Hui Wang, Hao Zhang, Wei Yuan
OBJECTIVE: This study evaluates the role of macrophage intracellular tyrosine phosphatase PTP1B in slowing the progression of Chronic Obstructive Pulmonary Disease (COPD) through the inhibition of the SHP-2/Src/ERK1/2/NLRP3 signaling pathway. METHODS: We administered PTP1B non-targeting control (NC) and PTP1B overexpression (OE) lentiviruses to mice. Post-infection, lung tissues underwent Hematoxylin and Eosin (HE) staining and immunofluorescence analysis to detect PTP1B, SHP2, Src, and FAK protein levels...
April 18, 2024: Alternative Therapies in Health and Medicine
Haidong Ding, Rina Wu
BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is characterized by airflow limitation and inflammation resulting from genetic and environmental factors, notably cigarette smoke. Pyroptosis, a cell death process, is implicated in COPD, but its mechanisms are unclear. SHP2, a phosphatase, modulates inflammatory pathways, suggesting a role in COPD pathogenesis and potential therapeutic avenues. OBJECTIVE: This study investigates the mechanism by which SHP2 regulates cell pyroptosis in bronchial epithelial cells in COPD patients...
April 18, 2024: Alternative Therapies in Health and Medicine
F Bozkuş, A Samur, O Yazıcı
OBJECTIVE: This study was designed to investigate the relationship between eosinophil count and cardiovascular disease (CVD) in subjects with chronic obstructive pulmonary disease (COPD) and the correlation between eosinophil count and the risk of exacerbations in COPD. PATIENTS AND METHODS: The study included 405 patients who met the study inclusion criteria. Of the participants, 100 (25%) were classified as Global Initiative for Chronic Obstructive Lung Disease (GOLD) A, 105 (26%) as GOLD B, and 200 (49%) as GOLD E...
April 2024: European Review for Medical and Pharmacological Sciences
Marta Solís García, Carolina Cisneros Serrano, Ana Sofía Martín Hernández, Jose María Eiros Bachiller, Celeste Marcos
INTRODUCTION: Mounier-Kuhn syndrome or tracheobronchomegaly, is a rare condition that consists of abnormal dilation of the trachea and main bronchi due to a pathological arrangement of smooth muscle fibers in this area. CASE REPORT: We present the case of a 46-year-old woman with poorly controlled asthma and recurrent infections, who was diagnosed with Mounier-Kuhn syndrome through a computed tomography scan revealing an unusual enlargement of the trachea with associated bronchiectasis...
April 19, 2024: Journal of Asthma
Zecheng Zhu, Shunjin Zhao, Jiahui Li, Yuting Wang, Luopiao Xu, Yubing Jia, Zihan Li, Wenyuan Li, Gang Chen, Xifeng Wu
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a frequently diagnosed yet treatable condition, provided it is identified early and managed effectively. This study aims to develop an advanced COPD diagnostic model by integrating deep learning and radiomics features. METHODS: We utilized a dataset comprising CT images from 2,983 participants, of which 2,317 participants also provided epidemiological data through questionnaires. Deep learning features were extracted using a Variational Autoencoder, and radiomics features were obtained using the PyRadiomics package...
April 18, 2024: Respiratory Research
Yangli Liu, Fengjia Chen, Zhimin Zeng, Chengcheng Lei, Dubo Chen, Xiaoyu Zhang
BACKGROUND AND OBJECTIVE: Endothelial dysfunction has been widely recognized in chronic airway diseases, including chronic obstructive pulmonary disease (COPD) and asthma; however, it remains unclear in asthma-COPD overlap (ACO). Neopterin (NP), a metabolite of guanosine triphosphate, is a novel biomarker for identifying the increased risk of adverse cardiovascular events. This study aims to investigate the association of NP with endothelial dysfunction and impaired lung function in COPD, asthma, and ACO patients...
April 18, 2024: Respiratory Research
Roland Fath
No abstract text is available yet for this article.
April 2024: MMW Fortschritte der Medizin
Rosa Girón, Rafael Golpe, Miguel Ángel Martínez-García
Bronchiectasis is a clinical-radiological condition composed of irreversible bronchial dilation due to inflammation and infection of the airways, which causes respiratory symptoms, usually productive cough and infectious exacerbations. Bronchiectasis can have multiple causes, both pulmonary and extrapulmonary, and its clinical presentation is very heterogenous. Its prevalence is unknown, although up to 35-50% of severe COPD and 25% of severe asthma present them, so their underdiagnosis is evident. Chronic bacterial bronchial infection is common, and Pseudomonas aeruginosa is the pathogen that has been found to imply a worse prognosis...
