Yupeng He, Wei Yang, Luojiao Huang, Marlien Admiraal-van Mever, Rawi Ramautar, Amy Harms, Yvonne Rijksen, Renata M C Brandt, Sander Barnhoorn, Kimberly Smit, Dick Jaarsma, Peter Lindenburg, Jan H J Hoeijmakers, Wilbert P Vermeij, Thomas Hankemeier
BACKGROUND: Sarcopenia is characterized by loss of skeletal muscle mass and function, and is a major risk factor for disability and independence in the elderly. Effective medication is not available. Dietary restriction (DR) has been found to attenuate aging and aging-related diseases, including sarcopenia, but the mechanism of both DR and sarcopenia are incompletely understood. METHODS: In this study, mice body weight, fore and all limb grip strength, and motor learning and coordination performance were first analysed to evaluate the DR effects on muscle functioning...
April 30, 2024: Journal of Cachexia, Sarcopenia and Muscle