Marta A Kisiel, Oscar Arnfelt, Eva Lindberg, Oscar Jogi, Andrei Malinovschi, Ane Johannessen, Bryndis Benediktsdottir, Karl Franklin, Mathias Holm, Francisco Gomez Real, Torben Sigsgaard, Thorarinn Gislason, Lars Modig, Christer Janson
INTRODUCTION: Previous studies on the association between abdominal and general obesity and respiratory disease have provided conflicting results. AIMS AND OBJECTIVES: We aimed to explore the associations of abdominal obesity with respiratory symptoms, asthma, and chronic obstructive pulmonary disease independently from general obesity in women and men. METHODS: This cross-sectional study was based on the Respiratory Health in Northern Europe (RHINE) III questionnaire (n = 12 290) conducted in 2010-2012...
March 16, 2023: Respiratory Medicine
Zheng Li, Xuesong Yan, Jin Liu, Xin Feng, Xiangyun Li
OBJECTIVE: To investigate the value of comprehensive rehabilitation therapy in chronic obstructive pulmonary disease (COPD) and its effect on improvement in patients' inflammation. METHODS: A total of 174 patients with acute COPD exacerbation in the Affiliated Hospital of Hebei University in China from March 2020 to January 2022 were selected as research subjects. They were divided into control, acute and stable groups according to the random number table method (n=58 in each group)...
March 20, 2023: Alternative Therapies in Health and Medicine
Aiping Gou, Guanzheng Tan, Xianbin Ding, Jiangbo Wang, Yan Jiao, Chunyan Gou, Qiang Tan
BACKGROUND: There are regional differences in the effect of green space on mortality of Chronic obstructive pulmonary disease (COPD). We conduct an ecological study, using the administrative divisions of Chongqing townships in China as the basic unit, to investigate the association between COPD mortality and green space based on data of 313,013 COPD deaths in Chongqing from 2012 to 2020. Green space is defined by Fractional vegetation cover (FVC), which is further calculated based on the normalised vegetation index (NDVI) from satellite remote sensing imagery maps...
March 17, 2023: BMC Pulmonary Medicine
A L Wangüemert-Pérez, J M Figueira-Gonçalves, Y Ramallo-Fariña, S Guanche-Dorta, R Golpe
INTRODUCTION: Air trapping is one of the main determinants of dyspnea in patients with chronic obstructive pulmonary disease (COPD). An increase in air trapping leads to a change in the normal diaphragmatic configuration with associated functional impairment. Said deterioration improves with bronchodilator therapy. Chest ultrasound (CU) has been used to assess changes in diaphragmatic motility after short-acting bronchodilator therapy, but there are no previous studies on these changes after long-acting bronchodilator treatment...
March 15, 2023: Revista Clínica Espanõla
Kevin James Baker, Emily Buskiewicz, Méabh Finucane, Adeleine Chelliah, Louise Burke, Aileen Houston, Elizabeth Brint
The IL-36 cytokines are a recently described subset of the IL-1 family of cytokines, and have been shown to play a role in the pathogenesis of respiratory diseases such as asthma and COPD. Given the common aetiological links between COPD and lung cancer development, as well as the involvement of other IL-1 family members in lung tumorigenesis, the aim of this work was to investigate the role of IL-36 cytokines in the pathogenesis of lung cancer. In this study we demonstrate that expression of IL-36 cytokines and receptor mRNA and protein are significantly increased in lung cancer tissue compared to adjacent non-tumour tissue...
March 15, 2023: Cytokine
M Okşul, Ö Bilge, E Taştan, F Işık, Ü İnci, H Akın, S Söner, A D Cömert, R Tüzün, M Çap, Y Z Şener, E Baysal
OBJECTIVE: The impact of COVID-19 infection still continues all over the world and is an important cause of mortality. The mortality rate due to infection varies between 1-5%. The mortality rate is higher in those with cardiovascular risk factors, especially in cases with hypertension. Some studies have shown that blood urea nitrogen (BUN) and albumin levels are associated with worse prognosis in patients with COVID-19. In our study, we aimed to investigate whether the BUN/albumin (BAR) ratio has an effect on in-hospital mortality in hypertensive COVID-19 patients...
March 2023: European Review for Medical and Pharmacological Sciences
Inderpreet Singh, Abhay Singh
PURPOSE OF REVIEW: This article summarizes the current knowledge about clonal hematopoiesis of indeterminate potential (CHIP), its association with cardiovascular disease (CVD), and other outcomes, pathogenesis, postulated mechanisms of various pathologies, current knowledge gaps, possible targets of intervention, and therapeutic implications. RECENT FINDINGS: Recently, a common age-related hematological entity known as CHIP has been identified as the independent risk factor for CVD...
