Archana Ramireddy, Harpriya Chugh, Kyndaron Reinier, Audrey Uy-Evanado, Eric C Stecker, Jonathan Jui, Sumeet S Chugh
BACKGROUND: In the absence of apparent triggers, sudden cardiac death (SCD) during nighttime hours is a perplexing and devastating phenomenon. There are few published reports in the general population with insufficient numbers to perform sex-specific analyses. Smaller studies of rare nocturnal SCD syndromes suggest a male predominance and implicate sleep-disordered breathing. OBJECTIVE: To identify mechanisms of nighttime SCD in the general population. METHODS: From the population-based Oregon Sudden Unexpected Death Study, we evaluated SCD cases that occurred in the community between 10 PM and 6 AM (nighttime) and compared them with daytime cases...
January 19, 2021: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Ernest Shen, Janet S Lee, Richard A Mularski, Phillip Crawford, Alan S Go, Sue H Sung, Grace H Tabada, Michael K Gould, Huong Q Nguyen
BACKGROUND: Multiple morbidity is the norm in advanced COPD and contributes to high symptom burden and worse outcomes. RESEARCH QUESTION: Can distinct comorbidity profiles be identified and validated in a community-based sample of patients with COPD from a large integrated health care system using a standard, commonly used diagnostic code-based comorbidity index and downstream 2-year health care utilization data? STUDY DESIGN AND METHODS: In this retrospective cohort study, we used latent class analysis (LCA) to identify comorbidity profiles in a population-based sample of 91,453 patients with a COPD diagnosis between 2011 and 2015...
January 19, 2021: Chest
Anne Compagnon, Laurent Nguyen, Zeina Antoun, Bruno Stach, Christophe Zanetti, Frédéric Le Guillou
BACKGROUND: The current prevalence of chronic obstructive pulmonary disease (COPD) in France is estimated to be 2.6 million and is predicted to increase to 2.8 million by 2025. Presently, there is a lack of data on COPD management within the private healthcare setting. The aim of this study was to investigate the management of COPD exacerbations by pulmonologists within private practices in France. METHODS: A prospective, online, qualitative survey was distributed to private practice pulmonologists in France...
2021: PloS One
Nihal E Mohamed, Emma K T Benn, Varuna Astha, Kennedy E Okhawere, Talia G Korn, William Nkemdirim, Ami Rambhia, Olajumoke A Ige, Hassan Funchess, Meredith Mihalopoulos, Kirolos N Meilika, Natasha Kyprianou, Ketan K Badani
PURPOSE: To evaluate mortality risk of CKD patients infected with COVID-19, and assess shared characteristics associated with health disparities in CKD outcome. METHODS: We extracted the data from a case series of 7624 patients presented at Mount Sinai Health System, in New York for testing between 3/28/2020 and 4/16/2020. De-identified patient data set is being produced by the Scientific Computing department and made available to the Mount Sinai research community at the following website: https://msdw...
January 22, 2021: World Journal of Urology
L Paglicci, V Borgo, N Lanzarone, M Fabbiani, C Cassol, M G Cusi, M Valassina, S Scolletta, E Bargagli, L Marchetti, P Paladini, L Luzzi, A Fossi, D Bennett, F Montagnani
To evaluate incidence of and risk factors for respiratory bacterial colonization and infections within 30 days from lung transplantation (LT). We retrospectively analyzed microbiological and clinical data from 94 patients transplanted for indications other than cystic fibrosis, focusing on the occurrence of bacterial respiratory colonization or infection during 1 month of follow-up after LT. Thirty-three percent of patients developed lower respiratory bacterial colonization. Bilateral LT and chronic heart diseases were independently associated to a higher risk of overall bacterial colonization...
