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JOURNAL ARTICLE
Seokjin Han, Ji Eun Lee, Seolhee Kang, Minyoung So, Hee Jin, Jang Ho Lee, Sunghyeob Baek, Hyungjin Jun, Tae Yong Kim, Yun-Sil Lee
Standigm ASK™ revolutionizes healthcare by addressing the critical challenge of identifying pivotal target genes in disease mechanisms-a fundamental aspect of drug development success. Standigm ASK™ integrates a unique combination of a heterogeneous knowledge graph (KG) database and an attention-based neural network model, providing interpretable subgraph evidence. Empowering users through an interactive interface, Standigm ASK™ facilitates the exploration of predicted results. Applying Standigm ASK™ to idiopathic pulmonary fibrosis (IPF), a complex lung disease, we focused on genes (AMFR, MDFIC and NR5A2) identified through KG evidence...
January 22, 2024: Briefings in Bioinformatics
#2
JOURNAL ARTICLE
Min Jiang, Jingyi Han, Qun Ma, Xue Chen, Renjie Xu, Qing Wang, Jia Zheng, Weimin Wang, Jun Song, Yefei Huang, Yansu Chen
Cigarette smoking substantially promotes tumorigenesis and progression of colorectal cancer; however, the underlying molecular mechanism remains unclear. Among 662 colorectal cancer patients, our investigation revealed a significant correlation between cigarette smoking and factors, such as large tumor size, poor differentiation, and high degree of invasion. Among the nicotine-derived nitrosamines, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) emerged as the most critical carcinogen, which significantly promoted the malignant progression of colorectal cancer both in vivo and in vitro...
February 3, 2024: Journal of Hazardous Materials
#3
JOURNAL ARTICLE
Michelle Mølgaard Thomsen, Morten Kelder Skouboe, Michelle Møhlenberg, Jian Zhao, Kerstin de Keukeleere, Johanna Laura Heinz, Marvin Werner, Anne Kruse Hollensen, Jonas Lønskov, Ian Nielsen, Madalina Elena Carter-Timofte, Baocun Zhang, Jacob Giehm Mikkelsen, Niels Fisker, Søren R Paludan, Kristian Assing, Trine H Mogensen
Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus exclusively infecting humans, causing two distinct pathologies: varicella (chickenpox) upon primary infection and herpes zoster (shingles) following reactivation. In susceptible individuals, VZV can give rise to more severe clinical manifestations, including disseminated infection, pneumonitis, encephalitis, and vasculopathy with stroke. Here, we describe a 3-year-old boy in whom varicella followed a complicated course with thrombocytopenia, hemorrhagic and necrotic lesions, pneumonitis, and intermittent encephalopathy...
January 26, 2024: Journal of Clinical Immunology
#4
JOURNAL ARTICLE
Qian Liu, Shengwen Chen, Renyun Tian, Binbin Xue, Huiyi Li, Mengmeng Guo, Shun Liu, Ming Yan, Ruina You, Luoling Wang, Di Yang, Mengyu Wan, Haizhen Zhu
The precise regulation of the innate immune response is essential for the maintenance of homeostasis. MAVS and STING play key roles in immune signaling pathways activated by RNA and DNA viruses, respectively. Here, we showed that DHCR24 impaired the antiviral response by targeting MAVS and STING. Notably, DHCR24 interacts with MAVS and STING and inhibits TRIM21-triggered K27-linked ubiquitination of MAVS and AMFR-triggered K27-linked ubiquitination of STING, restraining the activation of MAVS and STING, respectively...
November 30, 2023: Journal of Virology
#5
JOURNAL ARTICLE
Irene Lorenzini, Pierre Labendzki, Clémence Basire, Marielle Hababou-Bernson, Axelle Calcus, Laurianne Cabrera
The amplitude modulation following response (AMFR) is the steady-state auditory response signaling phase-locking to slow variations in the amplitude (AM) of auditory stimuli that provide fundamental acoustic information. From a developmental perspective, the AMFR has been recorded in sleeping infants, compared to sleeping or awake adults. The lack of AMFR recordings in awake infants limits conclusions on the development of phase-locking to AM. Moreover, previous studies assessing phase-locking to AM using non-speech carriers have not included slow AM rates (<20 Hz), which are particularly important for speech processing...
