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JOURNAL ARTICLE
Joseph J Boscarino, Daniel S Weitzner, Erin K Bailey, Joel E Kamper, Emily N Vanderbleek
Background: The Learning Ratio (LR) is a novel learning score that has shown improved utility over other learning metrics in detecting Alzheimer's disease (AD) across multiple memory tasks. However, its utility on the Consortium to Establish a Registry for Alzheimer's Disease Word List Memory Test (CERAD WLMT), a widely used list learning measure sensitive to decline in neurodegenerative disease, is unknown. The goal of the current study was to determine the utility of LR on the CERAD WLMT in differentiating between diagnostic (MiNCD vs MaNCD) and etiologic groups (VaD vs AD) in a veteran sample...
March 17, 2024: Clinical Neuropsychologist
#42
JOURNAL ARTICLE
Chong Sun, Hongfei Xiang, Xiaolin Wu, Bohua Chen, Zhu Guo
BACKGROUND: Anterior cervical discectomy and fusion surgery (ACDF) is a common technique in treating degenerative cervical spondylosis. This study is to evaluate the changes of cervical muscles after ACDF and analyze the correlation between related muscle changes and clinical efficacy. METHODS: Sixty-five postoperative patients (single-level ACDF) with cervical spondylotic myelopathy from January 2013 to December 2022 were analyzed. The measured parameters include: the axial section of longus colli cross-sectional area (AxCSA), the volume of cervical longus, the ratio of long and short diameter line (RLS), the cervical extensor cross-sectional area (CESA), the vertebral body area (VBA), and the CESA/VBA...
March 16, 2024: Journal of Orthopaedic Surgery and Research
#43
REVIEW
Anders Broström, Zainab Alimoradi, Elzana Odzakovic, Viktor Kaldo, Susanna Jernelöv, Jonas Lind, Martin Ulander, Amir Pakpour
OBJECTIVE: The primary aim was to estimate the pooled mean score of quality of life (QoL) (total, mental and physical health components) among patients with Restless Legs Syndrome (RLS). Secondary aims were to assess: (I) QoL differences for RLS vs. control groups, (II) heterogeneity and possible sources; and (III) moderating variables. METHODS: Studies identified in PubMed, Scopus, Web of Science, and ProQuest between January 2000 and December 2022 were included...
April 2024: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
#44
JOURNAL ARTICLE
Francisca Cornejo, Nayhara Franchini, Bastián I Cortés, Daniela Elgueta, Gonzalo I Cancino
Neurodevelopmental disorders are characterized by alterations in the development of the cerebral cortex, including aberrant changes in the number and function of neural cells. Although neurogenesis is one of the most studied cellular processes in these pathologies, little evidence is known about glial development. Genetic association studies have identified several genes associated with neurodevelopmental disorders. Indeed, variations in the PTPRD gene have been associated with numerous brain disorders, including autism spectrum disorder, restless leg syndrome, and schizophrenia...
2024: Frontiers in Cell and Developmental Biology
#45
Brendan Jen-Wei Tan, Yew-Long Lo, Ling-Ling Chan, Eng-King Tan
No abstract text is available yet for this article.
March 12, 2024: American Journal of Medicine
#46
REVIEW
Gaia Pellitteri, Salvatore Versace, Giovanni Merlino, Annacarmen Nilo, Gian Luigi Gigli, Mariarosaria Valente
INTRODUCTION: Restless legs syndrome/Willis-Ekbom disease (RLS/WED) is a sleep-related sensory-motor disorder associated with poor sleep quality and impaired daily functioning. In patients affected by chronic RLS/WED, a pharmacological therapy is recommended. International guidelines suggest to start the treatment with a α2δ calcium channel ligand in most cases, unless contraindicated. AREAS COVERED: The present review is based on an extensive Internet and PubMed search from 1986 to 2024...