January 21, 2021: European Journal of Clinical Microbiology & Infectious Diseases
Tom Hartley, Nicholas D Lane, John Steer, Mark W Elliott, Milind P Sovani, Helen Jane Curtis, Elizabeth R Fuller, Patrick B Murphy, Dinesh Shrikrishna, Keir E Lewis, Neil R Ward, Chris D Turnbull, Nicholas Hart, Stephen C Bourke
INTRODUCTION: Acute exacerbations of COPD (AECOPD) complicated by acute (acidaemic) hypercapnic respiratory failure (AHRF) requiring ventilation are common. When applied appropriately, ventilation substantially reduces mortality. Despite this, there is evidence of poor practice and prognostic pessimism. A clinical prediction tool could improve decision making regarding ventilation, but none is routinely used. METHODS: Consecutive patients admitted with AECOPD and AHRF treated with assisted ventilation (principally non-invasive ventilation) were identified in two hospitals serving differing populations...
January 21, 2021: European Respiratory Journal
Thomas Maitre, Jonathan Cottenet, Cendrine Godet, Adrien Roussot, Nafiz Abdoul Carime, Vichita Ok, Antoine Parrot, Philippe Bonniaud, Catherine Quantin, Jacques Cadranel
Chronic pulmonary aspergillosis (CPA) is an emerging disease in patients with common chronic pulmonary diseases (CPD). While its prevalence is linked to tuberculosis (TB) in endemic countries, epidemiologic and prognostic data are lacking in low TB incidence countries. The aim of this study was to describe these features in CPA patients hospitalised in France between 2009 and 2018.We estimated the prevalence and mortality of hospitalised CPA patients using the French nationwide administrative hospital database...
January 21, 2021: European Respiratory Journal
Martin Rune Hassan Hansen, Erik Jørs, Annelli Sandbæk, Daniel Sekabojja, John C Ssempebwa, Ruth Mubeezi, Philipp Staudacher, Samuel Fuhrimann, Torben Sigsgaard, Alex Burdorf, Bo Martin Bibby, Vivi Schlünssen
INTRODUCTION AND AIM: Exposure to some insecticides may cause airway obstruction, but existing evidence is limited by cross-sectional designs and inadequate confounder control. We investigated the relation between organophosphate and carbamate insecticides and pulmonary function in a prospective study accounting for important confounders. METHODS: In a cohort of 364 smallholder farmers in Uganda (69% women), participants underwent pre-bronchodilator spirometry at baseline (September/October 2018) and at two follow-up visits (November/December 2018 and January/February 2019)...
January 21, 2021: Thorax
Judith Garcia-Aymerich, Milo A Puhan, Solange Corriol-Rohou, Corina de Jong, Heleen Demeyer, Fabienne Dobbels, Damijan Erzen, Anja Frei, Elena Gimeno-Santos, Nicholas S Hopkinson, Nathalie Ivanoff, Niklas Karlsson, Zafeiris Louvaris, Michael I Polkey, Roberto A Rabinovich, Mario Scuri, Maggie Tabberer, Ioannis Vogiatzis, Thierry Troosters
BACKGROUND: The Daily-PROactive and Clinical visit-PROactive Physical Activity (D-PPAC and C-PPAC) instruments in chronic obstructive pulmonary disease (COPD) combines questionnaire with activity monitor data to measure patients' experience of physical activity. Their amount, difficulty and total scores range from 0 (worst) to 100 (best) but require further psychometric evaluation. OBJECTIVE: To test reliability, validity and responsiveness, and to define minimal important difference (MID), of the D-PPAC and C-PPAC instruments, in a large population of patients with stable COPD from diverse severities, settings and countries...
January 21, 2021: Thorax
Yingze Zhang, John Tedrow, Mehdi Nouraie, Xiaoyun Li, Divay Chandra, Jessica Bon, Daniel J Kass, Carl R Fuhrman, Joseph K Leader, Steven R Duncan, Naftali Kaminski, Frank C Sciurba
BACKGROUND: Pentraxin 3 (PTX3) influences innate immunity and inflammation, host defence, the complement cascade and angiogenesis. PTX3 expression in lung and blood of subjects with tobacco exposure, and its potential relationship with disease pattern and clinical outcome are poorly understood. METHODS: Using independent platforms and cohorts, we identified associations of PTX3 gene expression in lung tissue and plasma from current and former tobacco smokers (with and without chronic obstructive pulmonary disease, COPD) to disease phenotypes including quantitative CT determined emphysema, lung function, symptoms and survival...