September 1, 2023: Journal of the Acoustical Society of America
#6
JOURNAL ARTICLE
Transcriptomic Profiling of the Bovine Endosalpinx and Endometrium to Identify Putative Embryokines.
Quinn Hoorn, Maria Belen Rabaglino, Tatiane Silva Maia, Masroor Sagheer, Dailin Fuego, Zongliang Jiang, Peter James Hansen
Objectives were to characterize expression of genes encoding for cell signaling ligands in the bovine endosalpinx and endometrium and analyze spatial changes in gene expression. RNA sequencing was performed for endosalpinx from the ampulla of the oviduct and endometrium from the upper and middle uterine horn and uterine body at day 2 after ovulation from ipsilateral and contralateral sides relative to the ovulatory ovary. Of 17,827 unique mRNA transcripts mapped, 2,072 were affected by cranial-caudal position in the reproductive tract and 818 were affected by side (FDR < 0...
September 18, 2023: Physiological Genomics
#7
JOURNAL ARTICLE
Yao Zhang, Xiuping Wang, Guanghui Chen, Yajing Lu, Qiang Chen
OBJECTIVE: One of the important causes of death in cancer patients is malignant metastasis, invasion, and metastasis of tumor cells. Metastasis is also the most basic physiological characteristics and pathogenesis of various tumors. Previously published studies have suggested that autocrine motor factor receptor (AMFR) is the key regulator of tumor cell migration and invasion. Meanwhile, AMFR is highly expressed in esophageal tumors, gastrointestinal tumors, and bladder cancer, and it is also involved in its pathogenesis...
September 13, 2023: Neurological Research
#8
JOURNAL ARTICLE
Devendra Nath Tewari, Asim Biswas, Alok Kumar Chakrabarti, Shanta Dutta
Differential regulation of the 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), which is considered the rate-limiting enzyme of the cholesterol biosynthesis pathway, has been reported in case of infection with many viruses. In our study, we have found that influenza virus infection decreases total cellular cholesterol level which is directly related to the downregulation of HMGCR protein. We found that HMGCR is degraded through ubiquitination and proteasomal-mediated pathway upon viral infection. Upregulation of Autocrine Motility Factor Receptor (AMFR), which is an E3-ubiquitin ligase of HMGCR, was also observed...
August 31, 2023: Virology
#9
JOURNAL ARTICLE
Alexis González, Adriana Covarrubias-Pinto, Ramachandra M Bhaskara, Marius Glogger, Santosh K Kuncha, Audrey Xavier, Eric Seemann, Mohit Misra, Marina E Hoffmann, Bastian Bräuning, Ashwin Balakrishnan, Britta Qualmann, Volker Dötsch, Brenda A Schulman, Michael M Kessels, Christian A Hübner, Mike Heilemann, Gerhard Hummer, Ivan Dikić
The endoplasmic reticulum (ER) undergoes continuous remodelling via a selective autophagy pathway, known as ER-phagy1 . ER-phagy receptors have a central role in this process2 , but the regulatory mechanism remains largely unknown. Here we report that ubiquitination of the ER-phagy receptor FAM134B within its reticulon homology domain (RHD) promotes receptor clustering and binding to lipidated LC3B, thereby stimulating ER-phagy. Molecular dynamics (MD) simulations showed how ubiquitination perturbs the RHD structure in model bilayers and enhances membrane curvature induction...
June 2023: Nature
#10
JOURNAL ARTICLE
Suosi Liu, Ziying Zhang, Yu Wang, Yu Zhang, Jiali Min, Xia Li, Shanshan Liu
Macrophage M2 polarization has been identified in the pathogenesis of pulmonary fibrosis (PF), but the mediators that drive the macrophage M2 program in PF need to be clarified. We showed that the expression of AMFR and CCR8, two known receptors of CCL1, was increased in macrophages from lungs of mice with bleomycin (BLM)-induced PF. Deficiency in either AMFR or CCR8 in macrophages protected mice from BLM-induced PF. In vitro experiments revealed that CCL1 recruited macrophages by binding to its classical receptor CCR8 and drove the macrophage M2 phenotype via its interaction with the recently identified receptor AMFR...
