keyword
https://read.qxmd.com/read/38700964/maze-based-scalable-wireless-power-transmission-experimental-arena-for-freely-moving-small-animals-applications
#1
JOURNAL ARTICLE
Saeideh Pahlavan, Shahin Jafarabadi-Ashtiani, S Abdollah Mirbozorgi
This paper presents an innovative T/Y-maze-based wireless power transmission (WPT) system designed to monitor spatial reference memory and learning behavior in freely moving rats. The system facilitates uninterrupted optical/electrical stimulation and neural recording experiments through the integration of wireless headstages or implants in T/Y maze setups. Utilizing an array of resonators covering the entire underneath of the mazes, the wireless platform ensures scalability with various configurations. The array is designed to ensure a natural localization mechanism to localize the Tx power toward the location of the Rx coil...
May 3, 2024: IEEE Transactions on Biomedical Circuits and Systems
https://read.qxmd.com/read/38700601/elect-prospective-randomized-trial-comparing-microvascular-plug-versus-platinum-fibered-microcoils-for-embolization-of-aneurysm-sac-side-branches-before-endovascular-aortic-aneurysm-repair
#2
JOURNAL ARTICLE
Manuela Konert, Andrej Schmidt, Daniela Branzan, Tim Wittig, Dierk Scheinert, Sabine Steiner
BACKGROUND: Preemptive selective embolization of aneurysm sac side branches (ASSBs) has been proposed to prevent type II endoleak after endovascular aortic aneurysm repair (EVAR). This study aimed to explore if an embolization strategy using microvascular plugs (MVP) reduces intervention time and radiation dose compared to platinum-fibered microcoils. Furthermore, the effectiveness of the devices in occluding the treated artery was assessed. METHODS: Sixty patients scheduled for EVAR underwent percutaneous preemptive embolization of ASSBs using MVPs or coils after a 1:1 randomization...
May 3, 2024: CVIR Endovascular
https://read.qxmd.com/read/38700430/3d-mpea-a-graph-attention-model-guided-computational-approach-for-annotating-unknown-metabolites-in-interactomics-via-mass-spectrometry-focused-multilayer-molecular-networking
#3
JOURNAL ARTICLE
Zibian Fan, Wei Jia
The spectral matching strategy of MS2 fragment spectrograms serves as a ubiquitous method for compound characterization within the matrix. Nevertheless, challenges arise due to the deficiency of distinctions in spectra across instruments caused by coelution peak-derived fragments and incompleteness of the current spectral reference database, leading to dilemma of multidimensional omics annotation. The graph attention model embedded with long short-term memory was proposed as an optimized approach involving integrating similar MS2 spectra into molecular networks according to the isotopic ion peak cluster spacing features to collapse diverse ion species and expand the spectral reference library, which efficiently evaluated the substance capture capacity to 123...
May 3, 2024: Analytical Chemistry
https://read.qxmd.com/read/38699879/crystal-structure-of-human-cep57-c-terminal-domain-reveals-the-presence-of-leucine-zipper-and-the-potential-microtubule-binding-region
#4
JOURNAL ARTICLE
Sanskrita Sukla, Dhayanitha Ranganathan Dhakshinamoorthy, Arvind V Ramesh, Scott Lew, Min Su, Jayaraman Seetharaman
Cep57, a vital centrosome-associated protein, recruits essential regulatory enzymes for centriole duplication. Its dysfunction leads to anomalies, including reduced centrioles and mosaic-variegated aneuploidy syndrome. Despite functional investigations, understanding structural aspects and their correlation with functions is partial till date. We present the structure of human Cep57 C-terminal microtubule binding (MT-BD) domain, revealing conserved motifs ensuring functional preservation across evolution. A leucine zipper, with an adjacent possible microtubule-binding region, potentially forms a stabilizing scaffold for microtubule nucleation-accommodating pulling and tension from growing microtubules...
May 3, 2024: Proteins
https://read.qxmd.com/read/38699318/multimodal-surface-coils-for-low-field-mr-imaging
#5
Yunkun Zhao, Aditya A Bhosale, Xiaoliang Zhang
Low field MRI is safer and more cost effective than the high field MRI. One of the inherent problems of low field MRI is its low signal-to-noise ratio or sensitivity. In this work, we introduce a multimodal surface coil technique for signal excitation and reception to improve the RF magnetic field (B 1 ) efficiency and potentially improve MR sensitivity. The proposed multimodal surface coil consists of multiple identical resonators that are electromagnetically coupled to form a multimodal resonator. The field distribution of its lowest frequency mode is suitable for MR imaging applications...