March 2024: Expert Opinion on Drug Metabolism & Toxicology
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JOURNAL ARTICLE
Jasper P Sijberden, Tijs J Hoogteijling, Davit Aghayan, Francesca Ratti, Ek-Khoon Tan, Victoria Morrison-Jones, Jacopo Lanari, Louis Haentjens, Kongyuan Wei, Stylianos Tzedakis, John Martinie, Daniel Osei Bordom, Giuseppe Zimmitti, Kaitlyn Crespo, Paolo Magistri, Nadia Russolillo, Simone Conci, Burak Görgec, Andrea Benedetti Cacciaguerra, Daniel D'Souza, Gabriel Zozaya, Cèlia Caula, David Geller, Ricardo Robles Campos, Roland Croner, Shafiq Rehman, Elio Jovine, Mikhail Efanov, Adnan Alseidi, Riccardo Memeo, Ibrahim Dagher, Felice Giuliante, Ernesto Sparrelid, Jawad Ahmad, Tom Gallagher, Moritz Schmelzle, Rutger-Jan Swijnenburg, Åsmund Avdem Fretland, Federica Cipriani, Ye-Xin Koh, Steven White, Santi Lopez Ben, Fernando Rotellar, Pablo E Serrano, Marco Vivarelli, Andrea Ruzzenente, Alessandro Ferrero, Fabrizio Di Benedetto, Marc G Besselink, Iswanto Sucandy, Robert P Sutcliffe, Dionisios Vrochides, David Fuks, Rong Liu, Mathieu D'Hondt, Umberto Cillo, John N Primrose, Brian K P Goh, Luca A Aldrighetti, Bjørn Edwin, Mohammad Abu Hilal
OBJECTIVE: The aim of this study was to compare the perioperative outcomes of robotic liver surgery (RLS) and laparoscopic liver surgery (LLS) in various settings. SUMMARY BACKGROUND DATA: Clear advantages of RLS over LLS have rarely been demonstrated, and the associated costs of robotic surgery are generally higher than those of laparoscopic surgery. Therefore, the exact role of the robotic approach in minimally invasive liver surgery remains to be defined. METHODS: In this international retrospective cohort study, the outcomes of patients who underwent RLS and LLS for all indications between 2009 and 2021 in 34 hepatobiliary referral centers were compared...
March 14, 2024: Annals of Surgery
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JOURNAL ARTICLE
Hanife Kocakaya, Bahar Say
The aim of this study is to examine patients with restless legs syndrome (RLS) in terms of difficulty in emotion regulation and insomnia. A total of 52 patients with RLS and 57 healthy volunteers were enrolled. Difficulties in Emotion Regulation Scale Short Form (DERS-16), Insomnia Severity Index (ISI), Hospital Anxiety and Depression Scale (HADS), and International Restless Legs Syndrome rating scale were applied to participants. The mean age was 34.00 ± 8.27 years in patients and 31...
October 2023: Sleep and Biological Rhythms
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JOURNAL ARTICLE
Vanessa Short, Richard Allen, Christopher J Earley, Huzefa Bahrain, Stella Rineer, Kiumarce Kashi, Jesse Gerb, Michael Auerbach
Restless legs syndrome (RLS) is a neurological disorder that can have a profound effect on sleep and quality of life. Idiopathic RLS is associated with brain iron insufficiency despite normal peripheral iron stores. There is, however, a five- to six-fold increase in prevalence of RLS in patients with iron deficiency anemia (IDA). Several open-label trials have demonstrated symptomatic improvement in RLS following treatment of IDA using oral or intravenous iron supplementation. To date, there have been no randomized double-blind controlled trials of intravenous iron compared with oral iron for the treatment of RLS patients with IDA...
March 13, 2024: American Journal of Hematology
#50
JOURNAL ARTICLE
Mollie E Rischard, Tara R Buck, Kristi E Pruiksma, Aviva Johns, Lisa D Cromer
STUDY OBJECTIVES: To construct and evaluate the inter-rater reliability of the Structured Clinical Interview for DSM-5-TR Sleep Disorders - Kid (SCISD-Kid). METHOD: The SCISD-Kid was modeled on the adult SCISD-R and accounted for pediatric developmental and sociocultural factors. Fifty sleep-disturbed children ( M age = 11.9, SD = 2.9) and 50 caregivers responded to the final SCISD-Kid. Video recordings were double-scored to evaluate inter-rater reliability...
March 8, 2024: Behavioral Sleep Medicine
#51
JOURNAL ARTICLE
Myotonic Dystrophy Type 1 (DM1): Clinical Characteristics and Disease Progression in a Large Cohort.
