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Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Review
Are there any differences in the efficacy among second generation antipsychotics in the treatment of schizophrenia and related disorders?
Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists 2007 April
BACKGROUND: The goal of this review is to summarize the results of head to head efficacy studies that compare second generation antipsychotics in the treatment of schizophrenia and related disorders.
METHODS: A literature search through the Medline database and Google was conducted. Articles published up to September 2005 were included. Abstracts from conference papers and posters were not included.
RESULTS: Randomized controlled trial data on possible differences in efficacy among atypical antipsychotics are limited. Moreover, the comparison is difficult, as studies differ in outcome measures. The results indicate that first-line second-generation antipsychotics (amisulpride, aripiprazole, olanzapine, quetiapine, risperidone, ziprasidone and zotepine) show comparable efficacy.
CONCLUSION: Possible new studies should focus on long-term effects, including cost-effectiveness, quality of life, social functioning and service utilization.
METHODS: A literature search through the Medline database and Google was conducted. Articles published up to September 2005 were included. Abstracts from conference papers and posters were not included.
RESULTS: Randomized controlled trial data on possible differences in efficacy among atypical antipsychotics are limited. Moreover, the comparison is difficult, as studies differ in outcome measures. The results indicate that first-line second-generation antipsychotics (amisulpride, aripiprazole, olanzapine, quetiapine, risperidone, ziprasidone and zotepine) show comparable efficacy.
CONCLUSION: Possible new studies should focus on long-term effects, including cost-effectiveness, quality of life, social functioning and service utilization.
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