Giulia Marrone, Kevin Cornali, Manuela Di Lauro, Maria Josè Ceravolo, Luca Di Marco, Simone Manca di Villahermosa, Anna Paola Mitterhofer, Annalisa Noce
In chronic kidney disease (CKD) patients, several risk factors contribute to the development of endothelial dysfunction (ED), which can be described as an alteration in the cell structure or in the function of the endothelium. Among the well-known CKD-related risk factors capable of altering the production of endothelium-derived relaxing factors, we include asymmetric dimethylarginine increase, reduced dimethylarginine dimethylamine hydrolase enzyme activity, low-grade chronic systemic inflammation, hyperhomocysteinemia, oxidative stress, insulin resistance, alteration of calcium phosphorus metabolism, and early aging...
May 14, 2024: Biomedicines