Noriyuki Imazu, Takehiro Torisu, Akihito Yokote, Junji Umeno, Keisuke Kawasaki, Shin Fujioka, Yuichi Matsuno, Tomohiro Nagasue, Shinichiro Kawatoko, Tomohiko Moriyama, Tomoki Nitahata, Yushi Uchida, Seishi Aihara, Yoshiaki Taniguchi, Yoshinao Oda, Takanari Kitazono
BACKGROUND: Spermidine suppress oxidative stress and is involved in various disease pathogenesis including ulcerative colitis (UC). Arginase 2 (ARG2) plays a central role in the synthesis of spermidine. This study aimed to clarify the effect of endogenously produced spermidine on colitis. METHODS: The physiological role of ARG2 and spermidine was investigated using Arg2-deficient mice with reduced spermidine. Immunohistochemical staining of the rectum was used to analyze ARG2 expression and spermidine levels in healthy controls and UC patients...
May 2, 2024: Journal of Gastroenterology