Tanushree Chawla, Nishanth Reddy, Rahul Jankar, Seena Vengalil, Kiran Polavarapu, Gautham Arunachal, Veeramani Preethish-Kumar, Saraswati Nashi, Mainak Bardhan, Jamuna Rajeshwaran, Mohammad Afsar, Manjusha Warrier, Priya T Thomas, Kandavel Thennarasu, Atchayaram Nalini
BACKGROUND: DM1 is a multisystem disorder caused by expansion of a CTG triplet repeat in the 3' non-coding region of DMPK. Neuropsychological consequences and sleep abnormalities are important associations in DM1. OBJECTIVE: To describe the clinical phenotype, disease progression and characterize the sleep alterations and cognitive abnormalities in a sub-set of patients. MATERIALS AND METHODS: A retrospective study on 120 genetically confirmed DM1 cases...
January 1, 2024: Neurology India
#52
JOURNAL ARTICLE
Maham Fatima, Faisal Nabi, Rizwan Hasan Khan, Aabgeena Naeem
Protein aggregation induces profound changes in the structure along with the conformation of the protein, and is responsible for the pathogenesis of a number of neurodegenerative conditions such as Huntington's, Creutzfeldt-Jacob, Type II diabetes mellitus, Alzheimer's, etc. Numerous multi-spectroscopic approaches and in-silico experiments were utilized to investigate BSA's biomolecular interaction and aggregation in the presence of quinoline yellow. The present research investigation evaluated the interaction of BSA with the food colorant (QY) at two different pH (7...
February 25, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
#53
Sakiko Gohbara, Yasuhide Mochizuki, Takanari Fujii, Hideshi Tomita, Toshiro Shinke
BACKGROUND: Hypoxaemia in isolated right ventricular (RV) hypoplasia (IRVH) is primarily caused by a right-to-left shunt (RLS) at the atrial level, such as an atrial septal defect (ASD). When considering closure of the RLS, it should be closed only after ensuring that it will not cause right-sided heart failure (HF). CASE SUMMARY: A 21-year-old woman had been experiencing shortness of breath during exertion since childhood. Transthoracic and transoesophageal echocardiography revealed an ASD with bidirectional shunting, and microbubble test revealed a marked RLS...
March 2024: European Heart Journal. Case Reports
#54
JOURNAL ARTICLE
Neha Kausar Ansari, Amaan Rais, Aabgeena Naeem
Protein aggregation is related to numerous pathological conditions like Alzheimer's and Parkinson's disease. In our study, we have shown that an already existing FDA-approved drug; methotrexate (MTX) can be reprofiled on preformed α-chymotrypsinogen A (α-Cgn A) aggregates. The zymogen showed formation of aggregates upon interaction with mercuric ions, with increasing concentration of Hg2 Cl2 (0-150 µM). The hike in ThT and ANS fluorescence concomitant with blue shift, bathochromic shift and the hyperchromic effect in the CR absorbance, RLS and turbidity measurements, substantiate the zymogen β-rich aggregate formation...
March 2, 2024: Protein Journal
#55
JOURNAL ARTICLE
Benedikt Bernhard, Philippe Joss, Noah Greisser, Anselm W Stark, Jonathan Schütze, Isaac Shiri, Yasaman Safarkhanlo, Kady Fischer, Dominik P Guensch, Jessica A M Bastiaansen, Maryam Pavlicek, Dominik C Benz, Raymond Y Kwong, Christoph Gräni
According to updated Lake-Louise Criteria, impaired regional myocardial function serves as a supportive criterion in diagnosing myocarditis. This study aimed to assess visual regional wall motional abnormalities (RWMA) and novel quantitative regional longitudinal peak strain (RLS) for risk stratification in the clinical setting of myocarditis. In patients undergoing CMR and meeting clinical criteria for suspected myocarditis global longitudinal strain (GLS), late gadolinium enhancement (LGE), RWMA and RLS were assessed in the anterior, septal, inferior, and lateral regions and correlated to the occurrence of major adverse cardiac events (MACE), including heart failure hospitalization, sustained ventricular tachycardia, recurrent myocarditis, and all-cause death...