March 16, 2023: Current Oncology Reports
Aldiane Gomes de Macedo Bacurau, Juliana Armenio Moreira Ferreira, Núbia Garcia Vianna, Deborah Carvalho Malta, Priscila Mª Stolses Bergamo Francisco
OBJECTIVE: Hearing is one of the essential senses for communication and its loss can impact the functional status, quality of life, cognitive functions, and well-being of people. The study objectives were to project the absolute number of older adults with hearing impairment in Brazil; and to estimate the prevalence of acquired hearing impairment and its association with sociodemographic characteristics, self-rated health, and chronic diseases. METHODS: A cross-sectional study was conducted in Brazil with data from individuals (fifty-five years or older) from the 2013 National Health Survey (n=15,393)...
March 16, 2023: Revista Española de Salud Pública
Timothy F Murphy, Charmaine Kirkham, Adonis D'Mello, Sanjay Sethi, Melinda M Pettigrew, Hervé Tettelin
Chronic obstructive pulmonary disease (COPD) is a common debilitating disorder that is the third most common cause of death globally. Chronic lower airway infection by nontypeable Haemophilus influenzae (NTHi) in adults with COPD increases airway inflammation, causes increased symptoms, and accelerates progressive loss of lung function. Little is known about the mechanisms by which NTHi survives in COPD airways. To explore this question, the present study analyzes, in detail, 14 prospectively collected, serial isolates of a strain that persisted for 543 days in a patient with COPD, including analysis of four gap-free complete genomes...
March 16, 2023: MBio
Isabella Cattani-Cavalieri, Yue Li, Jordyn Margolis, Amy Bogard, Moom R Roosan, Rennolds S Ostrom
Human airway smooth muscle (HASM) is the primary target of ßAR agonists used to control airway hypercontractility in asthma and chronic obstructive pulmonary disease (COPD). ßAR agonists induce the production of cAMP by adenylyl cyclases (ACs), activate PKA and cause bronchodilation. Several other G-protein coupled receptors (GPCR) expressed in human airway smooth muscle cells transduce extracellular signals through cAMP but these receptors elicit different cellular responses. Some G-protein coupled receptors couple to distinct adenylyl cyclases isoforms with different localization, partly explaining this compartmentation, but little is known about the downstream networks that result...
2023: Frontiers in Physiology
Yaping Zhang, Lixing Wang, Yifei Liu, Furong Yan
Cigarette smoke exposure is a well-recognized causative factor for Chronic obstructive pulmonary disease (COPD), but the molecular mechanisms responsible for this effect need to be further investigated. An expanding number of studies suggest that m6A modification is involved in the progression of various diseases. Nevertheless, evidence on the regulatory function of m6A modification in human bronchial epithelial cells exposed to cigarette smoke is scarce. In this study, we investigated for the first time the effect of cigarette smoke exposure on contributing to high Mettl3 expression in HBE cells in vitro, an essential m6A writer...
March 14, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
María Granados Santiago, Ramón Romero Fernández, Andrés Calvache Mateo, Alejandro Heredia Ciuro, Javier Martin Nuñez, Laura López López, Marie Carmen Valenza
BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients experience a progressive limitation of their functionality accompanying their clinical evolution. Concretely, severe COPD patients usually require the figure of a caregiver. Caregiver burden have been yet explored in other similar chronic diseases. The objective is to propose a cut-off point in different functional impairment aspects, to predict the presence of caregiver burden. METHODS: Severe COPD patients were divided into two groups according to the caregiver burden, measured with the Zarit Burden Interview (ZBI)...
March 16, 2023: Expert Review of Respiratory Medicine
Raffaella Nenna, Jing Zhai, Amber Spangenberg, Duane L Sherrill, Fernando D Martinez, Marilyn Halonen, Stefano Guerra
INTRODUCTION: Cytomegalovirus (CMV) seropositivity has been recently linked to severity and progression of asthma, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). To date, no longitudinal study has addressed the relation of CMV serology to levels and decline of lung function in the general adult population. METHODS: We evaluated 403 participants from the Tucson Epidemiological Study of Airway Obstructive Disease (TESAOD) who at enrollment were aged 28-55 years and completed lung function tests...