January 21, 2021: Thorax
Rebecca Hasseli, Ulf Mueller-Ladner, Bimba F Hoyer, Andreas Krause, Hanns-Martin Lorenz, Alexander Pfeil, Jutta Richter, Martin Schäfer, Tim Schmeiser, Anja Strangfeld, Hendrik Schulze-Koops, Reinhard E Voll, Christof Specker, Anne Constanze Regierer
INTRODUCTION: Whether patients with inflammatory rheumatic and musculoskeletal diseases (RMD) are at higher risk to develop severe courses of COVID-19 has not been fully elucidated. Aim of this analysis was to describe patients with RMD according to their COVID-19 severity and to identify risk factors for hospitalisation. METHODS: Patients with RMD with PCR confirmed SARS-CoV-2 infection reported to the German COVID-19 registry from 30 March to 1 November 2020 were evaluated...
January 2021: RMD Open
Markus Braun, Doris Klingelhöfer, David A Groneberg
In the middle of the twentieth century, the from North America sooty bark disease (SBD) of maples was first discovered in England and has spread in the last decades in Central Europe, in particular. The trigger of SBD is the mould fungus Cryptostroma (C.) corticale. The most common infested maple is the sycamore, Acer pseudoplatanus, a common tree in woods and parks. The disease is characterised by peeling of the outer layer of the bark and brownish-black spores under the peeled off bark. These spores can cause maple bark disease (MBD) in humans, a hypersensitivity pneumonitis (HP) with similar symptoms like COPD, allergic asthma, influenza or flu-like infections and interstitial pneumonia...
January 21, 2021: Journal of Occupational Medicine and Toxicology
Helgo Magnussen, Sarah Lucas, Therese Lapperre, Jennifer K Quint, Ronald J Dandurand, Nicolas Roche, Alberto Papi, David Price, Marc Miravitlles
BACKGROUND: Inhaled corticosteroids (ICS) are indicated for prevention of exacerbations in patients with COPD, but they are frequently overprescribed. ICS withdrawal has been recommended by international guidelines in order to prevent side effects in patients in whom ICS are not indicated. METHOD: Observational comparative effectiveness study aimed to evaluate the effect of ICS withdrawal versus continuation of triple therapy (TT) in COPD patients in primary care...
January 21, 2021: Respiratory Research
A G Gravina, A Tessitore, V M Ormando, F Nagar, M Romeo, M R Amato, M Dallio, C Loguercio, A Federico, M Romano, F Ferraro
BACKGROUND: Percutaneous Endoscopic Gastrostomy (PEG) can involve some complications, despite the good safety of its track record. The Buried Bumper Syndrome (BBS) is a rare, late and dangerous complication that consists in the erosion of the internal bumper through the gastric wall. Case presentation We report the development of BBS in a man with chronic obstructive pulmonary disease (COPD) who had a persistent chronic cough which was prevalently but not solely in the morning and required placement of a PEG tube for continuous infusion of Levodopa/carbidopa intestinal gel for advanced Parkinson's disease...
January 21, 2021: BMC Gastroenterology
Sebastian Rutkowski, Jan Szczegielniak, Joanna Szczepańska-Gieracha
Anxiety has been estimated to occur in 21-96% and depression in 27-79% of patients with chronic obstructive pulmonary disorder (COPD). We found a scarcity of literature providing evidence on how virtual reality (VR) therapy affects the intensity of depressive and anxiety symptoms and stress levels in COPD patients undergoing in-hospital pulmonary rehabilitation (PR). This study enrolled 50 COPD patients with symptoms of stress, depression, and anxiety, randomly assigned to one of two groups. The two groups participated in the traditional PR programme additionally: the VR-group performed 10 sessions of immersive VR-therapy and the control group performed 10 sessions of Schultz autogenic training...