March 1, 2024: International Journal of Cardiovascular Imaging
#56
JOURNAL ARTICLE
Pauline Dodet, Marion Houot, Smaranda Leu-Semenescu, Jean-Christophe Corvol, Stéphane Lehéricy, Graziella Mangone, Marie Vidailhet, Emmanuel Roze, Isabelle Arnulf
In Parkinson's disease (PD), it remains unclear whether sleep disorders including insomnia, REM sleep behavior disorder (RBD), excessive daytime sleepiness (EDS), restless legs syndrome (RLS) and sleep-disordered breathing (SDB), are isolated or combined, interact with each other and are associated with clinical factors. We sought to determine the prevalence and combinations of the main sleep disorders, and their clinical and polysomnographic associations in early stage PD. Sleep disorders were systematically diagnosed after medical interview and video-polysomnography in 162 participants with early stage PD and 58 healthy controls from the baseline of the longitudinal ICEBERG cohort...
February 29, 2024: NPJ Parkinson's Disease
#57
JOURNAL ARTICLE
Jitender Aneja, Jawahar Singh, Bharat Udey
BACKGROUND: Restless legs syndrome (RLS) is a neuro-sensorimotor disorder which is scarcely researched and is commonly missed in routine psychiatry practice. AIM: To evaluate the prevalence of RLS and its correlates in patients with anxiety, depression, and somatoform disorders. METHODS: A cross-sectional single-center study was undertaken in patients aged 18-65 years suffering from ICD-10 (International Statistical Classification of Diseases-10th edition) diagnosis of anxiety, depressive, and somatoform disorders...
January 2024: Indian Journal of Psychiatry
#58
JOURNAL ARTICLE
Hong Pu, Qing Zhang, Jing Wu, Yuan Zhang, Yaxi Zhao, Ling Li
OBJECTIVE: This study aims to comprehensively assess the characteristics of patent foramen ovale (PFO) in relation to Cryptogenic Strok (CS) by utilizing transesophageal echocardiography (TEE) and contrast transthoracic echocardiography (c-TTE) and to identify high-risk factors associated with PFO-related CS. BACKGROUND: Transcatheter PFO closure has demonstrated its effectiveness in preventing PFO-related CS. Therefore, understanding the specific structural attributes of PFO associated with CS is imperative...
February 26, 2024: Current medical imaging
#59
JOURNAL ARTICLE
Stefan Toggweiler, Federico Moccetti, Nina Conrad, Lucca Loretz, Mehdi Madanchi, Matthias Bossard, Adrian Attiger-Toller, Florim Cuculi, Mathias Wolfrum
OBJECTIVES: Percutaneous closure of a patent foramen ovale (PFO) for the prevention of recurrent paradoxical thromboembolic events has been shown to be safe and effective in randomized controlled trials. However, it remains uncertain if differences in the structure and design of the occluder devices impact the outcomes. The aim of this study was to compare results of percutaneous PFO closure using 2 widely used double-disc occluders. METHODS: Consecutive patients who underwent percutaneous PFO closure with the Abbott Amplatzer occluder (APO) or the Occlutech Figulla-Flex-II occluder (OPO) at the Heart Center Lucerne between February 2017 and December 2022 were included in a registry...
February 23, 2024: Journal of Invasive Cardiology
#60
JOURNAL ARTICLE
Shuai Yan, Ning Wang, Huizhe Liu, Yunying Wei, Xin Liu, Luxuan Wang, Yuqing Huang, Meilin Lin
OBJECTIVE: This study aims to investigate the therapeutic efficacy of patent foramen ovale (PFO) closure in migraine patients with a massive right-to-left shunt (RLS) and white matter lesions (WMLs). METHODS: The research focused on migraine patients with a massive RLS who underwent PFO closure in our hospital from June 2020 to June 2021. The study included 51 patients without WMLs (control group, CG) and 27 patients with WMLs (observation group, OG). A 12-month postoperative follow-up survey was conducted to assess headache episodes (frequency and duration), evaluated using the Headache Impact Test-6 (HIT-6) and the Pain Intensity Visual Analog Scale (VAS)...
February 9, 2024: Alternative Therapies in Health and Medicine
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