Priyamvada S Chukowry, Daniella A Spittle, Alice M Turner
The response to treatment and progression of Chronic Obstructive Pulmonary Disease (COPD) varies significantly. Small airways disease (SAD) is being increasingly recognized as a key pathological feature of COPD. Studies have brought forward pathological evidence of small airway damage preceding the development of emphysema and the detection of obstruction using traditional spirometry. In recent years, there has been a renewed interest in the early detection of SAD and this has brought along an increased demand for physiological tests able to identify and quantify SAD...
2021: International Journal of Chronic Obstructive Pulmonary Disease
Dan Huang, Dong Wu, Jinhong He, Min Chen, Xuanna Zhao, Dongming Li, Bin Wu
Purpose: Chronic obstructive pulmonary disease (COPD) was the fourth leading cause of death in the world. Many studies have shown that COPD often exists with thyroid dysfunction; however, the relationship between thyroid function and COPD is often ignored in clinical. We retrospectively analyze the serum thyroid hormone levels in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and explore the association between thyroid function and AECOPD. Methods: The study included patients hospitalized for AECOPD in our institution between January 2018 and September 2020...
2021: International Journal of Chronic Obstructive Pulmonary Disease
Satomi Kitamura, Ayumi Igarashi, Satoru Yoshie, Kojiro Morita, Taisuke Jo, Katsuya Iijima, Noriko Yamamoto-Mitani
AIM: This study aimed to improve the understanding of the utilization rates and the characteristics of users of pulmonary rehabilitation (PR) among people with chronic obstructive pulmonary disease. METHODS: We used medical and long-term care claims data from between April 2012 and March 2013 from Kashiwa city in Chiba prefecture, Japan. The study participants included patients of ≥63 years of age, who had received outpatient treatment for COPD (ICD-10 codes: J41-J44) two or more times during the study period, and who had been prescribed two or more COPD-related drugs...
2021: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
Lucio Malvisi, Laura Taddei, Aparna Yarraguntla, Tom M A Wilkinson, Ashwani Kumar Arora
BACKGROUND: Infection with Haemophilus influenzae (Hi) or Moraxella catarrhalis (Mcat) is a risk factor for exacerbation in chronic obstructive pulmonary disease (COPD). The ability to predict Hi- or Mcat-associated exacerbations may be useful for interventions developed to reduce exacerbation frequency. METHODS: In a COPD observational study, sputum samples were collected at monthly stable-state visits and at exacerbation during two years of follow-up. Bacterial species (Hi, Mcat) were identified by culture and quantitative PCR assay...
February 24, 2021: Respiratory Research
Ti-Wei Miao, Wei Xiao, Long-Yi Du, Bing Mao, Wei Huang, Xue-Mei Chen, Cong Li, Yan Wang, Juan-Juan Fu
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation and fixed airflow obstruction. Patients with COPD have increased risk of lung cancer, and the coexistence of both diseases is associated with poorer survival. However, the mechanisms predisposing patients with COPD to lung cancer development and poor prognosis remain unclear. Gene expression profiles were downloaded from the Gene Expression Omnibus. Twenty-two datasets were included (n=876). We identified 133 DEGs and 145 DEGs in patients with COPD and lung cancer compared to healthy controls, respectively...
February 24, 2021: FEBS Open Bio
John P Ney, Stephanie A Robinson, Caroline R Richardson, Marilyn L Moy
Objective: To evaluate the cost-effectiveness of a technology-based physical activity (PA) intervention for chronic obstructive pulmonary disease (COPD). Design: A secondary data analysis was performed from a randomized controlled trial in COPD of an activity monitor alone or an activity monitor plus a web-based PA intervention. Models estimated cost per quality-adjusted life year (QALY) and incremental cost-effectiveness ratios (ICERs) compared with usual care. Results: The estimated ICER for both groups was below the willingness-to-pay threshold of $50,000/QALY (activity monitor alone = $10,437/QALY; website plus activity monitor intervention = $13,065/QALY)...
February 24, 2021: Telemedicine Journal and E-health
Alireza K Nazemi, Alexander Upfill-Brown, Armin Arshi, Troy Sekimura, Erik N Zeegen, Edward J McPherson, Alexandra I Stavrakis
BACKGROUND: Hip resection arthroplasty (HRA) is a salvage surgical technique for the management of complex hip conditions wherein arthroplasty may be contraindicated. The purpose of this study was to review modern-day indications for HRA and compare outcomes between patients undergoing HRA and revision total hip arthroplasty (RTHA). METHODS: The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) was used to identify patients undergoing HRA or RTHA between 2012 and 2017...
