Anna Boehm, Magdalena Aichner, Thomas Sonnweber, Ivan Tancevski, Thomas Fischer, Sabina Sahanic, Michael Joannidis, Guenter Weiss, Alex Pizzini, Judith Loeffler-Ragg
BACKGROUND: Triggers of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are diverse, potentially including airborne pollutants. OBJECTIVES: To analyze whether daily air pollution levels correlate with AECOPD frequency. METHODS: In this retrospective pilot-study, AECOPD frequency was recorded between 2010 and 2016 at the University Hospital of Innsbruck's emergency department and correlated with daily air quality parameters...
April 6, 2021: Heart & Lung: the Journal of Critical Care
Yu-Chi Chiu, Shih-Wei Lee, Chi-Wei Liu, Rebecca Chou-Jui Lin, Yung-Chia Huang, Tzuo-Yun Lan, Lawrence Shih-Hsin Wu
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease that reduces lung and respiratory function, with a high mortality rate. Severe and acute deterioration of COPD can easily lead to respiratory failure, resulting in personal, social, and medical burden. Recent studies have shown a high correlation between the gut microbiota and lung inflammation. In this study, we investigated the relationship between gut microbiota and COPD severity. A total of 60 COPD patients with varying severity according to GOLD guidelines were enrolled in this study...
2021: PloS One
C Arden Pope Iii
No abstract text is available yet for this article.
April 9, 2021: American Journal of Respiratory and Critical Care Medicine
Andrea Billé, James Buxton, Alessandro Viviano, David Gammon, Lukacs Veres, Tom Routledge, Karen Harrison-Phipps, Allison Dixon, Marco A Minetto
OBJECTIVES: To assess whether preoperative levels of physical activity predict the incidence of post-operative complications following anatomical lung resection. METHODS: Levels of physical activity (daily steps) were measured for 15 consecutive days using pedometers in 90 consecutive patients (prior to admission). Outcomes measured were cardiac and respiratory complications, length of stay, and 30-day re-admission rate. RESULTS: A total of 78 patients' datasets were analysed (12 patients were excluded due to non-compliance)...
January 2021: Integrative Cancer Therapies
Fang Feng, Weiwei Yang, Zhengxin Zhang, Chenghua Mu, Min Li, Yu Chen
OBJECTIVE: To analysis the risk factors and safety of administration of norepinephrine (NE) via peripheral vein line (PVL) in patients with septic shock. METHODS: A single-center retrospective study was conducted. According to the Lanzhou University Second Hospital information system (HIS) and nursing adverse events report cards, patients with septic shock administrated with NE via PVL to correct the hypotension from January 1st 2015 to December 31st, 2019 were enrolled...
March 2021: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Kamal U Saikh
The continuous emergence of infectious pathogens along with antimicrobial resistance creates a need for an alternative approach to treat infectious diseases. Targeting host factor(s) which are critically involved in immune signaling pathways for modulation of host immunity offers to treat a broad range of infectious diseases. Upon pathogen-associated ligands binding to the Toll-like/ IL-1R family, and other cellular receptors, followed by recruitment of intracellular signaling adaptor proteins, primarily MyD88, trigger the innate immune responses...
April 8, 2021: Immunologic Research
Jeremy A Scott, Harm Maarsingh, Fernando Holguin, Hartmut Grasemann
Nitric oxide (NO) is produced by a family of isoenzymes, nitric oxide synthases (NOSs), which all utilize L-arginine as substrate. The production of NO in the lung and airways can play a number of roles during lung development, regulates airway and vascular smooth muscle tone, and is involved in inflammatory processes and host defense. Altered L-arginine/NO homeostasis, due to the accumulation of endogenous NOS inhibitors and competition for substrate with the arginase enzymes, has been found to play a role in various conditions affecting the lung and in pulmonary diseases, such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), pulmonary hypertension, and bronchopulmonary dysplasia...
2021: Frontiers in Pharmacology
Chantal Raherison-Semjen, Karen Mezzi, Konstantinos Kostikas, Alexander J Mackay, Dave Singh
Objective: To evaluate the perception of physicians on gender-specific differences in the diagnosis of chronic obstructive pulmonary disease (COPD) using a qualitative and anonymous questionnaire-based survey. Methods: The survey was conducted amongst respiratory physicians attending a standalone educational conference (29-30 September 2017) using the SpotMe® App. The 20-item standardized closed questionnaire had pre-coded responses to questions on physician's profile, and perception of COPD diagnosis and existing comorbidities between genders...
2021: International Journal of Chronic Obstructive Pulmonary Disease
Zheng Wang, Yuqiang Zuo, Zhihong Gao
Background: Chronic obstructive pulmonary disease (COPD) is a major cause of death because of its high incidence and mortality, which is chiefly resulted from cigarette smoke exposure. A large number of studies show that circular RNA (circRNA) participates in regulating COPD process. This study aims to reveal the role of circRNA ankyrin repeat domain 11 (circANKRD11) in cigarette smoke extract (CSE)-induced cell apoptosis, inflammation, and oxidative stress. Methods: The expression of circANKRD11, microRNA-145-5p (miR-145-5p) and bromodomain-containing 4 (BRD4) mRNA was detected by quantitative real-time polymerase chain reaction...
2021: International Journal of Chronic Obstructive Pulmonary Disease
Zhi-Yuan Chen, Yi Zhang, Jian-Hua Wu, Xiao-Hua Gao, Chun-Ling Huang, Yu-Mei Lin, Xiao-Ting Xu, Yan Li
Background: Penehyclidine hydrochloride is a selective antagonist of M1 and M3 receptors. Clinical studies suggest that it is a potential drug for the treatment of chronic obstructive pulmonary disease (COPD). The purpose of this study was to evaluate the effect of penehyclidine hydrochloride on the inflammatory response of lung tissue during mechanical ventilation in rats with COPD and explore the role of the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) signaling pathway...