March 16, 2023: Clinical Respiratory Journal
Charlie Strange, N Gerard McElvaney, Claus F Vogelmeier, Marcos Marin-Galiano, Michaela Buch-Haensel, Xiang Zhang, Younan Chen, Oliver Vit, Marion Wencker, Kenneth R Chapman
BACKGROUND: Acute exacerbations of COPD (AECOPD) have unclear impacts on emphysema measurement using computed tomography (CT)-derived 15th percentile lung density (PD15). The aim of this study was to assess the influence of AECOPD on PD15 lung density in α1 -antitrypsin deficiency. METHODS: In a post hoc analysi s of the RAPID (Randomised Trial of Augmentation Therapy in α1 -Proteinase Inhibitor Deficiency) trial, raw marginal residuals of PD15 (measured - predicted) were determined by fitting a regression line to individual patient CT data...
March 2023: ERJ Open Research
Ali Unal, Basak Bayram, Begum Ergan, Kazim Can, Yagiz Kagan Ergun, Oguz Kilinc
BACKGROUND: While clinical decision rules have been developed to evaluate exacerbations and decisions on hospitalisation and discharge in emergency departments (EDs) in patients with chronic obstructive pulmonary disease (COPD), these rules are not widely used in EDs. In this study, we compare the predictive efficacy of the Ottawa Chronic Obstructive Pulmonary Disease Risk Scale (OCRS) and the Dyspnea, Eosinopenia, Consolidation, Acidemia, and Atrial Fibrillation (DECAF) score in estimating the short-term poor outcome of patients in our ED with exacerbations of COPD...
March 2023: ERJ Open Research
Meret Bauer, Julian Müller, Simon R Schneider, Simone Buenzli, Michael Furian, Tanja Ulrich, Arcangelo F Carta, Patrick R Bader, Mona Lichtblau, Ajian Taalaibekova, Madiiar Raimberdiev, Benoit Champigneulle, Talant Sooronbaev, Konrad E Bloch, Silvia Ulrich
BACKGROUND/AIMS: Amongst numerous travellers to high altitude (HA) are many with the highly prevalent COPD, who are at particular risk for altitude-related adverse health effects (ARAHE). We then investigated the hypoxia-altitude simulation test (HAST) to predict ARAHE in COPD patients travelling to altitude. METHODS: This prospective diagnostic accuracy study included 75 COPD patients: 40 women, age 58±9 years, forced expiratory volume in 1 s (FEV1 ) 40-80% pred, oxygen saturation measured by pulse oximetry ( S pO2 ) ≥92% and arterial carbon dioxide tension ( P aCO2 ) <6 kPa...
March 2023: ERJ Open Research
Yasmin S Cypel, Dawne Vogt, Shira Maguen, Paul Bernhard, Elizabeth Lowery, William J Culpepper, Irvine Armand-Gibbs, Aaron I Schneiderman
Large-scale epidemiological studies suggest that veterans may have poorer physical health than nonveterans, but this has been largely unexamined in post-9/11 veterans despite research indicating their high levels of disability and healthcare utilization. Additionally, little investigation has been conducted on sex-based differences and interactions by veteran status. Notably, few studies have explored veteran physical health in relation to national health guidelines. Self-reported, weighted data were analyzed on post-9/11 U...
April 2023: Preventive Medicine Reports
Yuling Yang, Haiyan Ge, Jinjuan Lu, Xuemei Huang, Kun Wang, Liang Jin, Lin Qi, Ming Li
BACKGROUND: Maximal mid-expiratory flow (MMEF) is an earlier predictor of chronic obstructive pulmonary disease (COPD) development than forced expiratory volume in 1 s (FEV1 ). Changes of lung structure in patients with MMEF impairment only is still not clear. Therefore, this study aimed to investigate the structural features of patients with decreased MMEF by quantitative computed tomography (QCT) and develop a predictive model for predicting patients with reduced MMEF in normal lung function population...
March 15, 2023: BMC Pulmonary Medicine
J G Spence, J Brincks, A Løkke, L Neustrup, E B Østergaard
Assessing changes in functional exercise capacity is highly relevant in the treatment of people with Chronic Obstructive Pulmonary Disease (COPD), as lung function is often static. In Denmark, most people with COPD are followed in general practice where traditional functional tests, like six-minute walk test, require too much time and space. Therefore, there is an urgent need for a quick functional exercise capacity test that can be performed in a limited setting, such as general practice. This study aimed to identify a quick test to measure functional exercise capacity in people with COPD and identify which factors could affect the implementation of such a test in general practice...
March 15, 2023: NPJ Primary Care Respiratory Medicine
M Miravitlles, M A Martinez-Garcia
No abstract text is available yet for this article.
March 13, 2023: Pulmonology
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