Jingcun Wang, Qiming Gan, Haojie Zhang, Qiuyun Xing, Yanjuan Wu, Xiaofen Su, Nuofu Zhang, Kang Wu
No abstract text is available yet for this article.
September 21, 2023: American Journal of Respiratory and Critical Care Medicine
Miguel Angel Martinez-Garcia, Alvar Agusti
No abstract text is available yet for this article.
September 21, 2023: American Journal of Respiratory and Critical Care Medicine
Gema Requena, Alexandrosz Czira, Victoria Banks, Robert Wood, Theo Tritton, Catherine Castillo, Jie Yeap, Rosie Wild, Chris Compton, Kieran J Rothnie, Felix J F Herth, Jennifer K Quint, Afisi S Ismaila
PURPOSE: Chronic obstructive pulmonary disease (COPD) exacerbations are associated with significant morbidity and mortality and increased economic healthcare burden for patients with COPD. Long-acting muscarinic antagonist (LAMA)/long-acting β2 -agonist (LABA) dual therapy is recommended for patients receiving mono-bronchodilator therapy who experience exacerbations or ongoing breathlessness. This study compared two single-inhaler LAMA/LABA dual therapies, umeclidinium/vilanterol (UMEC/VI) and indacaterol/glycopyrronium (IND/GLY), on moderate-to-severe exacerbation rates in patients with COPD in England...
2023: International Journal of Chronic Obstructive Pulmonary Disease
Jun-Jun Wang, Zhong Zhou, Li-Ying Zhang
BACKGROUND: At present, understanding of the most effective ventilation methods for treating chronic obstructive pulmonary disease (COPD) patients experiencing acute worsening symptoms and respiratory failure remains relatively limited. This report analyzed the efficiency and side effects of various ventilation techniques used for individuals experiencing an acute COPD exacerbation. AIM: To determine whether pressure-controlled ventilation (PCV) can lower peak airway pressures (PAPs) and reduce the incidence of barotrauma compared to volume-controlled ventilation (VCV), without compromising clinical outcomes and oxygenation parameters...
September 16, 2023: World Journal of Clinical Cases
Myriam Gagné, Aliki Karanikas, Samantha Green, Samir Gupta
INTRODUCTION: Climate change from greenhouse gas (GHG) emissions represents one of the greatest public health threats of our time. Inhalers (and particularly metred-dose inhalers (MDIs)) used for asthma and chronic obstructive pulmonary disease (COPD), constitute an important source of GHGs. In this analysis, we aimed to estimate the carbon footprint impact of improving three distinct aspects of respiratory care that drive avoidable inhaler use in Canada. METHODS: We used published data to estimate the prevalence of misdiagnosed disease, existing inhaler use patterns, medication class distributions, inhaler type distributions and GHGs associated with inhaler actuations, to quantify annual GHG emissions in Canada: (1) attributable to asthma and COPD misdiagnosis; (2) attributable to overuse of rescue inhalers due to suboptimally controlled symptoms; and (3) avoidable by switching 25% of patients with existing asthma and COPD to an otherwise comparable therapeutic option with a lower GHG footprint...
September 2023: BMJ Open Respiratory Research
Lena Basha, Alex Socarras, Mohammed Waseem Akhter, Mohamed Hamze, Ahmad Albaik, Imad Hussein, Ahmad Tarakji, Mufaddal Hamadeh, Randa Loutfi, Mazen Kewara, Aula Abbara
BACKGROUND: Despite a decade of conflict, there has been little exploration of respiratory health in Syria, notwithstanding the known impacts of conflict on lung health. Our aim is to explore the burden and trends of respiratory consultations in Syrian American Medical Society (SAMS) facilities in northwest Syria through an ecological analysis. METHODS: We performed a retrospective review of routinely collected data relating to respiratory presentations in SAMS' facilities between March 2017 and June 2020; we compared data by facility type, infectious versus non-infectious aetiologies and age...
September 2023: BMJ Open Respiratory Research
Anna Norweg, Brittany Hofferber, Cheongeun Oh, Michael Spinner, Kimberly Stavrolakes, Marykay Pavol, Angela DiMango, Victoria H Raveis, Charles G Murphy, John P Allegrante, David Buchholz, Alejandro Zarate, Naomi Simon
BACKGROUND: Although dyspnea is a primary symptom of chronic obstructive pulmonary disease (COPD), its treatment is suboptimal. In both COPD and acute anxiety, breathing patterns become dysregulated, contributing to abnormal CO2 , dyspnea, and inefficient recovery from breathing challenges. While pulmonary rehabilitation (PR) improves dyspnea, only 1-2% of patients access it. Individuals with anxiety who use PR have worse outcomes. METHODS: We present the protocol of a randomized controlled trial designed to determine the feasibility and acceptability of a new, four-week mind-body intervention that we developed, called "Capnography-Assisted Learned, Monitored (CALM) Breathing," as an adjunct to PR...
