Gabriele Chelini, Hadi Mirzapourdelavar, Peter Durning, David Baidoe-Ansah, Manveen K Sethi, Sinead M O'Donovan, Torsten Klengel, Luigi Balasco, Cristina Berciu, Anne Boyer-Boiteau, Robert McCullumsmith, Kerry J Ressler, Joseph Zaia, Yuri Bozzi, Alexander Dityatev, Sabina Berretta
Recent findings show that effective integration of novel information in the brain requires coordinated processes of homo- and heterosynaptic plasticity. In this work, we hypothesize that activity-dependent remodeling of the peri-synaptic extracellular matrix (ECM) contributes to these processes. We show that clusters of the peri-synaptic ECM, recognized by CS56 antibody, emerge in response to sensory stimuli, showing temporal and spatial coincidence with dendritic spine plasticity. Using CS56 co-immunoprecipitation of synaptosomal proteins, we identify several molecules involved in Ca2+ signaling, vesicle cycling, and AMPA-receptor exocytosis, thus suggesting a role in long-term potentiation (LTP)...
April 25, 2024: Cell Reports