Bench-to-bedside review: treating acid-base abnormalities in the intensive care unit - the role of buffers

Brian K Gehlbach, Gregory A Schmidt
Critical Care: the Official Journal of the Critical Care Forum 2004, 8 (4): 259-65
The recognition and management of acid-base disorders is a commonplace activity for intensivists. Despite the frequency with which non-bicarbonate-losing forms of metabolic acidosis such as lactic acidosis occurs in critically ill patients, treatment is controversial. This article describes the properties of several buffering agents and reviews the evidence for their clinical efficacy. The evidence supporting and refuting attempts to correct arterial pH through the administration of currently available buffers is presented.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.


Sort by: Most RecentHighest Rated

Ettienne Coetzee

When referring to lactic acidosis, do you mean lactate as the cause of the acidosis or hyperlactataemia with concomitant acidosis? As far as I understand, the term "lactic acidosis" can be misleading and that hyperlactataemia is merely a way of getting rid of pyruvate to enable glycolysis to continue in an environment where the mitochondria are dysfunctional. Please see Curr Opin Crit Care 12:315-321 2006.


Jose Antonio Flores

Great article. Useful


Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"