele Makhado, Frances Ayres, Donald Mhlanga, Brent Oosthuysen, Bronwen E Lambson, Prudence Kgagudi, Houriiyah Tegally, Arash Iranzadeh, Deelan Doolabh, Lynn Tyers, Lionel R Chinhoyi, Mathilda Mennen, Sango Skelem, Gert Marais, Constantinos K Wibmer, Jinal N Bhiman, Veronica Ueckermann, Theresa Rossouw, Michael Boswell, Tulio de Oliveira, Carolyn Williamson, Wendy A Burgers, Ntobeko Ntusi, Lynn Morris, Penny L Moore
No abstract text is available yet for this article.
April 7, 2021: New England Journal of Medicine
#8
LETTER
Yaniv Lustig, Ital Nemet, Limor Kliker, Neta Zuckerman, Ruti Yishai, Sharon Alroy-Preis, Ella Mendelson, Michal Mandelboim
No abstract text is available yet for this article.
April 7, 2021: New England Journal of Medicine
#9
Robert Y Chen, Ishita Mostafa, Matthew C Hibberd, Subhasish Das, Mustafa Mahfuz, Nurun N Naila, M Munirul Islam, Sayeeda Huq, M Ashraful Alam, Mahabub U Zaman, Arjun S Raman, Daniel Webber, Cyrus Zhou, Vinaik Sundaresan, Kazi Ahsan, Martin F Meier, Michael J Barratt, Tahmeed Ahmed, Jeffrey I Gordon
BACKGROUND: More than 30 million children worldwide have moderate acute malnutrition. Current treatments have limited effectiveness, and much remains unknown about the pathogenesis of this condition. Children with moderate acute malnutrition have perturbed development of their gut microbiota. METHODS: In this study, we provided a microbiota-directed complementary food prototype (MDCF-2) or a ready-to-use supplementary food (RUSF) to 123 slum-dwelling Bangladeshi children with moderate acute malnutrition between the ages of 12 months and 18 months...
April 7, 2021: New England Journal of Medicine
#10
EDITORIAL
Wendy S Garrett
No abstract text is available yet for this article.
April 7, 2021: New England Journal of Medicine
#11
LETTER
Nicole Doria-Rose, Mehul S Suthar, Mat Makowski, Sarah O'Connell, Adrian B McDermott, Britta Flach, Julie E Ledgerwood, John R Mascola, Barney S Graham, Bob C Lin, Sijy O'Dell, Stephen D Schmidt, Alicia T Widge, Venkata-Viswanadh Edara, Evan J Anderson, Lilin Lai, Katharine Floyd, Nadine G Rouphael, Veronika Zarnitsyna, Paul C Roberts, Mamodikoe Makhene, Wendy Buchanan, Catherine J Luke, John H Beigel, Lisa A Jackson, Kathleen M Neuzil, Hamilton Bennett, Brett Leav, Jim Albert, Pratap Kunwar
No abstract text is available yet for this article.
April 6, 2021: New England Journal of Medicine
#12
LETTER
Min-Chul Kim, Man-Seong Park, Jin-Won Chung
No abstract text is available yet for this article.
April 6, 2021: New England Journal of Medicine
#13
LETTER
Guo-Lin Wang, Zhuang-Ye Wang, Li-Jun Duan, Qing-Chuan Meng, Ming-Dong Jiang, Jing Cao, Lin Yao, Ka-Li Zhu, Wu-Chun Cao, Mai-Juan Ma
No abstract text is available yet for this article.
April 6, 2021: New England Journal of Medicine
#14
Sandra C Quinn, Michele P Andrasik
No abstract text is available yet for this article.
March 31, 2021: New England Journal of Medicine
#15
Mark A Hall, David M Studdert
No abstract text is available yet for this article.
March 31, 2021: New England Journal of Medicine
#16
Jean B Nachega, Nadia A Sam-Agudu, John W Mellors, Alimuddin Zumla, Lynne M Mofenson
No abstract text is available yet for this article.
March 31, 2021: New England Journal of Medicine
#17
Kushal T Kadakia, Adam L Beckman, Joseph S Ross, Harlan M Krumholz
No abstract text is available yet for this article.
March 24, 2021: New England Journal of Medicine
#18
Katrina Armstrong
No abstract text is available yet for this article.
March 24, 2021: New England Journal of Medicine
#19
James H Lee
No abstract text is available yet for this article.
March 24, 2021: New England Journal of Medicine
#20
LETTER
Salim S Abdool Karim, Tulio de Oliveira
No abstract text is available yet for this article.
March 24, 2021: New England Journal of Medicine
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