April 15, 2024: medRxiv
https://read.qxmd.com/read/38698472/factors-influencing-the-posterior-cruciate-ligament-buckling-phenomenon-a-multiple-linear-regression-analysis-of-bony-and-soft-tissue-structures-of-the-knee-joint
#6
JOURNAL ARTICLE
Jiaying Zhang, Tianwen Huang, Zhenyu Jia, Yangyang Yang, Tsung-Yuan Tsai, Pingyue Li
PURPOSE: To determine whether posterior cruciate ligament (PCL) buckling (angular change) is associated with anterior cruciate ligament (ACL) status (intact or ruptured), meniscal bone angle (MBA), anterior tibial translation (ATT), body weight, femoral-tibial rotation (FTR), posterior tibial slope (PTS), PCL length and femoral-tibial distance (FTD) and to identify the factors that have the greatest influence. METHODS: All enrolled participants were scanned with a 3...
May 3, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38698161/superior-semicircular-canal-dehiscence-in-relation-with-the-superior-petrosal-sinus-our-experience-surgical-management-and-systematic-review-of-literature
#7
JOURNAL ARTICLE
Monica Rueda Vega, Carolina López Granados, Ignacio Arístegui Torrano, Eduardo Martín Sanz, Miguel Arístegui Ruiz
PURPOSE: Most of Superior Semicircular Canal Dehiscence (SSCD) are located in the apical region of the SSC. However, in a small number of cases, it may be situated in the medial wall, causing the SSC to contact with the superior petrosal sinus (SPS). The aim of this study is to describe four patients with SSCD involving the superior petrosal sinus (SSCD-SPS) and to perform a review of the literature. METHODS: Observational retrospective study of patients diagnosed of SSCD-SPS in a tertiary referral center...
May 2, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38697262/one-stage-combined-open-and-endovascular-treatment-using-a-hybrid-operating-room-is-safe-and-effective-for-distal-middle-cerebral-artery-aneurysms
#8
JOURNAL ARTICLE
Yuji Kushi, Hirotoshi Imamura, Takaaki Itazu, Saya Ozaki, Akihiro Niwa, Koji Shimonaga, Taichi Ikedo, Eika Hamano, Kiyofumi Yamada, Tsuyoshi Ohta, Tetsu Satow, Tetsuya Yamamoto, Koji Iihara, Hiroharu Kataoka
BACKGROUND: Aneurysms located in the distal middle cerebral artery (MCA) are relatively rare and lack an established treatment strategy. For distal MCA (DMCA) aneurysms, we performed a one-stage combined procedure of endovascular parent artery occlusion (PAO) with coils and superficial temporal artery to middle cerebral artery (STA-MCA) bypass in a hybrid operating room (HOR). The aim of this study was to evaluate the safety and efficacy of this procedure. METHODS: Cases of unruptured DMCA aneurysms treated with the one-stage combined PAO and STA-MCA bypass in HOR were retrospectively examined, and patients' and aneurysmal backgrounds, surgical procedures, and treatment outcomes were analyzed...
April 30, 2024: World Neurosurgery
https://read.qxmd.com/read/38696466/the-hsv-1-pul37-protein-promotes-cell-invasion-by-regulating-the-kinesin-1-motor
#9
JOURNAL ARTICLE
DongHo Kim, Michael A Cianfrocco, Kristen J Verhey, Gregory A Smith
Neurotropic alphaherpesviruses, including herpes simplex virus type 1 (HSV-1), recruit microtubule motor proteins to invade cells. The incoming viral particle traffics to nuclei in a two-step process. First, the particle uses the dynein-dynactin motor to sustain transport to the centrosome. In neurons, this step is responsible for long-distance retrograde axonal transport and is an important component of the neuroinvasive property shared by these viruses. Second, a kinesin-dependent mechanism redirects the particle from the centrosome to the nucleus...
May 7, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38695864/-streptomyces-albipurpureus-sp-nov-a-novel-actinobacterium-with-antimicrobial-activity-isolated-from-the-rhizospheric-soil-of-fritillaria-cirrhosa-d-don
#10
JOURNAL ARTICLE
Xiao Jiang, Yun Tang, You Yang, Jin Tang, Mingyan Hou, Ruiling Liu, Qian Dong, Zhaoxu Ma
A novel actinobacterium, designated strain CWNU-1T , was isolated from the rhizospheric soil of Fritillaria cirrhosa D. Don and examined using a polyphasic taxonomic approach. The organism developed pale blue aerial mycelia that was simply branched and terminated in open or closed coils of three or more volutions on International Streptomyces Project 3 agar. Spores were ellipsoidal to cylindrical with wrinkled surfaces. The strain showed high 16S rRNA gene sequence similarity to Streptomyces kurssanovii NBRC 13192T (98...
