JOURNAL ARTICLE

Biological activity of five antibacterial flavonoids from Combretum erythrophyllum (Combretaceae)

N D Martini, D R P Katerere, J N Eloff
Journal of Ethnopharmacology 2004, 93 (2): 207-12
15234754
Preliminary studies with Combretum erythrophyllum showed antimicrobial activity against Gram-positive and Gram-negative bacteria. Seven antibacterial flavonoids were subsequently isolated by bioassay-guided fractionation, i.e. apigenin; genkwanin; 5-hydroxy-7,4'-dimethoxyflavone, rhamnocitrin; kaempferol; quercetin-5,3'-dimethylether; rhamnazin. All compounds had good activity against Vibrio cholerae and Enterococcus faecalis, with MIC values in the range of 25-50 microg/ml. Rhamnocitrin and quercetin-5,3'-dimethylether also inhibited Micrococcus luteus and Shigella sonei at 25 microg/ml. With the exception of 5-hydroxy-7,4'-dimethoxy-flavone the flavonoids were not toxic towards human lymphocytes. This compound is potentially toxic to human cells and exhibited the poorest antioxidant activity whereas rhamnocitrin and rhamnazin exhibited strong antioxidant activity. Genkwanin; rhamnocitrin; quercetin-5,3'-dimethylether; rhamnazin had a higher anti-inflammatory activity than the positive control mefenamic acid. Although these flavonoids are known, this is the first report of biological activity with several of these compounds.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
15234754
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"