Hasan Nadeem, Bo Zhou, Dana Goldman, John Romley
INTRODUCTION: Previous observational studies assessing β2-agonist/-antagonist use on PD risk have yielded conflicting results. We evaluated the relationship between β2-agonist use and the incidence of Parkinson's disease in patients with chronic lung disease. METHODS: We performed a retrospective cohort analysis on a 20% random sample abstracted from a traditional (fee-for-service) Medicare program in the United States. Inclusion criteria were individuals over 65 years old diagnosed with asthma, COPD, and/or bronchiectasis who were enrolled in a prescription drug (standalone Part D) plan over 2007-2010 and alive through 2014...
2022: PloS One
Yannic-Tomas Abulesz, Moritz Haugk
BACKGROUND: In 2015, the emergency department of a municipal hospital in Vienna began to perform noninvasive ventilation (NIV) on patients admitted for acute respiratory failure, given no intubation criteria were met. The intention of this study was to show to which type of hospital unit patients were transferred after undergoing NIV in the emergency department. Additionally, the impact of the underlying disease, a patient's sex and age and the year of intervention were analyzed...
November 28, 2022: Wiener Klinische Wochenschrift
Anne Beate Kroczek, Michael Mair, Tsogyal Latshang, Rudolf Bumm, Tomas V Karajan
The present case reports on a 53-year-old patient with severe chronic obstructive pulmonary disease (COPD) and acute pneumonia who complained of massive right-sided chest pain and hemoptysis after a severe coughing fit. To the authors' great surprise, further clinical and radiological investigations revealed a rupture of the right intercostal muscles caused by the coughing fit, with herniation of parts of the right lower lobe of the lung down to the subcutaneous and below the M. latissimus dorsi...
November 28, 2022: Inn Med (Heidelb)
Zhuoru Chen, Ningrui Liu, Hao Tang, Xuehuan Gao, Yinping Zhang, Haidong Kan, Furong Deng, Bin Zhao, Xiangang Zeng, Yuexia Sun, Hua Qian, Wei Liu, Jinhan Mo, Xiaohong Zheng, Chen Huang, Chanjuan Sun, Zhuohui Zhao
The burden of disease attributed to the indoor exposure to sulfur dioxide (SO2 ), nitrogen dioxide (NO2 ), ozone (O3 ), and carbon monoxide (CO) is not clear, and the quantitative concentration-response relationship is a prerequisite. This is a systematic review to summarize the quantitative concentration-response relationships by screening and analyzing the polled effects of population-based epidemiological studies. After collecting literature published between 1980 and 2019, a total of 19 health outcomes in 101 studies with 182 health risk estimates were recruited...
November 2022: Indoor Air
Eun-Yeong Cho, Jung-Eun Cho, Eun-Bin Lee, Seung Soo Yoo, Jung Hyun Chang
and objective: Umeclidinium/vilanterol (UMEC/VI; ANORO ELLIPTA) is a commonly used dual bronchodilator. This study evaluated the safety and effectiveness of UMEC/VI in Korean patients with chronic obstructive pulmonary disease (COPD) over a 6-year period. Methods: This was an open-label, multicentre, observational, post-marketing surveillance study. A total of 3375 patients were enrolled consecutively in 52 hospitals, by 53 physicians, between July 2014 and July 2020. Patients who were administered UMEC/VI (fixed-dose 62...
November 28, 2022: Tuberculosis and Respiratory Diseases
Stacie Hudgens, Louise Newton, Sonya Eremenco, Mabel Crescioni, Tara Symonds, Philip C G Griffiths, David S Reasner, Bill Byrom, Paul O'Donohoe, Susan Vallow
OBJECTIVE: To quantitatively compare equivalence and compliance of patient-reported outcome (PRO) data collected via provisioned device (PD) versus bring your own device (BYOD). METHODS: Participants with stable chronic obstructive pulmonary disease (COPD) completed the EXAcerbations of Chronic Pulmonary Disease Tool (EXACT® ) daily and COPD Assessment Test™ (CAT) and Patient Global Impression of Severity (PGIS) of COPD weekly on either PD or BYOD for 15 days, then switched device types for 15 days...
November 26, 2022: Journal of Patient-Reported Outcomes
Jennifer Richmond, Megan Hollister Murray, Cato M Milder, Jeffrey D Blume, Melinda C Aldrich
BACKGROUND: Black Americans are diagnosed at later stage of lung cancer more often than White Americans. We undertook a population-based study to identify factors contributing to racial disparities in lung cancer stage of diagnosis among low-income adults. RESEARCH QUESTION: Which multilevel factors contribute to racial disparities in stage of lung cancer at diagnosis? STUDY DESIGN AND METHODS: Incident lung cancers from the prospective observational Southern Community Cohort Study were identified by linkage with state cancer registries in 12 southeastern states...
