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Journals Critical Care : the Official J...

Critical Care : the Official Journal of the Critical Care Forum

https://read.qxmd.com/read/38796447/transpulmonary-pressure-monitoring-in-critically-ill-patients-pros-and-cons
#1
REVIEW
Lorenzo Ball, Daniel Talmor, Paolo Pelosi
The use of transpulmonary pressure monitoring based on measurement of esophageal pressure has contributed importantly to the personalization of mechanical ventilation based on respiratory pathophysiology in critically ill patients. However, esophageal pressure monitoring is still underused in the clinical practice. This technique allows partitioning of the respiratory mechanics between the lungs and the chest wall, provides information on lung recruitment and risk of barotrauma, and helps titrating mechanical ventilation settings in patients with respiratory failure...
May 25, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38790061/prompt-antimicrobial-therapy-and-source-control-on-survival-and-defervescence-of-adults-with-bacteraemia-in-the-emergency-department-the-faster-the-better
#2
MULTICENTER STUDY
Ching-Chi Lee, Po-Lin Chen, Ching-Yu Ho, Ming-Yuan Hong, Yuan-Pin Hung, Wen-Chien Ko
BACKGROUND: Bacteraemia is a critical condition that generally leads to substantial morbidity and mortality. It is unclear whether delayed antimicrobial therapy (and/or source control) has a prognostic or defervescence effect on patients with source-control-required (ScR) or unrequired (ScU) bacteraemia. METHODS: The multicenter cohort included treatment-naïve adults with bacteraemia in the emergency department. Clinical information was retrospectively obtained and etiologic pathogens were prospectively restored to accurately determine the time-to-appropriate antibiotic (TtAa)...
May 24, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38790054/vitamin-d-metabolism-in-critically-ill-patients-with-acute-kidney-injury-not-a-sole-player
#3
LETTER
Alexandre Braga Libório
No abstract text is available yet for this article.
May 24, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38783367/dyspnea-is-severe-and-associated-with-a-higher-intubation-rate-in-de-novo-acute-hypoxemic-respiratory-failure
#4
RANDOMIZED CONTROLLED TRIAL
Alexandre Demoule, Amandine Baptiste, Arnaud W Thille, Thomas Similowski, Stephanie Ragot, Gwénael Prat, Alain Mercat, Christophe Girault, Guillaume Carteaux, Thierry Boulain, Sébastien Perbet, Maxens Decavèle, Lisa Belin, Jean-Pierre Frat
BACKGROUND: Dyspnea is a key symptom of de novo acute hypoxemic respiratory failure. This study explores dyspnea and its association with intubation and mortality in this population. METHODS: This was a secondary analysis of a multicenter, randomized, controlled trial. Dyspnea was quantified by a visual analog scale (dyspnea-VAS) from zero to 100 mm. Dyspnea was measured in 259 of the 310 patients included. Factors associated with intubation were assessed with a competing risks model taking into account ICU discharge...
May 23, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38783313/prognostic-value-of-early-eeg-abnormalities-in-severe-stroke-patients-requiring-mechanical-ventilation-a-pre-planned-analysis-of-the-spice-prospective-multicenter-study
#5
MULTICENTER STUDY
Sarah Benghanem, Nathalie Kubis, Etienne Gayat, Ambre Loiodice, Estelle Pruvost-Robieux, Tarek Sharshar, Arnaud Foucrier, Samy Figueiredo, Viviane Bouilleret, Etienne De Montmollin, François Bagate, Jean-Pascal Lefaucheur, Bertrand Guidet, Emmanuelle Appartis, Alain Cariou, Olivier Varnet, Paul Henri Jost, Bruno Megarbane, Vincent Degos, Loic Le Guennec, Lionel Naccache, Stephane Legriel, France Woimant, Charles Gregoire, David Cortier, Isabelle Crassard, Jean-François Timsit, Mikael Mazighi, Romain Sonneville
INTRODUCTION: Prognostication of outcome in severe stroke patients necessitating invasive mechanical ventilation poses significant challenges. The objective of this study was to assess the prognostic significance and prevalence of early electroencephalogram (EEG) abnormalities in adult stroke patients receiving mechanical ventilation. METHODS: This study is a pre-planned ancillary investigation within the prospective multicenter SPICE cohort study (2017-2019), conducted in 33 intensive care units (ICUs) in the Paris area, France...
