Kallene S M Vidal, Laiss Bertola, Claudia K Suemoto, Arlinda B Moreno, Bruce Duncan, Maria Inês Schmidt, Marcelo Maestri, Sandhi M Barreto, Paulo A Lotufo, Isabela M Benseñor, Andre R Brunoni
Glaucoma, cataracts, and cognitive decline are most common in older ages. Although cross-sectional studies showed that these disorders are associated, follow-up studies are lacking. To investigate this issue, baseline and follow-up data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) were employed. We evaluated participants ≥ 55 years-old at follow-up without diagnosis of dementia, stroke, and other eye conditions except for glaucoma and cataracts. Cognition was evaluated using delayed word recall, verbal fluency, and trail making (version B) tests...
October 19, 2020: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
Xiaolin Wu, Xiaoyan Wang, Guoqing Zhang, Zhu Guo, Yan Wang, Ronghuan Wang, Hongfei Xiang, Bohua Chen
OBJECTIVE: To study the distribution of sympathetic nerves of the ligamentum flavum (LF), confirm its existence by histological observation and nuclear magnetic resonance spectroscopy, and analyze the relationship between sympathetic nerve fibers and the biomechanical structure of the LF. METHODS: Randomly controlled scientific research selected 15 cases of posterior surgery in the affiliated hospital of Qingdao University from January 2013 to December 2019. The average age was 67...
October 19, 2020: Orthopaedic Surgery
Kavitha Sothirasan, A J Anand, Rashmi Mittal, Poh Choo Khoo, Suresh Chandran
Background: Globally, mental health disorders and behavioural problems afflict persons with Down syndrome (DS) with a high prevalence reported in some studies. However, data on behavioural and emotional disorders in DS cohort in Asian countries are lacking. Aims: To assess the mental health status of children and adults with DS, using the Strength and Difficulties Questionnaire (SDQ) and its impact on caregivers using the impact supplement. Methods: The questionnaires were administered to caregivers of eligible participants aged ≥4 years...
October 2020: Heliyon
Catherine Schwinger, Ram K Chandyo, Manjeswori Ulak, Mari Hysing, Merina Shrestha, Suman Ranjitkar, Tor A Strand
Introduction: There is an increase in the double burden of malnutrition globally, with a particular rise documented in Asia. In Nepal, undernutrition has been prevalent for decades. Today, however, the incidence of overweight and obesity (OWOB) in the country has increased substantially. There is a need to conduct local studies reporting on the concurrent burden of both underweight and OWOB across adult populations. This study addresses this need by describing the distribution of body mass index (BMI) in a defined population of adults living in the peri-urban community of Bhaktapur, Nepal...
2020: Frontiers in Nutrition
Hung Manh Ngo, Hung Thanh Chu, Dong Duc Nguyen
Introduction: Pediatric intracranial aneurysms are rare, with some different characteristics from those in adults. Here, we present a case of distal anterior cerebral artery aneurysm which we believe the first case from Vietnam. Presentation of case: A 3 years old boy presented with headache, lethargic and hemiparesis was diagnosed ruptured distal anterior cerebral artery aneurysm with CTA. 10 days before admission in our hospital, the toddler was admitted in local hospital with diagnosis of SAH without more accurate findings...
October 14, 2020: International Journal of Surgery Case Reports
Ahmed Gharib Khamis, Mbazi Senkoro, Akwilina Wendelin Mwanri, Katharina Kreppel, Sayoki Godfrey Mfinanga, Bassirou Bonfoh, Gideon Kwesigabo
Background: Hypertension is among the growing non-communicable diseases (NCDs) in developing countries and the leading cause of death worldwide. Pastoral areas have been identified to be at a higher risk of diseases due to challenges in their daily food production, livelihoods or mobility. Unfortunately, the prevalence of hypertension and the risk factors particularly affecting rural and pastoral populations are not fully understood, making intervention efforts challenging. The aim of this study was to determine the prevalence of hypertension and identify the risk factors among adults living in Monduli district in Tanzania...
2020: Archives of Public Health, Archives Belges de Santé Publique
Nathan A Huebschmann, Teemu M Luoto, Justin E Karr, Ksenia Berghem, Kaj Blennow, Henrik Zetterberg, Nicholas J Ashton, Joel Simrén, Jussi P Posti, Jessica M Gill, Grant L Iverson
Objective: Identification and validation of blood-based biomarkers for the diagnosis and prognosis of mild traumatic brain injury (mTBI) is of critical importance. There have been calls for more research on mTBI in older adults. We compared blood-based protein marker glial fibrillary acidic protein (GFAP) concentrations in serum and in plasma within the same cohort of older adults and assessed their ability to discriminate between individuals based on intracranial abnormalities and functional outcome following mTBI...
