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Journals International Journal of Antim...

International Journal of Antimicrobial Agents

https://read.qxmd.com/read/38851463/impact-of-continuous-infusion-meropenem-degradation-and-infusion-bag-changes-on-bacterial-killing-of-pseudomonas-aeruginosa-based-on-model-informed-translation
#1
JOURNAL ARTICLE
Iris K Minichmayr, Lena E Friberg
Continuous infusion of meropenem has been proposed to increase target attainment in critically ill patients, although stability might limit its practical use. This study investigated the impact of meropenem degradation and infusion bag changes on the concentration-time profiles and bacterial growth and killing of P. aeruginosa given different continuous-infusion solutions. A semi-mechanistic PK-PD model quantifying meropenem concentrations (CMEM ) and bacterial counts of a resistant P. aeruginosa strain (ARU552, MIC=16 mg/L) over 24 hours was used to translate in vitro antibiotic effects to patients with severe infections...
June 6, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38851462/a-multicentre-randomised-double-blind-double-dummy-parallel-controlled-phase-3-clinical-trial-assessing-the-efficacy-and-safety-of-intravenous-nemonoxacin-malate-versus-levofloxacin-for-community-acquired-pneumonia-in-adult-patients
#2
JOURNAL ARTICLE
Ying Li, Demei Zhu, Shenghua Sun, Xiaoyue Chang, Zhaolong Cao, Yanping Yang, Xiuhua Fu, Xiangyang Li, Jinfu Xu, Yingqun Zhu, Fuxin Hui, Xingxiang Xu, Zhang Chen, Liping Peng, Zhuang Ma, Biwen Mo, Chen Li, Yuan Lv, Li Zhao, Guangfa Zhu, Yong He, Hua Liu, Jichao Chen, Ying Wang, Yongjie Liang, Youjin Lu, Zhiqiang Qin, Hongzhong Yang, Min Zhang, Shiman Wu, Zhaohui Tong, Feng Ye, Zuke Xiao, Xuefen Wang, Chen Qiu, Jiulong Kuang, Huaping Huang, Kai Wang, Kejing Ying, Faguang Jin, Xiaoju Lv, Yijiang Huang, Deling Liu, Wei Wang, Yingyuan Zhang
BACKGROUND: Nemonoxacin malate is a novel non-fluorinated quinolone for oral and intravenous (IV) administration. This phase 3 multicentre, randomised, double-blind, double-dummy, parallel-controlled clinical trial (NCT02205112) evaluated the efficacy and safety of IV nemonoxacin versus levofloxacin for treatment of community-acquired pneumonia (CAP) in adult patients. METHODS: The eligible patients were randomised to receive 500 mg nemonoxacin or levofloxacin via IV infusion, once daily for 7-14 days...
June 6, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38851461/tracking-emergence-and-outbreak-of-klebsiella-pneumoniae-co-producing-ndm-1-and-kpc-2-after-sulfamethoxazole-trimethoprim-treatment-insights-from-genetic-analysis
#3
JOURNAL ARTICLE
Mengyuan Wang, Mingju Hao, Xiaodi Cui, Min Liu, Chunyan Zhang, Shifu Wang
The co-production of KPC and NDM carbapenemases in carbapenem-resistant Klebsiella pneumoniae (CRKP) complicates clinical treatment and increases mortality rates. The emergence of KPC-NDM CRKP is believed to result from acquiring an NDM plasmid by KPC-CRKP, especially under the selective pressure of ceftazidime-avibactam (CZA). In this study, a CRKP-producing KPC-2 (JNP990) was isolated from a patient at a tertiary hospital in Shandong Province. Following sulfamethoxazole-trimethoprim (SXT) treatment, the isolate evolved into a strain that co-produces KPC and NDM (JNP989), accompanied by resistance to SXT (MIC>2/38 μg/mL) and CZA (dd≤14 mm)...
June 6, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38824973/evaluation-of-bacteriophage-%C3%AF-11-host-recognition-protein-and-its-host-binding-peptides-for-diagnosing-targeting-of-saphylococcus-aureus-infections
#4
JOURNAL ARTICLE
Senanur Dokuz, Semra Tasdurmazlı, Tayfun Acar, Gizem Nur Duran, Cilem Ozdemir, Utku Ozbey, Mehmet Ozbil, Sukriye Karadayı, Omer Faruk Bayrak, Serap Derman, John Yu-Shen Chen, Tulin Ozbek
Evaluating the potential of using both synthetic and biological products as targeting agents for the diagnosis, imaging, and treatment of infections due to particularly antibiotic-resistant pathogens is important for controlling infections. We examined the interaction between Gp45, a receptor-binding protein of the ϕ11 lysogenic phage, and its host S. aureus, a common cause of nosocomial infections. Using molecular dynamics and docking simulations, we identified the peptides that bind to S. aureus wall teichoic acids via Gp45...
