Penggang Tai, Shanshan Yang, Weiguo Liu, Shengshu Wang, Kai Chen, Wangping Jia, Ke Han, Miao Liu, Yao He
BACKGROUND & AIMS: How anthropometric and nutrition status indicators relate to cognitive function in the oldest old adults is an issue that needs to be explored. This study aimed to analyze the association of parameters and nutrition status indicators (waist circumference, BMI, calf circumference, and waist-calf circumference ratio [WCR]) with cognitive functions in centenarians. METHODS: A cross-sectional observational study was conducted with the full sample of 1002 centenarians from Hainan...
October 8, 2020: Clinical Nutrition
Kamil Zaworski, Zofia Kubińska, Adrianna Dziewulska, Olga Walasek
OBJECTIVE: The aim of this paper is to present the engagement of adult Poles in physical activity (PA) before and during the coronavirus pandemic, taking into consideration: frequency, duration and types of the activity depending on the gender and age of the participants. METHODS: The study was conducted using an online survey questionnaire. 688 residents of Poland aged 18 to 58 (28.61±9.5) years old participated in the study. RESULTS: A statistically significant decrease in the frequency of PA was noted in the group of men (p=0...
October 22, 2020: Disaster Medicine and Public Health Preparedness
Andrew Menzies-Gow, Sandhia Ponnarambil, John Downie, Karin Bowen, Åsa Hellqvist, Gene Colice
BACKGROUND: Tezepelumab is a human monoclonal antibody that blocks the activity of the epithelial cytokine thymic stromal lymphopoietin. The efficacy, safety and oral corticosteroid-sparing potential of tezepelumab are being investigated in two ongoing, phase 3, randomized, double-blind, placebo-controlled studies (NAVIGATOR [NCT03347279] and SOURCE [NCT03406078]). DESTINATION (NCT03706079) is a long-term extension (LTE) of these studies. METHODS: DESTINATION is a randomized, double-blind, placebo-controlled LTE study in adults (18-80 years old) and adolescents (12-17 years old) with severe, uncontrolled asthma who are receiving treatment with medium- or high-dose inhaled corticosteroids plus at least one additional controller medication with or without oral corticosteroids...
October 21, 2020: Respiratory Research
Tessa N Campbell, Bevan Frizzell, Paul MacMullan
Chronic non-bacterial osteomyelitis is a rare auto-inflammatory bone disease seen predominantly in the paediatric population. We describe a unique case of a 30-year-old female who presented with right-sided jaw pain and intermittent swelling over the course of 6 years. She was initially treated with antibiotics for possible osteomyelitis, then temporarily diagnosed with fibrous dysplasia. She underwent extensive investigations consisting of an infectious workup, numerous imaging modalities, and three separate biopsies of her right jaw...
July 2020: Modern rheumatology case reports
Ryuichiro Kanda, Kazuhisa Nakano, Ippei Miyagawa, Shigeru Iwata, Shingo Nakayamada, Yoshiya Tanaka
Chronic Non-bacterial Osteomyelitis (CNO) is an autoinflammatory bone disorder that causes non-bacterial and non-neoplastic osteomyelitis. CNO appeared to the long bone, clavicle, pelvis, and spine on children commonly. This time, we report a case with osteomyelitis of the mandible for the adult-onset. A 25-year-old woman presented pustulosis palmaris/pustular psoriasis after the extraction of the lower right tooth 1 year before hospitalisation. She felt pain and swelling of the right jaw and an antibiotic, NSAIDs, and glucocorticoids were ineffective...
July 2020: Modern rheumatology case reports
Naomi Yoshida, Gen Sugiyama, Suzuna Sugi, Koki Satake, Daisuke Wakasugi, Satoshi Yamasaki, Yutaro Mihara, Kotaro Matsuda, Hiroaki Ida, Koichi Ohshima, Rin Yamaguchi, Munetoshi Nakashima
A 70-year-old woman was hospitalised due to jaundice and fever. She was diagnosed with rheumatoid arthritis (RA) at 54 years of age. Treatment with methotrexate (MTX) was successful, and her RA was in remission. Five weeks before the hospitalisation, she was diagnosed with optic neuritis due to a decline in the visual acuity of the right eye. She was treated with methylprednisolone pulse therapy, followed by prednisolone (PSL), before the hospitalisation, which were not effective. Blood tests showed increased C-reactive protein (CRP) levels, liver injury, and thrombocytopenia...
