Ehizogie Edigin, Subuhi Kaul, Precious Obehi Eseaton
No abstract text is available yet for this article.
November 2, 2020: Journal of the American Academy of Dermatology
Paul Macklis, Kevin Adams, Jessica Kaffenberger, Purnima Kumar, Andrew Krispinsky, Benjamin Kaffenberger
OBJECTIVE: Oral health and mucocutaneous inflammation might play an important role in the etiopathogenesis of many skin diseases, especially those that also involve the oral mucosa. This review examines the relationship between skin conditions and various oral health metrics to better understand how oral diseases, especially periodontitis, might influence the development or prognosis of several conditions, including aphthous stomatitis, atopic dermatitis, lichen planus, pemphigus, pemphigoid, and psoriasis...
June 2020: Journal of Clinical and Aesthetic Dermatology
Xue-Min Xiao, Peng-Jun Zhou, Chang-Hua Zhu, Li-Hang Lin, Jing-Jing Liu, Yue Han
No abstract text is available yet for this article.
August 25, 2020: Chinese Medical Journal
S C Williams, J W Frew, J G Krueger
BACKGROUND: Hidradenitis Suppurativa (HS), also known as acne inversa, is a chronic inflammatory skin disease with still largely unknown pathogenesis. While infectious organisms have been identified in lesions of the disease since the 1980s, questions remain over the role that bacteria and microbiome play. Recent studies using 16S ribosomal RNA genesequencing and larger culture-based studies have begun to paint a clearer picture of the microbial world of HS. With this systematic review we summarizeall the work that has been done to date in HS bacteriology, analyze potential pitfalls and limitations of the current studies, and address future directions of investigation...
July 2, 2020: Experimental Dermatology
K M Darch, T L Holland, L J Spelman
Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic, relapsing inflammatory skin condition characterised by the presence of painful nodules, abscesses, and sinus tracts or scarring. Affecting up to 4% of the population, it is not uncommon and is seen predominantly in females at a ratio of 3 : 1. HS carries a substantial burden for those who suffer from it, from the significant psychosocial impact, to the cost of the multitude of topical and systemic treatments which often do not successfully control its symptoms...
2020: Case Reports in Obstetrics and Gynecology
Uwe Wollina, Piotr Brzezinski, André Koch, Wolfgang G Philipp-Dormston
Hidradenitis suppurativa/ acne inversa (HS/AI) is one of the most debilitating dermatoses with a strong negative impact on every dimension of quality of life. Treatment is dependent on the severity of clinical manifestations and comorbidities. While anti-inflammatory and antimicrobial approaches are recommended for mild and moderate stages, immunomodulatory drugs have gained increasing interest in all stages of HS/AI. We reviewed the available data on this subject in a narrative review and included not only substances with published final outcome but those where either the ongoing trials or experience from case report...
June 19, 2020: Dermatologic Therapy
C C Zouboulis
No abstract text is available yet for this article.
May 31, 2020: British Journal of Dermatology
C-Y Lu, M-S Hsieh, K-C Wei, M Ezmerli, C-H Kuo, W Chen
Less is known about gastrointestinal (GI) involvement of primary skin diseases due to the difference in embryology, histology, microbiology and physiology between integument and alimentary tract. Oesophagus, following the oropharyngeal mucosa, is the most common GI segment affected by primary skin diseases, especially by eosinophilic oesophagitis, lichen planus and autoimmune bullous dermatoses like pemphigus vulgaris, mucosal membrane pemphigoid and epidermolysis bullosa acquisita. Eosinophilic oesophagitis is an emerging chronic atopic disease with oesophageal dysfunction as the typical presentation, and oesophageal narrowing, rings and stricture as late complications...
May 26, 2020: Journal of the European Academy of Dermatology and Venereology: JEADV
A G Vaiopoulos, G Nikolakis, C C Zouboulis
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle affecting apocrine glands-rich areas of the body. The disease usually occurs after puberty leading to painful nodules, abscesses, tunnels and scarring. Although uncommonly, HS can also occur in children and adolescents. OBJECTIVE: Our objective was to describe the epidemiology, characteristics, predisposing factors and clinical course of HS in paediatric patients...
