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Case Reports
Journal Article
Erythrodermic cutaneous T cell lymphoma with hypereosinophilic syndrome: Treatment with interferon alfa and extracorporeal photopheresis.
International Journal of Dermatology 2007 November
BACKGROUND: Hypereosinophilic syndrome (HES) is a heterogeneous group of disorders characterized by a sustained eosinophilia leading to end organ dysfunction. The lymphoproliferative variant of HES is thought to be mediated by an underlying hematologic process that drives eosinophil production through specific cytokines. Eosinophilia is also recognized as a poor prognostic factor in cutaneous T-cell lymphoma (CTCL) in which neoplastic T cells may produce eosinophilopoietic cytokines.
OBJECTIVE: We report a case of HES with cardiac involvement that developed in the context of erythrodermic mycosis fungoides, discuss the possible relationship between these diseases, and speculate on the role that eosinophils might play as a prognostic factor in CTCL.
METHODS: Case report and review of the literature.
RESULTS: CTCL may be added to the group of lymphoproliferative disorders associated with HES.
CONCLUSION: A patient with erythroderma and concomitant diagnosis of "idiopathic" HES may warrant further investigation for CTCL.
OBJECTIVE: We report a case of HES with cardiac involvement that developed in the context of erythrodermic mycosis fungoides, discuss the possible relationship between these diseases, and speculate on the role that eosinophils might play as a prognostic factor in CTCL.
METHODS: Case report and review of the literature.
RESULTS: CTCL may be added to the group of lymphoproliferative disorders associated with HES.
CONCLUSION: A patient with erythroderma and concomitant diagnosis of "idiopathic" HES may warrant further investigation for CTCL.
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