May 2024: International Journal of Systematic and Evolutionary Microbiology
https://read.qxmd.com/read/38695533/postoperative-long-term-monitoring-of-mechanical-characteristics-in-reconstructed-soft-tissues-using-biocompatible-immune-tolerant-and-wireless-electronic-sutures
#11
JOURNAL ARTICLE
Mugeun Lee, Yeontaek Lee, Ji Hye Choi, Hwajoong Kim, Daun Jeong, Kijun Park, Jinho Kim, Jae Park, Woo Young Jang, Jungmok Seo, Jaehong Lee
Accurate postoperative assessment of varying mechanical properties is crucial for customizing patient-specific treatments and optimizing rehabilitation strategies following Achilles tendon (AT) rupture and reconstruction surgery. This study introduces a wireless, chip-less, and immune-tolerant in vivo strain-sensing suture designed to continuously monitor mechanical stiffness variations in the reconstructed AT throughout the healing process. This innovative sensing suture integrates a standard medical suturing thread with a wireless fiber strain-sensing system, which incorporates a fiber strain sensor and a double-layered inductive coil for wireless readout...
May 2, 2024: ACS Nano
https://read.qxmd.com/read/38694640/pulmonary-artery-stenosis-after-an-orthotopic-heart-transplantation-a-case-report-with-cardiac-imaging-findings-and-a-literature-review
#12
Pritish Aher, Nini Saad, Aman Aher, Sarv Priya, Alessandra Albini
Pulmonary artery stenosis is a rare complication of heart transplantation. It is typically a congenital condition or can be secondary to rheumatic fever, systemic vasculitis like Behcet's disease, or Takayasu's arteritis. It can also occur as a rarity of a delayed complication post-heart transplant. In this report, we describe the imaging findings of pulmonary artery stenosis in a patient who underwent an orthotopic heart transplant more than 10 years prior. Dynamic cardiac magnetic resonance imaging (MRI), phase contrast imaging, and MR angiography in the management of pulmonary artery stenosis helped in heart and pulmonary circulation...
April 2024: Curēus
https://read.qxmd.com/read/38694595/advances-in-the-endovascular-management-of-cerebrovascular-disease
#13
REVIEW
Ravi Nunna, Farzana Tariq, Fareed Jummah, Navpreet Bains, Adnan I Qureshi, Farhan Siddiq
The field of endovascular neurosurgery has experienced remarkable progress over the last few decades. Endovascular treatments have continued to gain traction as the advancement of technology, technique, and procedural safety has allowed for the expansion of treatment indications of various cerebrovascular pathologies. Interventions such as the coiling of intracranial aneurysms, carotid artery stenting, mechanical thrombectomy in the setting of ischemic stroke, and endovascular embolization of arteriovenous malformations have all seen transformations in their safety and efficacy, expanding the scope of endovascularly treatable conditions and offering new hope to patients who may have otherwise not been candidates for surgical intervention...
2024: Missouri Medicine
https://read.qxmd.com/read/38694106/subarachnoid-hemorrhage-with-takotsubo-syndrome-as-the-prominent-manifestation-a-case-and-literature-review
#14
Shihong Qin, Huifang Teng, Aiping Li, Lile Wang, Ruicheng Hu, Daiyan Fu
BACKGROUND: Takotsubo syndrome, which is often induced by physical or psychological stress, is typically a cardiac syndrome with transient left ventricular dysfunction in the absence of obstructive coronary artery disease. Subarachnoid hemorrhage with typical symptoms and signs is frequently reported, whereas the incidence of subarachnoid hemorrhage with Takotsubo syndrome as the prominent manifestation without a typical headache is rarely reported. CASE DESCRIPTION: We present a rare case of a 63-year-old male patient with cough and fever as the first manifestations, accompanied by mild dizziness, headache, and mental discomfort; however, the patient was eventually diagnosed with atypical subarachnoid hemorrhage with Takotsubo syndrome...
May 15, 2024: Heliyon
https://read.qxmd.com/read/38692120/coiling-an-aneurysm-in-the-twig-like-mca-via-a-marathon-microcatheter-a-case-report
#15
Zibo Zhou, Jinlu Yu
INTRODUCTION AND IMPORTANCE: The twig-like middle cerebral artery (MCA) is rare and has a plexiform network of small vessels that replaces the MCA trunk, with a prevalence ranging from 0.11 %-1.17 %. It can be associated with an aneurysm. A Marathon microcatheter may be an alternative for coiling procedures. However, this technique has rarely been reported. PRESENTATION OF CASE: A 63-year-old man suffered from headaches. The neurological examination results were unremarkable...