May 21, 2023: International Immunopharmacology
#11
JOURNAL ARTICLE
Ruizhi Deng, Eva Medico-Salsench, Anita Nikoncuk, Reshmi Ramakrishnan, Kristina Lanko, Nikolas A Kühn, Herma C van der Linde, Sarah Lor-Zade, Fatimah Albuainain, Yuwei Shi, Soheil Yousefi, Ivan Capo, Evita Medici van den Herik, Marjon van Slegtenhorst, Rick van Minkelen, Geert Geeven, Monique T Mulder, George J G Ruijter, Dieter Lütjohann, Edwin H Jacobs, Henry Houlden, Alistair T Pagnamenta, Kay Metcalfe, Adam Jackson, Siddharth Banka, Lenika De Simone, Abigail Schwaede, Nancy Kuntz, Timothy Blake Palculict, Safdar Abbas, Muhammad Umair, Mohammed AlMuhaizea, Dilek Colak, Hanan AlQudairy, Maysoon Alsagob, Catarina Pereira, Roberta Trunzo, Vasiliki Karageorgou, Aida M Bertoli-Avella, Peter Bauer, Arjan Bouman, Lies H Hoefsloot, Tjakko J van Ham, Mahmoud Issa, Maha S Zaki, Joseph G Gleeson, Rob Willemsen, Namik Kaya, Stefan T Arold, Reza Maroofian, Leslie E Sanderson, Tahsin Stefan Barakat
Hereditary spastic paraplegias (HSP) are rare, inherited neurodegenerative or neurodevelopmental disorders that mainly present with lower limb spasticity and muscle weakness due to motor neuron dysfunction. Whole genome sequencing identified bi-allelic truncating variants in AMFR, encoding a RING-H2 finger E3 ubiquitin ligase anchored at the membrane of the endoplasmic reticulum (ER), in two previously genetically unexplained HSP-affected siblings. Subsequently, international collaboration recognized additional HSP-affected individuals with similar bi-allelic truncating AMFR variants, resulting in a cohort of 20 individuals from 8 unrelated, consanguineous families...
April 29, 2023: Acta Neuropathologica
#12
JOURNAL ARTICLE
Gui Qian, Yihua Zhang, Yinan Liu, Manman Li, Bowen Xin, Wenyi Jiang, Wendong Han, Yu Wang, Xian Tang, Liuyan Li, Lingyan Zhu, Tao Sun, Bo Yan, Yongtang Zheng, Jianqing Xu, Baoxue Ge, Zheng Zhang, Dapeng Yan
Cyclic GMP-AMP synthase (cGAS) recognizes Y-form cDNA of human immunodeficiency virus type 1 (HIV-1) and initiates antiviral immune response through cGAS-stimulator of interferon genes (STING)-TBK1-IRF3-type I interferon (IFN-I) signalingcascade. Here, we report that the HIV-1 p6 protein suppresses HIV-1-stimulated expression of IFN-I and promotes immune evasion. Mechanistically, the glutamylated p6 at residue Glu6 inhibits the interaction between STING and tripartite motif protein 32 (TRIM32) or autocrine motility factor receptor (AMFR)...
April 25, 2023: Cell Reports
#13
JOURNAL ARTICLE
Lei Sun, Haibo Zhang, Huihui Zhang, Xinyi Lou, Zhiming Wang, Yaxian Wu, Xinyi Yang, Daijie Chen, Beining Guo, Ao Zhang, Feng Qian
Staphylococcus aureus invades cells and persists intracellularly, causing persistent inflammation that is notoriously difficult to treat. Here we investigated host-pathogen interactions underlying intracellular S. aureus infection in macrophages and discovered that the endoplasmic reticulum (ER) is an important cellular compartment for intracellular S. aureus infection. Using CRISPR-Cas9 guide RNA library screening, we determined that the autocrine motility factor receptor (AMFR), an ER-resident E3 ubiquitin ligase, played an essential role in mediating intracellular S...
