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JOURNAL ARTICLE
Ji Hyen Lee, Hyun-Myung Oh
To elucidate the function of proteorhodopsin in Candidatus Puniceispirillum marinum strain IMCC1322, a cultivated representative of SAR116, we produced RNA-seq data under laboratory conditions. We examined the transcriptomes of six different cultures, including sets of expression changes under constant dark (DD), constant light (LL), and diel-cycled (LD; 14 h light: 10 h dark) conditions at the exponential and stationary/death phases. Prepared mRNA extracted from the six samples was analyzed on the Solexa Genome Analyzer with 36 cycles...
April 25, 2024: Journal of Microbiology / the Microbiological Society of Korea
#2
JOURNAL ARTICLE
Hellen Hiza, Michaela Zwyer, Jerry Hella, Ainhoa Arbués, Mohamed Sasamalo, Sonia Borrell, Zhi Ming Xu, Amanda Ross, Daniela Brites, Jacques Fellay, Klaus Reither, Sébastien Gagneux, Damien Portevin
The Mycobacterium tuberculosis complex (MTBC) comprises nine human-adapted lineages that differ in their geographical distribution. Local adaptation of specific MTBC genotypes to the respective human host population has been invoked in this context. We aimed to assess if bacterial genetics governs MTBC pathogenesis or if local co-adaptation translates into differential susceptibility of human macrophages to infection by different MTBC genotypes. We generated macrophages from cryopreserved blood mononuclear cells of Tanzanian tuberculosis patients, from which the infecting MTBC strains had previously been phylogenetically characterized...
April 23, 2024: Scientific Reports
#3
REVIEW
Marta Calado, Rita Ferreira, David Pires, Quirina Santos-Costa, Elsa Anes, Dora Brites, José Miguel Azevedo-Pereira
Since the identification of human immunodeficiency virus type 1 (HIV-1) in 1983, many improvements have been made to control viral replication in the peripheral blood and to treat opportunistic infections. This has increased life expectancy but also the incidence of age-related central nervous system (CNS) disorders and HIV-associated neurodegeneration/neurocognitive impairment and depression collectively referred to as HIV-associated neurocognitive disorders (HAND). HAND encompasses a spectrum of different clinical presentations ranging from milder forms such as asymptomatic neurocognitive impairment or mild neurocognitive disorder to a severe HIV-associated dementia (HAD)...
May 2024: Reviews in Medical Virology
#4
JOURNAL ARTICLE
Carlos Brites, Marcus Lacerda, Eduardo Sprinz, Monica Bay, Gustavo Pinto, Pollyanna Azevedo, Estela Luz, Liliane Lins-Kusterer, Eduardo M Netto
BACKGROUND: Currently, integrase inhibitors (INIs)-based ART regimens are the preferred initial therapy for AIDS patients. There is scarce information on the use of dolutegravir (DTG) among late-presenter people living with HIV (PLHIV). OBJECTIVES: To compare the effect of DTG- or efavirenz (EFV)-based regimens on the outcomes of patients with advanced AIDS. METHODS: We compared two cohorts of consecutive symptomatic AIDS patients (WHO stage 4, CD4 count<50 cells/mL) starting therapy with DTG-based (2018-2021, prospective cohort) or EFV-based regimens (2013-2016, retrospective cohort) from five Brazilian cities...
2024: Frontiers in Medicine
#5
JOURNAL ARTICLE
Jianwei Ren, Detao Yu, Nianfeng Li, Shuo Liu, Hang Xu, Jiyuan Li, Fang He, Ling Zou, Zhi Cao, Jianxin Wen
Bacillus subtilis is an important part of the gut microbiota and a commonly used probiotic. In the present study, to assess the biological characteristics and probiotic properties of B. subtilis derived from mink, we isolated B. subtilis MG-1 isolate from mink fecal samples, characterized its biological characteristics, optimized the hydrolysis of casein by its crude extract, and comprehensively analyzed its potential as a probiotic in combination with whole-genome sequencing. Biological characteristics indicate that, under low-pH conditions (pH 2), B...