February 24, 2021: Archives of Orthopaedic and Trauma Surgery
Mereena George Ushakumary, Matthew Riccetti, Anne-Karina T Perl
Developing, regenerating, and repairing a lung all require interstitial resident fibroblasts (iReFs) to direct the behavior of the epithelial stem cell niche. During lung development, distal lung fibroblasts, in the form of matrix-, myo-, and lipofibroblasts, form the extra cellular matrix (ECM), create tensile strength, and support distal epithelial differentiation, respectively. During de novo septation in a murine pneumonectomy lung regeneration model, developmental processes are reactivated within the iReFs, indicating progenitor function well into adulthood...
February 24, 2021: Stem Cells Translational Medicine
Sanjay Ramakrishnan, Wim Janssens, Pierre-Regis Burgel, Marco Contoli, Frits M E Franssen, Neil J Greening, Timm Greulich, Iwein Gyselinck, Andreas Halner, Arturo Huerta, Rebecca L Morgan, Jennifer K Quint, Lowie E G W Vanfleteren, Kristina Vermeersch, Henrik Watz, Mona Bafadhel
Background: Despite hospitalization for exacerbation being a high-risk event for morbidity and mortality, there is little consensus globally regarding the assessment and management of hospitalised exacerbations of COPD. We aimed to establish a consensus list of symptoms, physiological measures, clinical scores, patient questionnaires and investigations to be obtained at time of hospitalised COPD exacerbation and follow-up. Methods: A modified Delphi online survey with pre-defined consensus of importance, feasibility and frequency of measures at hospitalisation and follow-up of a COPD exacerbation was undertaken...
2021: International Journal of Chronic Obstructive Pulmonary Disease
Claudia Gulea, Rosita Zakeri, Vanessa Alderman, Alexander Morgan, Jack Ross, Jennifer K Quint
BACKGROUND: Beta-blockers are associated with reduced mortality in patients with cardiovascular disease but are often under prescribed in those with concomitant COPD, due to concerns regarding respiratory side-effects. We investigated the effects of beta-blockers on outcomes in patients with COPD and explored within-class differences between different agents. METHODS: We searched the Cochrane Central Register of Controlled Trials, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Medline for observational studies and randomized controlled trials (RCTs) investigating the effects of beta-blocker exposure versus no exposure or placebo, in patients with COPD, with and without cardiovascular indications...
February 23, 2021: Respiratory Research
Nan Yang, Gurpreet K Singhera, Yi Xuan Yan, Michael P Pieper, Janice M Leung, Don D Sin, Delbert R Dorscheid
BACKGROUND: Airway inflammation is a key feature of chronic obstructive pulmonary disease (COPD) and inhaled corticosteroids (ICS) remain the main treatment for airway inflammation. Studies have noted the increased efficacy of ICS and long-acting beta 2 agonist (LABA) combination therapy in controlling exacerbations and improving airway inflammation than either monotherapy. Further studies have suggested that LABAs may have inherent anti-inflammatory potential, but this has not been well-studied...
February 23, 2021: Respiratory Research
Li-Juan Zhong, Min Yan, Yi Wang, Dai-Quan Zhou, Jian-Ming Tang, Shou-Hong Xiang
BACKGROUND: Long-term exposure to coal dust causes respiratory disease. In chest computer tomography (CT), pulmonary nodules, pulmonary interstitial fibrosis and emphysema manifest themselves. However, tracheal foreign bodies caused by coal dust are rarely reported. In this study, we report a special case of a tracheal coal foreign body, in which the patient has neither a history of coal work nor foreign body inhalation. CASE PRESENTATION: A 49-year-old man was diagnosed with chronic obstructive pulmonary disease (COPD) due to chronic cough and exertional dyspnoea...
February 23, 2021: BMC Medical Imaging
Ferdaous Yangui, Amany Touil, Saoussen Antit, Lilia Zakhama, Mohamed Ridha Charfi
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IHD) are common causes of mortality worldwide, with shared risk factors. COPD continues to be largely underdiagnosed and undertreated, especially in patients with IHD. OBJECTIVE: To investigate the prevalence of COPD in smokers with confirmed IHD and to compare IHD characteristics between COPD patients and those without COPD. METHODS: It was a cross-sectional study, conducted between August and December 2017, including patients over 40 years of age, current or former smokers, with stable and confirmed IHD...
February 16, 2021: Respiratory Medicine
Eugene Merzon, Ilan Green, Shlomo Vinker, Avivit Golan-Cohen, Alessandro Gorohovski, Eva Avramovich, Milana Frenkel-Morgenstern, Eli Magen
Acetylsalicylic acid (aspirin) is commonly used for primary and secondary prevention of cardiovascular diseases. Aspirin use is associated with better outcomes among COVID-19 positive patients. We hypothesized that aspirin use for primary cardiovascular disease prevention might have a protective effect on COVID-19 susceptibility and disease duration. We conducted a retrospective population-based cross-sectional study, utilizing data from the Leumit Health Services database. The proportion of patients treated with aspirin was significantly lower among the COVID-19-positive group, as compared to the COVID-19-negative group (73 (11...