2020: Frontiers in Neurology
Jie Fang, Hui Li, Wei Du, Ping Yu, Ying-Yun Guan, Shi-Yu Ma, Dong Liu, Wei Chen, Guo-Chao Shi, Xiao-Lan Bian
Objective: Since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan City, China, coronavirus disease 2019 (COVID-19) has become a global pandemic. However, no special therapeutic drugs have been identified for COVID-19. The aim of this study was to search for drugs to effectively treat COVID-19. Materials and Methods: We conducted a retrospective cohort study with a total of 162 adult inpatients (≥18 years old) from Ruijin Hospital (Shanghai, China) and Tongji Hospital (Wuhan, China) between January 27, 2020, and March 10, 2020...
2020: Frontiers in Pharmacology
Scott Mayer, Blake S Raggio, Adam Master, Nicholas Lygizos
Background: Langerhans cell histiocytosis (LCH) of the temporal bone is an uncommon disease that primarily affects the pediatric population; fewer than 40 adult cases have been reported in the literature. We present a rare case of LCH of the temporal bone in an adult patient and describe its clinical presentation, histopathologic findings, and management. Case Report : A 21-year-old male presented to the emergency department with progressively worsening right-sided ear pain refractory to outpatient oral antibiotics...
2020: Ochsner Journal
Raza M Ahmad, Kyle Ingram, Ralph Corsetti
Background: Feminizing adrenal tumors are rare and generally malignant tumors usually seen in male adults and children. We report the case of a benign feminizing adrenal tumor in a male patient. To our knowledge, only 2 other cases of benign, estrogen-only-secreting adrenal tumors have been reported. Case Report: A 44-year-old male with a history of hypertension presented to his primary care physician with chest tenderness, fatigue, and erectile dysfunction. Hormonal workup and imaging identified an estrogen-only-secreting adrenal adenoma...
2020: Ochsner Journal
Elise Whitley, Peter Craig, Frank Popham
In the context of worldwide ageing, increasing numbers of older people are lonely, isolated and excluded, with serious implications for health, and cognitive and physical functioning. Access to good public transport can improve mobility and social participation among older adults, and policies that improve access and promote use, such as concessionary travel schemes, are potentially important in promoting healthy and successful ageing. Concessionary travel schemes for older people are in place in many countries but are under threat following the global financial crisis...
November 2020: Ageing and Society
Masataka Mikai, Ryo Matsuzaki, Chie Nakada, Sayaka Terazono, Syunpei Ando, Masashi Harada, Hiroyuki Masuda, Kosuke Kondo, Naoyuki Harada, Nobuo Sugo
Intracranial teratoma is a rare disease that frequently occurs in children and young adults. It comprises of approximately 0.1% of the brain tumors. We report a case of a large mature teratoma in the third ventricle with Holmes tremor. A 5-year-old boy presented with tremors 2 years ago. CT showed a 56×48 mm tumor in the third ventricle and hydrocephalus. The tumor was well demarcated from the surrounding brain tissue and contained calcification. MRI indicated a partially high-intensity signal on T1-weighted and T2-weighted images...
October 2020: No Shinkei Geka. Neurological Surgery
Bezawit E Kase, Jihong Liu, Michael D Wirth, Nitin Shivappa, James R Hebert
OBJECTIVES: To examine the associations between Dietary Inflammatory Index (DII) scores and sleep measures of sleep duration and self-reported sleep disturbance. DESIGN: Cross-sectional study. SETTING: The United States. PARTICIPANTS: Participants from the 2005-2016 National Health and Nutrition Examination Survey (NHANES) who were 20 years old or older (n = 30,121). MEASUREMENTS: Sleep duration, classified as short (≤6 hours), long (≥9 hours) and recommended (6-9 hours) duration, and the presence of self-reported sleep disturbance were the outcome variables...
