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JOURNAL ARTICLE
Diego Rosado, Belen Intriago, Evelyn Loor, Flor Alcívar, Jorge Avila, Mario Sotomayor, Larissa Villacres, Marco Faytong-Haro
BACKGROUND: Schizophrenia, a complex neuropsychiatric disorder, is believed to be influenced by various factors including environmental exposures. A potential environmental factor is the infection by the obligate intracellular parasitic protozoan, Toxoplasma gondii which affects neurotransmitter levels, which could potentially exacerbate, trigger symptoms of schizophrenia or make them worst. OBJECTIVE: To investigate the association between Toxoplasma gondii seropositivity and psychopathological presentation in persons with schizophrenia in Ecuador...
2024: PloS One
#62
JOURNAL ARTICLE
Trine Lise Bakken, Jane Margrethe Askeland Hellerud, Arvid Nikolai Kildahl, Ann Magritt Solheim-Inderberg, Sissel Berge Helverschou, Oddbjørn Hove
Autistic people with intellectual disabilities appear to be at increased risk of schizophrenia. While current recommendations emphasize adapting interventions used for people with schizophrenia in general, few studies to date have investigated treatment of co-occurring schizophrenia in this specific population. To explore what interventions are provided to autistic people with intellectual disabilities and co-occurring schizophrenia in specialized mental health services, and to investigate whether changes in mental health symptoms and challenging behavior occurred during treatment...
February 23, 2024: Journal of Autism and Developmental Disorders
#63
JOURNAL ARTICLE
Zhaoxia Zhou, Hengyong Guan, Meihong Xiu, Fengchun Wu
Accumulating evidence has supported the implementation of dance/movement therapy (DMT) as a promising intervention for patients with schizophrenia (SCZ). However, its effect on body weight and metabolic profile in SCZ remains unclear. This study aimed to evaluate the outcome of a 12-week DMT session on weight and lipid profile in patients with SCZ using a randomized, single-blinded, controlled trial design. This study encompassed two groups of long-term hospitalized patients with SCZ, who were randomly assigned to the DMT intervention (n = 30) or the treatment as usual (TAU) group (n = 30)...
February 22, 2024: Schizophrenia (Heidelb)
#64
JOURNAL ARTICLE
Els van der Ven, Thomas M Olino, Katharina Diehl, Stephanie M Nuñez, Griffin Thayer, Miranda A Bridgwater, Sabrina Ereshefsky, Christie Musket, Sarah Hope Lincoln, R Tyler Rogers, Mallory J Klaunig, Emily Soohoo, Jordan E DeVylder, Rebecca E Grattan, Jason Schiffman, Lauren M Ellman, Tara A Niendam, Deidre M Anglin
IMPORTANCE: Studies suggest a higher risk of schizophrenia diagnoses in Black vs White Americans, yet a systematic investigation of disparities that include other ethnoracial groups and multiple outcomes on the psychosis continuum is lacking. OBJECTIVE: To identify ethnoracial risk variation in the US across 3 psychosis continuum outcomes (ie, schizophrenia and other psychotic disorders, clinical high risk for psychosis [CHR-P], and psychotic symptoms [PSs] and psychotic experiences [PEs])...
February 21, 2024: JAMA Psychiatry
#65
JOURNAL ARTICLE
Rui Ma, Yu Wang, Yu-Xin Li, Kai Yu, Xiao-Qing Wang, Zheng-Jun Wang, Yu-Qiu Zhou
Marital concerns can trigger emotional stress, especially among long-term hospitalised individuals diagnosed with schizophrenia, significantly affecting their treatment and recovery. Unfortunately, rehabilitation programs tend to overlook the marital needs of individuals with diagnosed schizophrenia. This research aimed to investigate the content related to marital concerns of Chinese individuals diagnosed with schizophrenia who were undergoing extended hospitalisation. Fifteen participants diagnosed with schizophrenia were recruited through purposive sampling for face-to-face semi-structured interviews...