April 17, 2024: Medicina Clínica
Rodrigo Abensur Athanazio, Laura Bernal Villada, Sergey N Avdeev, Hao-Chien Wang, Alejandra Ramírez-Venegas, Martín Sivori, Jorge Dreyse, Manuel Pacheco, Sin Kit Man, Lorena Noriega-Aguirre, Hisham Farouk
INTRODUCTION: The <u>EXA</u>cerbations of <u>C</u>hronic obstructive lung disease (COPD) and their <u>O</u>utcome<u>S</u> (EXACOS) International Study aimed to quantify the rate of severe exacerbations and examine healthcare resource utilisation (HCRU) and clinical outcomes in patients with COPD from low-income and middle-income countries. METHODS: EXACOS International was an observational, cross-sectional study with retrospective data collection from medical records for a period of up to 5 years...
April 18, 2024: BMJ Open Respiratory Research
Yun Soo Hong, Hye Yun Park, Seungho Ryu, Sun Hye Shin, Di Zhao, Dave Singh, Eliseo Guallar, Juhee Cho, Yoosoo Chang, Seong Yong Lim
BACKGROUND: Accelerated lung function decline is characteristic of chronic obstructive pulmonary disease (COPD). However, the association between blood eosinophil counts and lung function decline, accounting for current smoking status, in young individuals without prevalent lung disease is not fully understood. METHODS: This is a cohort study of 629 784 Korean adults without COPD or a history of asthma at baseline who participated in health screening examinations including spirometry and differential white blood cell counts...
April 18, 2024: European Respiratory Journal
Angelina L P Pieters, Tjeerd van der Veer, Jennifer J Meerburg, Eleni-Rosalina Andrinopoulou, Menno M Vd Eerden, Pierluigi Ciet, Stefano Aliberti, Pierre-Regis Burgel, Megan L Crichton, Amelia Shoemark, Pieter C Goeminne, Michal Shteinberg, Michael R Loebinger, Charles S Haworth, Francesco Blasi, Harm Awm Tiddens, Daan Caudri, James D Chalmers
RATIONALE: Chest computed tomography -scans (CTs) are essential to diagnose and monitor bronchiectasis (BE). To date, little quantitative data is available about the nature and extent of structural lung abnormalities (SLA) on CTs of BE patients. OBJECTIVES: to investigate SLA on CTs of patients with bronchiectasis and the relationship of SLAs to clinical features using the European Bronchiectasis Registry (EMBARC) Methods: CTs from BE patients included in the EMBARC registry were analyzed using the validated Bronchiectasis Scoring Technique for CT (BEST-CT)...
April 18, 2024: American Journal of Respiratory and Critical Care Medicine
Zhenjie Yu, Jingchun He, Yawen Chen, Ziqi Zhou, Lan Wang
Sarcopenia prevalence and its risk factors in chronic obstructive pulmonary disease (COPD) vary partly due to definition criteria. This systematic review aimed to identify the prevalence and risk factors of sarcopenia in COPD patients. This review was registered in PROSPERO (CRD42022310750). Nine electronic databases were searched from inception to September 1st, 2022, and studies related to sarcopenia and COPD were identified. Study quality was assessed using a validated scale matched to study designs, and a meta-analysis was performed to evaluate sarcopenia prevalence...
2024: PloS One
Dina Yehia, Clarus Leung, Don D Sin
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) accounts for 545 million people living with chronic respiratory disorders and is the third leading cause of morbidity and mortality around the world. COPD is a progressive disease, characterized by episodes of acute worsening of symptoms such as cough, dyspnea, and sputum production. AREAS COVERED: Airway inflammation is a prominent feature of COPD. Chronic airway inflammation results in airway structural remodeling and emphysema...
April 18, 2024: Expert Review of Molecular Diagnostics
Mirjam Grimm, Lucie Ziegler, Annina Seglias, Maamed Mademilov, Kamila Magdieva, Gulzada Mirzalieva, Aijan Taalaibekova, Simone Suter, Simon R Schneider, Fiona Zoller, Vera Bissig, Lukas Reinhard, Meret Bauer, Julian Müller, Tanja L Ulrich, Arcangelo F Carta, Patrick R Bader, Konstantinos Bitos, Aurelia E Reiser, Benoit Champigneulle, Damira Ashyralieva, Philipp M Scheiwiller, Silvia Ulrich, Talant M Sooronbaev, Michael Furian, Konrad E Bloch
Grimm, Mirjam, Lucie Ziegler, Annina Seglias, Maamed Mademilov, Kamila Magdieva, Gulzada Mirzalieva, Aijan Taalaibekova, Simone Suter, Simon R. Schneider, Fiona Zoller, Vera Bissig, Lukas Reinhard, Meret Bauer, Julian Müller, Tanja L. Ulrich, Arcangelo F. Carta, Patrick R. Bader, Konstantinos Bitos, Aurelia E. Reiser, Benoit Champigneulle, Damira Ashyralieva, Philipp M. Scheiwiller, Silvia Ulrich, Talant M. Sooronbaev, Michael Furian, and Konrad E. Bloch. SARS-CoV-2 Transmission during High-Altitude Field Studies...
