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JOURNAL ARTICLE
Panan Suntornsaratoon, Jayson M Antonio, Juan Flores, Ravij Upadhyay, John Veltri, Sheila Bandyopadhyay, Rhema Dadala, Michael Kim, Yue Liu, Iyshwarya Balasubramanian, Jerrold R Turner, Xiaoyang Su, Wei Vivian Li, Nan Gao, Ronaldo P Ferraris
BACKGROUND & AIMS: Lacticaseibacillus rhamnosus GG (LGG) is the world's most consumed probiotic but its mechanism of action on intestinal permeability and differentiation along with its interactions with an essential source of signaling metabolites, dietary tryptophan, are unclear. METHODS: Untargeted metabolomic and transcriptomic analyses were performed in LGG mono-colonized germ-free (GF) mice fed tryptophan (trp)-free or -sufficient diets. LGG-derived metabolites were profiled in vitro under anaerobic and aerobic conditions...
April 17, 2024: Cellular and Molecular Gastroenterology and Hepatology
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JOURNAL ARTICLE
Megan N Parker, Nasreen A Moursi, Praise E Adekola, Bess F Bloomer, Jennifer Te-Vazquez, Ejike E Nwosu, Julia Lazareva, Jeremiah L Jones, Shanna B Yang, Sara A Turner, Sheila M Brady, Kong Y Chen, Marian Tanofsky-Kraff, Jack A Yanovski
Dieting is theorized as a risk factor for loss-of-control (LOC)-eating (i.e., feeling a sense of lack of control while eating). Support for this association has largely relied on retrospective self-report data, which does not always correlate with objectively assessed eating behavior in youth. We hypothesized that during a laboratory-based LOC-eating paradigm, children and adolescents who reported current (at the time of the visit) dieting would consume meals consistent with LOC-eating (greater caloric intake, and intake of carbohydrates and fats, but less intake of protein)...
April 16, 2024: Eating Behaviors
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JOURNAL ARTICLE
Brett J Wong, Casey G Turner, Matthew J Hayat, Jeffrey S Otis, Arshed A Quyyumi
We assessed the combined effect of superoxide and iNOS inhibition on microvascular function in non-Hispanic Black and non-Hispanic White participants (n = 15 per group). Participants were instrumented with four microdialysis fibers: (1) lactated Ringer's (control), (2) 10 μM tempol (superoxide inhibition), (3) 0.1 mM 1400 W (iNOS inhibition), (4) tempol + 1400 W. Cutaneous vasodilation was induced via local heating and NO-dependent vasodilation was quantified...
April 2024: Physiological Reports
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JOURNAL ARTICLE
Daniel Turner, Priscilla Gregório Hertz, Laura Biedermann, Steffen Barra, Wolfgang Retz
Previous research has found some peculiarities in sexual functioning of adults with attention deficit/hyperactivity disorder (ADHD). Using a set of questionnaires that had to be answered online, we assessed the prevalence of paraphilic fantasies and behaviors in a sample of 160 adults with ADHD in comparison to 75 adults without ADHD and evaluated the association between paraphilias and hypersexuality in the ADHD group. Both groups reported high rates of paraphilic fantasies and behaviors. ADHD individuals were more likely to report about very sexually arousing paraphilic fantasies (ADHD: 58...
April 18, 2024: International Journal of Impotence Research
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JOURNAL ARTICLE
Allison Murawski, Thomas Fabrizio, Robert Ossiboff, Christina Kackos, Trushar Jeevan, Jeremy C Jones, Ahmed Kandeil, David Walker, Jasmine C M Turner, Christopher Patton, Elena A Govorkova, Helena Hauck, Suzanna Mickey, Brittany Barbeau, Y Reddy Bommineni, Mia Torchetti, Kristina Lantz, Lisa Kercher, Andrew B Allison, Peter Vogel, Michael Walsh, Richard J Webby
Since late 2021, highly pathogenic avian influenza (HPAI) viruses of A/goose/Guangdong/1/1996 (H5N1) lineage have caused widespread mortality in wild birds and poultry in the United States. Concomitant with the spread of HPAI viruses in birds are increasing numbers of mammalian infections, including wild and captive mesocarnivores and carnivores with central nervous system involvement. Here we report HPAI, A(H5N1) of clade 2.3.4.4b, in a common bottlenose dolphin (Tursiops truncatus) from Florida, United States...
