Prevalence of extended-spectrum beta-lactamase-producing Escherichia coli in a tertiary care hospital in Tehran, Iran

Hadi Mehrgan, Mohammad Rahbar
International Journal of Antimicrobial Agents 2008, 31 (2): 147-51
The prevalence of extended-spectrum beta-lactamase (ESBL) production by consecutive, non-repeated Escherichia coli isolates from hospitalised patients was determined over the period from July 2005 to November 2006. A total of 201 E. coli were isolated from various clinical specimens, 135 (67.2%) of which were confirmed as ESBL-positive using the combination disk synergy test. By univariate analysis, male sex, intravascular or urinary catheterisation, recent surgery or hospitalisation and isolation of E. coli from wound or respiratory tube specimens were found to be risk factors for acquisition of resistant bacteria (chi(2) test, P<0.05). However, binary logistic multivariate regression analysis confirmed that isolation of E. coli from urine samples of either males in any hospital ward (odd ratio (OR) 7.52, 95% confidence interval (CI) 1.21-47.62; P=0.031) or patients with prior surgery (OR 13.16, 95% CI 1.81-100.00; P=0.011) were significantly associated with ESBL production. Imipenem, amikacin and piperacillin/tazobactam were found to be highly active against ESBL-positive isolates in vitro (100%, 91.1% and 85.2% susceptibility, respectively). They showed co-resistance with other antibiotics such as fluoroquinolones, gentamicin and trimethoprim/sulfamethoxazole. Of the 135 ESBL-positive isolates, 22 (16.3%) appeared to be of the CTX-M type based on a phenotypic determination method.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"