2021: International Journal of Chronic Obstructive Pulmonary Disease
Nicola A Hanania, Abebaw M Yohannes, Ayca Ozol-Godfrey, Michael Tocco, Thomas Goodin, Sanjay Sharma, Shahin Sanjar
Background: Anxiety and depression (A/D) are common in patients with chronic obstructive pulmonary disease (COPD) and are often associated with lower adherence to treatment and worse patient-related outcomes. However, studies on the impact of comorbid A/D on responses to bronchodilators are limited. Methods: This post hoc analysis of pooled data (N=861) from the GOLDEN 3 and 4 studies compared the efficacy and safety of nebulized glycopyrrolate (GLY) 25 µg in patients with moderate-to-very-severe COPD, grouped by self-reported A/D...
2021: International Journal of Chronic Obstructive Pulmonary Disease
Yeonseok Choi, Sun Hye Shin, Hyun Lee, Hyun Kyu Cho, Yunjoo Im, Noeul Kang, Hye Sook Choi, Hye Yun Park
Purpose: Long-term macrolide treatment is recommended for patients with chronic obstructive pulmonary disease (COPD) with frequent exacerbations. Bronchiectasis is a common comorbid condition in patients with COPD, for which long-term azithromycin is effective in preventing exacerbation. This study aimed to compare the effect of long-term azithromycin between bronchiectasis patients with chronic airflow obstruction (CAO) and COPD patients without bronchiectasis. Patients and Methods: Patients with CAO who received azithromycin for more than 12 weeks were retrospectively identified at a single referral hospital...
2021: International Journal of Chronic Obstructive Pulmonary Disease
Charlotte Simonÿ, Claus Riber Højfeld, Brian Clausen, Regner Birkelund, Uffe Bodtger
PURPOSE: This study aims to investigate the experienced and measured development in physical capacity in people with Chronic Obstructive Pulmonary Disease (COPD) undergoing a standard pulmonary rehabilitation programme with a focus on the diverging experiences of responders and non-responders. METHODS: Twenty-one participants in standard pulmonary rehabilitation were included in the study. We measured the participants' change in the six-minute walk test (6MWT) during rehabilitation participation...
April 8, 2021: Disability and Rehabilitation
Renfeng Zeng, Ke Tian, Zhike Xiao
BACKGROUND: To our knowledge, only 1 study has investigated the effects of kinesio taping (KT) on pulmonary function and functional capacity of patients with chronic obstructive pulmonary disease (COPD). Therefore, there is still a lack of high-quality evidence to prove the effectiveness of KT for COPD patients. Our purpose was to investigate the effect of KT on respiratory function and muscle strength in the COPD patients who were in stable condition. METHODS: This research project has been received ethical approval from the Medical Research and Ethics Committee in Affiliated Nanhua Hospital, University of South China...
April 9, 2021: Medicine (Baltimore)
Laura Cordova-Rivera, Paul A Gardiner, Peter G Gibson, Elisabeth A H Winkler, Paola D Urroz, Vanessa M McDonald
Sedentary time (ST) and light-intensity physical activity (LIPA) are movement behaviours associated with important health outcomes, but are not widely explored in respiratory diseases. We aimed to describe their volume and/or accumulation patterns in moderate-severe COPD, bronchiectasis and severe asthma using the accurate postural-based accelerometer activPAL, contrasting these values with a non-respiratory population. We also sought to test the cross-sectional associations of these behaviours with disease characteristics by diagnostic group, and as a combined label-free disease group...
March 24, 2021: Respiratory Medicine
Alessandro Domingues Heubel, Erika Zavaglia Kabbach, Nathany Souza Schafauser, Shane Aaron Phillips, Valéria Amorim Pires Di Lorenzo, Audrey Borghi Silva, Renata Gonçalves Mendes
PURPOSE: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with an elevated risk of cardiovascular events, which can be linked to endothelial dysfunction. In this study, we aimed to investigate whether noninvasive ventilation (NIV) acutely changes endothelial function in hospitalized AECOPD patients. METHODS: Twenty-one AECOPD patients were assessed in a hospital ward setting from 24 to 48 h after admission. NIV was applied using a ventilator with bilevel pressure support...
April 2, 2021: Respiratory Medicine
J Alberto Neder, Juan Pablo de-Torres, Denis E O'Donnell
No abstract text is available yet for this article.
April 8, 2021: American Journal of Respiratory and Critical Care Medicine
Emiel F M Wouters
No abstract text is available yet for this article.
April 8, 2021: American Journal of Respiratory and Critical Care Medicine
Neil C Thomson
No abstract text is available yet for this article.
April 8, 2021: American Journal of Respiratory and Critical Care Medicine
Elizabeth A Gilliam, Tina Cheung, Kristen Kraemer, Daniel Litrownik, Peter M Wayne, Marilyn L Moy, Gloria Y Yeh
PURPOSE: Chronic obstructive pulmonary disease (COPD) is associated with multiple psychosocial and behavioral factors. Prior research suggests that mind-body interventions may support the development and maintenance of healthy behaviors and improve health-related quality-of-life in such patients. We sought to qualitatively explore cognitive, psychosocial, and behavioral changes in patients with COPD who participated in two different mind-body interventions compared to an education control...
2021: PloS One
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