Enitome E Bafor, Rebecca A Erwin-Cohen, Toni Martin, Clayton Baker, Adrienne E Kimmel, Olivier Duverger, John M Fenimore, Meredith Ramba, Thea Spindel, Megan M Hess, Michael Sanford, Vanja Lazarevic, Bérénice A Benayoun, Howard A Young, Julio C Valencia
INTRODUCTION: Interferon-gamma (IFN-γ) is pivotal in orchestrating immune responses during healthy pregnancy. However, its dysregulation, often due to autoimmunity, infections, or chronic inflammatory conditions, is implicated in adverse reproductive outcomes such as pregnancy failure or infertility. Additionally, the underlying immunological mechanisms remain elusive. METHODS: Here, we explore the impact of systemic IFN-γ elevation on cytotoxic T cell responses in female reproduction utilizing a systemic lupus-prone mouse model with impaired IFN-γ degradation...
2024: Frontiers in Immunology