Heming Li, Yang-Zhuangzhuang Zhu, Lu Xu, Tao Han, Jiasi Luan, Xin Li, Yuting Liu, Zhi Wang, Qiuge Liu, Xiangyu Kong, Chunpu Zou, Lin Su, Yifei Hou, Xiao Chen, Lujun Chen, Ruoyu Wang, Zihang Xu, Mingfang Zhao
BACKGROUND: Circulating tumor cells (CTCs) hold immense promise in guiding treatment strategies for advanced gastric cancer (GC). However, their clinical impact has been limited due to challenges in identifying epithelial-mesenchymal transition (EMT)-CTCs using conventional methods. METHODS: To bridge this knowledge gap, we established a detection platform for CTCs based on the distinctive biomarker cell surface vimentin (CSV). A prospective study involving 127 GC patients was conducted, comparing CTCs enumeration using both EpCAM and CSV...
April 30, 2024: Journal of Experimental & Clinical Cancer Research: CR