May 23, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38778416/assessing-the-impact-of-early-progressive-mobilization-on-moderate-to-severe-traumatic-brain-injury-a-randomized-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
Hsiao-Ching Yen, Hung-Jui Chuang, Wei-Ling Hsiao, Yun-Chen Tsai, Po-Min Hsu, Wen-Shiang Chen, Yin-Yi Han
INTRODUCTION: Traumatic brain injury (TBI) is a major cause of neurodisability worldwide, with notably high disability rates among moderately severe TBI cases. Extensive previous research emphasizes the critical need for early initiation of rehabilitation interventions for these cases. However, the optimal timing and methodology of early mobilization in TBI remain to be conclusively determined. Therefore, we explored the impact of early progressive mobilization (EPM) protocols on the functional outcomes of ICU-admitted patients with moderate to severe TBI...
May 22, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38773629/expiratory-flow-limitation-during-mechanical-ventilation-real-time-detection-and-physiological-subtypes
#7
JOURNAL ARTICLE
Detajin Junhasavasdikul, Akarawut Kasemchaiyanun, Tanakorn Tassaneyasin, Tananchai Petnak, Frank Silva Bezerra, Ricard Mellado-Artigas, Lu Chen, Yuda Sutherasan, Pongdhep Theerawit, Laurent Brochard
BACKGROUND: Tidal expiratory flow limitation (EFLT ) complicates the delivery of mechanical ventilation but is only diagnosed by performing specific manoeuvres. Instantaneous analysis of expiratory resistance (Rex) can be an alternative way to detect EFLT without changing ventilatory settings. This study aimed to determine the agreement of EFLT detection by Rex analysis and the PEEP reduction manoeuvre using contingency table and agreement coefficient. The patterns of Rex were explored...
May 21, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38769582/targeted-temperature-control-following-traumatic-brain-injury-esicm-naccs-best-practice-consensus-recommendations
#8
REVIEW
Andrea Lavinio, Jonathan P Coles, Chiara Robba, Marcel Aries, Pierre Bouzat, Dara Chean, Shirin Frisvold, Laura Galarza, Raimund Helbok, Jeroen Hermanides, Mathieu van der Jagt, David K Menon, Geert Meyfroidt, Jean-Francois Payen, Daniele Poole, Frank Rasulo, Jonathan Rhodes, Emily Sidlow, Luzius A Steiner, Fabio Silvio Taccone, Riikka Takala
AIMS AND SCOPE: The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and in patients with moderate TBI who deteriorate and require admission to the intensive care unit for intracranial pressure (ICP) management. METHODS: A group of 18 international neuro-intensive care experts in the acute management of TBI participated in a modified Delphi process. An online anonymised survey based on a systematic literature review was completed ahead of the meeting, before the group convened to explore the level of consensus on TTC following TBI...
May 20, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38762746/development-and-validation-of-the-tic-score-for-early-detection-of-traumatic-coagulopathy-upon-hospital-admission-a-cohort-study
#9
JOURNAL ARTICLE
Louis Brac, Albrice Levrat, Charles-Hervé Vacheron, Pierre Bouzat, Tristan Delory, Jean-Stéphane David
BACKGROUND: Critically injured patients need rapid and appropriate hemostatic treatment, which requires prompt identification of trauma-induced coagulopathy (TIC) upon hospital admission. We developed and validated the performance of a clinical score based on prehospital resuscitation parameters and vital signs at hospital admission for early diagnosis of TIC. METHODS: The score was derived from a level-1 trauma center registry (training set). It was then validated on data from two other level-1 trauma centers: first on a trauma registry (retrospective validation set), and then on a prospective cohort (prospective validation set)...
