Sara Torstensson, Angelo Ascani, Sanjiv Risal, Haojiang Lu, Allan Zhao, Alexander Espinosa, Eva Lindgren, Maria H Johansson, Gustaw Eriksson, Maya Barakat, Mikael C I Karlsson, Camilla Svensson, Anna Benrick, Elisabet Stener-Victorin
Polycystic ovary syndrome (PCOS) is associated with a low-grade inflammation, but it is unknown how hyperandrogenism, the hallmark of PCOS, affects the immune system. Using a PCOS-like mouse model, it is demonstrated that hyperandrogenism affects immune cell populations in reproductive, metabolic, and immunological tissues differently in a site-specific manner. Co-treatment with an androgen receptor antagonist prevents most of these alterations, demonstrating that these effects are mediated through androgen receptor activation...
May 20, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)