February 20, 2024: International Journal of Mental Health Nursing
#66
JOURNAL ARTICLE
Natasha Chilman, Dionne Laporte, Sarah Dorrington, Stephani L Hatch, Craig Morgan, Celestin Okoroji, Robert Stewart, Jayati Das-Munshi
PURPOSE: People with severe mental illness (SMI) experience high levels of unemployment. We aimed to better understand the associations between clinical, social, and demographic inequality indicators and unemployment. METHODS: Data were extracted from de-identified health records of people with SMI in contact with secondary mental health services in south London, UK. A Natural Language Processing text-mining application was applied to extract information on unemployment in the health records...
February 20, 2024: Social Psychiatry and Psychiatric Epidemiology
#67
Amit Jagtiani, Tarika Nagi, Raghu Gandhi, Abid Rizvi
Catatonia, which is associated with gamma-aminobutyric acid (GABA) hypoactivity, often responds robustly to benzodiazepines. It has been reported to be a consequence of abrupt discontinuation of clozapine, an antipsychotic used for treatment-resistant schizophrenia. Clozapine discontinuation, sometimes necessitated by medical concerns, can carry the risk of adverse outcomes, including catatonia. We present the case of a 66-year-old African-American male with schizoaffective disorder (depressive subtype) and a complex medical history...
January 2024: Curēus
#68
Jelle Lamsma, Adrian Raine, Seyed M Kia, Wiepke Cahn, Dominic Arold, Nerisa Banaj, Annarita Barone, Katharina Brosch, Rachel Brouwer, Arturo Brunetti, Vince D Calhoun, Qian H Chew, Sunah Choi, Young-Chul Chung, Mariateresa Ciccarelli, Derin Cobia, Sirio Cocozza, Udo Dannlowski, Paola Dazzan, Andrea de Bartolomeis, Marta Di Forti, Alexandre Dumais, Jesse T Edmond, Stefan Ehrlich, Ulrika Evermann, Kira Flinkenflügel, Foivos Georgiadis, David C Glahn, Janik Goltermann, Melissa J Green, Dominik Grotegerd, Amalia Guerrero-Pedraza, Minji Ha, Elliot L Hong, Hilleke Hulshoff Pol, Felice Iasevoli, Stefan Kaiser, Vasily Kaleda, Andriana Karuk, Minah Kim, Tilo Kircher, Matthias Kirschner, Peter Kochunov, Jun Soo Kwon, Irina Lebedeva, Rebekka Lencer, Tiago R Marques, Susanne Meinert, Robin Murray, Igor Nenadić, Dana Nguyen, Godfrey Pearlson, Fabrizio Piras, Edith Pomarol-Clotet, Giuseppe Pontillo, Stéphane Potvin, Adrian Preda, Yann Quidé, Amanda Rodrigue, Kelly Rootes-Murdy, Raymond Salvador, Antonin Skoch, Kang Sim, Gianfranco Spalletta, Filip Spaniel, Frederike Stein, Florian Thomas-Odenthal, Andràs Tikàsz, David Tomecek, Alexander Tomyshev, Mario Tranfa, Uyanga Tsogt, Jessica A Turner, Theo G M van Erp, Neeltje E M van Haren, Jim van Os, Daniela Vecchio, Lei Wang, Adrian Wroblewski, Thomas Nickl-Jockschat
BACKGROUND: Schizophrenia is associated with an increased risk of aggressive behaviour, which may partly be explained by illness-related changes in brain structure. However, previous studies have been limited by group-level analyses, small and selective samples of inpatients and long time lags between exposure and outcome. METHODS: This cross-sectional study pooled data from 20 sites participating in the international ENIGMA-Schizophrenia Working Group. Sites acquired T1-weighted and diffusion-weighted magnetic resonance imaging scans in a total of 2095 patients with schizophrenia and 2861 healthy controls...
February 5, 2024: medRxiv
#69
JOURNAL ARTICLE
Mariela E Jaffé, Sou Bouy Loew, Andrea H Meyer, Roselind Lieb, Frieder Dechent, Undine E Lang, Christian G Huber, Julian Moeller
Treatment guidelines state that evidence-based psychotherapy is effective for people with psychosis and bipolar disorder and should be offered during every phase of the treatment process. However, research has indicated a lack of outpatient psychotherapeutic services for this patient group, for example, in the United States or Germany. We extend this finding by presenting survey data from Switzerland. We surveyed 112 inpatients with a diagnosis of a schizophrenia spectrum disorder or bipolar disorder and assessed outpatient treatment over the 5 years prior to their index hospitalization by using retrospective self-reports...