April 23, 2020: Journal of the European Academy of Dermatology and Venereology: JEADV
Yu-Fei Yao, Shijie Lyu, Xianwei Wang, Zijing Zhang, Kaixing Qu, Jiawei Xu, Cuicui Cai, Zhiming Li, Jianliang Xie, Baorui Ru, Zejun Xu, Eryao Wang, Chuzhao Lei, Hong Chen, Bizhi Huang, Yongzhen Huang
Copy number variation (CNV) has been used as an important source of phenotypic and genetic diversity in recent years. Nicastrin ( NCSTN ) gene is usually attached to human diseases such as Alzheimer's disease, and Acne inversa. However, there are no essays about the NCSTN gene combining with cattle breeds. In our study, we discovered different distributions of NCSTN gene copy number and associated it with phenotypic traits in four Chinese yellow cattle breeds (XN, PN, QC and YL). The result turned out that the CNV of the NCSTN gene was associated with several growth traits, such as cannon circumference, chest girth and rump length ( p  < 0...
March 25, 2020: Animal Biotechnology
Robert Sabat, Gregor B E Jemec, Łukasz Matusiak, Alexa B Kimball, Errol Prens, Kerstin Wolk
Hidradenitis suppurativa (HS; also designated as acne inversa) is a chronic inflammatory disorder, which affects the intertriginous skin and is associated with numerous systemic comorbidities. The estimated prevalence of HS is ~1% in most studied countries. Typically starting in early adulthood, cutaneous inflamed nodules, abscesses and pus-discharging tunnels develop in axillary, inguinal, gluteal and perianal body sites. The comorbidities of HS include metabolic and cardiovascular disorders, which contribute to reduced life expectancy...
March 12, 2020: Nature Reviews. Disease Primers
S Hessam, F G Bechara
Hidradenitis suppurativa/acne inversa (HS/AI) is a chronic inflammatory skin disease. Several studies showed that perianal, perineal and gluteal involvement is more common in men. Axillary, submammary and inguinal localizations seem to be more prevalent in women. Involvement of the genitoanal region is associated with a higher reduced quality of live and sexual health compared to other locations. Moreover HS/AI in the genitoanal region can lead to serious complications. The knowledge of perianal fistula formation, pubogenital lymphedema and squamous cell carcinoma, which are three of the most severe complications, is critical for adequate treatment...
February 20, 2020: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Errol P Prens, Aida M Lugo-Somolinos, Amy S Paller, Francisco Kerdel, Yinghui Duan, Henrique D Teixeira, Michelle Longcore, Alexa B Kimball
BACKGROUND: Hidradenitis suppurativa (HS), also known as acne inversa, is a recurring, painful, chronic, and sometimes disfiguring inflammatory skin disease. OBJECTIVES: Our objective was to report the baseline clinical characteristics, natural history, and associated outcomes of patients with HS from the ongoing, prospective, non-interventional UNITE registry that is collecting data regarding the natural history and associated outcomes of HS. METHODS: Patients with inflammatory HS lesions were enrolled, including adolescents (aged 12 to < 18 years) and adults (aged ≥ 18 years)...
February 19, 2020: American Journal of Clinical Dermatology
Jin Huk Choi, Jonghee Han, Panayotis C Theodoropoulos, Xue Zhong, Jianhui Wang, Dawson Medler, Sara Ludwig, Xiaoming Zhan, Xiaohong Li, Miao Tang, Thomas Gallagher, Gang Yu, Bruce Beutler
γ-secretase is an intramembrane protease complex that catalyzes the proteolytic cleavage of amyloid precursor protein and Notch. Impaired γ-secretase function is associated with the development of Alzheimer's disease and familial acne inversa in humans. In a forward genetic screen of mice with N -ethyl- N -nitrosourea-induced mutations for defects in adaptive immunity, we identified animals within a single pedigree exhibiting both hypopigmentation of the fur and diminished T cell-independent (TI) antibody responses...