May 31, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38824972/risk-factor-analysis-for-the-occurrence-of-colistin-related-nephrotoxicity-a-retrospective-observational-cohort-study
#5
LETTER
Xiaoshuang He, Jie Fang, Juntao Zhao, Fengmei Hu, Qiuya Lu, Xiaolan Bian
No abstract text is available yet for this article.
May 31, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38824971/verapamil-increases-susceptibility-of-colistin-resistant-acinetobacter-baumannii-to-colistin
#6
JOURNAL ARTICLE
Sichen Liu, Huijing Zhou, Jingchun Kong, Huanchang Chen, Lei Chen, Miran Tang, Beibei Zhou, Mengxin Xu, Lijiang Chen, Tieli Zhou
Acinetobacter baumannii, which is predominantly responsible for hospital-acquired infections, presents a tremendous clinical challenge due to its increasing antibiotic resistance to colistin (COL), a last-line antibiotic. As a result, the combination of antimicrobial and non-antimicrobial agents is emerging as a more popular treatment approach against infections caused by colistin-resistant (COL-R) A. baumannii. This study administered COL and verapamil (VER), i.e., an antihypertensive and antiarrhythmic agent...
May 31, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38823494/dynamic-evolution-of-ceftazidime-avibactam-resistance-from-a-single-patient-through-the-incx3_ndm-5-plasmid-transfer-and-bla-kpc-mutation
#7
JOURNAL ARTICLE
Chengkang Tang, Siquan Shen, Weiwei Yang, Qingyu Shi, Li Ding, Renru Han, Fupin Hu
The rapid dissemination of carbapenem-resistant Enterobacterales (CRE) especially carbapenem-resistant K. pneumoniae (CRKP) poses a great threat to global public health. Ceftazidime-avibactam, a novel β-lactam/β-lactamase inhibitor combination, has been widely used due to its excellent antibacterial activity against KPC-producing K. pneumoniae. However, several resistance mechanisms have been reported since its use. Here, we conducted a series of in vitro experiments to reveal and demonstrate the dynamic evolution of ceftazidime-avibactam resistance including interspecies IncX3_NDM-5 plasmid transfer between E...
May 30, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38823493/the-ndm-1-biosensor-rapidly-and-accurately-detected-antibiotic-plasma-concentrations-in-cefuroxime-treated-patients
#8
JOURNAL ARTICLE
Qinglai Meng, Yao Wang, Yali Long, Qi Wang, Yajing Gao, Junsheng Tian, Changxin Wu, Bin Xie
Therapeutic drug monitoring (TDM) of β-lactam antibiotics in critically ill patients may benefit dose optimization, thus improving therapeutic outcomes. However, rapidly and accurately detecting these antibiotics in blood remains a challenge. Our research group recently developed a thermometric biosensor called the New Delhi metallo-β-lactamase-1 (NDM-1) biosensor, which detected multiple classes of β-lactam antibiotics in spiked plasma samples. This study assesses the NDM-1 biosensor's effectiveness in detecting plasma concentrations of β-lactam antibiotic in treated patients...
May 30, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38815701/dynamic-evolution-of-achromobacter-xylosoxydans-in-a-patient-with-leukemia-receiving-antibiotic-treatment
#9
LETTER
German Matias Traglia, Nicholas Furtado, Jenny Escalante, Marisa Almuzara, Roxana Marisa Cittadini, Marisel R Tuttobene, Tomás Subils, Carolina Dominguez Maldonado, Veronica Viard, Soledad Estela Gonzalez, Maria Ines Sormani, Marcelo E Tolmasky, Carlos Vay, Gauri Rao, Maria Soledad Ramirez
No abstract text is available yet for this article.