November 23, 2022: Chest
Mario Cazzola, Maria Gabriella Matera
Clinically important deterioration (CID) is a composite tool developed to measure COPD's progression. It is a promising concept that can improve treatment choices for COPD patients because it provides a more holistic assessment of their status in everyday clinical practice. The post hoc analysis of several trials that were important for improving COPD treatment provides increasing evidence of the importance of assessing CID. These retrospective evaluations suggest that dual bronchodilation should be preferred over a single bronchodilator if treatment aims to reduce a possible clinical deterioration of COPD...
November 15, 2022: Respiratory Medicine
Alessandro D Heubel, Erika Z Kabbach, Naiara T Leonardi, Nathany S Schafauser, Débora M O Kawakami, Anna Claudia Sentanin, Valéria A Pires Di Lorenzo, Audrey Borghi Silva, John R Hurst, Renata G Mendes
BACKGROUND: Patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) have decreased exercise tolerance, which may persist for months. In this context, little is known about the associations between muscle strength and recovery of exercise capacity. OBJECTIVE: To assess whether respiratory and peripheral muscle strength influence recovery of exercise capacity in patients hospitalized due to AECOPD. METHODS: Twenty-seven AECOPD patients (aged 69 ± 7 years, 56% male) were included...
November 23, 2022: Heart & Lung: the Journal of Critical Care
Ryusuke Machino, Koichiro Shimoyama, Takeshi Nagayasu, Tsutomu Tagawa
BACKGROUND: Research shows that even the short-term administration of inhaled drugs immediately before surgery can improve respiratory function in surgical candidates with chronic obstructive pulmonary disease (COPD). However, the long-term efficacies of different types of long-acting inhaled agents when used during a short preoperative period remain unclear. Therefore, we evaluated the efficacies of short-term, preoperative long-acting muscarinic antagonists (LAMAs), inhaled corticosteroids with long-acting β2-agonists (ICSs/LABAs), and long-acting muscarinic antagonists with long-acting β2-agonists (LAMAs/LABAs) in patients with COPD after lung resection...
November 24, 2022: Journal of Cardiothoracic Surgery
Peter D Wagner
This article lays out the determinants of maximal O2 consumption (VO2 max) achieved during high intensity endurance exercise. It is not a traditional topical review but rather an educational essay that intertwines chance observations made during an unrelated research project with a subsequent program of stepwise thought, analysis and experimentation to reveal how O2 is delivered to and used by the mitochondria. The centerpiece is the recognition that O2 is delivered by an inter-dependent system of transport components functioning as a "bucket brigade", made up of the lungs, heart, blood and circulation, and the muscles themselves, each of which affects O2 transport by similar amounts as they change...
November 25, 2022: Journal of Muscle Research and Cell Motility
Heayon Lee, Hwan Hee Kim, Kyu Yean Kim, Chang Dong Yeo, Hyeon Hui Kang, Sang Haak Lee, Sei Won Kim
PURPOSE: Intermittent hypoxia and sleep fragmentation, two main features of sleep-disordered breathing (SDB), have been shown to increase the aggressiveness of lung cancer, mainly in animal and in vitro studies. However, the association between SDB and lung cancer has not been well described in human studies. In this study, we investigated the associations among SDB, sleep quality, and lung cancer in Korean patients. METHODS: Patients with histologically diagnosed lung cancer performed a home sleep apnea test...
November 25, 2022: Sleep & Breathing
Thomas Laumon, Elie Courvalin, Geoffrey Dagod, Pauline Deras, Mehdi Girard, Orianne Martinez, Camille Maury, Hugues Weber, Xavier Capdevila, Jonathan Charbit
BACKGROUND: The aim of this study was to assess the interdependence of extracorporeal blood flow (Qec) and gas flow (GF) in predicting CO2 removal and reduction of minute mechanical ventilation under extracorporeal respiratory support. METHODS: All patients who benefited from V-V ECMO and high-flow ECCO2 R in our intensive care unit over a period of 18 months were included. CO2 removal was calculated from inlet/outlet blood port gases during the first 7 days of oxygenator use...
November 25, 2022: Artificial Organs
Yuka Shirai, Ryo Momosaki, Yoji Kokura, Yuki Kato, Yoshinaga Okugawa, Akio Shimizu
Low body mass index (BMI) is an independent predictor of prolonged hospital stay and mortality in patients with chronic obstructive pulmonary disease (COPD). However, to the best of our knowledge, no studies have examined the validity of Asian BMI cutoff values for classifying severity based on the Global Leadership Initiative on Malnutrition (GLIM) criteria in patients with acute COPD exacerbations. This study sought to validate whether Asian BMI cutoff values can accurately predict 30-day in-hospital mortality, length of stay, and 90-day readmission outcomes for patients with acute COPD exacerbations...