July 2020: Modern rheumatology case reports
C Bai, J Shang, D Kang, W Yu, F L Zhang, W F Zhang, F Wu, R X Guo, Y D Zhang, Z Z Zhao
Objective: To investigate the efficacy of sodium zirconium cyclosilicate on emergency correction of hyperkalemia in chronic kidney disease patients. Methods: Patients with chronic kidney disease who were admitted to the Department of Nephrology of the First Affiliated Hospital of Zhengzhou University from May to June 2020 were selected. Those who had hyperkalemia and took sodium zirconium cyclosilicate powder were finally included. The patient's clinical data and laboratory results were collected. Results: A total of 24 results were included from 21 patients...
October 20, 2020: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Trifon Spyridonidis, Nikolaos Papathanasiou, Maria Spiliotopoulou, Costas Papadimitropoulos, Dimitrios J Apostolopoulos
Although medulloblastoma constitutes the second most common malignant brain tumor in children, it encountered very rarely in adults. The incidence of adult medulloblastoma is approximately 0.6 to 1 case per million. It accounts for less than 1% of adult brain tumors and is located most commonly at the posterior cranial fossa. We present an extremely rare case of a 67-year-old man with cerebellar medulloblastoma with residual disease after surgery, chemotherapy, and radiation therapy, depicted with Tc-HYNIC-[D-Phe, Tyr-Octreotide] SPECT/CT...
October 20, 2020: Clinical Nuclear Medicine
Paul S Sung, Bradly Schalk, Ryan Camp, Moon Soo Park
BACKGROUND: Women have an increased likelihood of sustaining a fall-related injury compared to men; however, little is known about fall prevention strategies between genders. The purpose of this study was to compare the gender differences in lower limb reactions and three-dimensional recovery patterns following a treadmill-induced trip perturbation. METHODS: Seventy-six participants who are right limb dominant enrolled in the study, which included 41 females (26...
October 15, 2020: Clinical Biomechanics
Penghui Zhao, Li Meng, Mengxiao Dou, Jiawen Mao, Ge Zhang, Min Zheng, Xi Yin, Zifei Tao, Miao Gong, Li Song, Kaoqi Lian, Omar Israel Velez de-la-Paz, Qingjun Guo, Haishui Shi
BACKGROUND: The function of gut microbiota as its role in normal physiology and involvement in brain function has gained a great deal of attention. The potential long-lasting effects of postweaning sodium butyrate (SB) exposure on social behaviors are still unknown; however it acts as one of the metabolites of gut microbiota. METHODS: Male mice (24-day old) were exposed to SB through drinking water for 21 continuous days. A series of behavioral tests, mainly including bedding preference test (BP), sexual preference test (SP), social interaction test (SI), tube dominance test (SDT), forced swimming test (FST), open field test (OFT), novel object recognition task (NOR) were conducted at different time after 21-d SB exposure...
October 18, 2020: Brain Research Bulletin
Ahmet Ümit Güllü, Şahin Şenay, Egemen Ersin, Önder Demirhisar, Muharrem Kocyigit, Cem Alhan
BACKGROUND: The feasibility, safety and advantages of minimally invasive or robotic repair of atrial septal defect (ASD) in adult was reported previously. However, there is limited data forthe application of these systems in pediatric group of patients. Although current robotic systems still have large instruments for surgical repair in children, some appropriate patients may benefit from this technology. METHOD: A 6-year-old child with ASD undergone robotic assistant repair via Da-Vinci Robotic Systems...
October 21, 2020: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
Kenneth W Chow, Danielle J Kelly, Rajarsi Gupta, Joshua D Miller
Many patients admitted to the intensive care unit (ICU) with are acutely malnourished and often require aggressive and early nutritional support with total parenteral nutrition (TPN). However, TPN-induced hyperglycemia is a predictor of hospital mortality and is associated with increased length of stay. Elevated blood glucose in hospitalized patients with COVID-19 is also associated with increased mortality. Real-time continuous glucose monitoring (rtCGM) is primarily used in the outpatient setting but there is rapidly growing interest in its applicability to help treat dysglycemia in critically ill patients, especially during the ongoing COVID-19 pandemic...
October 21, 2020: JPEN. Journal of Parenteral and Enteral Nutrition
Mery Natali Silva Abreu, André Evaristo Eleotério, Fernanda Dos Anjos Oliveira, Larissa Cristine Bambirra Dos Reis Pedroni, Elisama Elioenai de Lacena
OBJECTIVE: To evaluate the prevalence and factors associated with binge drinking (BD) among young Brazilians. METHODS: This cross-sectional study used data from the 2013 National Health Survey. The sample consisted of 7,823 young people aged between 18 and 24 years. The outcome was BD: four or more doses on one occasion for women and five doses or more for men. Sociodemographic, health and behavioral explanatory variables were considered. Binary Logistic Regression was used, with estimation of odds ratio (OR) and 95% confidence intervals (95%CI)...
