Yiguang Chen, Xiaohai Liu, Yilamujiang Ainiwan, Mingchu Li, Jun Pan, Yongjian Chen, Zebin Xiao, Ziyu Wang, Xinru Xiao, Jie Tang, Gao Zeng, Jiantao Liang, Xin Su, Roberta Kungulli, Yuxiang Fan, Qingtang Lin, A Liya, Yifeng Zheng, Zexin Chen, Canli Xu, Hongqi Zhang, Ge Chen
Craniopharyngiomas (CPs), particularly Adamantinomatous Craniopharyngiomas (ACPs), often exhibit a heightened risk of postoperative recurrence and severe complications of the endocrine and hypothalamic function. The primary objective of this study is to investigate potential novel targeted therapies within the microenvironment of ACP tumors. Cancer-Associated Fibroblasts (CAFs) were identified in the craniopharyngioma microenvironment, notably in regions characterized by cholesterol clefts, wet keratin, ghost cells, and fibrous stroma in ACPs...
April 25, 2024: Cancer Letters