Yuri Kohara, Shuta Ikai, Akihide Yoshihara, Koji Murao, Yasunori Sugiyama
Glucotoxicity, impaired insulin secretion, suppression of insulin gene expression and apoptosis, in pancreatic β-cells caused by chronic hyperglycemia is a key component of the pathogenesis of type 2 diabetes. Recently, it has been reported that rare sugar D-allulose has antihyperglycemic and antihyperlipidemic effects in diabetic rats. However, the direct effects of rare sugars including D-allulose on pancreatic β-cell function are unclear. In this study, we investigated whether chronic exposure to ketohexoses causes glucotoxicity, suppression of insulin gene expression and apoptosis, in INS-1 rat pancreatic insulinoma cells...
November 22, 2022: Bioscience, Biotechnology, and Biochemistry