February 23, 2021: FEBS Journal
Huimei Zhang, Shaodi Ma, Tiantian Han, Guangbo Qu, Ce Cheng, John Patrick Uy, Mohammad Baseem Shaikh, Qin Zhou, Evelyn J Song, Chenyu Sun
Introduction: The highly infectious coronavirus disease 2019 (COVID-19) has now rapidly spread around the world. This meta-analysis was strictly focused on the influence of smoking history on the severe and critical outcomes on people with COVID-19 pneumonia. Methods: A systematic literature search was conducted in eight online databases before 1 February 2021. All studies meeting our selection criteria were included and evaluated. Stata 14.0 software was used to analyze the data. Results: A total of 109 articles involving 517,020 patients were included in this meta-analysis...
February 18, 2021: European Journal of Integrative Medicine
Jialin Xu, Diego Madureira de Oliveira, Matthew A Trudeau, Yang Yang, Jessica J Y Chin, Don D Sin, Andrew J Sandford, Judy M Y Wong
Chronic obstructive pulmonary disease (COPD) is a disorder of accelerated lung aging. Multiple pieces of evidence support that the aging biomarker short telomeres, which can be caused by mutations in telomerase reverse transcriptase (TERT), contribute to COPD pathogenesis. We hypothesized that short telomere risk-associated single nucleotide polymorphisms (SNPs) in TERT, while not able to drive COPD development, nonetheless modify the disease presentation. We set out to test the SNP carrying status in a longitudinal study of smokers with COPD and found that rapid decline of FEV1 in lung function was associated with the minor allele of rs61748181 (adjusted odds ratio 2...
February 22, 2021: Scientific Reports
Tingxuan Yin, Yuanjun Li, Ying Ying, Zhijun Luo
BACKGROUND: Coronavirus disease 2019 (COVID-19) is an infectious disease characterized by cough, fever, and fatigue and 20% of cases will develop into severe conditions resulting from acute lung injury with the manifestation of the acute respiratory distress syndrome (ARDS) that accounts for more than 50% of mortality. Currently, it has been reported that some comorbidities are linked with an increased rate of severity and mortality among COVID-19 patients. To assess the role of comorbidity in COVID-19 progression, we performed a systematic review with a meta-analysis on the relationship of COVID-19 severity with 8 different underlying diseases...
February 22, 2021: BMC Infectious Diseases
Astrid K Wahl, Richard H Osborne, Marie H Larsen, Marit H Andersen, Ingrid A Holter, Christine R Borge
BACKGROUND: The World Health Organization (WHO) points to health literacy as an important factor in prevention and control of non-communicable diseases (NCDs), including COPD. OBJECTIVE: To investigate associations between selected demographic and clinical variables, psychological well-being and health literacy. METHODS: Health literacy was measured using the nine domain Health Literacy Questionnaire (HLQ) and one domain from the eHealth Literacy Questionnaire (eHLQ)...
February 19, 2021: Heart & Lung: the Journal of Critical Care
Alan Kaplan, Hui Cao, J Mark FitzGerald, Nick Iannotti, Eric Yang, Janwillem W H Kocks, Konstantinos Kostikas, David Price, Helen K Reddel, Ioanna Tsiligianni, Claus F Vogelmeier, Pascal Pfister, Paul Mastoridis
Artificial intelligence (AI) and machine learning, a subset of AI, are increasingly utilized in medicine. AI excels at performing well-defined tasks, such as image recognition; for example, classifying skin biopsy lesions, determining diabetic retinopathy severity, and detecting brain tumors. This article provides an overview of the use of AI in medicine and particularly in respiratory medicine, where it is used to evaluate lung cancer images, diagnose fibrotic lung disease, and more recently is being developed to aid the interpretation of pulmonary function tests and the diagnosis of a range of obstructive and restrictive lung diseases...
February 19, 2021: Journal of Allergy and Clinical Immunology in Practice
Chan Xiong, Yu Li, Guangtong Zhuang, Yan Zeng, Hua Wei, Chenyi Li, Lin Li, Li Liao, Juanjuan Fu
OBJECTIVE: Randomized clinical trials and published meta-analyses assessing the clinical effectiveness of Chinese herbal medicine (CHM) on the treatment of stable chronic obstructive pulmonary disease (COPD) yielded inconsistent results in terms of disease outcomes, in which the design of placebo-controlled studies can contribute to the heterogeneity. This study aimed to evaluate the efficacy and safety of CHM compared to placebo on the treatment of stable COPD, to provide robust evidence for the use of CHM in COPD...
February 19, 2021: Complementary Therapies in Medicine
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