Zijing Zhou, Aiyuan Zhou, Yating Peng, Jiaxi Duan, Yuqin Zeng, Yiyang Zhao, Wei Cheng, Ping Chen
BACKGROUND: The Clinical COPD Questionnaire (CCQ) has been suggested by the Global Initiative of Chronic Obstructive Lung Disease (GOLD) as a comprehensive symptom measurement tool, which helps to classify patients in order to direct pharmacological treatment. Therefore, it is essential to understand its determinants. OBJECTIVES: To identify the determinants of the overall CCQ score and scores of its 3 subdomains among chronic obstructive pulmonary disease (COPD) patients from China...
July 13, 2020: Respiration; International Review of Thoracic Diseases
Zhi-Xiang Ma, Tian-Ran Zhou, Wei Li, De-Dong Ma
INTRODUCTION: In noninvasive positive-pressure ventilation (NPPV), the changes in the expiratory positive airway pressure (EPAP) directly affect the magnitude of the tidal volume. OBJECTIVES: this experimental study aims to verify the precise effects of end-expiratory fluctuation on the body tidal volume to better assist NPPV in clinical practice. METHODS: We selected the TestChest®-simulated lung simulation of different populations, including healthy subjects (normal group), patients with chronic obstructive pulmonary disease (COPD) with emphysema as their primary phenotype (COPD1 group), and patients with COPD with bronchitis as their primary phenotype (COPD2 group)...
July 13, 2020: Clinical Respiratory Journal
Xiaoyu Fang, Shen Li, Hao Yu, Penghao Wang, Yao Zhang, Zheng Chen, Yang Li, Liqing Cheng, Wenbin Li, Hong Jia, Xiangyu Ma
A systematic review and meta-analysis was conducted in an attempt to systematically collect and evaluate the associations of epidemiological, comorbidity factors with the severity and prognosis of coronavirus disease 2019 (COVID-19). The systematic review and meta-analysis was conducted according to the guidelines proposed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Sixty nine publications met our study criteria, and 61 studies with more than 10,000 COVID-19 cases were eligible for the quantitative synthesis...
July 13, 2020: Aging
Radostina Vl Cherneva, Stefan Veselinov Denchev, Zheina Vl Cherneva
Objectives Autonomic dysfunction (AD) and dynamic hyperinflation (DH) have been implicated as pathophysiological mechanisms of heart failure with preserved ejection fraction (HFpEF) in chronic obstructive pulmonary disease (COPD) patients. Their association, however, remains elusive: The aims of the study were: (1) to determine the prevalence of AD and DH in non-severe COPD patients, with exertional dyspnea, without clinically overt cardio-vascular (CV) comorbidities; (2) to analyze the correlation and clinical significance between DH, AD, and maksed HFpEF...
July 13, 2020: Journal of Basic and Clinical Physiology and Pharmacology
Chunli Che, Jialin Li, Fushi Dong, Chunling Zhang, Lu Liu, Xiazhong Sun, Lixin Ma, Hong Qi, Kun Wang
OBJECTIVE: To explore the composition characteristics of atmospheric fine particulate matter (PM2.5) and bronchoalveolar lavage fluid (BALF), and their impact on the development of chronic obstructive pulmonary disease (COPD). METHODS: The atmospheric PM2.5 samples and BALF samples from COPD patients were collected from June 2, 2017 to October 30, 2018, and allocated into a high-risk of PM2.5 inhalation group and a low-risk PM2.5 inhalation group according to the heating season in Harbin...
July 6, 2020: Respiratory Medicine
Jonathan M Iaccarino, Katrina Steiling, Christopher G Slatore, Mari-Lynn Drainoni, Renda Soylemez Wiener
BACKGROUND: While pulmonary nodule guidelines provide follow-up recommendations based on nodule size and malignancy risk, these are inconsistently followed in clinical practice. In this study, we sought to identify patient characteristics associated with guideline-concordant nodule follow-up. METHODS: We conducted a retrospective cohort study of patients diagnosed with a pulmonary nodule between 2011 and 2014 at Boston Medical Center. Appropriate nodule follow-up evaluation was based upon the 2005 Fleischner Society Guidelines...
June 30, 2020: Respiratory Medicine
Mahyar Etminan, Gary S Collins, Mohammad Ali Mansournia
Causal directed acyclic graphs (cDAGs) have become popular tools for researchers to better examine biases related to causal questions. DAGs comprise a series of arrows connecting nodes that represent variables and in doing so can demonstrate the causal relation between different variables. cDAGs can provide researchers with a blueprint of the exposure and outcome relation and the other variables that play a role in that causal question. cDAGs can be helpful in the design and interpretation of observational studies in pulmonary, critical care, sleep, and cardiovascular medicine...
July 2020: Chest
Xu Gao, Brent Coull, Xihong Lin, Pantel Vokonas, David Sparrow, Lifang Hou, Dawn L DeMeo, Augusto A Litonjua, Joel Schwartz, Andrea A Baccarelli
Importance: Chronic obstructive pulmonary disease (COPD) is a critical public health burden. The neutrophil to lymphocyte ratio (NLR), an inflammation biomarker, has been associated with COPD morbidity and mortality; however, its associations with lung function decline and COPD development are poorly understood. Objective: To explore the associations of NLR with lung function decline and COPD risks. Design, Setting, and Participants: This longitudinal cohort study included white male veterans in the US with more than 30 years of follow-up to investigate the associations of NLR with lung function, COPD, and hypomethylation of cg05575921, the top DNA methylation marker of lung function changes in response to tobacco smoking...
July 1, 2020: JAMA Network Open
Eileen M Harder, Aaron B Waxman
PURPOSE OF REVIEW: Despite worse outcomes associated with the development of pulmonary hypertension in chronic lung disease, there are no approved treatments for this population. The present review summarizes the recent clinical trials in World Symposium on Pulmonary Hypertension (WSPH) Group 3 pulmonary hypertension, with a particular focus on the study of pulmonary arterial hypertension (PAH)-targeted therapy. RECENT FINDINGS: Multiple recent randomized controlled trials have studied a host of PAH-specific medications in the treatment of WSPH Group 3 pulmonary hypertension, including endothelin receptor antagonists, phosphodiesterase type 5 inhibitors, and prostacyclins...
July 9, 2020: Current Opinion in Pulmonary Medicine
Manuela Karloh, Thiago Sousa Matias, Anamaria Fleig Mayer
Social distancing and quarantines have been implemented worldwide to reduce the spread of Coronavirus Disease (COVID-19). However, social distancing has had far-reaching health consequences, considering that the COVID-19 pandemic has exposed people to the hazard of physical inactivity and sedentary behavior. For patients with Chronic Obstructive Pulmonary Disease (COPD), which is one of the main diseases at risk for COVID-19, the impact is even greater since outpatient pulmonary rehabilitation (PR) programs are temporarily closed...
July 12, 2020: COPD
Ghada Mohamed Gamal El-Din, Fawzia Khalil Ibrahim, Hanan Hussein Shehata, Nehad Mohammed Osman, Omar Mohammed Abdel-Rahman, Marwa Ali
OBJECTIVES: Examine the diagnostic role of serum exosomal RAB27A mRNA in lung cancer and evaluate the relation of LncRNAs to lung cancer in association to RAB27A mRNA in Egyptian population. METHODS: Exosomal RNA-based biomarkers RAB27A mRNA and Lnc-RNA-RP11-510M2.10 were selected based on bioinformatic methods, followed by RT-qPCR validation of their expression in serum of 20 patients with lung cancer, 10 patients with COPD and 10 healthy volunteers. we examined their expression in 10 bronchoalveolar lavage samples and assessed correlation with the serum levels...
July 13, 2020: Archives of Physiology and Biochemistry
Idir Ramdani, Karen A Pescatore, Belaid Bouazza
Chronic obstructive pulmonary disease (COPD) is a progressive chronic inflammatory disease and the third cause of death worldwide in 2016. COPD epidemiology is well documented in high-income countries where the disease is well managed. However, the disease is neglected in low-income countries and there is lack of data. Our study aims to identify COPD patients' characteristics and hospital admission causes, and to determine disease etiologies and associated factors. A retrospective study was conducted in COPD Algerian patients using medical record data collected from January 2007 to May 2017 at the pulmonology department of the Belloua Hospital of Tizi-Ouzou city...
July 10, 2020: Monaldi Archives for Chest Disease
Christine R Jenkins
No abstract text is available yet for this article.
July 12, 2020: Respirology: Official Journal of the Asian Pacific Society of Respirology
Guillaume L Erny, Ricardo A Gomes, Mónica S F Santos, Lúcia Santos, Nuno Neuparth, Pedro Carreiro-Martins, João Gaspar Marques, Ana C L Guerreiro, Patrícia Gomes-Alves
Separation techniques hyphenated to high-resolution mass spectrometry are essential in untargeted metabolomic analyses. Due to the complexity and size of the resulting data, analysts rely on computer-assisted tools to mine for features that may represent a chromatographic signal. However, this step remains problematic, and a high number of false positives are often obtained. This work reports a novel approach where each step is carefully controlled to decrease the likelihood of errors. Datasets are first corrected for baseline drift and background noise before the MS scans are converted from profile to centroid...
July 7, 2020: ACS Omega
Hong Guo-Parke, Dermot Linden, Sinéad Weldon, Joseph C Kidney, Clifford C Taggart
Chronic obstructive pulmonary disease (COPD) is the integrated form of chronic obstructive bronchitis and pulmonary emphysema, characterized by persistent small airway inflammation and progressive irreversible airflow limitation. COPD is characterized by acute pulmonary exacerbations and associated accelerated lung function decline, hospitalization, readmission and an increased risk of mortality, leading to huge social-economic burdens. Recent evidence suggests ~50% of COPD acute exacerbations are connected with a range of respiratory viral infections...
2020: Frontiers in Immunology
Jose Thaiparambil, Lingyun Dong, Diana Jasso, Jian-An Huang, Randa A El-Zein
Chronic obstructive lung disease (COPD) is a long-term lung disease characterized by irreversible lung damage resulting in airflow limitation, abnormal permanent air-space enlargement and emphysema. Cigarette smoking is the major cause of COPD with 15% to 30% of smokers developing either disease. About 50% - 80% of lung cancer patients have pre-existing COPD and smokers who have COPD are at an increased risk for developing lung cancer. Therefore, COPD is considered an independent risk for lung cancer, even after adjusting for smoking...
July 12, 2020: Cancer Prevention Research
Suhani Patel, Matthew Maddocks, William D-C Man
No abstract text is available yet for this article.
July 2020: Chest
Miranda Kirby, Grace Parraga
No abstract text is available yet for this article.
July 2020: Chest
Auyon J Ghosh, Brian D Hobbs
No abstract text is available yet for this article.
July 2020: Chest
Marc Spielmanns, Tobias Boeselt, Stephan Huber, Pawandeep Kaur Bollinger, Bernhard Ulm, Anna-Maria Peckaka-Egli, Inga Jarosch, Tessa Schneeberger, Sabine Schoendorf, Rainer Gloeckl, A Rembert Koczulla
BACKGROUND: Increasing physical activity (PA) is considered to be an important factor for the efficient management of chronic obstructive pulmonary disease (COPD). Successful methods required to achieve improvements in PA following pulmonary rehabilitation (PR), however, are rarely reported. Therefore, we will conduct this trial to evaluate the effectiveness of using a COPD management program delivered to the patient via the KAIA COPD app, a mobile medical application, after the completion of PR...
July 11, 2020: Trials
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