2024: Health Services Insights
#70
JOURNAL ARTICLE
Tianyu Wang, Ruochen Sun, Jody L Sindelar, Xi Chen
Retirement, a major transition in the life course, may affect many aspects of retirees' well-being, including health and health care utilization. Leveraging differential statutory retirement age (SRA) by occupation for China's urban female workers, we provide some of the first evidence on the causal effect of retirement on hospitalizations attributable to mental illness and its heterogeneity. To address endogeneity in retirement decisions, we take advantage of exogeneity of the differing SRA cut-offs for blue-collar (age 50) and white-collar (age 55) female urban employees...
February 5, 2024: Economics and Human Biology
#71
JOURNAL ARTICLE
Panagiotis Ferentinos, Stamatina Douki, Vasiliki Yotsidi, Eleni Kourkouni, Dimitra Dragoumi, Nikolaos Smyrnis, Athanasios Douzenis
Expressed emotion (EE) toward patients with schizophrenia is typically reported to be lower in psychiatric halfway houses than in families. This is the first study directly comparing EE between these settings and investigating the pathways mediating EE differences. We included 40 inpatients in halfway houses and 40 outpatients living with their families and recorded 22 psychiatric nurses' and 56 parents' EE, respectively, through Five Minutes Speech Samples. Each inpatient was rated by 2-5 nurses and each outpatient by 1-2 parents...
February 1, 2024: Healthcare (Basel, Switzerland)
#72
JOURNAL ARTICLE
Isak Fredén Klenfeldt, Gunnar Skoog, Johan Skoog, Ingmar Skoog
OBJECTIVE: Few long-term studies have examined the life-time prevalence of comorbid psychiatric conditions in patients with obsessive-compulsive disorder (OCD). We therefore studied the frequency of comorbid psychiatric disorders, and their relation to onset and prognosis, in patients with OCD who were followed for almost half a century. METHODS: During 1947-1953, 285 OCD patients were admitted as inpatients to a university hospital in Gothenburg, Sweden. Among those, 251 (88%) accepted a structured comprehensive psychiatric examination in 1954-1956...
February 8, 2024: Acta Psychiatrica Scandinavica
#73
JOURNAL ARTICLE
Erica Cruvinel, Laura Mussulman, Taneisha Scheuermann, Elena Shergina, Jianghua He, Scott Sherman, Kathleen Harrington, Nancy A Rigotti, Hilary Tindle, Shu-Hong Zhu, Kimber Richter
BACKGROUND: Smoking rates among people living with behavioral health conditions (BHC) range from 30 to 65% and are 2-4 times higher than rates found in the general population. Starting tobacco treatment during a hospital stay is effective for smoking cessation, but little is known regarding treatment response among inpatients with BHC. OBJECTIVE: This study pooled data across multiple clinical trials to determine the relative success in quitting among participants with BHC compared to other study participants...
February 7, 2024: Journal of General Internal Medicine
#74
JOURNAL ARTICLE
Ting Xue, Jialing Sheng, Hui Gao, Yan Gu, Jingjing Dai, Xianghong Yang, Hong Peng, Hongrui Gao, Ruping Lu, Yi Shen, Li Wang, Lijun Wang, Yuan Shi, Zezhi Li, Donghong Cui
AIM: This study investigated the impact of an 8-month daily-guided intensive meditation-based intervention (iMI) on persistent hallucinations/delusions and health-related quality of life (QoL) in male inpatients with schizophrenia with treatment-refractory hallucinations and delusions (TRHDs). METHODS: A randomized controlled trial assigned 64 male inpatients with schizophrenia and TRHD equally to an 8-month iMI plus general rehabilitation program (GRP) or GRP alone...