April 21, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38691894/amino-acid-propensities-for-secondary-structures-and-its-variation-across-protein-structures-using-exhaustive-pdb-data
#16
JOURNAL ARTICLE
Chandra Sen, V Logashree, Ravindra D Makde, Biplab Ghosh
Amino acid propensities for protein secondary structures are vital for protein structure prediction, understanding folding, and design, and have been studied using various theoretical and experimental methods. Traditional assessments of average propensities using statistical methods have been done on relatively smaller dataset for only a few secondary structures. They also involve averaging out the environmental factors and lack insights into consistency of preferences across diverse protein structures. While a few studies have explored variations in propensities across protein structural classes and folds, exploration of such variations across protein structures remains to be carried out...
April 24, 2024: Computational Biology and Chemistry
https://read.qxmd.com/read/38691123/endovascular-treatment-of-pelvic-venous-congestion-syndrome-in-nulliparous-patients-preliminary-results-of-10%C3%A2-years-of-experience
#17
JOURNAL ARTICLE
Maciej Szmygin, Krzysztof Pyra, Viktor Bèrczi, Sławomir Woźniak, Łukasz Światłowski, Tomasz Paszkowski
PURPOSE: The aim of this article is to present our experience with minimally-invasive treatment for nulliparous patients with pelvic venous congestion syndrome (PVCS) with special attention to anatomical considerations, procedural and clinical outcome. MATERIALS AND METHODS: In this retrospective, monocentric study, 21 patients with PVCS treated from January 2014 to June 2023 were included. The preprocedural imaging evaluation of PVCS was based on color Doppler ultrasound, contrast-enhanced CT and/or MRI...
April 30, 2024: Cardiovascular and Interventional Radiology
https://read.qxmd.com/read/38690726/a-laing-distal-myopathy-associated-proline-substitution-in-the-%C3%AE-myosin-rod-perturbs-myosin-cross-bridging-activity
#18
JOURNAL ARTICLE
Massimo Buvoli, Genevieve Ck Wilson, Ada Buvoli, Jack F Gugel, Abbi Hau, Carsten G Bönnemann, Carmen Paradas, David M Ryba, Kathleen C Woulfe, Lori A Walker, Tommaso Buvoli, Julien Ochala, Leslie A Leinwand
Proline substitutions within the coiled-coil rod region of the β-myosin gene (MYH7) are the predominant mutations causing Laing distal myopathy (MPD1), an autosomal dominant disorder characterized by progressive weakness of distal/proximal muscles. We report that the MDP1 mutation R1500P, studied in what we believe to be the first mouse model for the disease, adversely affected myosin motor activity despite being in the structural rod domain that directs thick filament assembly. Contractility experiments carried out on isolated mutant muscles, myofibrils, and myofibers identified muscle fatigue and weakness phenotypes, an increased rate of actin-myosin detachment, and a conformational shift of the myosin heads toward the more reactive disordered relaxed (DRX) state, causing hypercontractility and greater ATP consumption...
May 1, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38690609/endovascular-coils-extrusion-after-internal-carotid-artery-occlusion-from-management-to-follow-up
#19
JOURNAL ARTICLE
Alessandro Vinciguerra, Mario Turri-Zanoni, Marco Ferrari, Davide Mattavelli, Andrea Giorgianni, Enrico Fazio, Francesco Di Pierro, Vittorio Rampinelli, Luca Gazzini, Benjamin Verillaud, Alberto Schreiber, Luca Calabrese, Maurizio Bignami, Paolo Battaglia, Piero Nicolai, Paolo Castelnuovo, Philippe Herman
ICA coil extrusion (ICA-CE) occurs most frequently in the nasopharyngeal/sinonasal site. Evaluating the ICA coils stability, through an angiography, is of primary importance. ICA-CE management needs to be decided based on the patient's symptoms and general status.
May 1, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38690547/pseudoaneurysm-formation-following-transarterial-embolization-of-traumatic-carotid-cavernous-fistula-with-detachable-balloon-an-institutional-cohort-long-term-study
#20
JOURNAL ARTICLE
Prasert Iampreechakul, Korrapakc Wangtanaphat, Songpol Chuntaroj, Yodkhwan Wattanasen, Sunisa Hangsapruek, Punjama Lertbutsayanukul, Pimchanok Puthkhao, Somkiet Siriwimonmas
BACKGROUND: The goal of therapy for traumatic carotid-cavernous fistula (TCCF) is the elimination of fistula while maintaining patency of the parent artery. The treatment for TCCF has evolved from surgery to endovascular management using detachable balloons, coils, liquid embolic agents, covered stents, or flow-diverter stent through arterial or venous approaches. Despite the withdrawal of detachable balloons from the market in the United States since 2004, transarterial embolization with detachable balloons has currently remained the best initial treatment for TCCF in several countries...
April 28, 2024: World Journal of Radiology
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