Beatriz Enguidanos Villena-Rueda, Gustavo Satoru Kajitani, Vanessa Kiyomi Ota, Jessica Honorato-Mauer, Marcos Leite Santoro, Amanda Victória Gomes Bugiga, Joice Santos Rosa, Paula Fontes Asprino, Paula Meneghetti, Ana Claudia Torrecilhas, Paula Intasqui, Ricardo Pimenta Bertolla, Maira Licia Foresti, Maria da Graça Naffah-Mazzacoratti, Luiz Eugênio Araújo de Moraes Mello, Sintia Iole Belangero
Traumatic brain injury (TBI) is a prevalent and debilitating condition, which often leads to the development of post-traumatic epilepsy (PTE), a condition that yet lacks preventive strategies. Biperiden, an anticholinergic drug, is a promising candidate that has shown efficacy in murine models of PTE. MicroRNAs (miRNAs), small regulatory RNAs, can help in understanding the biological basis of PTE and act as TBI- and PTE-relevant biomarkers that can be detected peripherally, as they are present in extracellular vesicles (EVs) that cross the blood-brain barrier...
April 26, 2024: Molecular Neurobiology