April 18, 2024: Communications Biology
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JOURNAL ARTICLE
Theodoros Evrenoglou, Silvia Metelli, Johannes-Schneider Thomas, Spyridon Siafis, Rebecca M Turner, Stefan Leucht, Anna Chaimani
Network meta-analysis (NMA) usually provides estimates of the relative effects with the highest possible precision. However, sparse networks with few available studies and limited direct evidence can arise, threatening the robustness and reliability of NMA estimates. In these cases, the limited amount of available information can hamper the formal evaluation of the underlying NMA assumptions of transitivity and consistency. In addition, NMA estimates from sparse networks are expected to be imprecise and possibly biased as they rely on large-sample approximations that are invalid in the absence of sufficient data...
April 2024: Biometrical Journal. Biometrische Zeitschrift
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JOURNAL ARTICLE
Daniel M Beswick, Christine M Liu, Jonathan B Overdevest, Anna Zemke, Aastha Khatiwada, David A Gudis, Jessa E Miller, Adam Kimple, Jeremy P Tervo, Emily DiMango, Jennifer L Goralski, Claire Keating, Brent Senior, Amanda L Stapleton, Patricia H Eshaghian, Jess C Mace, Karolin Markarian, Jeremiah A Alt, Todd E Bodner, Naweed I Chowdhury, Anne E Getz, Peter H Hwang, Ashoke Khanwalker, Jivianne T Lee, Douglas A Li, Meghan Norris, Jayakar V Nayak, Cameran Owens, Zara M Patel, Katie Poch, Rodney J Schlosser, Kristine A Smith, Timothy L Smith, Zachary M Soler, Jeffrey D Suh, Grant A Turner, Marilene B Wang, Milene T Saavedra, Jennifer L Taylor Cousar
OBJECTIVES: The 22-question SinoNasal Outcome Test (SNOT-22) assesses chronic rhinosinusitis (CRS) severity. We aimed to identify predictors of SNOT-22 score improvement following highly effective modulator therapy (HEMT) initiation and to corroborate the SNOT-22 minimal clinically important difference (MCID) in adults with cystic fibrosis (CF). METHODS: Prospective observational data was pooled from four studies across 10 US centers investigating people with CF (PwCF) and CRS...
April 18, 2024: Laryngoscope
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JOURNAL ARTICLE
Xuan Liu, Jay R Turner, Christopher R Oxford, Jacob McNeill, Brenna Walsh, Emmie Le Roy, Crystal L Weagle, Emily Stone, Haihui Zhu, Wenyu Liu, Zilin Wei, Nicole P Hyslop, Jason Giacomo, Ann M Dillner, Abdus Salam, Al-Amin Hossen, Zubayer Islam, Ihab Abboud, Clement Akoshile, Omar Amador-Muñoz, Nguyen Xuan Anh, Araya Asfaw, Rajasekhar Balasubramanian, Rachel Ying-Wen Chang, Craig Coburn, Sagnik Dey, David J Diner, Jinlu Dong, Tareq Farrah, Paterne Gahungu, Rebecca M Garland, Michel Grutter de la Mora, Sina Hasheminassab, Juanette John, Jhoon Kim, Jong Sung Kim, Kristy Langerman, Pei-Chen Lee, Puji Lestari, Yang Liu, Tesfaye Mamo, Mathieu Martins, Olga L Mayol-Bracero, Mogesh Naidoo, Sang Seo Park, Yoav Schechner, Robyn Schofield, Sachchida N Tripathi, Eli Windwer, Ming-Tsang Wu, Qiang Zhang, Michael Brauer, Yinon Rudich, Randall V Martin
Global ground-level measurements of elements in ambient particulate matter (PM) can provide valuable information to understand the distribution of dust and trace elements, assess health impacts, and investigate emission sources. We use X-ray fluorescence spectroscopy to characterize the elemental composition of PM samples collected from 27 globally distributed sites in the Surface PARTiculate mAtter Network (SPARTAN) over 2019-2023. Consistent protocols are applied to collect all samples and analyze them at one central laboratory, which facilitates comparison across different sites...
April 12, 2024: ACS EST Air
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JOURNAL ARTICLE
Jeffrey A Turner, Matthew Hartshorne, Kenneth L Cameron, Darin Padua
CONTEXT: Lower extremity joint (LE) kinematics during landing tasks are important predictors of injury risk and performance outcomes in athletes. OBJECTIVE: To establish sex-related differences and normative ranges for LE kinematics during the jump-landing task in a large cohort of healthy military service academy cadets. DESIGN: Cross-Sectional Study. SETTING: US Air Force, Naval, and Military Academies. PARTICIPANTS: 5308 cadets (2062 females [38...
