Hend M Hassan, Nehal H M Abdel-Halim, Ibrahim El-Shenbaby, Manar A Helmy, Maha O Hammad, Ola A Habotta, Eman M El Nashar, Mansour A Alghamdi, Rashid A Aldahhan, Khulood M Al-Khater, Basmah Almohaywi, Eman A E Farrag
Introduction: Administration of high doses of acetaminophen (APAP) results in liver injury. Oxidative stress and iron overload play roles in the pathogenesis of APAP-induced hepatotoxicity. The present study assessed the potential hepatoprotective effects of phytic acid (PA), a natural antioxidant and iron chelator, on APAP-induced hepatotoxicity and the possible underlying mechanism through its effects on CYP2E1 gene expression, iron homeostasis, oxidative stress, and SIRT -1 expression levels. Methods: Twenty-four adult male albino mice were used in this study...
2024: Frontiers in Pharmacology