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JOURNAL ARTICLE
Jiali Dai, Dawei Sun, Bohui Li, Yang Zhang, Meiling Wen, Haina Wang, Hongsheng Bi
BACKGROUND: People with schizophrenia often face challenges such as lower psychological resilience, reduced self-worth, and increased social stigma, hindering their recovery. Mindfulness-Based Cognitive Therapy (MBCT) has shown promise in boosting psychological resilience and self-esteem while diminishing stigma. However, MBCT demands professional involvement and substantial expenses, adding to the workload of professionals and the financial strain on patients. Mixed-mode Mindfulness-Based Cognitive Therapy (M-MBCT) integrates both "face-to-face" and "self-help" approaches to minimize staff effort and costs...
March 4, 2024: BMC Psychiatry
#42
REVIEW
Silvia Marcó-García, Kevin Ariyo, Gareth S Owen, Anthony S David
Decision-making capacity (DMC) among psychiatric inpatients is a pivotal clinical concern. A review by Okai et al. (2007) suggested that most psychiatric inpatients have DMC for treatment, and its assessment is reliable. Nevertheless, the high heterogeneity and mixed results from other studies mean there is considerable uncertainty around this topic. This study aimed to update Okai's research by conducting a systematic review with meta-analysis to address heterogeneity. We performed a systematic search across four databases, yielding 5351 results...
April 2024: Psychological Medicine
#43
REVIEW
Anne Rivelli, Veronica Fitzpatrick, Michael Nelson, Kimberly Laubmeier, Courtney Zeni, Srikrishna Mylavarapu
Schizophrenia is often characterized by recurring relapses, which are associated with a substantial clinical and economic burden. Early identification of individuals at the highest risk for relapse in real-world treatment settings could help improve outcomes and reduce healthcare costs. Prior work has identified a few consistent predictors of relapse in schizophrenia, however, studies to date have been limited to insurance claims data or small patient populations. Thus, this study used a large sample of health systems electronic health record (EHR) data to analyze relationships between patient-level factors and relapse and model a set of factors that can be used to identify the increased prevalence of relapse, a severe and preventable reality of schizophrenia...
February 29, 2024: Schizophrenia (Heidelb)
#44
RANDOMIZED CONTROLLED TRIAL
Leslie Citrome, Sergey Yagoda, Ilda Bidollari, Meihua Wang
Background: Aripiprazole lauroxil (AL) 1064 mg every 2 months following initiation using the AL NanoCrystal Dispersion formulation (ALNCD ) plus 30-mg oral aripiprazole was efficacious and well tolerated in a 25-week, randomized, double-blind phase 3 trial in adults with acute schizophrenia. This post hoc analysis further characterized the safety of AL 1064 mg administered every 2 months and that of active control paliperidone palmitate (PP) 156 mg monthly based on occurrence, timing, and severity of adverse events (AEs) associated with antipsychotic medications...
February 28, 2024: Journal of Clinical Psychiatry
#45
JOURNAL ARTICLE
Stefan Tschöke, Yvonne Knauer, Erich Flammer, Paula Usemann, Carmen Uhlmann
Psychotic experiences have been shown to be comparable in borderline personality disorder (BPD) and schizophrenia. Preliminary evidence suggests differences in the impact of psychotic experiences on daily functioning. Therefore, in this study, we aimed to investigate the role of psychotic experiences in daily functioning in BPD compared with schizophrenia. We performed post hoc analyses on data from 23 inpatients with BPD and 21 inpatients with schizophrenia, for whom results from the Psychotic Symptom Rating Scales were available...
March 1, 2024: Journal of Nervous and Mental Disease
#46
JOURNAL ARTICLE
Bangunawati Rahajeng, Betha Candra Sari, Nurul Maziyyah
Clozapine is an atypical antipsychotic indicated for treating patients resistant to antipsychotic therapy when other medications in this class have no therapeutic effect. Clozapine has greater efficacy but more side effects than other atypical antipsychotics (e.g., agranulocytosis, seizures, sedation, and weight gain). Side effects can cause discomfort to patients and can affect patient compliance, interfering with therapeutical outcomes. This study aims to identify the side effects of clozapine use in patients at the Psychiatric Hospital Grhasia, in Yogyakarta, Indonesia...