January 2, 2023: Nature Microbiology
#14
JOURNAL ARTICLE
Jing Xu, Hongfei Ma, Qi Wang, Hui Zhang
The aime of this study was to evaluate the clinicopathological significance of autocrine motility factor receptor (AMFR) expression in a variety of human invasive micropapillary carcinomas (IMPC). AMFR expression was compared in 111 samples of a variety of human IMPCs which had intrinsic non-micropapillary components and with 26 cases of control pulmonary adenocarcinoma (CPA, carcinoma without an IMPC component) by immunohistochemistry (IHC). In the 137 cases analysed, AMFR expression was significantly elevated in the IMPC components compared to the non-IMPC components (p = ...
December 28, 2022: International Journal of Experimental Pathology
#15
JOURNAL ARTICLE
Lepeng Gao, Chang Zhang, Yingying Zheng, Deyi Wu, Xinyuan Chen, Hainan Lan, Xin Zheng, Hao Wu, Suo Li
In vitro-cultured oocytes are separated from the follicular microenvironment in vivo and are more vulnerable than in vivo oocytes to changes in the external environment. This vulnerability disrupts the homeostasis of the intracellular environment, affecting oocyte meiotic completion and subsequent embryonic developmental competence in vitro. Glycine, one of the main components of glutathione (GSH), plays an important role in the protection of porcine oocytes in vitro. However, the protective mechanism of glycine needs to be further clarified...
December 27, 2022: Journal of Animal Science
#16
JOURNAL ARTICLE
Shuai Liu, Yang Li, Xian Wei, Dilare Adi, Yong-Tao Wang, Min Han, Fen Liu, Bang-Dang Chen, Xiao-Mei Li, Yi-Ning Yang, Zhen-Yan Fu, Yi-Tong Ma
BACKGROUND: Coronary heart disease has become the leading cause of death in developed countries, and dyslipidemia is closely associated with the risk of cardiovascular disease. Dyslipidemia is caused by the abnormal regulation of several genes and signaling pathways, and dyslipidemia is influenced mainly by genetic variation. AMFR, FBXW7, INSIG1, INSIG2 , and MBTPS1 genes are associated with lipid metabolism. In a recent GWAS study, the GRINA gene has been reported to be associated with dyslipidemia, but its molecular mechanism has not been thoroughly investigated...
2022: PeerJ
#17
JOURNAL ARTICLE
Niyazi O Arslan, Xin Luo
Various neural health estimates have been shown to indicate the density of spiral ganglion neurons in animal and modeling studies of cochlear implants (CIs). However, when applied to human CI users, these neural health estimates based on psychophysical and electrophysiological measures are not consistently correlated with each other or with the speech recognition performance. This study investigated whether the neural health estimates have stronger correlations with the temporal and place pitch sensitivity than with the speech recognition performance...
November 3, 2022: Journal of the Association for Research in Otolaryngology: JARO
#18
JOURNAL ARTICLE
Michiko Horiguchi, Yuya Tsurudome, Kentaro Ushijima
Type 1 diabetes mellitus (T1DM) is characterized by pancreatic beta cell destruction by autoantibodies and other factors, resulting in insulin secretion deficiency. Therefore, beta cell regeneration would be necessary to cure the disease. Nevertheless, the impact of type 1 diabetes on the stemness and transplantation efficiency of stem cells has not been previously described. In this study, we used next-generation sequencing to identify genes differentially expressed in T1DM adipose-derived stem cells (T1DM ADSCs) that originate from patients with type 1 diabetes...
2022: Frontiers in Pharmacology
#19
JOURNAL ARTICLE
Longze Sha, Guanjun Li, Xiuneng Zhang, Yarong Lin, Yunjie Qiu, Yu Deng, Wanwan Zhu, Qi Xu
Dysregulation of excitatory amino acid transporter 2 (EAAT2) contributes to the development of temporal lobe epilepsy (TLE). Several strategies for increasing total EAAT2 levels have been proposed. However, the mechanism underlying the oligomeric assembly of EAAT2, impairment of which inhibits the formation of functional oligomers by EAAT2 monomers, is still poorly understood. In the present study, we identified E3 ubiquitin ligase AMFR as an EAAT2-interacting protein. AMFR specifically increased the level of EAAT2 oligomers rather than inducing protein degradation through K542-specific ubiquitination...
August 8, 2022: JCI Insight
#20
JOURNAL ARTICLE
Huihui Zhang, Feng Qian, Lei Sun
No abstract text is available yet for this article.
August 26, 2022: Journal of Molecular Cell Biology
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