September 18, 2023: Contemporary Clinical Trials
James R Klinger, Benjamin Wu, Kellie Morland, Peter Classi, Ryan Fiano, Shannon Grabich
BACKGROUND: The burden of pulmonary hypertension (PH) among patients with chronic obstructive pulmonary disease (COPD) is not well understood. The present retrospective cohort study aimed to quantify the clinical and economic burden of PH in patients with COPD. METHODS: Adults with COPD were retrospectively identified in the Optum® Clinformatics® Data Mart between July 1, 2016 and June 30, 2021. Those diagnosed with PH were assigned to the PH-COPD cohort and those without a diagnosis of PH were assigned to the COPD cohort...
September 18, 2023: Respiratory Medicine
Cassandra Lenoir, Anaïs Pelletier, Sylvie Manuse, Hugo Millat, Adrien Ducret, Anne Galinier, Thierry Doan, Christophe Grangeasse
Penicillin-binding proteins (PBPs) are key to the assembly of peptidoglycan, the major component of the bacterial cell wall. Although several PBP-specific regulatory proteins have been identified in different species, little is known about how the activity of PBPs is controlled and coordinated during the cell cycle. In this study, we characterize the unknown function protein Spr1400 and demonstrate its regulatory function on two PBPs in Streptococcus pneumoniae . For that, we use a combination of technics ranging from bacterial genetics and protein biochemistry to microscopy imaging...
September 20, 2023: MBio
Usman Talat, Kelly A Schmidtke, Saval Khanal, Alice M Turner, Ivo Vlaev
BACKGROUND: Oxygen is one of the most commonly used emergency therapies. Like other therapies, oxygen can cause harm if used inappropriately. During the COVID-19 pandemic, guidelines were released to optimise oxygen and medication use. In the current study, we examine whether oxygen and medication use during the first wave of the COVID-19 pandemic was in concordance with new guidelines. METHODS: A retrospective cross-sectional study was conducted using routinely collected data from [ANON] Trust in England...
September 20, 2023: International Journal for Quality in Health Care
Jorge Vásconez-González, Karen Delgado-Moreira, Belén López-Molina, Juan S Izquierdo-Condoy, Esteban Gámez-Rivera, Esteban Ortiz-Prado
BACKGROUND: The prevalence of marijuana use and its derivatives has surged over the past century, largely due to increasing legalization globally. Despite arguments advocating its benefits, marijuana smoking exposes the lungs to harmful combustion byproducts, leading to various respiratory issues such as asthma, pneumonia, emphysema, and chronic obstructive pulmonary disease. METHODS: We embarked on an extensive literature search, utilizing PubMed/Medline, Scopus, Web of Science, and Google Scholar databases, identifying 200 studies...
September 20, 2023: Substance Abuse
Robert P Young, Raewyn J Scott
INTRODUCTION: In May 2022, the US Preventive Services Task Force published their recommendation against screening for chronic obstructive pulmonary disease (COPD) in asymptomatic adults. However, we argue the routine use of spirometry in both asymptomatic and symptomatic high-risk smokers has utility. AREAS COVERED: We provide published and unpublished observations from a secondary analyses of the American College of Radiology Imaging Network(ACRIN), arm of the National Lung Screening Trial, including 18,643 high-risk current or former smokers who underwent pre-bronchodilator spirometry at baseline...
September 20, 2023: Expert Review of Respiratory Medicine
Ovidiu Chioncel, Beth Davison, Marianna Adamo, Laura E Antohi, Mattia Arrigo, Marianela Barros, Jan Biegus, Kamilė Čerlinskaitė-Bajorė, Jelena Celutkiene, Alain Cohen-Solal, Albertino Damasceno, Rafael Diaz, Christopher Edwards, Gerasimos Filippatos, Antoine Kimmoun, Carolyn S P Lam, Marco Metra, Maria Novosadova, Matteo Pagnesi, Peter S Pang, Piotr Ponikowski, Razvan I Radu, Hadiza Saidu, Karen Sliwa, Adriaan A Voors, Koji Takagi, Jozine M Ter Maaten, Daniela Tomasoni, Gad Cotter, Alexandre Mebazaa
AIMS: To assess the potential interaction between noncardiac comorbidities (NCCs) and the efficacy and safety of high intensity care (HIC) versus usual care (UC) in STRONG-HF trial, including stable patients with improved but still elevated NPs METHODS AND RESULTS: In the trial, 8 NCCs were reported: anemia, diabetes, renal dysfunction, severe liver disease, COPD/asthma, stroke/TIA, psychiatric/neurological disorders, and malignancies. Patients were classified by NCC number (0, 1, 2 and ≥3)...
September 20, 2023: European Journal of Heart Failure
Shunde Wang, Chengguo Ge
PURPOSE: This study was designed to evaluate risk of mortality from chronic obstructive pulmonary disease (COPD) in patients with bladder cancer (BC). METHODS AND MATERIALS: Data on patients diagnosed with BC by pathology between 2000 and 2016 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Based on reference data from the general population, the standardized mortality rate (SMR) is calculated. Nelson-Aalen cumulative hazard curves were used for assessment of the risk of COPD mortality in BC patients...
September 17, 2023: Urology Journal
Siyang Zeng, Gang Luo, David A Lynch, Russell P Bowler, Mehrdad Arjomandi
RATIONALE: Lung volumes identify the "susceptible smokers" who progress to develop spirometric COPD. However, among susceptible smokers, development of spirometric COPD seems to be heterogeneous, suggesting the presence of different pathological mechanisms during early establishment of spirometric COPD. The objective of the present study was to determine the differential patterns of radiographic pathologies among susceptible smokers. METHODS: We categorised smokers with preserved spirometry (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 0) in the Genetic Epidemiology of COPD (COPDGene) cohort based on tertiles (low, intermediate and high) of lung volumes (either total lung capacity (TLC), functional residual capacity FRC or FRC/TLC) at baseline visit...
September 2023: ERJ Open Research
Louis-Marie Galerneau, Sébastien Bailly, Nicolas Terzi, Stéphane Ruckly, Maité Garrouste-Orgeas, Johanna Oziel, Vivien Hong Tuan Ha, Marc Gainnier, Shidasp Siami, Claire Dupuis, Jean-Marie Forel, Anaïs Dartevel, Julien Dessajan, Christophe Adrie, Dany Goldgran-Toledano, Virginie Laurent, Laurent Argaud, Jean Reignier, Jean-Louis Pepin, Michael Darmon, Jean-François Timsit
BACKGROUND: Non-ventilator-associated ICU-acquired pneumonia (NV-ICU-AP), a nosocomial pneumonia that is not related to invasive mechanical ventilation (IMV), has been less studied than ventilator-associated pneumonia, and never in the context of patients in an ICU for severe acute exacerbation of chronic obstructive pulmonary disease (AECOPD), a common cause of ICU admission. This study aimed to determine the factors associated with NV-ICU-AP occurrence and assess the association between NV-ICU-AP and the outcomes of these patients...
September 19, 2023: Critical Care: the Official Journal of the Critical Care Forum
Andrew Lynch, Rodrigo Arean-Sanz, Ana Sofia Ore, Giulio Cataldo, Kristen Crowell, Anne Fabrizio, Thomas E Cataldo, Evangelos Messaris
PURPOSE: Although not considered standard therapy, neoadjuvant chemotherapy (NAC) is an encouraging alternative for selected patients with locally advanced colon cancer (LAC). The aim of this study was to compare 30-day postoperative outcomes between patients undergoing upfront surgery and those undergoing NAC for LAC. METHODS: Using the ACS-NSQIP data from 2016 to 2020, 11,498 patients with LAC were divided into those who underwent upfront colectomy (96.2%) and those who received NAC (3...
September 19, 2023: Langenbeck's Archives of Surgery
Yaocong Liu, Jianhua You, Jiyuan Dong, Jiancheng Wang, Hairong Bao
At present, evidence of the associations between carbon monoxide (CO) and respiratory diseases (RD) in Northwest China is limited and controversial. The aim of this study is to evaluate the impact of ambient CO on outpatient visits for RD in Lanzhou, China. The daily amount of outpatient visits for total and cause-specific RD, air pollutant, and weather variables were collected in Lanzhou, China from 1st January 2013 to 31st December 2019. A generalized additive model and distributed lag nonlinear model were used to assess associations between CO and outpatient visits for RD...
September 20, 2023: International Journal of Biometeorology
Özge Aydın Güçlü, Ayna Sariyeva Ismayilov
OBJECTIVES: The aim of this study was to investigate ocular surface, intraocular pressure and lens condition in bronchodilator- and steroid-treated chronic pulmonary disease patients. METHODS: In this cross-sectional clinical study, 101 patients with chronic pulmonary disease were treated with an inhaler and/or nebulized therapy for bronchodilatation. The patients were evaluated in 2 groups namely chronic obstructive pulmonary disease (COPD) and asthma. We investigated the effects of patient demographic characteristics, smoking, and medications on the presence of dry eye disease (DED), intraocular pressure, and cataract...
September 19, 2023: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Chris H Wendt, Russell P Bowler, Connor Demorest, Annette Hastie, Wassim W Labaki, Menglan Chen, Steven G Carmella, Stephen S Hecht
Cigarette smoking is an established cause of chronic obstructive pulmonary disease (COPD). Numerous studies implicate acrolein, which occurs in relatively high concentrations in cigarette smoke and reacts readily with proteins, as one causative factor for COPD in smokers. Far less is known about the possible roles in COPD of the related α,β-unsaturated carbonyl compounds of cigarette smoke crotonaldehyde, methacrolein, and methyl vinyl ketone. In the study reported here, we analyzed mercapturic acids of these α,β-unsaturated compounds in the urine of 413 confirmed cigarette smokers in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)─202 with COPD and 211 without COPD...
September 19, 2023: Chemical Research in Toxicology
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