May 28, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38810941/large-scale-comparative-analysis-reveals-phylogenomic-preference-of-bla-ndm-1-and-bla-kpc-2-transmission-among-klebsiella-pneumoniae
#10
JOURNAL ARTICLE
Yali Zhang, Mengyue Liu, Jiangfeng Zhang, Jie Wu, Lijuan Hong, LiQiang Zhu, Jinzhao Long
blaNDM-1 and blaKPC-2 are responsible for the global rise of carbapenem-resistant K. pneumoniae, posing a great challenge to public health. However, the impact of phylogenetic factors on blaNDM-1 and blaKPC-2 dissemination is not yet fully understood. Here, we established a global dataset of 4051 blaNDM-1 + or 10223 blaKPC-2 + K. pneumoniae genomes and compared their transmission mode on a global scale. The results showed that blaNDM-1 + K. pneumoniae genomes exhibited a broader geographical distribution and higher ST richness than blaKPC-2 +, indicating higher transmissibility of the blaNDM-1 gene...
May 27, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38810940/noncanonical-mutations-in-ribosome-nascent-peptide-exit-tunnel-confer-clarithromycin-resistance-in-mycobacterium-abscessus-complex
#11
JOURNAL ARTICLE
Wei Liao, Xinyan Wang, Yi Wang, Pengjiao Ma, Ken Chen, Liang Ge, Xiaoyan Yang, Shushu Zeng, Wenfeng Gao, Shu Zhang, Hongren Wang, Xu Jia, Tao Luo
Mycobacterium abscessus is a non-tuberculous mycobacterial pathogen known to cause pulmonary and skin infections worldwide. Renowned for its multidrug resistance, M. abscessus infections often result in unfavorable clinical outcomes. Clarithromycin plays a pivotal role in treating M. abscessus infections, with resistance commonly leads to treatment failure. While canonical mutations in 23S rRNA residue 2270/2271 are recognized as a major mechanism for acquired clarithromycin resistance, resistant isolates devoid of such mutations have been widely reported...
May 27, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38810939/phage-therapy-combats-pandrug-resistant-acinetobacter-baumannii-infection-safely-and-efficiently
#12
JOURNAL ARTICLE
Wei-Xiao Wang, Jia-Zhen Wu, Bai-Ling Zhang, Jiao-Yang Yu, Li-Mei Han, Xiao-Liang Lu, Hui Li, Shi-Yong Fu, Yun-Yao Ren, Hui Dong, Yi Xu, Gong-Ting Wang, Jing-Han Gao, Chun Wang, Xiu-Zhen Chen, Du-Xian Liu, Ying Huang, Jin-Hong Yu, Shi-Wei Wang, Yong-Feng Yang, Wei Chen
Phage therapy offers a promising approach to combat the growing threat of antimicrobial resistance. Yet, key questions remain regarding dosage, administration routes, combination therapy, and the causes of therapeutic failure. In this study, we focused on a novel lytic phage, ФAb4B, which specifically targeted the A. baumannii strains with KL160 CPS, including the pan-drug resistant A. baumannii YQ4. ФAb4B exhibited the ability to effectively inhibit biofilm formation and eradicate mature biofilms independently of dosage...
May 27, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38810938/bacteriophage-resistant-carbapenem-resistant-klebsiella-pneumoniae-shows-reduced-antibiotic-resistance-and-virulence
#13
JOURNAL ARTICLE
Qiao Chen, Feiyang Zhang, Jiawei Bai, Qian Che, Li Xiang, Zhikun Zhang, Ying Wang, Åsa Sjöling, Alberto J Martín-Rodríguez, Baoli Zhu, Li Fu, Yingshun Zhou
Phage therapy has shown great promise in the treatment of bacterial infections. However, the effectiveness of phage therapy is compromised by the inevitable emergence of phage-resistant strains. In this study, a phage-resistant Carbapenem-Resistant Klebsiella pneumoniae (CRKP) strain SWKP1711R, derived from parental CRKP strain SWKP1711 was identified. The mechanism of bacteriophage resistance in SWKP1711R was investigated and the molecular determinants causing altered growth characteristics, antibiotic resistance, and virulence of SWKP1711R were tested...
May 27, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38810937/trial-sequential-analysis-of-intrathecal-intraventricular-antimicrobial-therapy-for-post-neurosurgical-gram-negative-bacillary-meningitis-or-ventriculitis
#14
LETTER
I-Wen Chen, Ting-Sian Yu, Chun-Ning Ho, Kuo-Chuan Hung
No abstract text is available yet for this article.