November 2023: Journal of Medicine and Life
#47
JOURNAL ARTICLE
Wenying Yi, Haibo Wu, Weibin Fu, Huimei Feng, Jie Huang, Haijing Li, Zhen Song, Yuwei Chen, Yingjun Zheng, Shenglin She
BACKGROUND: To assess the prevalence and risk factors of NAFLD in non-obese patients with schizophrenia in a public psychiatric hospital in China. METHODS: A total of 1,305 adult inpatients with schizophrenia in 2019 were included in this retrospective study. Body mass index (BMI) ≥ 25 kg/m2 was considered obese, and BMI < 25 kg/m2 was considered non-obese. We obtained the data from electronic records of the Affiliated Brain Hospital of Guangzhou Medical University...
2024: Diabetes, Metabolic Syndrome and Obesity
#48
JOURNAL ARTICLE
Diego Rosado, Belen Intriago, Evelyn Loor, Flor Alcívar, Jorge Avila, Mario Sotomayor, Larissa Villacres, Marco Faytong-Haro
BACKGROUND: Schizophrenia, a complex neuropsychiatric disorder, is believed to be influenced by various factors including environmental exposures. A potential environmental factor is the infection by the obligate intracellular parasitic protozoan, Toxoplasma gondii which affects neurotransmitter levels, which could potentially exacerbate, trigger symptoms of schizophrenia or make them worst. OBJECTIVE: To investigate the association between Toxoplasma gondii seropositivity and psychopathological presentation in persons with schizophrenia in Ecuador...
2024: PloS One
#49
JOURNAL ARTICLE
Trine Lise Bakken, Jane Margrethe Askeland Hellerud, Arvid Nikolai Kildahl, Ann Magritt Solheim-Inderberg, Sissel Berge Helverschou, Oddbjørn Hove
Autistic people with intellectual disabilities appear to be at increased risk of schizophrenia. While current recommendations emphasize adapting interventions used for people with schizophrenia in general, few studies to date have investigated treatment of co-occurring schizophrenia in this specific population. To explore what interventions are provided to autistic people with intellectual disabilities and co-occurring schizophrenia in specialized mental health services, and to investigate whether changes in mental health symptoms and challenging behavior occurred during treatment...
February 23, 2024: Journal of Autism and Developmental Disorders
#50
JOURNAL ARTICLE
Zhaoxia Zhou, Hengyong Guan, Meihong Xiu, Fengchun Wu
Accumulating evidence has supported the implementation of dance/movement therapy (DMT) as a promising intervention for patients with schizophrenia (SCZ). However, its effect on body weight and metabolic profile in SCZ remains unclear. This study aimed to evaluate the outcome of a 12-week DMT session on weight and lipid profile in patients with SCZ using a randomized, single-blinded, controlled trial design. This study encompassed two groups of long-term hospitalized patients with SCZ, who were randomly assigned to the DMT intervention (n = 30) or the treatment as usual (TAU) group (n = 30)...
February 22, 2024: Schizophrenia (Heidelb)
#51
JOURNAL ARTICLE
Els van der Ven, Thomas M Olino, Katharina Diehl, Stephanie M Nuñez, Griffin Thayer, Miranda A Bridgwater, Sabrina Ereshefsky, Christie Musket, Sarah Hope Lincoln, R Tyler Rogers, Mallory J Klaunig, Emily Soohoo, Jordan E DeVylder, Rebecca E Grattan, Jason Schiffman, Lauren M Ellman, Tara A Niendam, Deidre M Anglin
IMPORTANCE: Studies suggest a higher risk of schizophrenia diagnoses in Black vs White Americans, yet a systematic investigation of disparities that include other ethnoracial groups and multiple outcomes on the psychosis continuum is lacking. OBJECTIVE: To identify ethnoracial risk variation in the US across 3 psychosis continuum outcomes (ie, schizophrenia and other psychotic disorders, clinical high risk for psychosis [CHR-P], and psychotic symptoms [PSs] and psychotic experiences [PEs])...
