HSPH

The 1,3-addition of 1,2-diaryl-1,2-dibromodiboranes (B2 Br2 Ar2 ) to trans -[W(N2 )2 (dppe)2 ] (dppe = κ2 -(Ph2 PCH2 )2 ), which is accompanied by a Br-Ar substituent exchange between the two boron atoms, is followed by a spontaneous rearrangement of the resulting tungsten diboranyldiazenido complex to a 2-aza-1,3-diboraallenylimido complex displaying a linear, cumulenic B=N=B moiety. This rearrangement involves the splitting of both the B-B and N=N bonds of the N2 B2 ligand, formal insertion of a BAr boranediyl moiety into the N=N bond, and coordination of the remaining BArBr boryl moiety to the terminal nitrogen atom...

The Centers for Disease Control and Prevention (CDC)'s Division of Reproductive Health and Harvard T.H. Chan School of Public Health (HSPH) Program Evaluation Practicum (CDC/HSPH Practicum) is a mutually beneficial workforce development partnership formed to provide state, local, and tribal public health organizations with an evaluation plan for a maternal and child health (MCH) program. State, local, and tribal public health organizations submit an MCH program in need of evaluation for inclusion consideration...

Heat shock proteins (HSPs) play key roles in controlling the morphological transformation of germ cells during spermatogenesis and posttesticular maturation of sperm. This study aims to reveal the presence and localization patterns of large adenosine triphosphate (ATP)-dependent HSPs family members in adult domestic cat testis and excurrent ducts utilizing Western blot, immunohistochemistry, and immunofluorescence techniques. The results indicated that the relative amounts of heat shock protein D1 (HSPD1)/HSP60, heat shock protein C (HSPC)/HSP90, and heat shock protein H (HSPH)/HSP105/110 were highest in the testis, while heat shock protein A (HSPA)/HSP70 was highest in the corpus epididymis...

BACKGROUND: The treatment of shoulder osteoarthritis in the young patient remains challenging. The higher functional demands and higher expectations of the young patient cohort are often coupled with increased failure and revision rates. Consequently, shoulder surgeons are faced with a unique challenge with implant selection. The aim of this study was to compare the survivorship and reasons for revision of 5 classes of shoulder arthroplasty in patients aged <55 years with a primary diagnosis of osteoarthritis by use of data from a large national arthroplasty registry...

Cells employ a well-preserved physiological stress response mechanism, termed the heat shock response, to activate a certain type of molecular chaperone called heat shock proteins (HSPs). HSPs are activated by transcriptional activators of heat shock genes known as heat shock factors (HSFs). These molecular chaperones are categorized as the HSP70 superfamily, which includes HSPA (HSP70) and HSPH (HSP110) families; the DNAJ (HSP40) family; the HSPB family (small heat shock proteins (sHSPs)); chaperonins and chaperonin-like proteins; and other heat-inducible protein families...

Ferroptosis is a new form of regulatory cell death named by Dixon in 2012, which is characterized by the accumulation of lipid peroxides and iron ions. Molecular chaperones are a class of evolutionarily conserved proteins in the cytoplasm. They recognize and bind incompletely folded or assembled proteins to help them fold, transport or prevent their aggregation, but they themselves do not participate in the formation of final products. As the largest number of molecular chaperones, heat shock proteins can be divided into five families: HSP110 (HSPH), HSP90 (HSPC), HSP70 (HSPA), HSP40 (DNAJ) and small heat shock proteins (HSPB)...

Heat shock proteins (HSP) are significant regulators of cell proliferation, differentiation and apoptosis. HSP participate in ovarian physiology through proliferative and apoptotic mechanisms and the modulation of sex steroid receptor functions. We investigated whether the expression and localisation patterns of HSP in the domestic cat ovary vary with the oestrous cycle stage. Immunohistochemical analysis revealed cell type-specific localisation patterns of HSPD1/HSP60, HSPA/HSP70, HSPC/HSP90 and HSPH/HSP105 in several ovarian cells of the domestic cat, including oocytes, follicular (granulosa and theca cells) and luteal cells, stromal and thecal interstitial cells, stromal cells, and vascular endothelial and smooth muscle cells during the anoestrous, follicular and luteal phases of the oestrous cycle...