April 18, 2024: Journal of Athletic Training
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JOURNAL ARTICLE
Michelle S Rockwell, Emma G Oyese, Eshika Singh, Matthew Vinson, Isaiah Yim, Jamie K Turner, John W Epling
OBJECTIVES: Potentially harmful non-steroidal anti-inflammatory drugs (NSAIDs) utilisation persists at undesirable rates worldwide. The purpose of this paper is to review the literature on interventions to de-implement potentially harmful NSAIDs in healthcare settings and to suggest directions for future research. DESIGN: Scoping review. DATA SOURCES: PubMed, CINAHL, Embase, Cochrane Central and Google Scholar (1 January 2000 to 31 May 2022)...
April 17, 2024: BMJ Open
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JOURNAL ARTICLE
Jessie Hewitt, Nada Hamad, Claire Beecher, Tari Turner, Samantha Chakraborty
OBJECTIVE: Actively addressing issues of equity, diversity and inclusion (EDI) in healthcare guidelines provides an important avenue ensure that individuals and communities receive high-quality health care that meets their needs. In 2020, the National Clinical Evidence Taskforce was charged with developing Australian living guidelines for COVID-19 (the Guidelines). It was intended that the Guidelines would consider the biological and social determinants of health underpinning evidence-based recommendations for of the treatment of COVID-19...
April 15, 2024: Journal of Clinical Epidemiology
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JOURNAL ARTICLE
Richard B Mink, Alan Schwartz, John D Mahan, Jill J Fussell, Roshan George, Daniel J Schumacher, Vanessa McFadden, David A Turner, Mark P Atlas
OBJECTIVES: To compare level of supervision (LOS) ratings of graduating pediatric residents with their assessments as fellows for the 5 Entrustable Professional Activities (EPAs) common to general pediatrics and the subspecialties and to determine if the difference between ratings from residency to fellowship is less for the QI and PRACTICE MANAGEMENT EPAs, since the skills needed to perform these may be less context-dependent. METHODS: We compared ratings of graduating residents with their assessments as fellows using LOS data from 2 sequential EPA studies...
April 15, 2024: Academic Pediatrics
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JOURNAL ARTICLE
Rebekah Laidsaar-Powell, Sarah Giunta, Phyllis Butow, Rachael Keast, Bogda Koczwara, Judy Kay, Michael Jefford, Sandra Turner, Christobel Saunders, Penelope Schofield, Frances Boyle, Patsy Yates, Kate White, Annie Miller, Zoe Butt, Melanie Bonnaudet, Ilona Juraskova
BACKGROUND: Carers often assume key roles in cancer care. However, many carers report feeling disempowered and ill-equipped to support patients. Our group published evidence-based guidelines (the Triadic Oncology [TRIO] Guidelines) to improve oncology clinician engagement with carers and the management of challenging situations involving carers. OBJECTIVE: To facilitate implementation of the TRIO Guidelines in clinical practice, we aimed to develop, iteratively refine, and conduct user testing of a suite of evidence-based and interactive web-based education modules for oncology clinicians (e-Triadic Oncology [eTRIO]), patients with cancer, and carers (eTRIO for Patients and Carers [eTRIO-pc])...
April 17, 2024: JMIR Medical Education
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JOURNAL ARTICLE
Sven Sandin, Benjamin H K Yip, Weiyao Yin, Lauren A Weiss, Joseph D Dougherty, Stuart Fass, John N Constantino, Zhu Hailin, Tychele N Turner, Natasha Marrus, David H Gutmann, Stephan J Sanders, Benjamin Christoffersson
IMPORTANCE: Autism spectrum disorder (ASD) is a neurodevelopmental disorder more prevalent in males than in females. The cause of ASD is largely genetic, but the association of genetics with the skewed sex ratio is not yet understood. To our knowledge, no large population-based study has provided estimates of heritability by sex. OBJECTIVE: To estimate the sex-specific heritability of ASD. DESIGN, SETTING, AND PARTICIPANTS: This was a population-based, retrospective analysis using national health registers of nontwin siblings and cousins from Sweden born between January 1, 1985, and December 31, 1998, with follow-up to 19 years of age...