January 18, 2021: Journal of Clinical Medicine
Jian Zhou, Chuanzong Qi, Xin Fang, Zihao Wang, Shuyi Zhang, Dalang Li, Jue Song
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is an inflammatory disease characterized by airway obstruction and abnormal inflammatory responses. Multidrug resistance-related protein 1 (MRP1) can reduce lung inflammation and damage by excreting various toxic exogenous substances and certain pro-inflammatory molecules. AIMS: We studied whether DJ-1 modulates nuclear factor erythroid 2-related factor 2 (Nrf2) by activating the Wnt3a/β-catenin signalling pathway to further regulate MRP1 expression and pulmonary antioxidant defences in alveolar epithelial (A549) cells treated with smoke extract (CSE) and lipopolysaccharide (LPS)...
January 18, 2021: Life Sciences
Laura C Myers, Rebecca Cash, Vincent X Liu, Carlos A Camargo
RATIONALE: In August 2013, the Hospital Readmission Reduction Program (HRRP) announced financial penalties on hospitals with higher-than-expected risk-adjusted 30-day readmission rates for Medicare beneficiaries hospitalized for chronic obstructive pulmonary disease (COPD) exacerbation. In October 2014, penalties were imposed. We hypothesized that penalties would be associated with decreased readmissions after COPD hospitalizations. OBJECTIVE: To determine if announcement and enactment of financial penalties for COPD were associated with decreases in hospital readmissions for COPD...
January 21, 2021: Annals of the American Thoracic Society
Nicole M Robertson, Trishul Siddharthan, Suzanne L Pollard, Patricia Alupo, Oscar Flores-Flores, Natalie A Rykiel, Elisa D Romani, Ivonne Ascencio-Días, Bruce Kirenga, William Checkley, John R Hurst, Shumonta Quaderi
RATIONALE: The majority of the morbidity and mortality related to chronic obstructive pulmonary disease (COPD) occurs in low- and middle-income countries (LMICs). Despite the increasing burden of COPD, disease-specific knowledge among healthcare workers (HCWs) and patients in LMICs remains limited. COPD knowledge questionnaires are valid and reliable tools to assess COPD knowledge and can be employed in settings with limited health literacy. OBJECTIVE: To develop and assess validity and reliability of a COPD knowledge questionnaire among individuals with COPD in three LMIC settings...
January 21, 2021: Annals of the American Thoracic Society
Aysel Sunnetcioglu, Mehmet Berkoz, Metin Yildirim, Gulhan Bora, Serap Yalin
Objectives: The aim of this study was to assess the influence of plasminogen activator inhibitor-1 (PAI-1) 4G/5G or tissue plasminogen activator (tPA) I/D polymorphisms in chronic obstructive pulmonary disease (COPD) cases in a sample of Turkish population. METHODS: PAI-1 4G/5G and tPA Alu-repeat I/D genetic polymorphisms in 153 COPD subjects and 160 controls were investigated using PCR-RFLP and PCR methods, respectively. RESULTS: 4G allele frequency was 0...
December 2020: JPMA. the Journal of the Pakistan Medical Association
Xueting Wang, Linlin Huang, Shan Jiang, Kang Cheng, Dan Wang, Qianqian Luo, Xiaomei Wu, Li Zhu
Testosterone deficiency is common in male patients with chronic obstructive pulmonary disease (COPD) and may correlate with the deterioration of COPD. Clinical research suggests that testosterone replacement therapy may slow the COPD progression, but the specific biological pathway remains unclear. In this study, we explored the effect of testosterone on pulmonary inflammation in male COPD rats. The animals were co-treated with lipopolysaccharide (LPS) and cigarette to induce COPD. In COPD rats, nuclear respiratory factor 1 (NRF1) and NF-κB p65 were upregulated...
January 20, 2021: Journal of Molecular Cell Biology
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