Background: Estimates of the burden of cardio-metabolic risk factors in Latin America and the Caribbean (LAC) rely on relative risks (RRs) from non-LAC countries. Whether these RRs apply to LAC remains unknown. Methods: We pooled LAC cohorts. We estimated RRs per unit of exposure to body mass index (BMI), systolic blood pressure (SBP), fasting plasma glucose (FPG), total cholesterol (TC) and non-HDL cholesterol on fatal (31 cohorts, n=168,287) and non-fatal (13 cohorts, n=27,554) cardiovascular diseases, adjusting for regression dilution bias...

Surface ligands play critical roles in determining the surface properties of metal clusters. However, modulating the properties and controlling the surface structure of clusters through surface-capping agent displacement remain a challenge. In this work, a silver cluster, [Ag 14 (SPh(CF 3 ) 2 ) 12 (PPh 3 ) 4 (DMF) 4 ] ( Ag 14 -DMF , where HSPh(CF 3 ) 2 is 3,5-bis(trifluoromethyl)benzenethiol, PPh 3 is triphenylphosphine and DMF is N,N-Dimethylformamide), with weakly coordinated DMF ligands on the surface silver sites, was synthesized by using a mixed ligands strategy (bulky thiolates, phosphines and small solvents)...

The prototypical iron(0) complex [Fe(CO)3(PMe3)2] (1) forms a frustrated Lewis pair (FLP) with B(C6F5)3 (BCF). In this FLP, the iron complex acts as the Lewis base partner, and the borane as the Lewis acid partner. This FLP is able to cleave H-H, H-Cl, H-O and H-S bonds in H2, HCl, H2O and HSPh. The FLP 1/BCF is shown to catalyze the hydrogenation of alkenes under mild conditions, where terminal alkenes are preferentially reduced. Mechanistic studies using D2 gas suggest that a branched intermediate in an alkene insertion cycle or an ionic cycle is favored for this catalytic reaction...

BACKGROUND: Strong Women Strong Girls (SWSG) supports positive mentoring relationships between college women and preadolescent girls in underserved communities. Harvard T.H. Chan School of Public Health (HSPH) seeks to advance population health through learning, discovery, and communication. OBJECTIVE: To establish a community-academic partnership between SWSG staff and HSPH researchers, understand the mental health experiences and needs of SWSG girls, and inform research-based mental health promotion activities for SWSG girls...

Here, we report the synthesis of selenophenol (HSePh) protected Au36(SePh)24 nanomolecules via a ligand-exchange reaction of 4-tert-butylbenzenethiol (HSPh-tBu) protected Au36(SPh-tBu)24 with selenophenol, and its spectroscopic and theoretical analysis. Matrix assisted laser desorption ionization (MALDI) mass spectrometry, electrospray ionization (ESI) mass spectrometry and optical characterization confirm that the composition of the as synthesized product is predominantly Au36(SePh)24 nanomolecules. Size exclusion chromatography (SEC) was employed to isolate the Au36(SePh)24 and temperature dependent optical absorption studies and theoretical analysis were performed...

The reactions of the title complex (1) with different p-block element (E) molecules was examined. Compound 1 reacted with BH3 ·THF at room temperature to give the trihydride [W2 Cp2 (μ-H)H2 (μ-PPh2 )(NO)2 ], which formally results from hydrogenation of 1, a reaction that actually does not take place when neat dihydrogen is used. Clean E-H bond oxidative addition, however, took place when 1 was reacted with HSnPh3 , to give the related dihydride stannyl derivative [W2 Cp2 (μ-H)H(μ-PPh2 )(NO)2 (SnPh3 )]...