November 21, 2023: Microorganisms
#6
JOURNAL ARTICLE
Luis Granadeiro, Violeta Enríquez Zarralanga, Ricardo Rosa, Filipa Franquinho, Sofia Lamas, Pedro Brites
Acyl-CoA binding domain containing 5 (ACBD5) is a critical player in handling very long chain fatty acids (VLCFA) on route for peroxisomal β-oxidation. Mutations in ACBD5 lead to the accumulation of VLCFA, and patients present retinal dystrophy, ataxia, psychomotor delay, and a severe leukodystrophy. Using CRISPR/Cas9, we generated and characterized an Acbd5 Gly357* mutant allele. Gly357* mutant mice recapitulated key features of the human disorder, including reduced survival, impaired locomotion and reflexes, loss of photoreceptors, and demyelination...
December 8, 2023: Brain
#7
RANDOMIZED CONTROLLED TRIAL
Maria Esther Suarez Alpire, Daniel Vitor de Souza, Carolina Marquez da Costa Brites Masutti, Marcos Montani Caseiro, Daniel Araki Ribeiro
OBJECTIVE: The objective of this study was to evaluate cytogenetic changes in individuals submitted to oral human immunodeficiency virus pre-exposure prophylaxis use through the micronucleus test in oral mucosa. METHODS: This study consisted of 37 individuals, of whom 17 comprised the pre-exposure prophylaxis group and 20 comprised the control group. A total of 2,000 cells per slide were analyzed for the determination of micronuclei, binucleation, nuclear buds, and cytotoxicity parameters: pyknosis, karyolysis, and karyorrhexis (KR), in a double-blind manner...
2023: Revista da Associação Médica Brasileira
#8
MULTICENTER STUDY
Bruna Ramos Tosta, Ingrid Marins de Almeida, Laiane da Cruz Pena, Hatilla Dos Santos Silva, Fabiane S Reis-Goes, Nívia N Silva, João Victor Andrade Cruz, Mailane Dos Anjos Silva, Jéssica Francisco de Araújo, Juliana Lopes Rodrigues, Gabriella Oliveira, Ricardo Gassmann Figueiredo, Sara Nunes Vaz, Iris Montaño-Castellón, Daniele Santana, Fabyan Esberard de Lima Beltrão, Valdirene Leão Carneiro, Gubio Soares Campos, Carlos Brites, Vitor Fortuna, Camila Alexandrina Figueiredo, Soraya Castro Trindade, Helton Estrela Ramos, Ryan Dos Santos Costa
BACKGROUND: The worst outcomes linked to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been attributed to the cytokine storm, which contributes significantly to the immunopathogenesis of the disease. The mammalian target of rapamycin (mTOR) pathway is essential for orchestrating innate immune cell defense including cytokine production and is dysregulated in severe Coronavirus Disease 2019 (COVID-19) individuals. The individual genetic background might play a role in the exacerbated immune response...
December 2023: International Immunopharmacology
#9
JOURNAL ARTICLE
Érico C Cardoso-Neto, Eduardo Martins Netto, Carlos Brites
BACKGROUND: Excessive weight gain is a current concern among People Living with HIV (PLHIV) starting ART. OBJECTIVES: To evaluate the weight gain after 48-weeks of ART in naive patients, according with baseline CD4 count. METHODS: PLHIV starting 3TC + TDF + DTG with at least 48-weeks of follow up in two AIDS referral centers were stratified by baseline CD4 count (lower or higher than 200 cells/mm3 ). Data on CD4 count, HIV viral load, weight/Body Mass Index (BMI), lipids and glucose levels were collected at baseline, 24 and 48 weeks of treatment...
2023: Brazilian Journal of Infectious Diseases
#10
JOURNAL ARTICLE
Maria Esther Suarez Alpire, Daniel Vitor de Souza, Carolina Marquez da Costa Brites Masutti, Marcos Montani Caseiro, Daniel Araki Ribeiro
OBJECTIVE: The objective of this study was to evaluate possible cytogenetic changes in children and adolescents with human immunodeficiency virus on antiretroviral therapy, through the micronucleus test in oral mucosa. METHODS: This was a prospective study consisted of 40 individuals, of whom 21 comprised the human immunodeficiency virus group and 19 comprised the control group. Children and adolescents with human immunodeficiency virus were enrolled. The inclusion criteria were <18 years old and consent in participating in the study...