October 15, 2020: Sleep Health
Yichun Hu, Siran Li, Zhen Liu, Xiaoguang Yang, Lichen Yang
OBJECTIVE: To study the relationship between 25-hydroxyvitamin D [25(OH)D] concentration and intact parathyroid hormone(iPTH) concentration in the Chinese non-clinical population aged 18-44 y, and to explore the threshold value of determining the appropriate nutritional status of vitamin D. METHODS: A total of 650 plasma samples of adults aged 18-44 years old were selected from the established biological samples' bank of Chinese Chronic Diseases and Nutrition Survey(CCDNS, 2015-2018)...
September 2020: Wei Sheng Yan Jiu, Journal of Hygiene Research
Jaewon Kim, Tae-Jin Lee, Cheong-Seok Kim
OBJECTIVES: The purpose of this study was to investigate the association between the Basic Old-Age Pension (BOP), which is a noncontributory pension, and depression in BOP beneficiaries in Korea. METHODS: We used the second and third waves (2007-2008) of the Korea Welfare Panel Study to identify the effect of the BOP on mental health in the year of its introduction. The Center for Epidemiological Studies-Depression Scale, applied in a Korean context, was used to evaluate mental health...
September 2020: Journal of Preventive Medicine and Public Health
Marta Zatta, Stefano Di Bella, Daniele Roberto Giacobbe, Filippo Del Puente, Maria Merelli, Anna Maria Azzini, Pierluigi Brugnaro, Claudio Vedovelli, Anna Maria Cattelan, Marina Busetti, Giuseppe Gatti, Matteo Bassetti, Roberto Luzzati
INTRODUCTION: Being elderly is a well-known risk factor for candidemia, but few data are available on the prognostic impact of candidemia in the very old (VO) subjects, as defined as people aged ≥75 years. OBJECTIVE: The aim of this study was to assess risk factors for nosocomial candidemia in two groups of candidemia patients, consisting of VO patients (≥75 years) and adult and old (AO) patients (18-74 years). In addition, risk factors for death (30-day mortality) were analysed separately in the two groups...
October 16, 2020: Gerontology
Chenshuang Li, Ying Zhou
Despite growing evidence of the relationship between residential environment and depressive symptoms, little is known about this longitudinal relationship for elderly. Based on the follow-up survey (2011, 2013, and 2015) of the China Health and Retirement Longitudinal Study (CHARLS), this study investigated the association between residential environment and depressive symptoms among Chinese middle- and old-aged adults using repeated measures mixed models and Cox proportional hazards regression models. We found that external building characteristics, indoor space layout, household facilities, and indoor environment have significant effects on depressive symptoms in the elderly...
October 15, 2020: Health & Place
Yonah B Esterson, Sheila Sheth, Satomi Kawamoto
Acute splenic sequestration crisis, the sudden pooling of red blood cells in the spleen, is an emergent process typically seen in children with homozygous sickle cell disease. Splenic sequestration has rarely been reported in adults with heterozygous sickle cell conditions, including sickle cell beta(+)-thalassemia disease (HbS/β+ -thalassemia). Here we present a case of a 32-year-old man with HbS/β+ -thalassemia who suffered an acute splenic sequestration crisis. We review the CT and ultrasound appearance of splenic sequestration, which include splenic enlargement and an irregular rim of hypoenhancing or hypoechoic tissue at the periphery of the spleen, and discuss imaging differential considerations...
October 12, 2020: Clinical Imaging
Hoyoun Kim, Kyoung Min Kim, Min Ji Kang, Soo Lim
Sarcopenia is a pathologic status characterized by impaired muscle strength or function accompanying decreased muscle mass. It results in increased vulnerability to chronic diseases. Despite growing clinical concerns about sarcopenia in an aging society, there are few validated biomarkers for age-related sarcopenia. We tested the potential of growth differentiation factor-15 (GDF-15) as a biomarker for sarcopenia in mice and humans across wide age ranges. We used four groups of mice (6, 10, 14, and 18 months old) to explore the association between GDF-15 levels and age, muscle mass, and endurance capacity...
October 15, 2020: Experimental Gerontology
M-C Rousseau, K Baumstarck, I Hamouda, M Valkov, A Felce, S Khaldi-Cherif, C Brisse, A Loundou, P Auquier, T Billette de Villemeur
OBJECTIVES: Providing a new tool, based on the point of view of experts in polyhandicap, which assesses the global severity of the health status of polyhandicapped persons is necessary. We present herein the initial validation of the polyhandicap severity scale (PSS). METHODS: The initial development of the tool was undertaken in two steps: item selection and validation process. The final set included 10 items related to abilities and 17 items related to comorbidities and impairments...
October 14, 2020: Revue Neurologique
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