February 21, 2024: JAMA Psychiatry
#52
JOURNAL ARTICLE
Rui Ma, Yu Wang, Yu-Xin Li, Kai Yu, Xiao-Qing Wang, Zheng-Jun Wang, Yu-Qiu Zhou
Marital concerns can trigger emotional stress, especially among long-term hospitalised individuals diagnosed with schizophrenia, significantly affecting their treatment and recovery. Unfortunately, rehabilitation programs tend to overlook the marital needs of individuals with diagnosed schizophrenia. This research aimed to investigate the content related to marital concerns of Chinese individuals diagnosed with schizophrenia who were undergoing extended hospitalisation. Fifteen participants diagnosed with schizophrenia were recruited through purposive sampling for face-to-face semi-structured interviews...
February 20, 2024: International Journal of Mental Health Nursing
#53
JOURNAL ARTICLE
Natasha Chilman, Dionne Laporte, Sarah Dorrington, Stephani L Hatch, Craig Morgan, Celestin Okoroji, Robert Stewart, Jayati Das-Munshi
PURPOSE: People with severe mental illness (SMI) experience high levels of unemployment. We aimed to better understand the associations between clinical, social, and demographic inequality indicators and unemployment. METHODS: Data were extracted from de-identified health records of people with SMI in contact with secondary mental health services in south London, UK. A Natural Language Processing text-mining application was applied to extract information on unemployment in the health records...
February 20, 2024: Social Psychiatry and Psychiatric Epidemiology
#54
Amit Jagtiani, Tarika Nagi, Raghu Gandhi, Abid Rizvi
Catatonia, which is associated with gamma-aminobutyric acid (GABA) hypoactivity, often responds robustly to benzodiazepines. It has been reported to be a consequence of abrupt discontinuation of clozapine, an antipsychotic used for treatment-resistant schizophrenia. Clozapine discontinuation, sometimes necessitated by medical concerns, can carry the risk of adverse outcomes, including catatonia. We present the case of a 66-year-old African-American male with schizoaffective disorder (depressive subtype) and a complex medical history...
January 2024: Curēus
#55
Jelle Lamsma, Adrian Raine, Seyed M Kia, Wiepke Cahn, Dominic Arold, Nerisa Banaj, Annarita Barone, Katharina Brosch, Rachel Brouwer, Arturo Brunetti, Vince D Calhoun, Qian H Chew, Sunah Choi, Young-Chul Chung, Mariateresa Ciccarelli, Derin Cobia, Sirio Cocozza, Udo Dannlowski, Paola Dazzan, Andrea de Bartolomeis, Marta Di Forti, Alexandre Dumais, Jesse T Edmond, Stefan Ehrlich, Ulrika Evermann, Kira Flinkenflügel, Foivos Georgiadis, David C Glahn, Janik Goltermann, Melissa J Green, Dominik Grotegerd, Amalia Guerrero-Pedraza, Minji Ha, Elliot L Hong, Hilleke Hulshoff Pol, Felice Iasevoli, Stefan Kaiser, Vasily Kaleda, Andriana Karuk, Minah Kim, Tilo Kircher, Matthias Kirschner, Peter Kochunov, Jun Soo Kwon, Irina Lebedeva, Rebekka Lencer, Tiago R Marques, Susanne Meinert, Robin Murray, Igor Nenadić, Dana Nguyen, Godfrey Pearlson, Fabrizio Piras, Edith Pomarol-Clotet, Giuseppe Pontillo, Stéphane Potvin, Adrian Preda, Yann Quidé, Amanda Rodrigue, Kelly Rootes-Murdy, Raymond Salvador, Antonin Skoch, Kang Sim, Gianfranco Spalletta, Filip Spaniel, Frederike Stein, Florian Thomas-Odenthal, Andràs Tikàsz, David Tomecek, Alexander Tomyshev, Mario Tranfa, Uyanga Tsogt, Jessica A Turner, Theo G M van Erp, Neeltje E M van Haren, Jim van Os, Daniela Vecchio, Lei Wang, Adrian Wroblewski, Thomas Nickl-Jockschat
BACKGROUND: Schizophrenia is associated with an increased risk of aggressive behaviour, which may partly be explained by illness-related changes in brain structure. However, previous studies have been limited by group-level analyses, small and selective samples of inpatients and long time lags between exposure and outcome. METHODS: This cross-sectional study pooled data from 20 sites participating in the international ENIGMA-Schizophrenia Working Group. Sites acquired T1-weighted and diffusion-weighted magnetic resonance imaging scans in a total of 2095 patients with schizophrenia and 2861 healthy controls...
