Dennis G Moledina, Wassim Obeid, Rex N Smith, Ivy Rosales, Meghan E Sise, Gilbert Moeckel, Michael Kashgarian, Michael Kuperman, Kirk N Campbell, Sean Lefferts, Kristin Meliambro, Markus Bitzer, Mark A Perazella, Randy L Luciano, Jordan S Pober, Lloyd G Cantley, Robert B Colvin, F Perry Wilson, Chirag R Parikh
BackgroundAcute tubulointerstitial nephritis (AIN) is one of the few causes of acute kidney injury with diagnosis-specific treatment options. However, due to the need to obtain a kidney biopsy for histological confirmation, AIN diagnosis can be delayed, missed, or incorrectly assumed. Here, we identify and validate urinary CXCL9, an IFN-γ-induced chemokine involved in lymphocyte chemotaxis, as a diagnostic biomarker for AIN.MethodsIn a prospectively enrolled cohort with pathologist-adjudicated histological diagnoses, termed the discovery cohort, we tested the association of 180 immune proteins measured by an aptamer-based assay with AIN and validated the top protein, CXCL9, using sandwich immunoassay...
July 3, 2023: Journal of Clinical Investigation