February 6, 2024: Psychiatry and Clinical Neurosciences
#75
Michael R Hower, Surya Kumar Karlapati, Anil K Bachu
Antipsychotics are considered a gold standard treatment for schizophrenia. However, there is considerable variation in antipsychotic medication choice. Factors considered involved include symptomatology, prior response, and adverse reactions. This case report presents a 38-year-old male patient with schizophrenia in acute psychosis refractory to several antipsychotics. Hypotheses for the mechanism of action of antipsychotics and psychopharmacology are discussed, and treatment resistance is defined. The patient's psychiatric, medical, and social history and past antipsychotic medications are reviewed...
January 2024: Curēus
#76
JOURNAL ARTICLE
Toshihiro Terui, Yasuto Kunii, Hiroshi Hoshino, Takeyasu Kakamu, Tomoo Hidaka, Tetsuhito Fukushima, Nobuo Anzai, Daisuke Gotoh, Itaru Miura, Hirooki Yabe
This study sought to explore factors related to community transition after the mandatory evacuation of psychiatric inpatients to other hospitals owing to the Fukushima Daiichi Nuclear Power Plant accident. A retrospective cohort design was adopted and 391 psychiatric patients were examined. Univariate and multivariate analyses were conducted to confirm the association between the achievement or non-achievement of discharge to community living and their backgrounds (age, gender, evacuation destination, psychiatric diagnoses, and physical complications)...
February 3, 2024: Community Mental Health Journal
#77
JOURNAL ARTICLE
Brook T Alemu, Hind A Baydoun, Olaniyi Olayinka, Robyn M Treadwell
OBJECTIVES: Substance use disorders (SUDs) are characterized by impairment caused by the recurrent use of alcohol, illicit drugs, or both. SUDs are pervasive and endemic among US adolescents, with potentially negative health and social consequences. Although the term experimentation normalizes adolescent substance abuse, the long-term consequences of this behavior beginning in adolescence can be detrimental to not only the adolescent but also the adult into which he or she develops. Our objective was to examine the epidemiology of SUD among hospitalized US adolescents, 13 to 19 years of age, during the time period 2000-2019...
February 2024: Southern Medical Journal
#78
JOURNAL ARTICLE
Panagiotis Ferentinos, Stamatina Douki, Eleni Kourkouni, Dimitra Dragoumi, Nikolaos Smyrnis, Athanassios Douzenis
PURPOSE: This study systematically searched for differential correlates of criticism vs. emotional overinvolvement (EOI) towards patients with schizophrenia in families and halfway houses, which have only incidentally been reported in previous research. Identified patterns were compared across settings. METHODS: We included 40 inpatients with schizophrenia living in halfway houses and 40 outpatients living with their families and recorded the expressed emotion (EE) of 22 psychiatric nurses or 56 parents, respectively, through Five Minutes Speech Samples...
January 31, 2024: Social Psychiatry and Psychiatric Epidemiology
#79
JOURNAL ARTICLE
Svetlina S Vasileva, Yuanhao Yang, Andrea Baker, Dan Siskind, Jacob Gratten, Darryl Eyles
IMPORTANCE: There is growing interest in the role of gut microbiome composition in schizophrenia. However, lifestyle factors are often neglected, and few studies have investigated microbiome composition in treatment-resistant schizophrenia. OBJECTIVE: To explore associations between the gut microbiome and schizophrenia diagnosis, treatment resistance, clozapine response, and treatment-related adverse effects while adjusting for demographic and lifestyle factors...
March 1, 2024: JAMA Psychiatry
#80
JOURNAL ARTICLE
Nicolas Hoertel, Marina Sánchez-Rico, Sandra Abou Kassm, Benjamin Brami, Mark Olfson, Katayoun Rezaei, Valentin Scheer, Frédéric Limosin
Excess mortality observed in people with schizophrenia may persist in later life. The specific causes of increased mortality observed in older adults with schizophrenia and the potential influence of psychotropic medications remain partly unknown. We compared 5-year mortality and its causes of older adults with schizophrenia to bipolar disorder (BD) or major depressive disorder (MDD). We used a 5-year prospective cohort, including 564 older inpatients and outpatients with schizophrenia, BD or MDD (mean age: 67...
January 31, 2024: European Archives of Psychiatry and Clinical Neuroscience
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