November 10, 2022: Nutrients
Alexandru Tudor Steriade, Mihai Gologanu, Roxana Silvia Bumbacea, Stefan Nicolae Bogdan, Dragos Bumbacea
Esophageal pressure (Pes) measurements could optimise ventilator parameters in acute respiratory failure (ARF) patients requiring noninvasive ventilation (NIV). Consequently, the objectives of our study were to evaluate the safety and accuracy of applying a Pes measuring protocol in ARF patients with AECOPD under NIV in our respiratory intermediate care unit (RICU). An observational cohort study was undertaken. The negative inspiratory swing of Pes (ΔPes) was measured: in an upright/supine position in the presence/absence of NIV at D1 (day of admission), D3 (3rd day of NIV), and DoD (day of discharge)...
November 17, 2022: Journal of Clinical Medicine
Marc Miravitlles, Tomotaka Kawayama, Michael Dreher
Inhaled bronchodilators (alone or in combination) are the cornerstone of treatment for symptomatic patients with COPD, either as initial/first-line treatment or for second-line/treatment escalation in patients who experience persistent symptoms or exacerbations on monotherapy. The Global Initiative for Chronic Obstructive Lung Disease 2022 report recommends initial pharmacological treatment with a long-acting muscarinic antagonist (LAMA) or a long-acting β2 -agonist (LABA) as monotherapy for most patients, or dual bronchodilator therapy (LABA/LAMA) in patients with more severe symptoms, regardless of exacerbation history...
November 8, 2022: Journal of Clinical Medicine
Lei Fang, Ming Zhang, Junling Li, Liang Zhou, Michael Tamm, Michael Roth
Chronic obstructive pulmonary disease (COPD) is characterized by irreversible deterioration of the airway wall. Cigarette smoking is the major trigger, and in vitro studies showed that cigarette smoke extract (CSE) induced mitophagy in airway epithelial cells via oxidative stress, but this mechanism was not studied in airway smooth muscle cells (ASMCs). Primary ASMCs isolated from COPD patients or non-disease donors were investigated for CSE-induced remodeling and mitochondria structure. Proteins were assessed by Western blots for remodeling: collagen type-I, α-smooth muscle actin (α-SMA) and fibronectin; autophagy: beclin-1, protein62 (p62), light chain (LC)3A/B; mitochondria activity: mitochondrially encoded cytochrome c oxidase II & -IV (MTCO2, MTCO4), peroxisome proliferator activated receptor gamma coactivator 1α (PGC-1α); lysosomes: early endosome antigen 1, lysosome activated membrane protein 1; and cell signaling: extracellular signal regulated kinase (ERK1/2)...
November 12, 2022: International Journal of Molecular Sciences
Aleksandra Szylińska, Marta Bott-Olejnik, Paweł Wańkowicz, Dariusz Karoń, Iwona Rotter, Katarzyna Kotfis
BACKGROUND: The aim of our study was to search for predictive factors and to develop a model (index) for the risk of pneumonia following acute ischemic stroke. MATERIAL AND METHODS: This study is an analysis of prospectively collected data from the neurology department of a district general hospital in Poland, comprising 1001 patients suffering from an acute ischemic stroke. Based on the medical data, the formula for the prediction of pneumonia was calculated. RESULTS: Multivariate assessment for pneumonia occurrence was performed using the new PNEUMOINDEX...
November 19, 2022: International Journal of Environmental Research and Public Health
Sara Isernia, Chiara Pagliari, Luca Nicola Cesare Bianchi, Paolo Innocente Banfi, Federica Rossetto, Francesca Borgnis, Monica Tavanelli, Lorenzo Brambilla, Francesca Baglio
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is at the top of the list of non-communicable diseases with related rehabilitation needs. Digital medicine may provide continuative integrated intervention, overcoming accessibility and cost barriers. METHODS: We systematically searched for randomized controlled trials on telerehabilitation (TR) in people with COPD to profile the adopted TR strategies, focusing on TR models and the main rehabilitation actions: monitoring and assessment, decision, and feedback...
November 17, 2022: International Journal of Environmental Research and Public Health
Ilaria Tocco Tussardi, Ahmad Tfaily, Francesca Locatelli, Leonardo Antonicelli, Salvatore Battaglia, Roberto Bono, Angelo G Corsico, Nicola Murgia, Pietro Pirina, Marcello Ferrari, Stefano Tardivo, Deborah L Jarvis, Giuseppe Verlato
Early life conditions are associated with lung function and the development of respiratory and non-respiratory illnesses. The relationship with birthweight (BW), however, is conflicting. We examined associations of self-reported BW with lung function and the development of respiratory and also non-respiratory diseases within the GEIRD (Gene-Environment Interaction in Respiratory Diseases) project, an Italian multi-centre, multi-case control study involving cases of COPD, asthma, allergic rhinitis and controls...
November 16, 2022: International Journal of Environmental Research and Public Health
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