May 18, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38762578/acute-kidney-injury-after-out-of-hospital-cardiac-arrest
#10
RANDOMIZED CONTROLLED TRIAL
Karoline Korsholm Jeppesen, Sebastian Buhl Rasmussen, Jesper Kjaergaard, Henrik Schmidt, Simon Mølstrøm, Rasmus Paulin Beske, Johannes Grand, Hanne Berg Ravn, Matilde Winther-Jensen, Martin Abild Stengaard Meyer, Christian Hassager, Jacob Eifer Møller
BACKGROUND: Acute kidney injury (AKI) is a significant risk factor associated with reduced survival following out-of-hospital cardiac arrest (OHCA). Whether the severity of AKI simply serves as a surrogate measure of worse peri-arrest conditions, or represents an additional risk to long-term survival remains unclear. METHODS: This is a sub-study derived from a randomized trial in which 789 comatose adult OHCA patients with presumed cardiac cause and sustained return of spontaneous circulation (ROSC) were enrolled...
May 18, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38760871/challenging-icu-dogmas-a-new-perspective-on-venous-congestion-and-preload-dependency
#11
LETTER
Pierre-Grégoire Guinot, Dan Longrois
No abstract text is available yet for this article.
May 17, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38760833/protocolized-reduction-of-non-resuscitation-fluids-versus-usual-care-in-septic-shock-patients-reduse-a-randomized-multicentre-feasibility-trial
#12
RANDOMIZED CONTROLLED TRIAL
Anja Lindén, M Spångfors, M H Olsen, J Fisher, G Lilja, F Sjövall, M Jungner, M Lengquist, T Kander, L Samuelsson, J Johansson, E Palmnäs, J Undén, J Oras, M Cronhjort, M Chew, A Linder, M Lipcsey, N Nielsen, J C Jakobsen, P Bentzer
BACKGROUND/PURPOSE: Non-resuscitation fluids constitute the majority of fluid administered for septic shock patients in the intensive care unit (ICU). This multicentre, randomized, feasibility trial was conducted to test the hypothesis that a restrictive protocol targeting non-resuscitation fluids reduces the overall volume administered compared with usual care. METHODS: Adults with septic shock in six Swedish ICUs were randomized within 12 h of ICU admission to receive either protocolized reduction of non-resuscitation fluids or usual care...
May 17, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38750543/effects-of-mechanical-ventilation-on-the-interstitial-extracellular-matrix-in-healthy-lungs-and-lungs-affected-by-acute-respiratory-distress-syndrome-a-narrative-review
#13
REVIEW
Lou'i Al-Husinat, Saif Azzam, Sarah Al Sharie, Ahmed H Al Sharie, Denise Battaglini, Chiara Robba, John J Marini, Lauren T Thornton, Fernanda F Cruz, Pedro L Silva, Patricia R M Rocco
BACKGROUND: Mechanical ventilation, a lifesaving intervention in critical care, can lead to damage in the extracellular matrix (ECM), triggering inflammation and ventilator-induced lung injury (VILI), particularly in conditions such as acute respiratory distress syndrome (ARDS). This review discusses the detailed structure of the ECM in healthy and ARDS-affected lungs under mechanical ventilation, aiming to bridge the gap between experimental insights and clinical practice by offering a thorough understanding of lung ECM organization and the dynamics of its alteration during mechanical ventilation...
May 15, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38745319/predicting-outcome-after-aneurysmal-subarachnoid-hemorrhage-by-exploitation-of-signal-complexity-a-prospective-two-center-cohort-study
#14
MULTICENTER STUDY
Stefan Yu Bögli, Ihsane Olakorede, Michael Veldeman, Erta Beqiri, Miriam Weiss, Gerrit Alexander Schubert, Jan Folkard Willms, Emanuela Keller, Peter Smielewski
BACKGROUND: Signal complexity (i.e. entropy) describes the level of order within a system. Low physiological signal complexity predicts unfavorable outcome in a variety of diseases and is assumed to reflect increased rigidity of the cardio/cerebrovascular system leading to (or reflecting) autoregulation failure. Aneurysmal subarachnoid hemorrhage (aSAH) is followed by a cascade of complex systemic and cerebral sequelae. In aSAH, the value of entropy has not been established yet. METHODS: aSAH patients from 2 prospective cohorts (Zurich-derivation cohort, Aachen-validation cohort) were included...