2023: Revista da Associação Médica Brasileira
#11
JOURNAL ARTICLE
Martin Maximiliano, Impa Condori Anabel, Davico Belén, Gómez Rosso Leonardo, Gaete Laura, Tetzlaff Walter, Lozano Chiappe Ezequiel, Sáez María Soledad, Lorenzon González María Victoria, Godoy María Fernanda, Osta Viviana, Trifone Liliana, Ballerini María Gabriela, Cherñavsky Alejandra, Boero Laura, Tonietti Miriam, Feliu Susana, Brites Fernando
BACKGROUND: Abdominal obesity is an important cardiovascular risk factor. Plasma fatty acids display a complex network of both pro and antiatherogenic effects. High density lipoproteins (HDL) carry out the antiatherogenic pathway called reverse cholesterol transport (RCT), which involves cellular cholesterol efflux (CCE), and lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) activities. OBJECTIVE: Our aim was to characterize RCT and its relation to fatty acids present in plasma in pediatric abdominal obesity...
September 14, 2023: Journal of Nutrition
#12
JOURNAL ARTICLE
G Ribeiro, G Ferreira, U D Menda, M Alexandre, M J Brites, M A Barreiros, S Jana, H Águas, R Martins, P A Fernandes, P Salomé, M J Mendes
By taking advantage of the outstanding intrinsic optoelectronic properties of perovskite-based photovoltaic materials, together with the strong near-infrared (NIR) absorption and electronic confinement in PbS quantum dots (QDs), sub-bandgap photocurrent generation is possible, opening the way for solar cell efficiencies surpassing the classical limits. The present study shows an effective methodology for the inclusion of high densities of colloidal PbS QDs in a MAPbI3 (methylammonium lead iodide) perovskite matrix as a means to enhance the spectral window of photon absorption of the perovskite host film and allow photocurrent production below its bandgap...
August 29, 2023: Nanomaterials
#13
JOURNAL ARTICLE
Gabriella von Essen, Erik Lindsund, Elaina M Maldonado, Petr Zouhar, Barbara Cannon, Jan Nedergaard
OBJECTIVE: The possibility to counteract the development of obesity in humans by recruiting brown or brite/beige adipose tissue (and thus UCP1) has attracted much attention. Here we examine if a diet that can activate diet-induced thermogenesis can exploit pre-enhanced amounts of UCP1 to counteract the development of diet-induced obesity. METHODS: To investigate the anti-obesity significance of highly augmented amounts of UCP1 for control of body energy reserves, we physiologically increased total UCP1 amounts in brown and brite/beige tissues in mice...
July 25, 2023: Molecular Metabolism
#14
JOURNAL ARTICLE
Jens D Lundgren, Abdel G Babiker, Shweta Sharma, Birgit Grund, Andrew N Phillips, Gail Matthews, Virginia L Kan, Bitten Aagaard, Inka Abo, Beverly Alston, Alejandro Arenas-Pinto, Anchalee Avihingsanon, Sharlaa Badal-Faesen, Carlos Brites, Cate Carey, Jorge Casseb, Amanda Clarke, Simon Collins, Giulio Maria Corbelli, Sounkalo Dao, Eileen T Denning, Sean Emery, Nnakelu Eriobu, Eric Florence, Hansjakob Furrer, Gerd Fätkenheuer, Jan Gerstoft, Magnus Gisslén, Katharine Goodall, Keith Henry, Andrzej Horban, Jennifer Hoy, Fleur Hudson, Raja Iskandar Shah Raja Azwa, Eynat Kedem, Anthony Kelleher, Cissy Kityo, Karin Klingman, Alberto La Rosa, Nicolas Leturque, Alan R Lifson, Marcelo Losso, Joseph Lutaakome, Juan Sierra Madero, Patrick Mallon, Kamal Mansinho, Kamal Marhoum El Filali, Jean-Michel Molina, Daniel D Murray, Kumarasamy Nagalingeswaran, Silvia Nozza, Vidar Ormaasen, Roger Paredes, Luiz Carlos Peireira, Sandy Pillay, Mark N Polizzotto, Dorthe Raben, Armin Rieger, Adriana Sanchez, Mauro Schechter, Dalibor Sedlacek, Therese Staub, Giota Touloumi, Melissa Turner, Jose Valdez Madruga, Michael Vjecha, Marcelo Wolff, Robin Wood, Kai Zilmer, H Clifford Lane, James D Neaton
BACKGROUND: For people with HIV and CD4+ counts >500 cells/mm3 , early initiation of antiretroviral therapy (ART) reduces serious AIDS and serious non-AIDS (SNA) risk compared with deferral of treatment until CD4+ counts are <350 cells/mm3 . Whether excess risk of AIDS and SNA persists once ART is initiated for those who defer treatment is uncertain. METHODS: The Strategic Timing of AntiRetroviral Treatment (START) trial, as previously reported, randomly assigned 4684 ART-naive HIV-positive adults with CD4+ counts ...