The first goal of the United Nations' 90-90-90 HIV/AIDS elimination strategy is to ensure that, by 2020, 90% of HIV-positive people know their HIV status. Estimating the prevalence of HIV among people eligible for screening allows assessment of the number of additional cases that might be diagnosed through continued screening efforts in this group. Here, we present methods for estimating prevalence when HIV status is verified by a gold standard only among those who test positive on an initial, imperfect screening test with known sensitivity and specificity...

Summary: bioBakery is a meta'omic analysis environment and collection of individual software tools with the capacity to process raw shotgun sequencing data into actionable microbial community feature profiles, summary reports, and publication-ready figures. It includes a collection of pre-configured analysis modules also joined into workflows for reproducibility. Availability and implementation: bioBakery (https://huttenhower.sph.harvard.edu/biobakery) is publicly available for local installation as individual modules and as a virtual machine image...

Phenylethanethiol protected nanomolecules such as Au25 , Au38 , and Au144 are widely studied by a broad range of scientists in the community, owing primarily to the availability of simple synthetic protocols. However, synthetic methods are not available for other ligands, such as aromatic thiol and bulky ligands, impeding progress. Here we report the facile synthesis of three distinct nanomolecules, Au38 (SCH2 CH2 Ph)24 , Au36 (SPh-tBu)24 , and Au30 (S-tBu)18 , exclusively, starting from a common Aun (glutathione)m (where n and m are number of gold atoms and glutathiolate ligands) starting material upon reaction with HSCH2 CH2 Ph, HSPh-tBu, and HStBu, respectively...

Ultrasmall nanomolecules (<2 nm) such as Au25 (SCH2 CH2 Ph)18 , Au38 (SCH2 CH2 Ph)24 , and Au144 (SCH2 CH2 Ph)60 are well studied and can be prepared using established synthetic procedures. No such synthetic protocols that result in high yield products from commercially available starting materials exist for Au36 (SPh-X)24 . Here, we report a synthetic procedure for the large-scale synthesis of highly stable Au36 (SPh-X)24 with a yield of ∼42%. Au36 (SPh-X)24 was conveniently synthesized by using tert-butylbenzenethiol (HSPh-tBu, TBBT) as the ligand, giving a more stable product with better shelf life and higher yield than previously reported for making Au36 (SPh)24 from thiophenol (PhSH)...

Heat shock proteins (Hsps) co-operate in multi-protein machines that counter protein misfolding and aggregation and involve DNAJ (Hsp40), HSPA (Hsp70), and HSPH (Hsp105α). The HSPA family is a multigene family composed of inducible and constitutively expressed members. Inducible HSPA6 (Hsp70B') is found in the human genome but not in the genomes of mouse and rat. To advance knowledge of this little studied HSPA member, the targeting of HSPA6 to stress-sensitive neuronal sites with components of a disaggregation/refolding machine was investigated following thermal stress...

Au38 (SR)24 is one of the most extensively investigated gold nanomolecules along with Au25 (SR)18 and Au144 (SR)60 . However, so far it has only been prepared using aliphatic-like ligands, where R = -SC6 H13 , -SC12 H25 and -SCH2 CH2 Ph. Au38 (SCH2 CH2 Ph)24 when reacted with HSPh undergoes core-size conversion to Au36 (SPh)24 , and existing literature suggests that Au38 (SPh)24 cannot be synthesized. Here, contrary to prevailing knowledge, we demonstrate that Au38 (SPh)24 can be prepared if the ligand exchanged conditions are optimized, under delicate conditions, without any formation of Au36 (SPh)24 ...

Although some widespread, native cow parsnips (Heracleum L. spp., Apiaceae) had broad medicinal and culinary applications throughout history, the knowledge about their volatile constituents is insufficient. This work investigates the composition and bioactivities of H. sphondylium L. (HSPH), H. sibiricum L. (HSIB) and H. montanum Schleich. ex Gaudin (HMON) essential oils. The composition was tested by GC and GC-MS. (Z)-β-Ocimene was the most abundant in HSPH (28.9%) and HMON (20.4%) root oils, while in HSIB root oil, β-pinene (26...