May 14, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38745253/causes-and-attributable-fraction-of-death-from-ards-in-inflammatory-phenotypes-of-sepsis
#15
JOURNAL ARTICLE
Bruno Evrard, Pratik Sinha, Kevin Delucchi, Carolyn M Hendrickson, Kirsten N Kangelaris, Kathleen D Liu, Andrew Willmore, Nelson Wu, Lucile Neyton, Emma Schmiege, Antonio Gomez, V Eric Kerchberger, Ann Zalucky, Michael A Matthay, Lorraine B Ware, Carolyn S Calfee
BACKGROUND: Hypoinflammatory and hyperinflammatory phenotypes have been identified in both Acute Respiratory Distress Syndrome (ARDS) and sepsis. Attributable mortality of ARDS in each phenotype of sepsis is yet to be determined. We aimed to estimate the population attributable fraction of death from ARDS (PAFARDS ) in hypoinflammatory and hyperinflammatory sepsis, and to determine the primary cause of death within each phenotype. METHODS: We studied 1737 patients with sepsis from two prospective cohorts...
May 14, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38741192/potential-implications-of-long-acting-glp-1-receptor-agonists-for-critically-ill
#16
LETTER
Luping Wang, Hao Yang, Xiaoxiao Xia, Bo Wang, Qin Wu
No abstract text is available yet for this article.
May 13, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38741176/organ-donation-after-extracorporeal-cardiopulmonary-resuscitation-a-nationwide-retrospective-cohort-study
#17
JOURNAL ARTICLE
Tetsuya Yumoto, Kohei Tsukahara, Takafumi Obara, Takashi Hongo, Tsuyoshi Nojima, Hiromichi Naito, Atsunori Nakao
BACKGROUND: Limited data are available on organ donation practices and recipient outcomes, particularly when comparing donors who experienced cardiac arrest and received extracorporeal cardiopulmonary resuscitation (ECPR) followed by veno-arterial extracorporeal membrane oxygenation (ECMO) decannulation, versus those who experienced cardiac arrest without receiving ECPR. This study aims to explore organ donation practices and outcomes post-ECPR to enhance our understanding of the donation potential after cardiac arrest...
May 13, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38741141/qsofa-combined-with-supar-for-early-risk-detection-and-guidance-of-antibiotic-treatment-in-emergency-department-a-bit-sweet-and-a-bit-sour-randomized-controlled-trial
#18
LETTER
Bharat Paliwal, Nikhil Kothari, Trishita Saha, Pradeep Bhatia
No abstract text is available yet for this article.
May 13, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38741134/efficacy-of-expanded-periurethral-cleansing-in-reducing-catheter-associated-urinary-tract-infection-in-comatose-patients-a-randomized-controlled-clinical-trial
#19
RANDOMIZED CONTROLLED TRIAL
Xingsong Qin, He Zhao, Wei Qin, Xinglei Qin, Songying Shen, Hongyu Wang
BACKGROUND: The effect of the periurethral cleansing range on catheter-associated urinary tract infection (CAUTI) occurrence remains unknown. The purpose of this study was to evaluate the efficacy of expanded periurethral cleansing for reducing CAUTI in comatose patients. METHODS: In this randomized controlled trial, eligible patients in our hospital were enrolled and allocated randomly to the experimental group (expanded periurethral cleansing protocol; n = 225) or the control group (usual periurethral cleansing protocol; n = 221)...
May 13, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38730424/incidence-risk-factors-and-outcomes-of-nosocomial-infection-in-adult-patients-supported-by-extracorporeal-membrane-oxygenation-a-systematic-review-and-meta-analysis
#20
JOURNAL ARTICLE
Ali Ait Hssain, Amir Vahedian-Azimi, Abdulsalam Saif Ibrahim, Ibrahim Fawzy Hassan, Elie Azoulay, Michael Darmon
BACKGROUND: An increasing number of patients requires extracorporeal membrane oxygenation (ECMO) for life support. This supportive modality is associated with nosocomial infections (NIs). This systematic review and meta-analysis aim to assess the incidence and risk factors of NIs in adult. METHODS: We searched PubMed, Scopus, Web of Science, and ProQuest databases up to 2022. The primary endpoint was incidence of NI. Secondary endpoints included time to infection, source of infection, ECMO duration, Intensive care and hospital length of stay (LOS), ECMO survival and overall survival...
May 10, 2024: Critical Care: the Official Journal of the Critical Care Forum
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