April 18, 2024: High Altitude Medicine & Biology
Heng Mu, Qunxia Zhang
Chronic Obstructive Pulmonary Disease (COPD) is a prevalent condition that poses a significant burden on individuals and society due to its high morbidity and mortality rates. The diaphragm is the main respiratory muscle, its function has a direct impact on the quality of life and prognosis of COPD patients. This article aims to review the structural measurement and functional evaluation methods through the use of diaphragmatic ultrasound and relevant research on its application in clinical practice for COPD patients...
December 2024: COPD
Emily Fitzgerald, Shelby Parker, Sarah Hancock, Courtney Marie-Cora Jones, Julie Kittel, John DeAngelis, Maia Dorsett
OBJECTIVES: Patients with chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF) exacerbations present with similar history and physical examination findings. This complicates both the diagnostic process and the creation of appropriate treatment plans for patients presenting in respiratory distress, particularly in the prehospital setting. Thoracic point-of-care-ultrasound (POCUS) may increase diagnostic accuracy; however, its potential to improve patient management by emergency medical services clinicians is unknown...
April 2024: Journal of the American College of Emergency Physicians open
Sandhya Kolagatla, Dedeepya Gullapalli, Avinash Vangara, Regina Chan, Derek Jernigan, Nagabhishek Moka, Subramanya Shyam Ganti
Alpha-1 antitrypsin (AAT) deficiency, an autosomal co-dominant inherited condition, significantly impacts lung and liver functions, with mutations in the SERPINA1 gene, notably the Z allele, playing a pivotal role in disease susceptibility. This retrospective descriptive study from a rural Eastern Kentucky pulmonary clinic aimed to characterize patients with AAT deficiency, focusing on demographic, clinical, and laboratory parameters extracted from electronic health records (EHR) of Appalachian Regional Healthcare (ARH)...
March 2024: Curēus
Zhiwei Long, Xiaotong Li, Zhengtu Li, Jieying Hu, Ye Qiu, Shaoqiang Li, Yangqing Zhan, Feng Ye, Yan Wang
BACKGROUND: The prevalence of invasive pulmonary aspergillosis (IPA) among patients with chronic obstructive pulmonary disease (COPD) is steadily increasing, leading to high mortality. Although early diagnosis can significantly reduce mortality, the efficacy of current diagnostic methods is limited. Consequently, there is a need for novel approaches for early IPA detection. METHODS: This retrospective study involved 383 hospitalized COPD patients with GOLD stages III and IV...
2024: Frontiers in Cellular and Infection Microbiology
Lingfang Tan, Xuefeng Yang, Jianxin Zhang, Kebing Zhou
BACKGROUND: Airway remodeling is a significant pathological characteristic of chronic obstructive pulmonary disease (COPD). In recent years, hypoxia-inducible factor 1-α (HIF-1α), a member of the hypoxia-inducible factor protein family, has gained attention. However, the potential correlation between HIF-1α and COPD airway remodeling remains unclear. OBJECTIVE: This study explored the expression patterns of HIF-1α in patients with COPD and its association with airway remodelling...
2024: International Journal of Chronic Obstructive Pulmonary Disease
Jesús Domínguez, Denys Prociuk, Branko Marović, Kristijonas Čyras, Oana Cocarascu, Francis Ruiz, Ella Mi, Emma Mi, Christian Ramtale, Antonio Rago, Ara Darzi, Francesca Toni, Vasa Curcin, Brendan Delaney
INTRODUCTION: Clinical decision support (CDS) systems (CDSSs) that integrate clinical guidelines need to reflect real-world co-morbidity. In patient-specific clinical contexts, transparent recommendations that allow for contraindications and other conflicts arising from co-morbidity are a requirement. In this work, we develop and evaluate a non-proprietary, standards-based approach to the deployment of computable guidelines with explainable argumentation, integrated with a commercial electronic health record (EHR) system in Serbia, a middle-income country in West Balkans...
April 2024: Learning Health Systems
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