March 3, 2020: Proceedings of the National Academy of Sciences of the United States of America
Ewan A Langan, Andreas Recke, Therezia Bokor-Billmann, Franck Billmann, Birgit K Kahle, Detlef Zillikens
The development of next generation sequencing, coupled with advances in bio-informatics, has provided new insights into the role of the cutaneous microbiome in the pathophysiology of a range of inflammatory skin diseases. In fact, it has even been suggested that the identification of specific skin microbial signatures may not only be useful in terms of diagnosis of skin diseases but they may also ultimately help inform personalised treatment strategies. To date, research investigating the role of microbiota in the development of inflammatory skin diseases has largely focused on atopic eczema and psoriasis vulgaris...
February 11, 2020: International Journal of Molecular Sciences
Christos C Zouboulis, André Nogueira da Costa, Sabine Fimmel, Konstantin C Zouboulis
BACKGROUND: Apocrine glands have been long considered as the initial targeted skin compartment in hidradenitis suppurativa/acne inversa (HS). OBJECTIVE: Detection of apocrine gland involvement in HS. METHODS: Apocrine glands were isolated from skin biopsies of involved and uninvolved skin of HS patients (n=16, females:males 1:1) by laser capture microscopy and studied by whole transcriptome profiling. Dysregulated genes were detected by comparing lesional and non-lesional skin obtained from female and male HS patients using the Agilent array platform...
February 7, 2020: Journal of the European Academy of Dermatology and Venereology: JEADV
I Iesalnieks, U Dornseifer
Hidradenitis suppurativa (acne inversa) is a chronic inflammatory follicular skin disease which leads to fistulae, abscesses and scarring. The Hurley classification is used to quantify the extent of the disease whereby stage III is associated with extensive disfiguring lesions. The most frequently used conservative treatment options are topical clindamycin, systemic antibiotics, e.g. clindamycin and rifampicin, anti-TNF antibodies and laser epilation. Complete excision of fistulae with or without plastic coverage of defects are the mainstays of surgical treatment...
January 8, 2020: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Jun Yang, Lianqing Wang, Yingzhi Huang, Keqiang Liu, Chaoxia Lu, Nuo Si, Rongrong Wang, Yaping Liu, Xue Zhang
Familial acne inversa (AI) is an autoinflammatory disorder that affects hair follicles and is caused by loss-of-function mutations in γ-secretase component genes. We and other researchers showed that nicastrin (NCSTN) is the most frequently mutated gene in familial AI. In this study, we generated a keratin 5-Cre-driven epidermis-specific Ncstn conditional knockout mutant in mice. We determined that this mutant recapitulated the major phenotypes of AI, including hyperkeratosis of hair follicles and inflammation...
December 28, 2019: Frontiers of Medicine
C C Zouboulis, A Nogueira da Costa, E Makrantonaki, X X Hou, D Almansouri, J T Dudley, H Edwards, B Readhead, O Balthasar, G B E Jemec, N G Bonitsis, G Nikolakis, D Trebing, K C Zouboulis, A M Hossini
BACKGROUND: The large unmet need of hidradenitis suppurativa/acne inversa (HS) therapy requires the elucidation of disease-driving mechanisms and tissue targeting. OBJECTIVE: Robust characterization of the underlying HS mechanisms and detection of the involved skin compartments. METHODS: Hidradenitis suppurativa/acne inversa molecular taxonomy and key signalling pathways were studied by whole transcriptome profiling. Dysregulated genes were detected by comparing lesional and non-lesional skin obtained from female HS patients and matched healthy controls using the Agilent array platform...
December 14, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
Dimitra Koumaki, Ourania Efthymiou, Evangelia Bozi, Alexander C Katoulis
Objective: To review current knowledge on how patients with hidradenitis suppurativa (HS) experience stigmatization, as well as on its associations with clinical and psychosocial characteristics of the disease. A better understanding of these may help dermatologists improve screening and management for the benefit of HS patients. Methods: A MEDLINE search using the terms stigmatization, perceived stigma, self-stigma, and HS/acne inversa. Results: Stigmatization is common among HS patients and has a strong psychosocial impact, which is often disproportional to the extent and severity of skin involvement...
2019: Clinical, Cosmetic and Investigational Dermatology
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