March 2023: NEJM Evid
#15
JOURNAL ARTICLE
Anelise Reis Gaya, Rodolfo Brum, Keith Brites, Adroaldo Gaya, Letícia de Borba Schneiders, Miguel Angelo Duarte Junior, José Francisco López-Gil
BACKGROUND: Considering the evident risk in the literature between the use of screen devices and sleep, there are still few studies on the relationship between each electronic screen device, media programs and sleep duration and sleep-related problems among adolescents and which variables interfere in these relationships. Therefore, this study has the following objectives: (1) to determine which are the most common electronic display devices related to sleep time and outcomes and (2) to determine which are the most common social network applications, such as Instagram and WhatsApp, associated with sleep outcomes...
May 19, 2023: BMC Public Health
#16
Yuriy Pomeshchik, Oxana Klementieva, Jeovanis Gil, Isak Martinsson, Marita Grønning Hansen, Tessa de Vries, Anna Sancho-Balsells, Kaspar Russ, Ekaterina Savchenko, Anna Collin, Ana Rita Vaz, Silvia Bagnoli, Benedetta Nacmias, Claire Rampon, Sandro Sorbi, Dora Brites, György Marko-Varga, Zaal Kokaia, Melinda Rezeli, Gunnar K Gouras, Laurent Roybon
No abstract text is available yet for this article.
May 9, 2023: Stem Cell Reports
#17
JOURNAL ARTICLE
Deliang Li, Liping Liu, Feng Li, Chengshan Ma, Keli Ge
The aim of the present study was to investigate the molecular mechanism of nifuroxazide (NFZ) in the induction of apoptosis of NCI-H1299 human non-small cell lung cancer (NSCLC) cells through the reactive oxygen species (ROS)/Ca2+ /protein kinase R-like ER kinase (PERK)-activating transcription factor 4 (ATF4)-DNA damage inducible transcript 3 (CHOP) signaling pathway. Morphological changes of cells were observed by microscopy, and the apoptosis and intracellular ROS levels of cells were observed by inverted fluorescence microscopy...
June 2023: Oncology Letters
#18
JOURNAL ARTICLE
Farah Omran, Alice M Murphy, Awais Z Younis, Ioannis Kyrou, Jana Vrbikova, Vojtech Hainer, Petra Sramkova, Martin Fried, Graham Ball, Gyanendra Tripathi, Sudhesh Kumar, Philip G McTernan, Mark Christian
BACKGROUND: Dysfunctional adipose tissue (AT) is known to contribute to the pathophysiology of metabolic disease, including type 2 diabetes mellitus (T2DM). This dysfunction may occur, in part, as a consequence of gut-derived endotoxaemia inducing changes in adipocyte mitochondrial function and reducing the proportion of BRITE (brown-in-white) adipocytes. Therefore, the present study investigated whether endotoxin (lipopolysaccharide; LPS) directly contributes to impaired human adipocyte mitochondrial function and browning in human adipocytes, and the relevant impact of obesity status pre and post bariatric surgery...
April 19, 2023: BMC Medicine
#19
JOURNAL ARTICLE
Muhammad Hamza Bokhari, Carina Halleskog, Irina Shabalina, Tore Bengtsson
Induction of thermogenesis in brown and brite adipocytes has recently emerged as a therapeutic target for novel anti obesogenic therapies necessitating the development of methods that can accurately measure heat production in these cells. Modern isothermal microcalorimetric techniques allow for the high throughput quantitative measurement of cellular heat production with limited sample material. Here, we describe the application of this technique for the measurement of thermogenesis in both floating and adherent adipocytes from various murine depots and human cell lines...
2023: Methods in Molecular Biology
#20
JOURNAL ARTICLE
Jasleen Kaur, Dhirendra Pratap Singh, Vijay Kumar, Simranjit Kaur, Rupam Kumar Bhunia, Kanthi Kiran Kondepudi, Anurag Kuhad, Mahendra Bishnoi
BACKGROUND & AIM: Obesity is a worldwide epidemic leading to decreased quality of life, higher medical expenses and significant morbidity. Enhancing energy expenditure and substrate utilization in adipose tissues through dietary constituents and polypharmacological approaches is gaining importance for the prevention and therapeutics of obesity. An important factor in this regard is Transient Receptor Potential (TRP) channel modulation and resultant activation of "brite" phenotype...
April 17, 2023: Life Sciences
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