May 27, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38810936/exploring-the-therapeutic-potential-of-endolysin-cd27l_ead-against-clostridioides-difficile-infection
#15
JOURNAL ARTICLE
Youngjin Cho, Kyungah Park, Jeongseok Park, Jieun An, Heejoon Myung, Hyunjin Yoon
Clostridioides difficile has emerged as a major cause of life-threatening diarrheal disease. Conventional antibiotics used in current standards of care exacerbate the emergence of antibiotic-resistant strains and pose a risk of recurrent C. difficile infection (CDI). Thus, there is an urgent need for alternative therapeutics that selectively eliminate C. difficile without disturbing the commensal microbiota. Endolysin is a bacteriophage-derived peptidoglycan hydrolase that aids in the release of phage progeny during the final stage of infection...
May 27, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38795933/%C3%AE-ketoglutarate-downregulates-thiosulfate-metabolism-to-enhance-antibiotic-killing
#16
JOURNAL ARTICLE
Liao-Tian Peng, Si-Qi Tian, Wei-Xu Guo, Xuan-Wei Chen, Jia-Han Wu, Ying-Li Liu, Bo Peng
Potentiation of the effects of currently available antibiotics is urgently required to tackle the rising antibiotics resistance. The pyruvate (P) cycle has been shown to play a critical role in mediating aminoglycoside antibiotic killing, but the mechanism remains unexplored. In this study, we investigated the effects of intermediate metabolites of the P cycle regarding the potentiation of gentamicin. We found that α-ketoglutarate (α-KG) has the best synergy with gentamicin compared to the other metabolites...
May 23, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38795932/shifting-trends-in-bloodstream-infection-causing-microorganisms-and-their-clinical-impact-in-patients-with-haematologic-malignancies-in-south-korea-a-propensity-score-matched-study
#17
JOURNAL ARTICLE
Heekang Choi, Min Hyuk Choi, Dokyun Kim, Kyoung Hwa Lee, Seok Hoon Jeong
BACKGROUND: This study aimed to identify recent trends in the epidemiology of bloodstream infection (BSI)-causing microorganisms among patients with haematologic malignancies (HMs) between 2011 to 2021, and to determine their impact on patient outcomes. METHODS: This retrospective study included 6792 patients with HMs, of whom 1308 (19.3%) developed BSI within 1 year of diagnosis. The incidence of BSI-causing microorganisms was determined, and a propensity score-matched study was performed to identify risk factors for 28-day all-cause mortality (ACM) in patients with HM...
May 23, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38795931/population-pharmacokinetics-of-nirmatrelvir-in-chinese-patients-with-covid-19-therapeutic-drug-monitoring-and-dosing-regimen-selection-in-clinical-practice
#18
JOURNAL ARTICLE
Ping Yang, Wei Liu, Yingqiu Ying, Libo Zhao, Xin Xiong, Xianhua Zhang, Yinchu Cheng, Congya Zhou, Yuanyuan Zhang, Xiaona Li, Jiamin Xu, Li Yang, Rongsheng Zhao
OBJECTIVES: To establish a population pharmacokinetics (PopPK) model of nirmatrelvir in Chinese COVID-19 patients and provide reference for refining the dosing strategy of nirmatrelvir in patients confirmed to be infected with SARS-CoV-2. METHODS: A total of 80 blood samples were obtained from 35 mild moderate COVID-19 patients who were orally administered nirmatrelvir/ritonavir tablets. The PopPK model of nirmatrelvir was developed using a nonlinear mixed effects modeling approach...
May 23, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38795930/crf08_bc-subtype-is-more-prone-to-art-failure-and-new-generation-nnrti-resistance-under-long-term-first-line-art
#19
JOURNAL ARTICLE
Min Wu, Yuan Dong, Liyan Zeng, Yi Lin, Liang Yao, Yong Zhang, Weiwei Sun, Jianjun Sun, Qianqian Wang, Dan Yuan, Hong Xiao
OBJECTIVE: To investigate the characteristics of drug resistance mutations (DRMs) and their contextual influence on drug susceptibility in CRF07_BC and CRF_08BC subtypes. METHODS: Patients with virological failure were genotyped using phylogenetic analysis. DRMs and susceptibility to antiretroviral drugs were analyzed using the Stanford University HIV Drug Resistance Database. RESULTS: Six HIV subtypes were identified among 1296 successfully amplified sequences, with the CRF07_BC subtype prevailing at a rate of 91...
May 23, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38795929/the-emergence-of-ceftazidime-avibactam-resistance-through-in-vivo-bla-kpc-2-to-bla-kpc-33-conversion-during-treatment-of-st11-klebsiella-pneumoniae-associated-infections
#20
LETTER
Yi-Chyi Lai, Luo-Wei Lin, Yu-Lin Lee
No abstract text is available yet for this article.
May 23, 2024: International Journal of Antimicrobial Agents
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