Gregory K Friedman, James M Johnston, Asim K Bag, Joshua D Bernstock, Rong Li, Inmaculada Aban, Kara Kachurak, Li Nan, Kyung-Don Kang, Stacie Totsch, Charles Schlappi, Allison M Martin, Devang Pastakia, Rene McNall-Knapp, Sameer Farouk Sait, Yasmin Khakoo, Matthias A Karajannis, Karina Woodling, Joshua D Palmer, Diana S Osorio, Jeffrey Leonard, Mohamed S Abdelbaki, Avi Madan-Swain, T Prescott Atkinson, Richard J Whitley, John B Fiveash, James M Markert, G Yancey Gillespie
BACKGROUND: Outcomes in children and adolescents with recurrent or progressive high-grade glioma are poor, with a historical median overall survival of 5.6 months. Pediatric high-grade gliomas are largely immunologically silent or "cold," with few tumor-infiltrating lymphocytes. Preclinically, pediatric brain tumors are highly sensitive to oncolytic virotherapy with genetically engineered herpes simplex virus type 1 (HSV-1) G207, which lacks genes essential for replication in normal brain tissue...
April 10, 2021: New England Journal of Medicine