Daisuke Hoshi, Emiri Kita, Yoshiaki Maru, Hiroyuki Kogashi, Yuki Nakamura, Yasutoshi Tatsumi, Osamu Shimozato, Kazuyoshi Nakamura, Kentaro Sudo, Akiko Tsujimoto, Ryo Yokoyama, Atsushi Kato, Tetsuo Ushiku, Masashi Fukayama, Makiko Itami, Taketo Yamaguchi, Yoshitaka Hippo
Acinar cell carcinoma (ACC) of the pancreas is a malignant tumor of the exocrine cell lineage with a poor prognosis. Due to its rare incidence and technical difficulties, few authentic human cell lines are currently available, hampering detailed investigations of ACC. Therefore, we applied the organoid culture technique to various types of specimens obtained from a single ACC patient, such as bile, biopsy, and resected tumor. Despite initial propagation, none of these organoids achieved long-term proliferation or tolerated cryopreservation, confirming the challenging nature of establishing ACC cell lines...
November 16, 2022: Cancer Science