April 17, 2024: JAMA Psychiatry
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JOURNAL ARTICLE
Melinda L Hsu, Mary C Boulanger, Sarah Olson, Cyd Eaton, Laura Prichett, Matthew Guo, Mattea Miller, Julie Brahmer, Patrick M Forde, Kristen A Marrone, Michelle Turner, Josephine L Feliciano
IMPORTANCE: Despite a growing population of survivors of lung cancer, there is limited understanding of the survivorship journey. Survivors of lung cancer experience unmet physical, social, emotional, and medical needs regardless of stage at diagnosis or treatment modalities. OBJECTIVE: To investigate the association of unmet needs with quality of life (QOL) and financial toxicity (FT) among survivors of lung cancer. DESIGN, SETTING, AND PARTICIPANTS: This survey study was conducted at Johns Hopkins Sidney Kimmel Comprehensive Cancer Center thoracic oncology clinics between December 1, 2020, and September 30, 2021, to assess needs (physical, social, emotional, and medical), QOL, and FT among survivors of lung cancer...
April 1, 2024: JAMA Network Open
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JOURNAL ARTICLE
Miriam T Y Leung, Justin P Turner, Clara Marquina, Jenni Ilomaki, Tim Tran, J Simon Bell
CONTEXT: Current clinical guidelines recommend a drug holiday after extended use of oral bisphosphonates. However, no studies have investigated the impact of drug holidays before hip fractures on post-fracture mortality. OBJECTIVE: To investigate the effect of drug holiday on post-fracture mortality in patients with extended use of oral bisphosphonates. DESIGN: Retrospective population-based cohort study. SETTING: All patients with hip fractures in Victoria, Australia from 2014-18...
April 17, 2024: Journal of Clinical Endocrinology and Metabolism
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JOURNAL ARTICLE
Joshua H Marks, Xilin Bai, Anatoliy A Nikolayev, Qi'ang Gong, Cheng Zhu, N Fabian Kleimeier, Andrew M Turner, Santosh K Singh, Jia Wang, Jiuzhong Yang, Yang Pan, Tao Yang, Alexander M Mebel, Ralf I Kaiser
Orthocarboxylic acids─organic molecules carrying three hydroxyl groups at the same carbon atom─have been distinguished as vital reactive intermediates by the atmospheric science and physical (organic) chemistry communities as transients in the atmospheric aerosol cycle. Predicted short lifetimes and their tendency to dehydrate to a carboxylic acid, free orthocarboxylic acids, signify one of the most elusive classes of organic reactive intermediates, with even the simplest representative methanetriol (CH(OH)3 )─historically known as orthoformic acid─not previously been detected experimentally...
April 17, 2024: Journal of the American Chemical Society
#58
JOURNAL ARTICLE
Ha-Kyung Kong, Fariha Zainab, Anne M Turner, Betty Bekemeier, Uba Backonja
Health infographics are often used to improve knowledge or change behaviors. However, a systematic understanding of the current landscape and evidence of health infographics is lacking. The objective of this study was to explore trends in health-related infographics research and health infographic effectiveness. We conducted a scoping review of peer-reviewed publications describing health-related infographic development, using health and computer science databases. We extracted information from included articles to understand current trends in health-related infographics research and design elements that support infographic effectiveness...
April 17, 2024: Health Communication
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JOURNAL ARTICLE
Amani Kais, Stell Patadji Santiago, Peng Cheng Han, David A Clump, William A Stokes, Tanya Fancy, Ruifeng Cui, Elizabeth Martin, Meghan T Turner
INTRODUCTION: Neck mass is the most common presentation of human papillomavirus-related (HPV-related) oropharyngeal squamous cell carcinoma (OPSCC). Recently, circulating tumor HPV-DNA (ctHPVDNA) assays have been developed to detect active OPSCC. This pilot study investigates the diagnostic accuracy of ctHPVDNA in establishing HPV status for known vs. unknown OPSCC presenting as a neck mass. METHODS: A single-institution pilot study was conducted on all patients with OPSCC presenting as a neck mass between 2021 and 2022...
2024: Frontiers in Oncology
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JOURNAL ARTICLE
Jade Howard, Karen Forrest Keenan, Fadhila Mazanderani, Martin R Turner, Louise Locock
Predictive genetic testing is increasingly available for individuals with a heightened risk of motor neuron disease (MND). However, little is known about how they decide whether or not to get tested, and how they experience this process. This paper reports findings from a constructivist grounded theory-informed interview study with 24 family members of people with identified or suspected inherited MND (iMND). Fourteen did not know their genetic status, and nine had decided to have predictive testing, of whom six tested positive for the pathogenic gene variant identified in their family and three tested negative...
April 16, 2024: Journal of Genetic Counseling
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