February 5, 2024: medRxiv
#56
JOURNAL ARTICLE
Mariela E Jaffé, Sou Bouy Loew, Andrea H Meyer, Roselind Lieb, Frieder Dechent, Undine E Lang, Christian G Huber, Julian Moeller
Treatment guidelines state that evidence-based psychotherapy is effective for people with psychosis and bipolar disorder and should be offered during every phase of the treatment process. However, research has indicated a lack of outpatient psychotherapeutic services for this patient group, for example, in the United States or Germany. We extend this finding by presenting survey data from Switzerland. We surveyed 112 inpatients with a diagnosis of a schizophrenia spectrum disorder or bipolar disorder and assessed outpatient treatment over the 5 years prior to their index hospitalization by using retrospective self-reports...
2024: Health Services Insights
#57
JOURNAL ARTICLE
Tianyu Wang, Ruochen Sun, Jody L Sindelar, Xi Chen
Retirement, a major transition in the life course, may affect many aspects of retirees' well-being, including health and health care utilization. Leveraging differential statutory retirement age (SRA) by occupation for China's urban female workers, we provide some of the first evidence on the causal effect of retirement on hospitalizations attributable to mental illness and its heterogeneity. To address endogeneity in retirement decisions, we take advantage of exogeneity of the differing SRA cut-offs for blue-collar (age 50) and white-collar (age 55) female urban employees...
February 5, 2024: Economics and Human Biology
#58
JOURNAL ARTICLE
Panagiotis Ferentinos, Stamatina Douki, Vasiliki Yotsidi, Eleni Kourkouni, Dimitra Dragoumi, Nikolaos Smyrnis, Athanasios Douzenis
Expressed emotion (EE) toward patients with schizophrenia is typically reported to be lower in psychiatric halfway houses than in families. This is the first study directly comparing EE between these settings and investigating the pathways mediating EE differences. We included 40 inpatients in halfway houses and 40 outpatients living with their families and recorded 22 psychiatric nurses' and 56 parents' EE, respectively, through Five Minutes Speech Samples. Each inpatient was rated by 2-5 nurses and each outpatient by 1-2 parents...
February 1, 2024: Healthcare (Basel, Switzerland)
#59
JOURNAL ARTICLE
Isak Fredén Klenfeldt, Gunnar Skoog, Johan Skoog, Ingmar Skoog
OBJECTIVE: Few long-term studies have examined the life-time prevalence of comorbid psychiatric conditions in patients with obsessive-compulsive disorder (OCD). We therefore studied the frequency of comorbid psychiatric disorders, and their relation to onset and prognosis, in patients with OCD who were followed for almost half a century. METHODS: During 1947-1953, 285 OCD patients were admitted as inpatients to a university hospital in Gothenburg, Sweden. Among those, 251 (88%) accepted a structured comprehensive psychiatric examination in 1954-1956...
February 8, 2024: Acta Psychiatrica Scandinavica
#60
JOURNAL ARTICLE
Erica Cruvinel, Laura Mussulman, Taneisha Scheuermann, Elena Shergina, Jianghua He, Scott Sherman, Kathleen Harrington, Nancy A Rigotti, Hilary Tindle, Shu-Hong Zhu, Kimber Richter
BACKGROUND: Smoking rates among people living with behavioral health conditions (BHC) range from 30 to 65% and are 2-4 times higher than rates found in the general population. Starting tobacco treatment during a hospital stay is effective for smoking cessation, but little is known regarding treatment response among inpatients with BHC. OBJECTIVE: This study pooled data across multiple clinical trials to determine the relative success in quitting among participants with BHC compared to other study participants...
February 7, 2024: Journal of General Internal Medicine
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