Jürgen Braun, Johannes Bernarding, Joachim Snellings, Tom Meyer, Pedro Augusto Dantas de Moraes, Yasmine Safraou, Rebecca G Wells, Jing Guo, Heiko Tzschätzsch, Andreas Zappe, Kevin Pagel, Igor M Sauer, Karl H Hillebrandt, Ingolf Sack
Magnetic resonance elastography (MRE) and diffusion-weighted imaging (DWI) are complementary imaging techniques that detect disease based on viscoelasticity and water mobility, respectively. However, the relationship between viscoelasticity and water diffusion is still poorly understood, hindering the clinical translation of combined DWI-MRE markers. We used DWI-MRE to study 129 biomaterial samples including native and cross-linked collagen, glycosaminoglycans (GAGs) with different sulfation levels, and decellularized specimens of pancreas and liver, all with different proportions of solid tissue, or solid fractions...
May 8, 2024: Acta Biomaterialia