2020: Brazilian Journal of Epidemiology
Justin Godbout, Sean W Moore, Bruce Sawadsky, Andy Pan, Christian Vaillancourt
OBJECTIVES: We aimed to determine the rate of adverse events during interfacility transport of cardiac patients identified as low risk by a consensus-derived screening tool and transported by primary care flight paramedics (PCP(f)). METHODS: We conducted a health records review of adult patients diagnosed with a cardiac condition who were identified as low risk by the screening tool and transported by PCP(f). We excluded patients transported by an advanced care crew, those accompanied by a clinical escort from hospital, and those transported from a scene call, by rotary wing or ground vehicle...
September 2020: CJEM
Margaret Addabbo, Ermanno Quadrelli, Nadia Bolognini, Elena Nava, Chiara Turati
Several adult studies have proved the existence of a shared neural circuit in the somatosensory cortices that responds to both the body being touched and the sight of the body being touched. Despite the fundamental role of touch in infancy, the existence of similar visuo-tactile mirroring processes, supporting both felt and seen touch, still needs an in-depth empirical investigation. To this aim, we explored 8-month-olds mu desynchronization over somatosensory sites in response to felt and observed touch in a live experimental setting...
October 21, 2020: Social Neuroscience
Shiho Nishimura, Yoshiyuki Kobayashi, Hidenori Ohnishi, Kunihiko Moriya, Miyuki Tsumura, Sonoko Sakata, Yoko Mizoguchi, Hidetoshi Takada, Zenichiro Kato, Vanessa Sancho-Shimizu, Capucine Picard, Sarosh R Irani, Osamu Ohara, Jean-Laurent Casanova, Anne Puel, Nobutsune Ishikawa, Satoshi Okada, Masao Kobayashi
IRAK4 deficiency is an inborn error of immunity predisposing patients to invasive pyogenic infections. Currently, there is no established simple assay that enables precise characterization of IRAK4 mutant alleles in isolation. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune condition that is characterized by psychiatric symptoms, involuntary movement, seizures, autonomic dysfunction, and central hypoventilation. It typically occurs in adult females associated with tumors. Only a few infantile cases with anti-NMDAR encephalitis have been so far reported...
October 20, 2020: Journal of Clinical Immunology
Nishtha Yadav, Hima Pendharkar, Girish Baburao Kulkarni
The "man in barrel syndrome" is a condition which resembles the aspect of patient being constrained in a barrel in which patient presents with bilateral upper limb weakness. It has classically been attributed to supratentorial lesions in watershed zones. We present such a case in a 12-year-old child who presented with bibrachial weakness and was noted to have cervical cord infarct on imaging. Spinal cord infarct is a rare cause of this syndrome, and until now only 20 cases have been described in which cervical cord infarct led to this presentation, all of them being adults...
October 21, 2020: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Mina Nicola, Youssef M A Soliman, Raghda Hussein, Haitham Saeed, Mohamed Abdelrahim
Add-on devices that are attached to metered-dose inhalers (MDIs) were introduced to improve aerosol delivery. The objective of this study was to determine the efficacy of drug delivery from an MDI when attached to different add-on devices at different inhalation volumes. The total emitted dose (TED) of salbutamol was estimated for the MDI alone and the MDI connected to five different add-on devices (Able valved holding chamber, Tips-haler valved holding chamber, Aerochamber plus flow Vu valved holding chamber, Dolphin chamber, and a handmade water bottle spacer), at inhalation flow of 28...
October 2020: ERJ Open Research
Yon Hee Kim, Jihyoun Lee
BACKGROUND: A cutaneous ciliated cyst (CCC) is a rare, benign tumor in young female adults, which is usually found on the lower extremities. CASE SUMMARY: We found an uncommon location of CCC in the anterolateral cervical area and reviewed the literature. A 20-year-old female complained of a well-defined, painless, palpable mass that started several years ago. The mass was tense and movable and located at the anterolateral aspect of the neck. Imaging showed a non-enhancing round mass...
October 6, 2020: World Journal of Clinical Cases
César Burgi Vieira, Ana Teresa Ferreira, Filipa Botelho Cardoso, Jorge Pelicano Paulos, Nuno Germano
Background: Kawasaki-like syndrome occurring in children during the COVID-19 pandemic has been labelled multisystem inflammatory syndrome in children (MIS-C) by the CDC and paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS) by the ECDC. Case report: We report the case of an 18-year-old male patient presenting with a 72-hour history of abdominal pain, fever, erythematous skin rash, vomiting and diarrhoea. Examination showed he also had shock and he was first thought to have oedematous cholecystitis...
2020: European Journal of Case Reports in Internal Medicine
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