Giovanni Tonon, Matteo Mauceri, Enrico Cavarzerani, Rachele Piccolo, Claudio Santo, Nicola Demitri, Laura Orian, Pablo A Nogara, João Batista T Rocha, Vincenzo Canzonieri, Flavio Rizzolio, Fabiano Visentin, Thomas Scattolin
In continuation of our previous works on the cytotoxic properties of organopalladium compounds, in this contribution we describe the first systematic study of the anticancer activity of Pd(II)-aryl complexes. To this end, we have prepared and thoroughly characterized a wide range of palladium derivatives bearing different diphosphine, aryl and halide ligands, developing, when necessary, specific synthetic protocols. Most of the synthesized compounds showed remarkable cytotoxicity towards ovarian and breast cancer cell lines, with IC50 values often comparable to or lower than that of cisplatin...
April 30, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry